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The identification of the first confirmed neutron star - black hole (NS-BH) binary mergers by the LIGO, Virgo and KAGRA collaboration provides the opportunity to investigate the properties of the early sample of confirmed and candidate events. Here, we focus primarily on the tilt angle of the black hole's spin relative to the orbital angular momentum vector of the binary, and the implications for the physical processes that determine this tilt. The posterior tilt distributions of GW200115 and the candidate events GW190426_152155 and GW190917_114630 peak at significantly anti-aligned orientations (though display wide distributions). Producing these tilts through isolated binary evolution would require stronger natal kicks than are typically considered (and preferentially-polar kicks would be ruled out), and/or an additional source of tilt such as stable mass transfer. The early sample of NS-BH events are less massive than expected for classical formation channels, and may provide evidence for efficient mass transfer that results in the merger of more massive NS-BH binaries before their evolution to the compact phase is complete. We predict that future gravitational-wave detections of NS-BH events will continue to display total binary masses of \\(\\approx 7\\) M\\(_{\\odot}\\) and mass ratios of \\(q \\sim 3\\) if this interpretation is correct. Conversely, the high mass of the candidate GW191219_163120 suggests a dynamical capture origin. Large tilts in a significant fraction of merging NS-BH systems would weaken the prospects for electromagnetic detection. However, EM observations, including non-detections, can significantly tighten the constraints on spin and mass ratio.

We present a semi-analytic model for predicting kilonova light curves from the mergers of neutron stars with black holes (NSBH). The model is integrated into the MOSFiT platform, and can generate light curves from input binary properties and nuclear equation-of-state considerations, or incorporate measurements from gravitational wave (GW) detectors to perform multi-messenger parameter estimation. The rapid framework enables the generation of NSBH kilonova distributions from binary populations, light curve predictions from GW data, and statistically meaningful comparisons with an equivalent BNS model in MOSFiT. We investigate a sample of kilonova candidates associated with cosmological short gamma-ray bursts, and demonstrate that they are broadly consistent with being driven by NSBH systems, though most have limited data. We also perform fits to the very well sampled GW170817, and show that the inability of an NSBH merger to produce lanthanide-poor ejecta results in a significant underestimate of the early (\\(\\lesssim 2\\) days) optical emission. Our model indicates that NSBH-driven kilonovae may peak up to a week after merger at optical wavelengths for some observer angles. This demonstrates the need for early coverage of emergent kilonovae in cases where the GW signal is either ambiguous or absent; they likely cannot be distinguished from BNS mergers by the light curves alone from \\(\\sim 2\\) days after the merger. We also discuss the detectability of our model kilonovae with the Vera C. Rubin Observatory's Legacy Survey of Space and Time (LSST).

Gravitational waves provide a unique tool for observational astronomy. While the first LIGO--Virgo catalogue of gravitational-wave transients (GWTC-1) contains eleven signals from black hole and neutron star binaries, the number of observations is increasing rapidly as detector sensitivity improves. To extract information from the observed signals, it is imperative to have fast, flexible, and scalable inference techniques. In a previous paper, we introduced BILBY: a modular and user-friendly Bayesian inference library adapted to address the needs of gravitational-wave inference. In this work, we demonstrate that BILBY produces reliable results for simulated gravitational-wave signals from compact binary mergers, and verify that it accurately reproduces results reported for the eleven GWTC-1 signals. Additionally, we provide configuration and output files for all analyses to allow for easy reproduction, modification, and future use. This work establishes that BILBY is primed and ready to analyse the rapidly growing population of compact binary coalescence gravitational-wave signals.

We present a pan-chromatic study of AT2017bcc, a nuclear transient that was discovered in 2017 within the skymap of a reported burst-like gravitational wave candidate, G274296. It was initially classified as a superluminous supernova, and then reclassified as a candidate tidal disruption event. Its optical light curve has since shown ongoing variability with a structure function consistent with that of an active galactic nucleus, however earlier data shows no variability for at least 10 years prior to the outburst in 2017. The spectrum shows complex profiles in the broad Balmer lines: a central component with a broad blue wing, and a boxy component with time-variable blue and red shoulders. The H\\(\\alpha\\) emission profile is well modelled using a circular accretion disc component, and a blue-shifted double Gaussian which may indicate a partially obscured outflow. Weak narrow lines, together with the previously flat light curve, suggest that this object represents a dormant galactic nucleus which has recently been re-activated. Our time-series modelling of the Balmer lines suggests that this is connected to a disturbance in the disc morphology, and we speculate this could involve a sudden violent event such as a tidal disruption event involving the central supermassive black hole, though this cannot be confirmed, and given an estimated black hole mass of \\(\\gtrsim10^7-10^8\\) M\\(_\\odot\\) instabilities in an existing disc may be more likely. Although we find that the redshifts of AT2017bcc (\\(z=0.13\\)) and G274296 (\\(z>0.42\\)) are inconsistent, this event adds to the growing diversity of both nuclear transients and multi-messenger contaminants.

SIR: Soon after the organization of the State geological survey, the members of the corps under my direction were requested to take note of such facts in relation to the different objects of natural history, within the limits of the State, as might, incidentally, come under their notice; so far as it could be done without interfering with their respective duties.

Background The support of student wellbeing features highly in all higher education institutional agendas. For medical students good physical and mental health can help prevent burnout, equip students for their future healthcare setting and indirectly improve patient care. At the University of Nottingham (UK), we were keen to explore undergraduate medical students perceived wellbeing before, during, and after an early years’ (years 1-3) curriculum change. A restructure of the curriculum enabled personal wellbeing sessions to be embedded and directly linked to the pastoral support system. Methods Students’ perceived wellbeing was assessed through a questionnaire distributed to three cohorts of first year students at the start and end of the autumn semester. Results The data showed a clear improvement of perceived physical health at the end of the first semester following the curriculum change, alongside increased mood and ability to relax. A surprising outcome of this study was that students reported increased stress levels at the end of the semester, which we believe may be attributed to the change in assessment within the new curriculum. Our medical students are now facing end of year summative examinations, but are acutely aware of their progress as they undertake frequent formative assessments during the year. We propose that comparison of performance with peers is having a direct impact on perceived stress in these cohorts. Conclusions The study has shown that embedding wellbeing in the curriculum can have positive effects even within a changing curriculum. The importance of evolving wellbeing provision and support based on the needs of the student population is essential and probably never more in need than at this moment in time.

ObjectivesThe aims of this study were to (1) investigate the relative time-dependent disruption and bactericidal effects of detergent-type surfactants on single- or dual-species biofilms of root canal isolates and (2) to examine the utility of polygonal graphs for depiction of biofilm disruption and cell killing.Materials and methodsSingle-species biofilms of Streptococcus sanguinis, Enterococcus faecalis, Fusobacterium nucleatum and Porphyromonas gingivalis were grown on nitro-cellulose membranes for 72 h and immersed in Tween®80, cetyltrimethylammoniumbromide (CTAB), and sodium dodecyl sulphate (SDS) for 1-, 5- or 10-min (n = 3 per test). The number of viable and non-viable bacteria “disrupted” from the biofilm and those “remaining-attached” was determined using a viability stain in conjunction with fluorescence microscopy. The data were analysed using non-parametric Kruskal-Wallis test with 5% significance level.ResultsGram-negative obligate anaerobes were more susceptible to cell removal than gram-positive facultative anaerobes. The majority of cells were disrupted after 1-min of exposure; however, the extent varied according to the agent and species. CTAB and SDS were more effective than Tween 80™ at disrupting biofilms and killing cells but all agents failed to achieve 100% disruption/kill.ConclusionsBiofilm disruption and cell viability were influenced by the species, the test agent and the duration of exposure. CTAB and SDS were more effective in biofilm disruption than Tween 80™. Graphical depiction of biofilm disruption- and viability-outcomes provides an alternative means of simultaneously visualising and analysing relative efficacy in different domains.Clinical relevanceSurfactants were not as effective at biofilm disruption as NaOCl but may be added to other non-disruptive antibacterial agents to enhance this property.

Although foods are considered enhancing factors for dental caries and periodontitis, laboratory researches indicate that several foods and beverages contain components endowed with antimicrobial and antiplaque activities. A low molecular mass (LMM) fraction of an aqueous mushroom extract has been found to exert these activities in in vitro experiments against potential oral pathogens. We therefore conducted a clinical trial in which we tested an LMM fraction of shiitake mushroom extract formulated in a mouthrinse in 30 young volunteers, comparing the results with those obtained in two identical cohorts, one of which received water (placebo) and the other Listerine. Plaque index, gingival index and bacterial counts in plaque samples were determined in all volunteers over the 11 days of the clinical trial. Statistically significant differences (P<0.05) were obtained for the plaque index on day 12 in subjects treated with mushroom versus placebo, while for the gingival index significant differences were found for both mushroom versus placebo and mushroom versus Listerine. Decreases in total bacterial counts and in counts of specific oral pathogens were observed for both mushroom extract and Listerine in comparison with placebo. The data suggest that a mushroom extract may prove beneficial in controlling dental caries and/or gingivitis/periodontitis.

The link between diet and health has lead to the promotion of functional foods which can enhance health. In this study, the oral health benefits of a number of food homogenates and high molecular mass and low molecular mass fractions were investigated. A comprehensive range of assays were performed to assess the action of these foods on the development of gingivitis and caries using bacterial species associated with these diseases. Both antigingivitis and anticaries effects were investigated by assays examining the prevention of biofilm formation and coaggregation, disruption of preexisting biofilms, and the foods' antibacterial effects. Assays investigating interactions with gingival epithelial cells and cytokine production were carried out to assess the foods' anti- gingivitis properties. Anti-caries properties such as interactions with hydroxyapatite, disruption of signal transduction, and the inhibition of acid production were investigated. The mushroom and chicory homogenates and low molecular mass fractions show promise as anti-caries and anti-gingivitis agents, and further testing and clinical trials will need to be performed to evaluate their true effectiveness in humans.

The grand challenges of contemporary fundamental physics---dark matter, dark energy, vacuum energy, inflation and early universe cosmology, singularities and the hierarchy problem---all involve gravity as a key component. And of all gravitational phenomena, black holes stand out in their elegant simplicity, while harbouring some of the most remarkable predictions of General Relativity: event horizons, singularities and ergoregions. The hitherto invisible landscape of the gravitational Universe is being unveiled before our eyes: the historical direct detection of gravitational waves by the LIGO-Virgo collaboration marks the dawn of a new era of scientific exploration. Gravitational-wave astronomy will allow us to test models of black hole formation, growth and evolution, as well as models of gravitational-wave generation and propagation. It will provide evidence for event horizons and ergoregions, test the theory of General Relativity itself, and may reveal the existence of new fundamental fields. The synthesis of these results has the potential to radically reshape our understanding of the cosmos and of the laws of Nature. The purpose of this work is to present a concise, yet comprehensive overview of the state of the art in the relevant fields of research, summarize important open problems, and lay out a roadmap for future progress.