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Driving strontium titanate ferroelectricHidden phases are metastable collective states of matter that are typically not accessible on equilibrium phase diagrams. Nova et al. used infrared pulses to excite higher-frequency lattice modes that drive the crystal into a metastable ferroelectric phase, a phase that can persist for many hours. X. Li et al. used terahertz fields to drive the soft mode that moves the ions in the crystal into the positions they occupy in the new phase. The ferroelectric phase in this case was transient, lasting on the order of 10 picoseconds. Because these hidden phases can host exotic properties in otherwise conventional materials, the accessibility to and control of such hidden phases may broaden potential functionality and applications.Science, this issue p. 1075, p. 1079“Hidden phases” are metastable collective states of matter that are typically not accessible on equilibrium phase diagrams. These phases can host exotic properties in otherwise conventional materials and hence may enable novel functionality and applications, but their discovery and access are still in early stages. Using intense terahertz electric field excitation, we found that an ultrafast phase transition into a hidden ferroelectric phase can be dynamically induced in quantum paraelectric strontium titanate (SrTiO3). The induced lowering in crystal symmetry yields substantial changes in the phonon excitation spectra. Our results demonstrate collective coherent control over material structure, in which a single-cycle field drives ions along the microscopic pathway leading directly to their locations in a new crystalline phase on an ultrafast time scale.

Acoustic waves, capable of transmitting through optically opaque objects, have been widely used in biomedical imaging, industrial sensing and particle manipulation. High-fidelity wave front shaping is essential to further improve performance in these applications. An acoustic analog to the successful spatial light modulator (SLM) in optics would be highly desirable. To date there have been no techniques shown that provide effective and dynamic modulation of a sound wave and which also support scale-up to a high number of individually addressable pixels. In the present study, we introduce a dynamic spatial ultrasound modulator (SUM), which dynamically reshapes incident plane waves into complex acoustic images. Its transmission function is set with a digitally generated pattern of microbubbles controlled by a complementary metal–oxide–semiconductor (CMOS) chip, which results in a binary amplitude acoustic hologram. We employ this device to project sequentially changing acoustic images and demonstrate the first dynamic parallel assembly of microparticles using a SUM. The authors introduce a dynamic spatial ultrasound modulator, based on digitally generated patterns of microbubbles controlled by a complementary metal–oxide–semiconductor (CMOS) chip. They achieve reshaping of incident plane waves into complex acoustic images and demonstrate dynamic parallel assembly of microparticles.

Polyploidy is a pervasive and recurring phenomenon across the tree of life, which occurred at variable time scales, ecological amplitudes and cell types, and is especially prominent in the evolutionary histories of plants. Importantly, many of the world’s most important crops and noxious invasive weeds are recent polyploids. Polyploidy includes two major types, autopolyploidy, referring to doubling of a single species genome, and allopolyploidy referring to doubling of two or more merged genomes via biological hybridization of distinct but related species. The prevalence of both types of polyploidy implies that both genome doubling alone and doubling coupled with hybridization confer selective advantages over their diploid progenitors under specific circumstances. In cases of allopolyploidy, the two events, genome doubling and hybridization, have both advantages and disadvantages. Accumulated studies have established that, in allopolyploidy, some advantage(s) of doubling may compensate for the disadvantage(s) of hybridity and vice versa , although further study is required to validate generality of this trend. Some studies have also revealed a variety of non-Mendelian genetic and genomic consequences induced by doubling and hybridization separately or concertedly in nascent allopolyploidy; however, the significance of which to the immediate establishment and longer-term evolutionary success of allopolyploid species remain to be empirically demonstrated and ecologically investigated. This review aims to summarize recent advances in our understanding of the roles of hybridization and genome doubling, in separation and combination, in the evolution of allopolyploid genomes, as well as fruitful future research directions that are emerging from these studies.

We report two newly identified Ordovician ophiolite belts in west Junggar, NW China: Tajin–Tarbahatai–Kujibai–Honguleleng (TTKH) and Tangbale–Baijiantan–Baikouquan (TBB) ophiolitic belts. These two ophiolitic belts provide constraints for the Palaeozoic reconstruction of Central Asia and the geological evolution of this region. The TTKH and TBB ophiolitic belts are dismembered parts of different ophiolitic belts which represent relics of Ordovician oceanic floor; they subducted to the north under the Chingiz–Tarbahatai arc and to the south under the Junggar plate, respectively. The Baijiantan–Baikouquan ophiolite mélanges comprise the major part of the TBB. Flat rare Earth element (REE) patterns with positive Eu anomalies and insignificant depletion of high-field-strength elements (HFSE) relative to melts of primitive mantle suggest a mid-ocean-ridge basalt (MORB) origin for the metagabbro. Lherzolite samples define a Sm–Nd isotopic isochron with age of 474 Ma and ɛ Nd(t) of +8.9. Lherzolite samples with positive ɛ Nd(t) values of +8.8 to +9.1 and initial 87Sr/86Sr ratios of 0.7037–0.7040 are rather homogeneous in Sr–Nd isotopic composition, whereas metagabbro samples show wider Sr–Nd isotopic compositional ranges with ɛ Nd(t) of +5.9 to +11.0. The Sm–Nd isotopic isochron age (c. 380 Ma) for garnet amphibolite samples, consistent with a zircon U–Pb age (c. 385 Ma) for metagabbro, represents a magmatic event prior to subduction. Thermodynamic calculations for garnet amphibolite yield a clockwise pressure–temperature path with peak metamorphic condition of c. 15 kbar and 520–560°C at 342 Ma, indicating a subduction-channel setting. The Rb–Sr isochron ages (335 Ma, 333 Ma) for metagabbro represent a metamorphic event during exhumation.

RNA methylation is emerging as an important regulator of gene expression. Dysregulation of methyltransferase that is essential for RNA modification contributes to the development and progression of human cancers. Here we show that methyltransferase-like 1 (METTL1) is upregulated in hepatocellular carcinoma (HCC) and exhibits oncogenic activities via PTEN/AKT signaling pathway. High expression of METTL1 is correlated with larger tumor size, higher serum AFP level, tumor vascular invasion, and poor prognosis in two independent cohorts containing 892 patients with HCC. Multivariate analyses suggest METTL1 as an independent factor for unfavorable overall survival. In vitro studies demonstrate that METTL1 overexpression promotes cell proliferation and migration, whereas its knockdown results in opposite phenotypes. Gene set enrichment analysis (GSEA) indicates PTEN pathway is activated in patients with low METTL1 expression. Ectopic expression of PTEN or inhibition of AKT activity significantly attenuates the METTL1-mediated malignant phenotypes. In clinical samples, METTL1 expression is reversely associated with PTEN expression. Combination of low METTL1 expression and high PTEN expression is significantly correlated with overall survival, more so than either METTL1 or PTEN expression alone. Collectively, our data suggest that METTL1 serves as a promising prognostic biomarker and that targeting METTL1/PTEN axis may provide therapeutic potential in HCC intervention.Key messagesMETTL1 is upregulated in HCC and correlated with poor outcomes.METTL1 promotes cell proliferation and migration in HCC.METTL1 exerts oncogenic activities via suppression of PTEN signaling.

Quantification of behavior is critical in diverse applications from neuroscience, veterinary medicine to animal conservation. A common key step for behavioral analysis is first extracting relevant keypoints on animals, known as pose estimation. However, reliable inference of poses currently requires domain knowledge and manual labeling effort to build supervised models. We present SuperAnimal, a method to develop unified foundation models that can be used on over 45 species, without additional manual labels. These models show excellent performance across six pose estimation benchmarks. We demonstrate how to fine-tune the models (if needed) on differently labeled data and provide tooling for unsupervised video adaptation to boost performance and decrease jitter across frames. If fine-tuned, SuperAnimal models are 10–100× more data efficient than prior transfer-learning-based approaches. We illustrate the utility of our models in behavioral classification and kinematic analysis. Collectively, we present a data-efficient solution for animal pose estimation. Quantifying animal behavior is crucial in various fields such as neuroscience and ecology, yet we lack data-efficient methods to perform behavioral quantification. Here, the authors provide new unified models across 45+ species without manual labeling, thus enhancing analysis in behavioral studies.

Background Deregulation of microtubules and centrosome integrity is response for the initiation and progression of human cancers. Sperm-associated antigen 5 (SPAG5) is essential for the spindle apparatus organization and chromosome segregation, but its role in hepatocellular carcinoma (HCC) remains undefined. Methods The expression of SPAG5 in HCC were examined in a large cohort of patients by RT-PCR, western blot and IHC. The clinical significance of SPAG5 was next determined by statistical analyses. The biological function of SPAG5 in HCC and the underlying mechanisms were investigated, using in vitro and in vivo models. Results Here, we demonstrated that SPAG5 exhibited pro-HCC activities via the activation of PI3K/AKT signaling pathway. SPAG5 expression was increased in HCC and correlated with poor outcomes in two independent cohorts containing 670 patients. High SPAG5 expression was associated with poor tumor differentiation, larger tumor size, advanced TNM stage, tumor vascular invasion and lymph node metastasis. In vitro and in vivo data showed that SPAG5 overexpression promoted tumor growth and metastasis, whereas SPAG5 knockdown led to the opposite phenotypes. SPAG5 interacted with centrosomal protein CEP55 to trigger the phosphorylation of AKT at Ser473. Inhibition of PI3K/AKT signaling markedly attenuated SPAG5-mediated cell growth. Furthermore, SPAG5 expression was suppressed by miR-363-3p which inhibited the activity of SPAG5 mRNA 3’UTR. Ectopic expression of SPAG5 partly abolished the miR-363-3p-caused cell cycle arrest and suppression of cell proliferation and migration. Conclusions Collectively, these findings indicate that SPAG5 serves a promising prognostic factor in HCC and functions as an oncogene via CEP55-mediated PI3K/AKT pathway. The newly identified miR-363-3p/SPAG5/CEP55 axis may represent a potential therapeutic target for the clinical intervention of HCC.

Geophysical investigations and laboratory experiments provide strong evidence for subduction of ancient oceanic crust, and geological and mineralogical observations suggest that subducted oceanic crust is recycled into the upper mantle. This model is supported by some direct petrologic and miner-alogical evidence, principally the recovery of super-deep diamonds from kimberlites and the presence of crustal materials in ophiolitic chromitites and peridotites, but many details are still unclear. Here we report the discovery of ophiolite-hosted diamonds in the podiform chromitites of the Skenderbeu massif of the Mirdita ophiolite in the western part of Neo-Tethys. The diamonds are characterized by exceedingly light C isotopes (δ13CPDB ∼ -25 ppm), which we interpret as evidence for subduction of organic carbon from Earth's surface. They are also characterized by an exceptionally large range in δ15Nair (-12.9 ppm to +25.5 ppm), accompanied by a low N aggregation state. Materials sparsely included in diamonds include amorphous material, Ni-Mn-Co alloy, nanocrystals (20 × 20 nm) of calcium silicate with an orthorhombic perovskite structure (Ca-Pv), and fluids. The fluids coexisting with the alloy and Ca-Pv provide clear evidence that the diamonds are natural rather than synthetic. We suggest that the Skenderbeu diamonds nucleated and grew from a C-saturated, NiMnCo-rich melt derived from a subducted slab of ocean crust and lithosphere in the deep mantle, at least in the diamond stability field, perhaps near the top of the mantle transition zone. The subsequent rapid upward transport in channeled networks related to slab rollback during subduction initiation may explain the formation and preservation of Skenderbeu diamonds. The discovery of diamonds from the Mirdita ophiolite not only provides new evidence of diamonds in these settings but also provides a valuable opportunity to understand deep cycling of subducted oceanic crust and mantle composition.

Microorganisms move in challenging environments by periodic changes in body shape. In contrast, current artificial microrobots cannot actively deform, exhibiting at best passive bending under external fields. Here, by taking advantage of the wireless, scalable and spatiotemporally selective capabilities that light allows, we show that soft microrobots consisting of photoactive liquid-crystal elastomers can be driven by structured monochromatic light to perform sophisticated biomimetic motions. We realize continuum yet selectively addressable artificial microswimmers that generate travelling-wave motions to self-propel without external forces or torques, as well as microrobots capable of versatile locomotion behaviours on demand. Both theoretical predictions and experimental results confirm that multiple gaits, mimicking either symplectic or antiplectic metachrony of ciliate protozoa, can be achieved with single microswimmers. The principle of using structured light can be extended to other applications that require microscale actuation with sophisticated spatiotemporal coordination for advanced microrobotic technologies. Soft biomimetic microswimmers and microrobots made of photoactive liquid-crystal elastomers and whose body shape is controlled by structured light are able to self-propel and perform complex motion patterns on demand.

With the rapid improvement of equipment integration technology, multi-spectrum detectors are integrated into compact volumes and widely used for object detection. Confront with this challenge, it is essential to propose a strategy to design a single-layer metasurface with multi-spectrum responses in microwave and infrared ranges. In this work, we proposed a method of designing meta-atoms, which is capable of achieving functional electromagnetic response at microwave and infrared individually. As a demonstration, a metasurface with four different occupation ratios and coding permutation features is designed, fabricated, and tested. In the microwave band, the pixel meta-atom is designed to realize highly efficient cross-polarization conversion between 5.0 and 10.0 GHz, which shows the metasurface can behave as ultra-low Radar Cross Section (RCS) reflectors in the working band; In the infrared band, different occupation ratio of meta-atoms are designed to realize the infrared emissivity from 0.60 to 0.80 in 3–14 μm, which can be used to exhibit digital infrared camouflage pattern. This work promotes the ability to use single-layer design to achieve digital infrared camouflage and microwave RCS reduction simultaneously. The one-layer design is simple in geometry, simplified in process, low cost in economy, and large scale in fabrication, which can promote practical use in compatible microwave stealth and infrared camouflage.