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To evaluate the efficacy of switching to once-weekly subcutaneous semaglutide in patients with type 2 diabetes mellitus (T2DM) who were previously treated with other glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in a real-world setting in Spain. The REAL Life study of SEMaglutide in Patients with Type 2 diabetes in Spain (REALSEM-SP) was conducted in four endocrinology departments in Madrid, Spain. Adult patients with T2DM who were prescribed once-weekly (OW) subcutaneous semaglutide and had been previously treated with other GLP-1 RAs were included. Baseline characteristics, including demographic, anthropometric, and laboratory variables, were recorded at baseline and at 6 ± 3 and 12 ± 3 months of follow-up. The primary outcome was the change in HbA1c at 12 ± 3 months of follow-up, with secondary outcomes including changes in weight, BMI, and other glycemic parameters. A total of 267 patients were included in the analysis, with a mean age of 61.6 years and a mean T2DM duration of 11.3 years. The majority of patients had grade 1 or 2 obesity at baseline. Switching to OW-semaglutide was associated with a significant reduction in HbA1c from baseline to 13 months (−0.35 % ± 0.81). Patients who reached the 1.0 mg OW-dose showed a significant reduction in HbA1c compared to those on the ≤0.5 mg OW-dose. Significant reductions in weight, BMI, and fasting plasma glucose were also observed. Adverse events were mostly gastrointestinal and led to treatment withdrawal in few cases. Switching to OW-subcutaneous semaglutide in patients with T2DM previously treated with other GLP-1 RAs was associated to improvements in glycemic control and weight management in a real-world setting in Spain. These findings support the use of OW-semaglutide as an effective option for patients with T2DM who require additional glycemic control and weight management. •Semaglutide superior to GLP-1 RAs: Real-world switch achieves better glycemic control and weight loss.•Efficacy confirmed: 1.0 mg OW dose shows significant HbA1c reduction compared to lower dose.•No baseline therapy bias: Equal HbA1c reduction regardless of prior insulin or SGLT2i therapy.•Gender disparity: Males exhibit superior glycemic control post-switch to semaglutide.•Significant weight reduction observed, more pronounced in higher BMI, insulin naïve, SGLT2i naïve and in women.

This systematic review examined the validity and reliability of wearable inertial sensor systems to quantify spatiotemporal gait parameters in post-stroke adults, a population in which gait asymmetry and altered motor control challenge accurate measurement. Sixteen studies involving 300 participants were included. Spatial parameters gait speed, cadence, and step/stride length showed consistently good-to-excellent agreement with reference systems (ICC 0.85-0.98; 95% LoA ±0.03-0.08 m/s for gait speed, ±4-10 steps/min for cadence, and ±3-8 cm for step/stride length) and high test-retest reliability. Temporal parameters demonstrated greater heterogeneity, with larger errors and lower concordance (ICC 0.40-0.85; LoA ±0.04-0.12 s), particularly for swing time (ICC 0.40-0.70; LoA up to ±0.15 s). Paretic-side measurements showed 10-20% lower concordance and 30-50% wider limits of agreement compared with the non-paretic side, although within-subject reliability remained moderate to high. No consistent influence of sensor number on measurement accuracy was observed. Overall, wearable inertial sensors provide robust estimates of spatial gait parameters, whereas temporal outcomes especially swing time remain limited due to challenges in gait event detection under stroke-related biomechanical alterations. These findings highlight the need for standardized protocols and improved algorithms to enhance comparability across studies and support broader clinical adoption.

This article analyses the energy behaviour of an electric golf car as the penultimate step to developing a fuel cell electric light-duty vehicle. The configuration used is that of an extended range electric vehicle with a fuel cell (FCEREV). The system includes two energy storage sources to drive the powertrain: the first consists of using energy stored in a lead-acid battery pack and the second consists of hydrogen stored in metal hydrides and its use is based on a 200 W polymer electrolyte membrane (PEM) type fuel cell. The type of system also allows charging the vehicle by connecting it to the electrical grid. The aim of the proposed design is to extend the autonomy of the golf car allowing it to make several trips in one day without having to charge it by connecting it to the electrical grid, considering the large amount of time this would take. The analysis of the performance has been set based on the current regulation and is therefore within the range for these types of vehicles. This arrangement extends autonomy by 38% as opposed to the pure EV electrical mode, which allows for making at least two more trips with a hydrogen tank filled with 0.085 kg H2.

Late blight (LB) is the main potato disease worldwide and one of the most important ways to control it is the use of resistant varieties. Twenty-two potato clones from the B3 breeding population developed by the International Potato Center with high resistance to the disease and two susceptible controls were inoculated with four Peruvian complex isolates (POX67, PPA61, PLL69, and PPI112) of Phytophthora infestans, with complex virulence on potato. Whole plant inoculation assays were carried out under greenhouse and humid chamber conditions in Lima, Peru, and data obtained were correlated with data from field assays carried out in Oxapampa (Pasco), a CIP breeding site in the Peruvian rain forest. High significant correlations (α = 0.01) were found in the resistance to LB shown by potato clones, the values of the correlations under greenhouse conditions between the isolates POX67, PPA61, and PLL69 with the resistance in the field were r = 0.93, 0.92 and 0.80, respectively and under humid chamber conditions were r = 0.94, 0.93 and 0.94, respectively. Moderate correlations were found between resistance in the field and in the greenhouse (r = 0.69) and the field and in humid chamber conditions (r = 0.77) for inoculations with PPI112 isolate. The twenty-two clones tested in this study showed phenotypic stability for LB resistance according to non-parametric analysis.

Solar energy storage is key to overcoming the intermittent character of sunlight. Herein, we present new norbornadiene-quadricyclane pairs for molecular solar thermal energy storage working in highly concentrated neutral water solutions and solid state. This provides a sustainable approach to the storage of solar energy through the photochemical preparation of high-energy, metastable isomers in previously unattainable 1.64 M solutions. New compounds can be stored for 1.9 years and are stable in solid state, allowing for the preparation of up to 3 M water solutions. Catalyzed back-conversion ensures efficient heat release and starting material recovery with remarkable fatigue resistance. Affordable and scalable synthesis enables gram-scale use and macroscopic heat release in two different regimes: prompt temperature boost or extended constant heating. The best candidate can also be utilized in solid state, providing a ΔT of 39.6ºC and fully recyclable use. These results highlight a promising avenue for the practical application of MOST technology.

Objectives. To test the hypothesis that law enforcement efforts to disrupt local drug markets by seizing opioids or stimulants are associated with increased spatiotemporal clustering of overdose events in the surrounding geographic area. Methods. We performed a retrospective (January 1, 2020 to December 31, 2021), population-based cohort study using administrative data from Marion County, Indiana. We compared frequency and characteristics of drug (i.e., opioids and stimulants) seizures with changes in fatal overdose, emergency medical services nonfatal overdose calls for service, and naloxone administration in the geographic area and time following the seizures. Results. Within 7, 14, and 21 days, opioid-related law enforcement drug seizures were significantly associated with increased spatiotemporal clustering of overdoses within radii of 100, 250, and 500 meters. For example, the observed number of fatal overdoses was two-fold higher than expected under the null distribution within 7 days and 500 meters following opioid-related seizures. To a lesser extent, stimulant-related drug seizures were associated with increased spatiotemporal clustering overdose. Conclusions. Supply-side enforcement interventions and drug policies should be further explored to determine whether they exacerbate an ongoing overdose epidemic and negatively affect the nation’s life expectancy. (Am J Public Health. 2023;113(7):750–758. https://doi.org/10.2105/AJPH.2023.307291 )

Mycorrhizal plants display enhanced resistance to several pathogens. However, the molecular mechanisms regulating mycorrhiza-induced resistance (MIR) are still elusive. We aim to study the mechanisms underlying MIR against Botrytis cinerea and the role of callose accumulation during this process. Mycorrhizal tomato plants inoculated with Rhizoglomus irregularis displayed callose priming upon B. cinerea infection. The callose inhibitor 2-deoxy-d-glucose abolished MIR, confirming the relevance of callose in the bioprotection phenomena. While studying the mechanisms underlying mycorrhiza-induced callose priming, we found that mycorrhizal plants display an enhanced starch degradation rate that is correlated with increased levels of β-amylase1 transcripts following pathogen infection. Starch mobilization in mycorrhizal plants seems coordinated with the increased transcription of sugar transporter and invertase genes. Moreover, the expression levels of genes encoding the vesicular trafficking proteins ATL31 and SYP121 and callose synthase PMR4 were higher in the mycorrhizal plants and further boosted by subsequent pathogen infection. All these proteins play a key role in the priming of callose accumulation in Arabidopsis, suggesting that callose priming is an induced resistance mechanism conserved in different plant species. This evidence highlights the importance of sugar mobilization and vesicular trafficking in the priming of callose as a defence mechanism in mycorrhizainduced resistance.

Arbuscular mycorrhizal (AM) symbioses are mutualistic associations between soil fungi and most vascular plants. The symbiosis significantly affects the host physiology in terms of nutrition and stress resistance. Despite the lack of host range specificity of the interaction, functional diversity between AM fungal species exists. The interaction is finely regulated according to plant and fungal characters, and plant hormones are believed to orchestrate the modifications in the host plant. Using tomato as a model, an integrative analysis of the host response to different mycorrhizal fungi was performed combining multiple hormone determination and transcriptional profiling. Analysis of ethylene-, abscisic acid-, salicylic acid-, and jasmonate-related compounds evidenced common and divergent responses of tomato roots to Glomus mosseae and Glomus intraradices, two fungi differing in their colonization abilities and impact on the host. Both hormonal and transcriptional analyses revealed, among others, regulation of the oxylipin pathway during the AM symbiosis and point to a key regulatory role for jasmonates. In addition, the results suggest that specific responses to particular fungi underlie the differential impact of individual AM fungi on plant physiology, and particularly on its ability to cope with biotic stresses.

Arbuscular mycorrhizal (AM) symbioses can improve plant tolerance to multiple stresses. We compared three AM fungi (AMF) from different genera, one of them isolated from a dry and saline environment, in terms of their ability to increase tomato tolerance to moderate or severe drought or salt stress. Plant physiological parameters and metabolic profiles were compared in order to find the molecular mechanisms underlying plant protection against stress. Mycorrhizal growth response was determined, and ultrahigh-performance LC-MS was used to compare the metabolic profile of plants under the different treatments. All AMF increased plant tolerance to stress, and the positive effects of the symbiosis were correlated with the severity of the stress. The AMF isolated from the stressful environment was the most effective in improving plant tolerance to salt stress. Differentially accumulated compounds were identified and the antistress properties of some of them were confirmed. We demonstrate that AM symbioses increase plant metabolic plasticity to cope with stress. Some responses were common to all AMF tested, while others were specifically related to particular isolates. Important metabolism reprograming was evidenced upon salt stress, and we identified metabolic pathways and compounds differentially accumulated in mycorrhizas that may underlie their enhanced tolerance to stress.

A bstract Using an effective field theory approach, we study coherent neutrino scattering on nuclei, in the setup pertinent to the COHERENT experiment. We include non-standard effects both in neutrino production and detection, with an arbitrary flavor structure, with all leading Wilson coefficients simultaneously present, and without assuming factorization in flux times cross section. A concise description of the COHERENT event rate is obtained by introducing three generalized weak charges, which can be associated (in a certain sense) to the production and scattering of ν e , ν μ and ν ¯ μ on the nuclear target. Our results are presented in a convenient form that can be trivially applied to specific New Physics scenarios. In particular, we find that existing COHERENT measurements provide percent level constraints on two combinations of Wilson coefficients. These constraints have a visible impact on the global SMEFT fit, even in the constrained flavor-blind setup. The improvement, which affects certain 4-fermion LLQQ operators, is significantly more important in a flavor-general SMEFT. Our work shows that COHERENT data should be included in electroweak precision studies from now on.