Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
14,889
result(s) for
"Qi, Lu"
Sort by:
Gene-Diet Interaction and Precision Nutrition in Obesity
The rapid rise of obesity during the past decades has coincided with a profound shift of our living environment, including unhealthy dietary patterns, a sedentary lifestyle, and physical inactivity. Genetic predisposition to obesity may have interacted with such an obesogenic environment in determining the obesity epidemic. Growing studies have found that changes in adiposity and metabolic response to low-calorie weight loss diets might be modified by genetic variants related to obesity, metabolic status and preference to nutrients. This review summarized data from recent studies of gene-diet interactions, and discussed integration of research of metabolomics and gut microbiome, as well as potential application of the findings in precision nutrition.
Journal Article
الحزام والطريق : ماذا ستقدم الصين للعالم ؟
حاول هذا الكتاب الذي بين أيديكم أن يقدم إجابات معيارية قياسية لكافة الأسئلة الجذرية المتعلقة بمبادرة \"الحزام والطريق\" والتي تقدم الصين من خلالها حلا لاستغلال قدراتها التي لا تتوقف عن التنامي لتتبوأ مقعدها كمحرك للنمو الاقتصادي العالمي في المستقبل و المتشوقين للتعرف على الملامح الحقيقية للتنين الصيني وتجربته مع سياسة الإصلاح والانفتاح طوال أكثر من ثلاثين عاما ومبادرته الجديدة ذات السمات الفوق عولمية نقدم الحزام والطريق ماذا ستقدم الصين للعالم.
Book
Sea urchin-like microstructure pressure sensors with an ultra-broad range and high sensitivity
Sensitivity and pressure range are two significant parameters of pressure sensors. Existing pressure sensors have difficulty achieving both high sensitivity and a wide pressure range. Therefore, we propose a new pressure sensor with a ternary nanocomposite Fe
2
O
3
/C@SnO
2
. The sea urchin-like Fe
2
O
3
structure promotes signal transduction and protects Fe
2
O
3
needles from mechanical breaking, while the acetylene carbon black improves the conductivity of Fe
2
O
3
. Moreover, one part of the SnO
2
nanoparticles adheres to the surfaces of Fe
2
O
3
needles and forms Fe
2
O
3
/SnO
2
heterostructures, while its other part disperses into the carbon layer to form SnO
2
@C structure. Collectively, the synergistic effects of the three structures (Fe
2
O
3
/C, Fe
2
O
3
/SnO
2
and SnO
2
@C) improves on the limited pressure response range of a single structure. The experimental results demonstrate that the Fe
2
O
3
/C@SnO
2
pressure sensor exhibits high sensitivity (680 kPa
−1
), fast response (10 ms), broad range (up to 150 kPa), and good reproducibility (over 3500 cycles under a pressure of 110 kPa), implying that the new pressure sensor has wide application prospects especially in wearable electronic devices and health monitoring.
Pressure sensors with high sensitivity and large pressure range is crucial to their various applications in electronic engineering. Here, Wang et al. propose a new design based on a ternary nanocomposite material and show high pressure sensitivity of 680 kPa
−1
and fast response of 10 ms up to 150 kPa.
Journal Article
PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages
Background
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 expression was reportedly associated with tumor development and progression. This study assessed PCSK9 expression and functions in human colon cancer and then explored the underlying molecular events.
Methods
Colon cancer tissues were utilized for analysis of PCSK9 expression for association with clinicopathological factors from patients by immunohistochemistry assay. Manipulation of PCSK9 expression was assessed in vitro and in vivo for colon cancer cell proliferation, migration, and invasion using cell viability CCK-8, Transwell tumor cell migration and invasion, and wound-healing assays. Next, proteomic analysis, Western blot, qRT-PCR and Flow cytometry were conducted to assess downstream targets and tumor cell-derived PCSK9 action on macrophage polarization.
Results
PCSK9 expression was upregulated in colon cancer tissues versus the normal tissues, and associated with advanced tumor pathological grade. Knockdown of PCSK9 expression reduced colon cancer cell proliferation, migration, and invasion and suppressed tumor metastasis in vivo. PCSK9 directly or indirectly upregulated Snail 1 and in turn to downregulate E-cadherin expression, but upregulate N-cadherin and MMP9 levels and thereafter, to induce colon cancer cell epithelial-mesenchymal transition (EMT) process and activated PI3K/AKT signaling. However, PCSK9 overexpression showed the inverse effects on colon cancer cells. Knockdown of PCSK9 expression inhibited M2 macrophage polarization, but also promoted M1 macrophage polarization by reduction of lactate, protein lactylation and macrophage migration inhibitory factor (MIF) levels.
Conclusion
PCSK9 played an important role in the progression and metastasis of colon cancer by regulation of tumor cell EMT and PI3K/AKT signaling and in the phenotypic polarization of macrophages by mediating MIF and lactate levels. Targeting PCSK9 expression or activity could be used to effectively control colon cancer.
Journal Article
A nonlinear vibration isolator supported on a flexible plate: analysis and experiment
To address low-frequency vibration isolation, an issue that engineers often face, this paper first studies the nonlinear energy transfer of a flexible plate, with arbitrary boundary, with the coupling of high-static-low-dynamic-stiffness (HSLDS) isolator. The nonlinear coupled dynamic equation was derived via the Lagrange method, and the improved Fourier series and Rayleigh–Ritz methods provide modal coefficients of the arbitrary boundary flexible plate with nonlinear vibration isolators. The Galerkin and harmonic balance methods approximate the frequency response functions of power flow for the coupled system. The numerical method, via direct integration of the dynamic equation, validates the analytical results of the frequency response functions. In addition, the finite element simulation, used here, validates the analytical results of the mode shapes for flexible plate. The experiment is carried out to validate the isolation performance of the nonlinear vibrator supported on a flexible plate. On these bases, increasing damping and controlling HSLDS can improve the low-frequency isolation efficiency, and nonlinear jumping-phenomena could disappear over a low-frequency range (either frequency overlap or frequency jump). Hence, a properly configured flexible plate could improve the bearing capacity and low-frequency isolation efficiency while avoiding frequency mistune. An explanation for these is offered in the article.
Journal Article
Sports-ACtrans Net: research on multimodal robotic sports action recognition driven via ST-GCN
Accurately recognizing and understanding human motion actions presents a key challenge in the development of intelligent sports robots. Traditional methods often encounter significant drawbacks, such as high computational resource requirements and suboptimal real-time performance. To address these limitations, this study proposes a novel approach called Sports-ACtrans Net.
In this approach, the Swin Transformer processes visual data to extract spatial features, while the Spatio-Temporal Graph Convolutional Network (ST-GCN) models human motion as graphs to handle skeleton data. By combining these outputs, a comprehensive representation of motion actions is created. Reinforcement learning is employed to optimize the action recognition process, framing it as a sequential decision-making problem. Deep Q-learning is utilized to learn the optimal policy, thereby enhancing the robot's ability to accurately recognize and engage in motion.
Experiments demonstrate significant improvements over state-of-the-art methods. This research advances the fields of neural computation, computer vision, and neuroscience, aiding in the development of intelligent robotic systems capable of understanding and participating in sports activities.
Journal Article
Strong decays of the newly observed narrow Ωb structures
Motivated by the newly observed narrow structures
Ω
b
(
6316
)
-
,
Ω
b
(
6330
)
-
,
Ω
b
(
6340
)
-
, and
Ω
b
(
6350
)
-
in the
Ξ
b
0
K
-
mass spectrum, we investigate the strong decays of the low-lying
Ω
b
states within the
3
P
0
model systematically. According to their masses and decay widths, the observed
Ω
b
(
6316
)
-
,
Ω
b
(
6330
)
-
,
Ω
b
(
6340
)
-
, and
Ω
b
(
6350
)
-
resonances can be reasonably assigned as the
λ
-
mode
Ω
b
(
1
P
)
states with
J
P
=
1
/
2
-
,
3
/
2
-
,
3
/
2
-
, and
5
/
2
-
. Meanwhile, the remaining
P
-
wave state with
J
P
=
1
/
2
-
should have a rather broad width, which can hardly be observed by experiments. For the
Ω
b
(
2
S
)
and
Ω
b
(
1
D
)
states, our predictions show that these states have relatively narrow total widths and mainly decay into the
Ξ
b
K
¯
,
Ξ
b
′
K
¯
and
Ξ
b
′
∗
K
¯
final states. These abundant theoretical predictions may be valuable for searching more excited
Ω
b
states in future experiments.
Journal Article
Associations between gut microbiota and Alzheimer’s disease, major depressive disorder, and schizophrenia
Background
Growing evidence has shown that alterations in the gut microbiota composition were associated with a variety of neuropsychiatric conditions. However, whether such associations reflect causality remains unknown. We aimed to reveal the causal relationships among gut microbiota, metabolites, and neuropsychiatric disorders including Alzheimer’s disease (AD), major depressive disorder (MDD), and schizophrenia (SCZ).
Methods
A two-sample bi-directional Mendelian randomization analysis was performed by using genetic variants from genome-wide association studies as instrumental variables for gut microbiota, metabolites, AD, MDD, and SCZ, respectively.
Results
We found suggestive associations of host-genetic-driven increase in
Blautia
(OR, 0.88; 95%CI, 0.79–0.99;
P
= 0.028) and elevated γ-aminobutyric acid (GABA) (0.96; 0.92–1.00;
P
= 0.034), a downstream product of
Blautia
-dependent arginine metabolism, with a lower risk of AD. Genetically increased
Enterobacteriaceae family
and
Enterobacteriales order
were potentially associated with a higher risk of SCZ (1.09; 1.00–1.18;
P
= 0.048), while
Gammaproteobacteria class
(0.90; 0.83–0.98;
P
= 0.011) was related to a lower risk for SCZ. Gut production of serotonin was potentially associated with an increased risk of SCZ (1.07; 1.00–1.15;
P
= 0.047). Furthermore, genetically increased
Bacilli class
was related to a higher risk of MDD (1.07; 1.02–1.12;
P
= 0.010). In the other direction, neuropsychiatric disorders altered gut microbiota composition.
Conclusions
These data for the first time provide evidence of potential causal links between gut microbiome and AD, MDD, and SCZ. GABA and serotonin may play an important role in gut microbiota-host crosstalk in AD and SCZ, respectively. Further investigations in understanding the underlying mechanisms of associations between gut microbiota and AD, MDD, and SCZ are required.
Journal Article