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Background Breastfeeding is a critical health equalizer and predictor of significant maternal and infant health outcomes, profoundly influenced by the socioeconomic and cultural status of mothers. Previous research has suggested that migration negatively impacts the breastfeeding practices of immigrant mothers. Given that Iran hosts approximately 3 million Afghan refugees, this study aimed to compare the breastfeeding practices of immigrant Afghan mothers in Iran with those of Iranian mothers. Methods This prospective cohort study included postpartum Iranian mothers ( n  = 209) and Afghan immigrant mothers ( n  = 327) referred to Nekuei Hedayati Forqani Hospital in Qom and Imam Khomeini Hospital complex in Tehran from January 1, 2023, to May 1, 2023. Breastfeeding quality was assessed using the Bristol Breastfeeding Assessment Tool (BBAT) at baseline (after birth) and at 2-, 4-, and 6-month follow-ups. Breastfeeding continuity was qualitatively assessed based on mothers’ reports of daily frequency and duration of breastfeeding episodes over six months. Results The mean BBAT score of the Iranian cohort was significantly higher than that of Afghan mothers at baseline (7.0 ± 1.5 vs. 6.7 ± 1.7; P-value = 0.032) and at the 6-month follow-up (7.7 ± 0.5 vs. 7.1 ± 1.3; P-value < 0.001), with no significant differences at 2- and 4-month follow-ups (P-values > 0.05). Additionally, the Iranian cohort demonstrated a higher frequency of daily breastfeeding episodes (P-value = 0.001) and longer mean duration per episode compared to the Afghan cohort (P-value < 0.001). Conclusions Our findings suggested that Afghan immigrant mothers tend to have poorer breastfeeding practices than Iranian mothers, which highlights the need for Iran’s healthcare system to offer a multicultural, accessible, educational, and supportive framework to improve these outcomes. Nonetheless, our relatively small sample size, significant sociodemographic disparities between the Iranian and Afghan cohorts, and restriction to urban sampling may limit the generalizability of our results. Future research would benefit from larger, longitudinal studies with nationally representative samples that systematically examine how socioeconomic factors influence breastfeeding practices among Afghan migrant populations in Iran. Trial registration Not applicable.

All components of Ziziphus jujube (ZJ) were used in medicine and food in ancient Iran and China. Cisplatin is one of the most important drugs in the treatment of solid tumors. Taking this drug can result in nephrotoxicity through several mechanisms. The purpose of this study was to evaluate the effects of ZJ on the nephrotoxicity induced by cisplatin in rats. Thirty-five experimental rats were randomly divided into the following five groups ( n  = 7 per group) for an 8-day study: 1- Group C1 was the control group and received distilled water (1 ml/day); 2- Group C2 received a single dose of intraperitoneal cisplatin (5 mg/kg); 3- Group ZJ received 1500 mg/kg/day Ziziphus Jujube extract orally; 4- Group ZJ1 was given 1500 mg/kg/day of Ziziphus Jujube extract orally with taking a single dose of cisplatin (5 mg/kg) on the first day only; 5- Group ZJ2 received 3000 mg/kg/day of Ziziphus jujube extract orally with taking a single dose of cisplatin (5 mg/kg) on the first day only. Eventually, histopathological parameters, blood urea nitrogen (BUN), malondialdehyde (MDA), alanine transaminase (ALT), and aspartate transaminase (AST) were assessed. The findings showed that cisplatin administration resulted in severe degeneration in all parts of the nephron tubules. Also, the present study showed that MDA levels were significantly lower in both ZJ1 and ZJ2 groups compared with those in group C2 ( p  < 0.01). Moreover, the cisplatin-induced elevation of serum BUN levels significantly decreased in both ZJ1 and ZJ2 groups in comparison with that in group C2 ( p  < 0.01). In addition, serum levels of both ALT and AST were significantly higher in group C2 in comparison with those in group C1 ( p  < 0.05). Extensive tubular necrosis was seen in group C2. In brief, results of this research indicated that ZJ could prevent cisplatin-induced kidney injury in rats.

Cutaneous Leishmaniasis is a self-limiting disease caused by protozoan parasites of the genus Leishmania, which affects the skin with full-thickness wounds, which are prone to scar formation even after treatment. Taurine (Tu) is one of the most abundant amino acids that has antioxidant and anti-inflammatory effects, which play an important role in the process of wound healing. Herein, we have investigated the effects of Tu on cutaneous Leishmaniasis wounds and L. major promastigotes. Eighteen mice were induced with Leishmaniasis wounds (with L. Major) on the base of their tails and divided into three groups, T1: Treated with Tu injection, T2: Treated with Tu gel, and C: No treatment. Treatments were carried out every 24 hours for 21 days. The volume densities of the collagen bundles and vessels, vessel's length density and diameter, and fibroblast populations were estimated by stereological methods. Flow cytometry was used in order to investigate the direct Tu effect on parasites. The Mann-Whitney U test was used and P ≤ 0.05 was considered to be statistically significant. The numerical density of the fibroblasts, volume density of the collagen bundles, and length densities of the vessels in groups T1 and T2 were significantly higher than in group C (P < 0.05). The fibroblast numerical density of group T1 was higher than that of group T2 (P = 0.02). Incidentally, Tu had no direct effect on L. major parasites according to the flow cytometry analysis. Tu showed the ability to improve the wound healing process and tissue regeneration although it had no direct anti-leishmaniasis effect.

Delayed wound healing process is one of the most important concerns in diabetes. Healing of wounds has four phases, namely, hemostasis, inflammation, proliferation, and remodeling. For a successful repair, all four factors must occur properly. Hence, we aimed to evaluate the healing effects of Hypericum perforatum (HP) on full-thickness diabetic skin wounds by using stereological methods. Forty-eight female diabetic rats were randomly divided into four groups (n=12): gel base treated group, HP 5% gel treated group, HP 10% gel treated group, and the control group which received no treatment. A circular 1 cm2 full-thickness wound was created on the animal’s neck and wound area was measured every three days. After sacrificing the animals, skin samples were fixed and prepared for stereological evaluations. Based on the results, HP treated group showed faster wound closure rate in comparison with control and vehicle groups (P<0.05). In addition, numerical density of fibroblasts, volume density of collagen bundles, and mean diameter and volume densities of the vessels in HP group were significantly higher than control and vehicle groups. The results of this study showed that HP has the ability to improve tissue regeneration by enhancing fibroblast proliferation, collagen bundle synthesis, and revascularization.

BackgroundIntroducing home-based telerehabilitation (TR) approaches helps clinical experts to choose appropriate and effective interventions and researchers identify knowledge gaps to design clinical trial studies and systematic reviews.PurposeThis study aimed to review the knowledge of home-based TR in multiple sclerosis.MethodThis scoping review study was conducted based on Arksey and O'Malley’s five-step approach. The Embase, PubMed, Cochrane, Web of Sciences, Scopus and ProQuest databases were searched in 2017–2024 to find full-text English-language articles.FindingsIn 25 studies reviewed, various and extensive home-based interventions have been used in physical and cognitive aspects.ConclusionHome-based rehabilitation is applicable, useful, safe and affordable, maintains the continuity of the rehabilitation process and increases patients’ adherence to the rehabilitation programme. However, there are challenges such as patients’ lack of familiarity with technology and limitations of outcome measurement tools that should be addressed in future studies.

Background: Colorectal cancer (CRC) is one of the most common cancers worldwide. Although colonoscopy is considered as the \"Gold Standard\" technique to detect CRC, its application is invasive and cost incurred. Thus, noninvasive or minimally invasive approaches are of utmost importance. The aberrant expression of some microRNAs (miRNAs, miRs) has been suggested in association with CRC pathogenesis. This study aimed to validate if circulating serum miR-1229 and miR-1246 are diagnostic biomarkers for CRC. Materials and Methods: Serum samples were isolated from 45 CRC patients and also 45 healthy controls (HC). The expression levels of circulating serum-derived miR-1229 and miR-1246 were evaluated by quantitative real-time polymerase chain reaction. Receiver operating characteristic (ROC) curves were constructed to evaluate the CRC diagnostic accuracy of selected miRNAs. Furthermore, the association of candidate miRNAs and clinicopathological characteristics were evaluated. Functional enrichment of the candidate miRNAs was applied using in silico tools. Results: The expression of miR-1229 and miR-1246 was significantly higher in CRC patients than HC (P < 0.0001) and also was found in association with lymph node metastasis (P < 0.05). We demonstrated a significant up-regulation of serum-derived miR-1246 in advanced tumor-node-metastasis stage III of CRC patients (P < 0.05). Areas under the ROC curve of miR-1229 and miR-1246 were 0.81 and 0.84, respectively (P < 0.0001). Conclusion: We confirmed the capability of circulating serum miR-1229 and miR-1246 as novel diagnostic biomarkers for CRC.