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Background: Nab-paclitaxel and gemcitabine have demonstrated a survival benefit over gemcitabine alone in advanced pancreatic cancer (PDA). This study aimed to investigate the clinical, biological, and imaging effects of the regimen in patients with operable PDA. Methods: Patients with operable PDA received two cycles of nab-paclitaxel and gemcitabine before surgical resection. FDG-PET and CA19.9 tumour marker levels were used to measure clinical activity. Effects on tumour stroma were determined by endoscopic ultrasound (EUS) elastography. The collagen content and architecture as well as density of cancer-associated fibroblasts (CAFs) were determined in the resected surgical specimen and compared with a group of untreated and treated with conventional chemoradiation therapy controls. A co-clinical study in a mouse model of PDA was conducted to differentiate between the effects of nab-paclitaxel and gemcitabine. Results: A total of 16 patients were enrolled. Treatment resulted in significant antitumour effects with 50% of patients achieving a >75% decrease in circulating CA19.9 tumour marker and a response by FDG-PET. There was also a significant decrement in tumour stiffness as measured by EUS elastography. Seven of 12 patients who completed treatment and were operated had major pathological regressions. Analysis of residual tumours showed a marked disorganised collagen with a very low density of CAF, which was not observed in the untreated or conventionally treated control groups. The preclinical co-clinical study showed that these effects were specific of nab-paclitaxel and not gemcitabine. Conclusion: These data suggest that nab-paclitaxel and gemcitabine decreases CAF content inducing a marked alteration in cancer stroma that results in tumour softening. This regimen should be studied in patients with operable PDA.

The 2030 Agenda sets out seventeen Sustainable Development Goals (SDGs). The educational goal is to promote the education of citizens on sustainable development, among other things. Educating today’s digital citizens on sustainability means training them for justice and social activism, commitment and political engagement. However, research into the subject shows a lack of consistency in the education of university students. This paper presents a study of students of Education, on education on sustainability through the practice of active and critical digital citizenship. A quasi-experimental method was used to learn about the behaviors of digital citizens, and intervention was carried out by means of an SDG-focused workshop and observation of the final level of commitment. The results show a positive level of commitment and digital activism around content related to sustainable development, which can be addressed from the university syllabus in a cross-curricular way.

This empirical study investigates the transformation of religiosity in Spain over the two decades from 1998 to 2018, with a focus on social changes in belief, religiosity, and religious controversies, as well as the evolution of religious socialization. By incorporating the concepts of religious socialization and religious controversy into the theoretical framework, the study analyzes data from three waves of surveys on religious topics conducted in Spain during this period. The descriptive findings reveal a clear trend towards a decline in religious belief, religiosity, and practice, coupled with a significant rise in atheistic and non-religious attitudes. Moreover, the explanatory analysis indicates a reduction in the impact of primary religious socialization during childhood, while sociodemographic variables such as age and ideology have either maintained or increased their influence in shaping religious or non-religious positions. The study identifies religious polarization, driven by a marked increase in atheism and non-religion, and suggests that intergenerational and ideological shifts are more critical in explaining changes in religious beliefs than traditional religious socialization processes.

Generational approaches to climate engagement among older adults remain limited. This study examines the evolution of eco-anxiety, environmental activism, and pro-environmental behavior from a life course perspective, focusing on older adults in Spain. A nationwide CATI survey of 3000 residents aged 18 and older was conducted, employing validated multidimensional scales for eco-anxiety, environmental activism, and pro-environmental behavior, each rescaled to a 0–10 range. Data were analyzed using descriptive statistics, analyses of variance, and hierarchical regression models to estimate linear and quadratic age effects beyond sex, education, and subjective social class. Results show that (1) eco-anxiety follows an inverted-U pattern, peaking at ages 45–49 and declining significantly after 60; (2) environmental activism remains high until the late sixties, while everyday pro-environmental behaviors sharply decline after retirement; and (3) eco-anxiety and environmental action in older adults are partially decoupled, reflecting the role of supportive personal and contextual factors beyond emotional concern. The findings challenge prevailing stereotypes of passive older adults by demonstrating that older age can constitute a significant period of climate engagement. Despite a slight decline in climate concern following retirement, the willingness to take action remains notably resilient. Older adults maintain consistent involvement in environmental volunteering and activism, often motivated by a desire to leave a lasting legacy and shaped by personal experiences of past crises and collective struggles. However, pro-environmental behaviors show a marked decrease in older adults, not due to diminished interest but likely as a result of structural constraints such as declining health, limited income, and inadequate housing conditions. This study suggests that, in the context of liquid modernity marked by rapid change and uncertainty, older adults may serve as societal anchors—preserving narratives, emotional bonds, and civic networks. Through policies that address structural barriers, this anchor role can be supported, empowering older adults to improve their well-being and strengthening community resilience in the face of climate change.

This article deals with the different religious counterpoints or beliefs that traditions of philosophy and thought have fundamentally defined around five positions or options: atheist, agnosticism, deism, skepticism, and belief. The aim is to explore the sociological conditioning factors behind these profiles, offering a meaningful explanation to help us understand the trends and recent changes in Spanish society. To this end, we analyzed two surveys, for the years 2008 and 2018, of the International Social Survey Programme (ISSP) on Religion in the context of Spain. The results highlight the variables of gender, age, and ideology to describe specific profiles, explain religious choices, and understand trends. In addition to the trend towards secularization, the results manifest an increase in the number of atheists and a decrease of believers, show increasing radicalization and right-wing ideology among believers, and a greater grounding of the meaning of life in the existence of God alone.

Globally, current food consumption and trade are placing unprecedented demand on agricultural systems and increasing pressure on natural resources, requiring tradeoffs between food security and environmental impacts especially given the tension between market-driven agriculture and agro-ecological goals. In order to illustrate the wicked social, economic and environmental challenges and processes to find transformative solutions, we focus on the largest concentration of greenhouses in the world located in the semi-arid coastal plain of South-east Spain. Almería family farming, predominantly cooperative, greenhouse intensive production, commenced after the 1960s and has resulted in very significant social and economic benefits for the region, while also having important negative environmental and biodiversity impacts, as well as creating new social challenges. The system currently finds itself in a crisis of diminishing economic benefits and increasing environmental and social dilemmas. Here, we present the outcomes of multi-actor, transdisciplinary research to review and provide collective insights for solutions-oriented research on the sustainability of Almeria’s agricultural sector. The multi-actor, transdisciplinary process implemented collectively, and supported by scientific literature, identified six fundamental challenges to transitioning to an agricultural model that aims to ameliorate risks and avoid a systemic collapse, whilst balancing a concern for profitability with sustainability: (1) Governance based on a culture of shared responsibility for sustainability, (2) Sustainable and efficient use of water, (3) Biodiversity conservation, (4) Implementing a circular economy plan, (5) Technology and knowledge transfer, and (6) Image and identity. We conclude that the multi-actor transdisciplinary approach successfully facilitated the creation of a culture of shared responsibility among public, private, academic, and civil society actors. Notwithstanding plural values, challenges and solutions identified by consensus point to a nascent acknowledgement of the strategic necessity to locate agricultural economic activity within social and environmental spheres.This paper demonstrates the need to establish transdisciplinary multi-actor work-schemes to continue collaboration and research for the transition to an agro-ecological model as a means to remain competitive and to create value.

The ability to diagnose, monitor, and treat CNS tumors has been improved by new imaging techniques such as positron emission tomography (PET) scanning and functional MR imaging, stereotactic surgery, delivery of radiotherapy with brachytherapy and radio-surgery, and novel methods for delivering chemotherapy.