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"Powell, A."
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Global Epidemiology of Lung Cancer
While lung cancer has been the leading cause of cancer-related deaths for many years in the United States, incidence and mortality statistics - among other measures - vary widely worldwide. The aim of this study was to review the evidence on lung cancer epidemiology, including data of international scope with comparisons of economically, socially, and biologically different patient groups. In industrialized nations, evolving social and cultural smoking patterns have led to rising or plateauing rates of lung cancer in women, lagging the long-declining smoking and cancer incidence rates in men. In contrast, emerging economies vary widely in smoking practices and cancer incidence but commonly also harbor risks from environmental exposures, particularly widespread air pollution. Recent research has also revealed clinical, radiologic, and pathologic correlates, leading to greater knowledge in molecular profiling and targeted therapeutics, as well as an emphasis on the rising incidence of adenocarcinoma histology. Furthermore, emergent evidence about the benefits of lung cancer screening has led to efforts to identify high-risk smokers and development of prediction tools. This review also includes a discussion on the epidemiologic characteristics of special groups including women and nonsmokers. Varying trends in smoking largely dictate international patterns in lung cancer incidence and mortality. With declining smoking rates in developed countries and knowledge gains made through molecular profiling of tumors, the emergence of new risk factors and disease features will lead to changes in the landscape of lung cancer epidemiology.
Journal Article
Racing to Justice
Renowned social justice advocate john a. powell persuasively argues that we have not achieved a post-racial society and that there is much work to do to redeem the American promise of inclusive democracy. Culled from a decade of writing about social justice and spirituality, these meditations on race, identity, and social policy provide an outline for laying claim to our shared humanity and a way toward healing ourselves and securing our future. Racing to Justice challenges us to replace attitudes and institutions that promote and perpetuate social suffering with those that foster relationships and a way of being that transcends disconnection and separation.
eBook
Vanishing America : species extinction, racial peril, and the origins of conservation
Vanishing America examines discourses of extinction - of species and of peoples - to identify key transitions in American environmental and racial thought between the mid nineteenth and mid twentieth centuries. By 1900 many whites had begun to see themselves as an imperiled race and increasingly identified with the nation's dwindling wildlife. Fearing they would share Indians' anticipated extinction, elite environmental pundits developed racially-charged preservationist arguments that influenced the development of scientific racism, eugenics, immigration restriction, and population control, and which still inform the modern environmental movement. Vanishing America suggests that a long history of drawing connections between environmental health and the mental and physical wellbeing of white Americans has helped create an enduring divide between the nation's environmental movement, on the one hand, and the nation's poor people and nonwhite races on the other.-- Provided by publisher
Book
Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock
Inflammatory caspases, such as caspase-1 and -11, mediate innate immune detection of pathogens. Caspase-11 induces pyroptosis, a form of programmed cell death, and specifically defends against bacterial pathogens that invade the cytosol. During endotoxemia, however, excessive caspase-11 activation causes shock. We report that contamination of the cytoplasm by lipopolysaccharide (LPS) is the signal that triggers caspase-11 activation in mice. Specifically, caspase-11 responds to penta- and hexa-acylated lipid A, whereas tetra-acylated lipid A is not detected, providing a mechanism of evasion for cytosol-invasive Francisella. Priming the caspase-11 pathway in vivo resulted in extreme sensitivity to subsequent LPS challenge in both wild-type and Tlr4-deficient mice, whereas Casp11-deficient mice were relatively resistant. Together, our data reveal a new pathway for detecting cytoplasmic LPS.
Journal Article
The climate action handbook : a visual guide to 100 climate solutions for everyone
\"Every Action Matters will lay out the issues facing the planet and offer up 100 important actions that readers can take to help slow the adverse affects of climate change. Each action will get a spread and be accompanied by an infographic, statistic, or display quote to provide visual impact to the topic at hand\"-- Provided by publisher.
Book
Huygens’ Metadevices for Parametric Waves
Huygens’ metasurfaces demonstrate almost arbitrary control over the shape of a scattered beam; however, its spatial profile is typically fixed at the fabrication time. The dynamic reconfiguration of this beam profile with tunable elements remains challenging, due to the need to maintain the Huygens’ condition across the tuning range. In this work, we experimentally demonstrate that a time-varying metadevice which performs frequency conversion can steer transmitted or reflected beams in an almost arbitrary manner, with fully dynamic control. Our time-varying Huygens’ metadevice is made of both electric and magnetic meta-atoms with independently controlled modulation, and the phase of this modulation is imprinted on the scattered parametric waves, controlling their shapes and directions. We develop a theory which shows how the scattering directionality, phase, and conversion efficiency of sidebands can be manipulated almost arbitrarily. We demonstrate novel effects including all-angle beam steering and frequency-multiplexed functionalities at microwave frequencies around 4 GHz, using varactor diodes as tunable elements. We believe that the concept can be extended to other frequency bands, enabling metasurfaces with an arbitrary phase pattern that can be dynamically tuned over the complete2πrange.
Journal Article
Extinction and optical depth retrievals for CALIPSO's Version 4 data release
The Cloud–Aerosol Lidar with Orthogonal Polarization (CALIOP) on board the Cloud–Aerosol Lidar Infrared Pathfinder Satellite Observations (CALIPSO) satellite has been making near-global height-resolved measurements of cloud and aerosol layers since mid-June 2006. Version 4.10 (V4) of the CALIOP data products, released in November 2016, introduces extensive upgrades to the algorithms used to retrieve the spatial and optical properties of these layers, and thus there are both obvious and subtle differences between V4 and previous data releases. This paper describes the improvements made to the extinction retrieval algorithms and illustrates the impacts of these changes on the extinction and optical depth estimates reported in the CALIPSO lidar level 2 data products. The lidar ratios for both aerosols and ice clouds are generally higher than in previous data releases, resulting in generally higher extinction coefficients and optical depths in V4. A newly implemented algorithm for retrieving extinction coefficients in opaque layers is described and its impact examined. Precise lidar ratio estimates are also retrieved in these opaque layers. For semi-transparent cirrus clouds, comparisons between CALIOP V4 optical depths and the optical depths reported by MODIS collection 6 show substantial improvements relative to earlier comparisons between CALIOP version 3 and MODIS collection 5.
Journal Article