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The COVID-19 pandemic poses a major burden on healthcare and economic systems across the globe. Even though a majority of the population develops only minor symptoms upon SARS-CoV-2 infection, a significant number are hospitalized at intensive care units (ICU) requiring critical care. While insights into the early stages of the disease are rapidly expanding, the dynamic immunological processes occurring in critically ill patients throughout their recovery at ICU are far less understood. Here, we have analysed whole blood samples serially collected from 40 surviving COVID-19 patients throughout their recovery in ICU using high-dimensional cytometry by time-of-flight (CyTOF) and cytokine multiplexing. Based on the neutrophil-to-lymphocyte ratio (NLR), we defined four sequential immunotypes during recovery that correlated to various clinical parameters, including the level of respiratory support at concomitant sampling times. We identified classical monocytes as the first immune cell type to recover by restoration of HLA-DR-positivity and the reduction of immunosuppressive CD163 + monocytes, followed by the recovery of CD8 + and CD4 + T cell and non-classical monocyte populations. The identified immunotypes also correlated to aberrant cytokine and acute-phase reactant levels. Finally, integrative analysis of cytokines and immune cell profiles showed a shift from an initially dysregulated immune response to a more coordinated immunogenic interplay, highlighting the importance of longitudinal sampling to understand the pathophysiology underlying recovery from severe COVID-19.

Laughter is a nonverbal vocalization occurring in every known culture, ubiquitous across all forms of human social interaction. Here, we examined whether listeners around the world, irrespective of their own native language and culture, can distinguish between spontaneous laughter and volitional laughter—laugh types likely generated by different vocal-production systems. Using a set of 36 recorded laughs produced by female English speakers in tests involving 884 participants from 21 societies across six regions of the world, we asked listeners to determine whether each laugh was real or fake, and listeners differentiated between the two laugh types with an accuracy of 56% to 69%. Acoustic analysis revealed that sound features associated with arousal in vocal production predicted listeners’ judgments fairly uniformly across societies. These results demonstrate high consistency across cultures in laughter judgments, underscoring the potential importance of nonverbal vocal communicative phenomena in human affiliation and cooperation.

Mate value is an important concept in mate choice research although its operationalization and understanding are limited. Here, we reviewed and evaluated previously established conceptual and methodological approaches measuring mate value and presented original research using individual differences in how people view themselves as a face-valid proxy for mate value in long- and short-term contexts. In data from 41 nations ( N  = 3895, M age  = 24.71, 63% women, 47% single), we tested sex, age, and relationship status effects on self-perceived mate desirability, along with individual differences in the Dark Triad traits, life history strategies, peer-based comparison of desirability, and self-reported mating success. Both sexes indicated more short-term than long-term mate desirability; however, men reported more long-term mate desirability than women, whereas women reported more short-term mate desirability than men. Further, individuals who were in a committed relationship felt more desirable than those who were not. Concerning the cross-sectional stability of mate desirability across the lifespan, in men, short- and long-term desirability rose to the age of 40 and 50, respectively, and decreased afterward. In women, short-term desirability rose to the age of 38 and decreased afterward, whereas long-term desirability remained stable over time. Our results suggest that measuring long- and short-term self-perceived mate desirability reveals predictable correlates.

The aim of this study was to investigate the variation of channel bed roughness in two rivers, as important parameter in hydraulic modelling especially with regard to flood control. The universities of Ghent (UG) and Antwerp (UA) are conducting scientific research in the river Aa in Belgium and the Biebrza river in Poland in order to better understand the phenomena involved and to come to a more accurate determination of the different parameters influencing flow. In this paper, the determination of the roughness coefficient ‘n' from the Manning equation is used. This coefficient is not easy to determine and is varying constantly. It is influenced by the meandering character of the river, the bed material and the average grain size, the channel bed forms, the channel obstructions, the geometry changes between sections and the vegetation in the channel. Furthermore, due to these parameters, the roughness of the channel is not equally distributed over the channel, the banks and the floodplains. So, using literature data does not always lead to satisfactory results, due to the different situation in the field (Werner et al. J Hydrol 314:139-157, 2005). Therefore, measurements are necessary to determine the variation of the Manning coefficient. The Manning coefficient is a function of the discharge, but will also vary over the time due to the mentioned influences. In a multidisciplinary research project on the fundamental exchange processes in river ecosystems, hydraulic measurements were performed on a regular base in the river Aa. During these measurement campaigns, velocity and discharge measurements were carried out in multiple cross-sections. Once a month, the discharge and the water levels were measured at the upstream and the downstream end of the test stretch. On the river Biebrza, similar intensive measurement campaigns took place along a 6 km stretch in the upstream part of the river. An accurate determination of the Manning coefficient according a seasonal variation is an important tool in hydraulic modelling.

Based on the well‐known pin‐on‐disc test rig, a new test setup has been developed for online measuring of the wear and friction behavior of polymer matrix composites. Contrasting with a traditional friction and wear test rig, a steel pin and composite disc are presently used to study the influence of wear debris and fiber orientation. This test setup has a main influence on the results. The polymer materials, a thermoset polyester, and a thermoplastic polyphenylene sulfide were reinforced with glass and carbon fibers, respectively. The results show two different promising aspects of “new” materials for wear and friction applications and more specific to different machine components, namely self‐lubricating and self‐protecting ability. The self‐lubricating ability exists from creating a polymer film on the surface which reduces the coefficient of friction, and the self‐protecting behavior is because of the creation of a protecting carbon film on the surface. The self‐lubricating ability depends on the test parameters, while the self‐protecting ability was due to the material and the structure. POLYM. COMPOS., 2009. © 2008 Society of Plastics Engineers