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Although extensively used, concerns have been expressed about the reliability and generalizability of grammaticality judgment tasks (GJTs; Alanazi, 2015). It has been argued that learners might guess grammaticality based on feel (Bialystock, 1979) and that the GJT-based results ignore grammatical complexity (Ellis, 1991). While several studies have attempted to validate the results of a GJT against other tasks, the tasks used in these studies required language production (e.g., Leow, 1996; Mandell, 1999), which is different from error identification and correction. The current study used an editing task (ET) to validate learners' performance on a GJT. An editing task, like a GJT, requires identification of grammatical inaccuracies. Besides, it situates errors in a meaningful context and offers opportunities for multiple corrections of the same error. Overall, 311 participants took part in the study. A paired sample t-test showed a significant difference (¬t = 24.10, p = .00, d = 1.91) between the two tasks. Fifteen percent of the data (45 participants) was further inspected to have a better understanding of learners' error correction-pattern on the editing task. The results revealed that about 20% of the errors identified were wrongly corrected, which exposes limitations of the GJTs that only require judging the well-formedness of a construction. Moreover, performance on the editing task revealed a greater level of diversity in learners' responses. On average, eight of the total twelve grammatical features were corrected in 5.87 (SD = 2.47) different ways. The variety of responses on the ET reveals the dynamic nature of learners' interlanguage that allows for multiple ways for correction. The ET, as compared to the GJT, provides an ecologically more valid way to assess L2 learners' grammatical proficiency.

Globalization persists the tendency to alter numerous aspects of today’s world including religion, transport, language, living styles, and international relations; however, its potential to influence quality of environment is the prime concern for trade and environmental policies guidelines (Audi and Ali 2018 ). In response to the growing interest for identifying the dynamic relationship between globalization and environmental performance, the present study seeks to investigate the critical link between globalization and ecological footprints in top 15 globalized countries between 1970 and 2016. Applying the novel methods of quantile-on-quantile regression (QQ) and Granger causality in quantiles, the findings examine the manners in which quantiles of globalization affect the quantiles of ecological footprints and vice versa. The empirical results suggest that globalization has a long-term positive effect on ecological footprint and vice versa in case of Belgium, the Netherlands, Sweden, Switzerland, Denmark, Norway, Canada, and Portugal. On the other hand, the estimated results indicate a negative effect between globalization and ecological footprint in the case of France, Germany, the UK, and Hungary. These results extend the recent findings on the globalization–environment nexus implying that the magnitude of relationship among both variables varies with countries demanding individual focus and cautions for postulating environmental and trade policies.

We describe the seroprevalence of severe fever with thrombocytopenia syndrome virus (SFTSV) and the association of antibody occurrence with location, sex, and age among the human population in Pakistan. Our results indicate substantial activity of SFTSV and SFTSV-related viruses in this country.

Solid powder lubricants provide distinct advantages over conventional coolants in machining applications. Various novel approaches have been used over the years for delivering these lubricants to the machining zone. This work employs air-assisted approach using air as carrier medium and reports on the effects of “lubricant/air mixture ratio,” powder particle size,” and “lubricant laden airflow rate” on surface roughness, microhardness, and residual stresses when AISI 1045 steel is ground with boric acid as lubricant. Nested-factorial mixed model design of experiment is used for structured inquiry; two levels (25 and 96.5 μm) of lubricant “powder particle size” are in factorial arrangement with three levels (1:1/2, 1:1, 1:2) of “lubricant/air mixture ratio.” Three distinct levels of “lubricant laden airflow rate” are nested within the levels of “lubricant/air mixture ratio.” Results show that coarse particles and concentrated mixture give favorable results in general, except for residual stresses. Balanced analysis of variance (ANOVA) reveals that “powder particle size” is statistically significant (95% confidence) for all three response measures whereas “lubricant/air mixture ratio” is significant for microhardness and residual stresses. Further, interaction of “powder particle size” with “lubricant laden airflow rate” is significant for surface roughness and residual stresses. Values obtained with 96.5 μm particle size, 1:1/2 mixture ratio and 0.74 g/s flow rate are within 2% and 22% for microhardness and surface roughness respectively w.r.t. “grinding with conventional coolant”; 7% better microhardness, 48% less surface roughness, and 75% less residual stresses are obtained w.r.t “dry grinding.”

The objective of the present article is to highlight the concept of innovation performance, its importance and the different elements that could potentially enhance it within an organization. Through critical appraisal of the literature, the paper has attempted to shed light on how innovation performance is essentially important for businesses to thrive in the current global economy via focusing on prospects like corporate entrepreneurship and employee engagement. The review has concluded that Innovation and more importantly, employee performance towards bringing innovative is critical for businesses. Corporate entrepreneurship is an evolving concept that talks about nurturing and establishing such an environment that supports and motivates people to work with initiative mindset, indulging in creativity and innovation within the organization. Notably, past empirical evidence has underscored employee engagement to be highly significant in enhancing performance focused outcomes. The paper had attempted to establish how corporate entrepreneurship can enhance innovation performance within an organization. Importantly, the paper has also outlined pivotal role of employee engagement as a potential moderator to enrich this relationship. The paper has forwarded research model highlighting severe paucity of research and mature significance for fostering innovation performance at the workplace.

Background Breast cancer is a heterogeneous illness in terms of histologic variants, natural history of disease, clinical behaviour, and response to therapy. Triple-negative breast cancer (TNBC) is a biologically aggressive tumour with the worst prognosis among all subtypes, owing to higher grade and high proliferation capacity, and, restricted therapeutic choices. Despite numerous attempts to identify therapeutic aberrations that can be targeted, chemotherapy continues to be the primary systemic treatment for TNBC. It should be noted, however, that multiple studies have shown racial variation in the clinical behaviour of TNBCs and there remains a need to identify alternative, novel driver mutations in our ethnically diverse population, especially actionable mutations that might prove to be potential targets for precision therapy. This study was taken up with the aim to identify distinct targetable genetic alterations in TNBC patients and to report the frequencies of various subtypes. Results Among 353 breast cancer patients, 75 were TNBC, and 10 treatment-naïve TNBC cases were selected for the study. Selected TNBC FFPE (formalin fixed paraffin embedded) tissue samples were subjected to Genomic DNA extraction and whole-exome sequencing followed by bioinformatics analysis for detection of deleterious variants. A total of 812,598 non-synonymous SNPs were identified over the 10 samples. Following application of insilico prediction tools, 275 SNPs were identified. The most frequently mutated genes were OR9G1 and MUC6 . Six out of 10 TNBC cases in this study were found to harbour missense variants, c.505 C > T (p.Arg169Cys) and c.335 A > G (p.Tyr112Cys) in the OR9G1 gene. The second most frequently mutated gene in our samples was MUC6 with 5 samples harbouring the variant c.5618 C > A. Conclusion Detection of these variants in six out of 10 cases indicates probable role of these vastly unexplored genes in the pathogenesis of triple-negative breast tumours and warrants further exploration to establish their significance as targetable sites and facilitate drug development.

Purpose An individual’s standard of living is profoundly affected by industrialization and technology’s continuous revolution. At present, the environment is uncontrollable and global warming is increasing. Therefore, there is a need to protect the earth immediately as the lives of all creatures are at risk. The purpose of this paper is to determine the factors related to green purchase behavior (GPB) by incorporating religious values (RGV) as a moderator. Moreover, the moderating role of RGV has been incorporated so that the importance of RGV in the life of millennials can be examined. Design/methodology/approach Smart partial least square (PLS) has been used for data analysis, and PLS-structural equation modeling has been used to assess measurement and structural models. Findings The findings reveal that environmental concern, environmental knowledge and green perceived value positively and significantly affect attitude and subjective norm (SN). Moreover, attitudes toward the purchase of green products and SNs also show a positive and significant relationship with green purchase intention (GPI). In addition, GPI is also positively and significantly associated with GPB. However, green brand knowledge portrays a positive but insignificant relationship with attitude and SN. Finally, RGV does not strengthen the relationship between intention and behavior. Originality/value Religion is a strong predictor of individual behavior as people are emotionally connected with Islam’s teachings. Therefore, the study provides a unique contribution by adding RGV as a moderator in the model of TRA. Also, the authors targeted the specific generation, i.e. millennials, so that millennials’ behavior can be identified as it covers Pakistan’s large population. Also, millennials are the people who are more involved in decision-making.

This study reports findings of a meta-analysis on the effects of the age of first exposure, known as the age of onset (AO), on the acquisition of morphosyntax in a second language (L2). Several studies report restrictive effects of AO on L2 grammar acquisition (Abrahamsson, 2012; DeKeyser et al., 2010; Qureshi, 2016); however, there is a disagreement about the way sensitivity to second language acquisition declines (Birdsong, 2009; Long, 2013). Researchers disagree about the nature of the decline and argue whether the decrease that occurs in learners' ultimate proficiency in the second language is gradual and continuous or gradual but followed by a plateau, without further decline. To explore the nature of AO, 29 samples from 14 studies were analyzed. The results revealed a large effect size (d = 1.13, SD = .06) for the impact of AO on ultimate proficiency in L2 morphosyntax. However, for the disaggregated data (i.e., when earlier & late learners are separated), a linear decline was observed for the 6 to 16 age-group (21 samples), while a flattening of the regression line was detected for the 17 to 24 age-group (8 samples). More importantly, the findings revealed two different shapes of decline based on participants' first language and the target L2. Overall, the findings support a bounded critical period for second language acquisition and indicate the typological distance between the two languages as a major influencing factor.

Background A group of genetically altered cells that have not transformed into a clinical or histologically identifiable state of malignancy but contains a higher risk of transforming into one is known as the field of cancerization. Numerous molecules are being investigated for their significance in the development of this phenomenon. One such protein of this family is Kaiso also known as ZBTB33 (Zinc Finger and BTB Domain containing 33). This protein belongs to the POZ-ZF family of transcription factors and may have functional tasks similar to its other siblings such as the growth and development of vertebrates and the pathogenesis of neoplastic diseases. Nevertheless, its role in the pathogenesis, progression, epithelial mesenchyal transition and field cancerization in case of oral cancer still needs exploration. Hence, this study was designed to explore the expressional differences between the mucosa of controls and those diagnosed with oral squamous cell carcinoma (OSCC). Methods Soft tissue samples were obtained from the main tumor, tumor periphery and opposite buccal mucosa of 50 oral cancer patients, whereas normal mucosa was taken from 50 volunteers undergoing elective tooth removal. The acquired samples were subjected to Immunohistochemical exploration for expression of Kaiso and E-Cadherin. The expression was measured using Image-J IHC profiler and summed as Optical density. The Optical density values were then subjected to statistical analysis. Results Results revealed a significant differential expression of Kaiso between the mucosal tissues taken from oral cancer patients and controls ( p -value: < 0.0001), showing almost 50% down-regulation of Kaiso in all three tissue samples taken from oral cancer patients as compared to normal mucosa. Conclusion Kaiso has a significant difference of expression in the mucosa of oral cancer patients as compared to the mucosa of normal patients, making it a probable contributor to disease pathogenesis and field cancerization.

The popularity of green innovation has dramatically increased in the recent times because of the potential benefits attached with it. Therefore, in order to make the technology more affordable, green innovation is the key to enhancing the affordability factor. On the other hand, in order to safeguard the environment, the role of media is one of fundamental importance. In contrast, energy consumption is often regarded as a key indicator of economic prosperity, mostly at the cost of the environment. Hence, the present study attempts to explore the asymmetric effect of the film and drama industry, energy efficiency, and economic growth on green innovation, with the help of the latest quantile autoregressive distributed lag (QARDL) method for the period 2000Q1 to 2019Q4. The results have reported a positive and significant association of the Film and Drama Industry, Energy Efficiency, and economic growth on the quantiles of Green Innovation. Based on the findings, it is recommended that there is a dire need to develop content that promotes the green innovation, whereas, more investments are to be sought after, so as to enhance the level of energy efficiency.