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"Powell, Robert G"
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Classroom Communication and Diversity
Classroom Communication and Diversity by Robert G. Powell and Dana Caseau is reviewed.
Book Review
High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes
Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening （HTS） data for 3 762 distinct global gene knockout （KO） mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type （WT） cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging, ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass： 23 previously reported genes （Calcr, Cebpb, Crtap, Dcstamp, Dkkl, Duoxa2, Enppl, Fgf23, Kissl/Kisslr, Kl （Klotho）, Lrp5, Mstn, Neol, Npr2, Ostml, Postn, Sfrp4, S1c30a5, Sic39a13, Sost, Sumf1, Src, Wnt10b）, five novel genes extensively characterized （Cldn18, Fam20c, Lrrkl, Sgpll, Wnt16）, five novel genes with preliminary characterization （Agpat2, RassfS, Slc10a7, Stc26a7, Slc30a10） and three novel undisclosed genes coding for potential osteoporosis drug targets.
Journal Article
How importers can protect themselves in international transactions
In their negotiations, importers often fail to give adequate attention to including the proper payment mechanism, document control, and/or analysis of the performance risk of the exporter. The 4 primary methods of payment used in international transactions are reviewed. Exporters may require payment in advance, wherein importers wire transfer funds in anticipation of receipt of their goods. This is the least desirable option for importers. Letters of credit (L/C) ensure payment by one party to another by substituting the full faith and credit of a commercial bank for that of the buyer. International collections, a universally accepted banking mechanism governed by the Uniform Rules for Collection, are frequently used when the creditworthiness and performance of the parties to the transaction are reasonably well established. In open account transactions, importers receive the goods, followed by the invoice and related documents, and then make payment.
Magazine Article
Climbing the risk ladder
There are 4 primary methods of making payment: open account, collection, letters of credit, and cash in advance. The risk ladder displays each of these payment methods arranged in terms of the degree of payment risk assumed by the seller. As sellers move down the ladder from open account toward cash in advance, they reduce their degree of payment risk. Buyers have the opposite experience, with open account terms being the most advantageous and cash in advance the least beneficial.
Magazine Article
Transform your foreign receivables into borrowing power
Companies that rely upon foreign receivables to obtain working capital financing may find borrowing difficult. However, bankers may accept certain foreign receivables for inclusion in an exporter's borrowing formula if they are government insured. The Export-Import Bank of the US offers a Multi-Buyer Insurance Policy that insures an exporter's short-term export sales with repayment terms up to 180 days. Receivables from approved sovereign obligors are 100% insured without applications of a deductible. When assignment of the proceeds of an insurance policy is acknowledged by Eximbank, a domestic bank with trade finance experience can more comfortably lend against the approved foreign receivables up to the coverage percentage and for the terms offered by Eximbank. The Multi-Buyer policy allows exporters to move into new markets more easily by allowing them to offer better terms to potential customers.
Magazine Article
Robot-Assisted Therapy for Long-Term Upper-Limb Impairment after Stroke
In this randomized study evaluating rehabilitative therapies in patients with long-term upper-limb impairment after stroke, outcomes at 12 weeks were similar with robot-assisted therapy, intensive comparison therapy, and usual care. In secondary analyses, modest improvements were observed over 36 weeks in both intensive-therapy groups, as compared with the usual-care group.
In patients with long-term upper-limb impairment after stroke, outcomes at 12 weeks were similar with robot-assisted therapy, intensive comparison therapy, and usual care. Modest improvements were observed over 36 weeks in both intensive-therapy groups.
Stroke is a leading cause of long-term disability in the United States, affecting an estimated 6.4 million Americans.
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Long-term disability is often associated with persistent impairment of an upper limb.
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Despite the development of many programs for recovery after stroke, the effectiveness of rehabilitation in improving functioning and quality of life for patients with deficits more than 6 months after a stroke has not been definitively shown. Robotic rehabilitation devices have the potential to deliver high-intensity, reproducible therapy. Advances in robotics and an increased understanding of the latent neurologic potential for stroke recovery led to our initiation of this multicenter, . . .
Journal Article