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This paper presents the conceptual design of a modular unmanned aerial vehicle (UAV) platform featuring vertical/conventional take-off and landing (VTOL/CTOL) and interchangeable cabin modules tailored for different mission profiles, aimed at enhancing operational flexibility and reducing logistical complexity, thereby improving overall economic efficiency. The study addresses aerodynamic, structural, and propulsion aspects of a unified UAV configuration that can be reconfigured for a variety of missions, including cargo and passenger transport, intelligence, surveillance and reconnaissance (ISR), medical evacuation (MEDEVAC/CASEVAC), search and rescue (SAR), combat/escort support, and electronic warfare (EW). A parametric analysis of propulsion sizing, aerodynamic performance, wing structural loading and landing gear sizing is conducted to assess the feasibility of the concept. The modular approach aims to enables significant cost savings, shorter turnaround times, and reduced logistical burden, without compromising mission capability.

Background: The main cause of chronic nasal obstruction in ENT practice is represented by the deviated nasal septum. Septoplasty remains the gold standard treatment, performed using either conventional or endoscopic techniques. Methods: A narrative review of the literature was conducted using PubMed and Google Scholar for studies published between May 1999 and October 2024. Eligible studies included adult patients (≥16 years) undergoing conventional or endoscopic septoplasty, with at least one reported outcome measure: NOSE, VAS, or SNOT-22 scores; operative time; or complication rates. Results: Across multiple clinical studies, both conventional and endoscopic septoplasty provided significant improvements in nasal airflow and symptom relief. Endoscopic septoplasty was consistently associated with superior intraoperative visualization, more precise correction of posterior deformities and isolated septal spurs, and lower rates of intraoperative and postoperative complications. Complication rates were low overall for both approaches. Conclusions: Current evidence supports both conventional and endoscopic septoplasty as effective treatments for nasal obstruction due to septal deviation. However, endoscopic septoplasty offers distinct advantages in terms of visualization, operative efficiency, and safety, making it an increasingly preferred technique.

In recent years, Bucharest’s residential dynamics have thrived, fueled by growing demand and an insufficient housing fund. This study aimed to analyze the residential satisfaction of those living in newly built dwellings. Its objectives were to identify the characteristics of three new residential areas and analyze the satisfaction level among residents regarding both their dwellings and neighborhoods. The investigation employed direct observations during the fieldwork phase (through observation sheets and mapping methods) and surveys (through questionnaires with residents and interviews with developers). Its results highlighted spaces that exhibit an increase in residential constructions, with a tendency to expand toward suburban areas, without necessarily meeting legislative requirements. When measuring the population’s residential satisfaction level, the study observed a general satisfaction regarding dwellings’ modernity and price but noticeable differences within the sample residential nuclei. The solutions proposed by residents mainly target authorities, who were held responsible for developing the urban infrastructure prior to granting building permits, as well as for vetting developers better and requiring them to respect the legislation. Hence, scientists, local authorities, real-estate developers and the local population represent the beneficiaries of the current study’s results.

Culture is the mark we leave on history, and cultural infrastructure supports the quality of life of people in a community. This paper describes the interaction between sustainable development (an economic component, GDP per capita, and a social component, poverty) and cultural infrastructure in the cases of France and Romania, through a comparative analysis and how multidisciplinary education can help strengthen this link. To achieve this goal, the authors used linear regression combined with bibliometric analyses (a hybrid model), which gives this paper originality. This systematic literature review and bibliometric analysis will help to map the culture, education, and sustainable development sector and to establish new research directions. The authors of this study identified four future research themes and formulated policy recommendations and a practical smart technology solution in the context of sustainability.

Background and Objectives: This study reviews the current literature on ocular movements, specifically focusing on nystagmus associated with peripheral vestibular disorders, to enhance diagnostic accuracy. The evaluation of ocular movements, particularly nystagmus, provides essential insights into the function and dysfunction of the vestibular system, helping clinicians distinguish between peripheral and central causes of vertigo and imbalance. Materials and Methods: A comprehensive search of PubMed was conducted using key terms such as “ocular movements”, “nystagmus”, “vestibular nystagmus”, and “peripheral vestibular disorders”. Results: The search yielded 2739 titles, and after a rigorous selection process, 52 articles were reviewed in full. Discussion: The review highlights different classifications and types of nystagmus, including physiological and pathological forms, and their diagnostic relevance in vestibular disorders such as benign paroxysmal positional vertigo (BPPV), vestibular neuritis, and Meniere’s disease. Diagnostic techniques like video/electro-oculography are emphasized for their role in assessing vestibular function and identifying abnormalities. The study underscores the importance of detailed ocular examination in the diagnosis of peripheral vestibular disorders and proposes an algorithm to aid this process. Conclusions: While not a systematic review, this study highlights the importance of detailed ocular examination in diagnosing peripheral vestibular disorders and presents an algorithm to facilitate this process. It also emphasizes the need for continued research and advancements in vestibular medicine to further understand ocular movements and their clinical significance, ultimately contributing to improved patient outcomes.

The long-term control strategy of SARS-CoV-2 and other major respiratory viruses needs to include antivirals to treat acute infections, in addition to the judicious use of effective vaccines. Whilst COVID-19 vaccines are being rolled out for mass vaccination, the modest number of antivirals in use or development for any disease bears testament to the challenges of antiviral development. We recently showed that non-cytotoxic levels of thapsigargin (TG), an inhibitor of the sarcoplasmic/endoplasmic reticulum (ER) Ca2+ ATPase pump, induces a potent host innate immune antiviral response that blocks influenza A virus replication. Here we show that TG is also highly effective in blocking the replication of respiratory syncytial virus (RSV), common cold coronavirus OC43, SARS-CoV-2 and influenza A virus in immortalized or primary human cells. TG’s antiviral performance was significantly better than remdesivir and ribavirin in their respective inhibition of OC43 and RSV. Notably, TG was just as inhibitory to coronaviruses (OC43 and SARS-CoV-2) and influenza viruses (USSR H1N1 and pdm 2009 H1N1) in separate infections as in co-infections. Post-infection oral gavage of acid-stable TG protected mice against a lethal influenza virus challenge. Together with its ability to inhibit the different viruses before or during active infection, and with an antiviral duration of at least 48 h post-TG exposure, we propose that TG (or its derivatives) is a promising broad-spectrum inhibitor against SARS-CoV-2, OC43, RSV and influenza virus.

Purpose: This review aims to analyze the diagnostic methods used to evaluate inferior vestibular nerve neuritis. Methods: We performed an electronic search on the PubMed database for clinical studies investigating the diagnostic techniques used for inferior vestibular nerve neuritis. Results: We initially identified 114 records in our search. After applying the inclusion and exclusion criteria, we narrowed it down to 12 studies. These studies collectively examined a total of 642 patients diagnosed with vestibular nerve neuritis, 64 of whom had inferior vestibular neuritis. Conclusions: The inferior vestibular neuritis is an unfrequent form of vestibular neuritis, often misdiagnosed. The diagnosis of inferior vestibular neuritis (IVN) is based on clinical history and vestibular testing, specifically reduced posterior canal gain on video head impulse test (vHIT), absent cervical VEMP (cVEMP), normal caloric responses, and preserved ocular VEMP (oVEMP). This review highlights the gaps in current diagnostic strategies and emphasizes the need for integrating advanced vestibular testing methods to enhance diagnostic accuracy for inferior vestibular nerve neuritis. Future studies should address the standardization of diagnostic protocols to facilitate broader clinical application.

The economic naturally meets the cultural because both spheres deal, differently albeit convergingly, with values and valuations. Materially crafted and spiritually charged, tactile/tangible and ineffable/intangible, privately owned and collectively enjoyed, nourished currently and cherished diachronically, the supply of demandable cultural goods and services defines and refines us as humans. The economics of culture, notwithstanding its deeply rooted epistemological fragilities - pricing the pricelessness of masterpieces or fitting artistry into production functions -, is in greater distress when asked to predict how tech sense will affect human sensibility. Job specifications and business structures become under assail when technologies unfold, as it is the case with the Fourth Industrial Revolution (IR 4.0) and its long prophesized and still surprising Artificial Intelligence (AI). The present article aims at shedding some critical and creative light onto three lines of inquiry at the byroads of industriousness and artfulness with economics, as well as ethics. Firstly, the outstanding social-political-economic traits pertaining to the historical waves of Industrial Revolutions are re-inventoried, observing both peculiarities and patterns. Secondly, there are emphasized, although hardly exhausted, the prevailing economic reciprocations between the technological shifts and the cultural movements (in visual arts). And thirdly, given envisageable megatrends, catalysts/inhibitors and game-changers, Als impact upon the art economy is investigated and illustrated via some emblematic cases. This study aims to open up a frontier research - the future of cultural ecosystems -, addressable/assessable as exercises of immersive foresight, and not as detached forecasting.

This review focuses on the contribution of medical imaging in the diagnosis of peripheral vestibular disorders. This is a narrative review based on a focused literature search conducted using PubMed and the Cochrane Library. Imaging is not usually recommended in initial consultations for vestibular disorders because only 5–10% of MRI scans reveal findings directly related to the disease. The study is a review of the literature that highlights the utility and limitations of imaging such as computed tomography (CT) and magnetic resonance imaging (MRI). It follows the diagnostic approach from history and physical examination to laboratory tests and imaging. Some conditions like vestibular neuritis and benign paroxysmal positional vertigo (BPPV) have limited imaging utility due to the fine details required. Conversely, high-resolution CT and MRI are important for diagnosing Meniere’s disease, acoustic neuroma, and superior canal dehiscence. The role of imaging varies a lot among specific conditions. Advances in imaging technology, particularly high-resolution MRI, promise enhanced diagnostic capabilities.

Purpose This paper aims to investigate a double puzzle, empirical and theoretical. Empirically, can the authors document the influence of groups on financial decisions in investments and trading? Theoretically, if decisions in a group context can be documented, how can we account for them, against the background of the normative models, according to which financial decisions are individualized and atomized? Based on interviews and ethnographic observations with fund managers, analysts and traders, the authors document here decision-making in finance. Theoretically, the authors argue that financial decisions can be explained if, in addition to cognitive processes, the authors take into account the impact of social interactions on the decision-making process. Social interactions are not restricted to imitation processes, and can be seen here as the efforts deployed by decision-makers at maintaining and managing the context of their decisions. The authors present and discuss empirical evidence and argue that the study of social interactions can productively contribute to understanding how decisions are made in finance. Design/methodology/approach The data analyzed here have been gathered between 2001 and 2011, and include: interviews with investment professionals (fund managers and analysts) from the UK and Turkey; interviews with individual investors from the UK and the USA; and observations with individual investors from the UK and the USA. This captures decision activities conducted in different regulatory frameworks of those countries. The authors focussed in the interviews on general decision-making practices. Findings Conclusion the authors have sought to answer a double puzzle, empirical and theoretical. Empirically, the puzzle is how investors and traders resort to groups in their decision-making. Theoretically, the puzzle consists not only in providing an explanation for such processes but also in taking into account that they do not fit the normative models of decisions in mainstream finance. The argument has been that in addition to the cognitive processes identified and discussed in behavioural finance, the authors need to take into account the impact of social processes as well. Social processes include the efforts deployed by financial decision-makers at maintaining and managing the contexts within which decisions are made. The work of context maintenance is intrinsic to the logic of decision-making. The authors have identified, documented and discussed here the social dynamics in financial decisions with respect to performance, managing group relationships and possible conflicts. Originality/value Managing relationships within groups is not without consequences with regard to trading decisions. Oftentimes, avoiding group conflicts – or being confronted with them – leads to decisional adjustments, which have less to do with returns on trades than with the necessity of accommodating social relationships. As several of the interviewees emphasized, making decisions implies consensus and reaching consensus requires accommodating relationships.