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"Prendergast, Christopher"
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Clinical and Biochemical Outcomes in Transgender Individuals Undergoing Hormone Therapy: Protocol for a Systematic Review
Monitoring of various clinical outcomes and parameters, such as lipid levels, is recommended in transgender individuals undergoing hormone therapies. However, comprehensive data to inform these recommendations is scarce.
This study aims to conduct a systematic review and meta-analysis to synthesize evidence from existing literature on the effect of exogenous hormone therapy on clinical and biochemical outcomes for transgender adolescents and adults.
We will search multiple electronic databases and will include prospective and retrospective observational studies with and without a control group. The study population will include transgender individuals undergoing hormone therapy with testosterone or estrogen. Comparisons will include age-matched, cisgender individuals and changes from baseline. Primary outcomes include changes in or the development of abnormal lipid parameters. Secondary outcomes include BMI, weight, height, and blood pressure for age, serum testosterone or estrogen levels, and development of disease including hypertension, diabetes, fatty liver disease, obesity, adverse cardiac events, as well as all-cause mortality. The meta-analysis will pool the studies where applicable, and meta-regressions will be conducted to evaluate effect modifiers. The GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach will be used to evaluate the overall certainty of evidence.
We will summarize the selection of the eligible studies using a PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart. The results will be presented in a table summarizing the evidence. Data collection is ongoing, and the paper is expected to be published in Spring 2025.
This systematic review will summarize and evaluate the evidence of the clinical and biochemical outcomes associated with hormone therapies for transgender individuals.
PROSPERO CRD42024483138; https://tinyurl.com/yc4sfvnb.
PRR1-10.2196/57931.
Journal Article
The Classic
Focusing on a moment and a source in the 19th century, this book ponders the question: what is a classic? This question is, by virtue of its insistent recurrence, itself a classic question that returns to haunt us. It provided the title of a text for French critic Charles-Augustin Sainte-Beuve in 1850 (‘Qu'est-ce qu'un classique?’), as it did in the 20th century for T.S. Eliot and John Coetzee. Centring on Sainte-Beuve in his 19th-century context, this book's inquiry takes us historically to many places (antiquity, the middle ages, the 17th and 18th as well as the 19th and early 20th centuries). The book also provides an intellectual history that travels across multiple disciplinary territories (in addition to literary criticism and literary history, classical studies, comparative philology, historiography and political thought). Against this background, this book maps the evolution of Sainte-Beuve's thought from an initially cosmopolitan conception of the classic (close in spirit to Goethe's notion of Weltliteratur) to an increasingly nationalist conception, with a strong emphasis on the heritage of Latinity and France as its principal legatee. The final chapter deals with this appropriation and ends with a question about Sainte-Beuve's original question: in the light of this bleak history, perhaps the time has come to dispense with the term ‘classic’ altogether.
eBook
Lp(a) in Childhood
Elevated plasma concentration of lipoprotein (a) (Lp(a)) is an independent risk factor for the development of atherosclerotic coronary vascular disease. There is a causal relationship between Lp(a) elevation and myocardial infarction. In the pediatric population, Lp(a) has been associated with risk for ischemic stroke. However, a consensus regarding the clinical utility of Lp(a) measurement in children has not been established. In this article, we review recent literature regarding Lp(a) metabolism, its role in disease states such as in pediatric thrombosis and familial hypercholesterolemia (FH), and therapy directed at Lp(a) levels. Our findings show that Lp(a) remains a controversial but emerging risk factor for cardiovascular disease, especially in children. However, new and important research continues to contribute to our understanding of Lp(a) metabolism in children and to cardiovascular risk in diseases such as FH. What is clear is that Lp(a) has the potential to play a role in the management of cardiovascular risk in children and adults.
Journal Article
The Triangle of Representation
Moving deftly among literary and visual arts, as well as the modern critical canon, Christopher Prendergast's book explores the meaning and value of representation as both a philosophical challenge (What does it mean to create an image that \"stands for\" something absent?) and a political issue (Who has the right to represent whom?). The Triangle of Representation raises a range of theoretical, historical, and aesthetic questions, and offers subtle readings of such cultural critics as Raymond Williams, Paul de Man, Edward Said, Walter Benjamin, and Hélène Cixous, in addition to penetrating investigations of visual artists like Gros, Ingres, and Matisse and significant insights into Proust and the onus of translating him. Above all, Prendergast's work is a striking display of how a firm grounding in theory is essential for the exploration of art and literature.
eBook