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IntroductionThe Crisis and Home Treatment Teams (CRHT) in psychiatry manages patients with risk to self and others in the community. The number of patents under CRHT who attempt or die of suicide is high in the UK (Hunt et al BJPsych Bull. 2016;40:172-4). The CRHT is an option to help support patients in managing their risk using various interventions and also aim to prevent admission to acute psychiatric wards where possible.ObjectivesWe intended to study the change in risk to self and others and the factors associated with it during the intervention from a CRHT taking care of adult patients in the West Midlands region of England.MethodsThe study was conducted as a service evaluation of patients admitted under the CRHT. Data was collected from the case records, for 100 patients for whom details were available. Risk to self and others were checked, along with overall risk as red (highest risk), amber (intermediate risk) and green (low risk). Demographic and clinical information was collected and the data quality was checked.ResultsThere were 46 male and 54 female patients in the study, with mean age of 40.4 ± 12.4 and 40.2 ± 12.8 Years respectively (not significant). They were comparable in number of diagnoses (mean 1.2 each) and number of days (22.2 ± 13.1 v 20.2 ± 17.8) in CRHT respectively. There was no significant association of risk with gender (56.3% females and 44.2% of males), being on benefits or type of accommodation the service users live at. Similarly, there was no significant difference of risk of self-harm based on ethnicity; it was noted that 61.2% of patients of British White ethnicity had a risk of self on admission compared to 41.7% Black and ethnic minority patients. On admission, 89% of patients were categorised as red, amber 8% and 1% green; which changed to 18%, 2% and 77% respectively (missing data was not included, so percentages do not add up to 100%). The risk to self was present in 46% on admission and 18% on discharge (p<0.005); and in 14% this risk continued without change. The risk to others on admission was recorded in 12% which was at 1% on the point of discharge (p<0.05). Eight people had both risk to self and others. In 15 patients the risk continued to remain in red category, while in two patients it changed from amber to red.ConclusionsThe risk levels for patients admitted under the CRHT improved. The majority with overall high risk changed to majority presenting as low risk on discharge. The percentage of patients portraying a risk to self and others also decreased from admission to discharge. Although there was considerable decrease in risk, a proportion of patients did not have any change, or even an increase in their risk, which highlights need for additional risk management strategy for these patients in CRHT.Disclosure of InterestNone Declared

Organic semiconductors (OSCs) promise to deliver next‐generation electronic and energy devices that are flexible, scalable and printable. Unfortunately, realizing this opportunity is hampered by increasing concerns about the use of volatile organic compounds (VOCs), particularly toxic halogenated solvents that are detrimental to the environment and human health. Here, a cradle‐to‐grave process is reported to achieve high performance p‐ and n‐type OSC devices based on indacenodithiophene and diketopyrrolopyrrole semiconducting polymers that utilizes aqueous‐processes, fewer steps, lower reaction temperatures, a significant reduction in VOCs (>99%) and avoids all halogenated solvents. The process involves an aqueous mini‐emulsion polymerization that generates a surfactant‐stabilized aqueous dispersion of OSC nanoparticles at sufficient concentration to permit direct aqueous processing into thin films for use in organic field‐effect transistors. Promisingly, the performance of these devices is comparable to those prepared using conventional synthesis and processing procedures optimized for large amounts of VOCs and halogenated solvents. Ultimately, the holistic approach reported addresses the environmental issues and enables a viable guideline for the delivery of future OSC devices using only aqueous media for synthesis, purification and thin‐film processing. An environmentally benign cradle‐to‐grave process from synthesis‐to‐device is demonstrated for high performance organic field‐effect transistors. This holistic approach uses aqueous processes from mini‐emulsion polymerization to purification and thin‐film deposition. Compared to conventional approaches, the process requires fewer steps, lower reaction temperatures, a significant reduction in the use of volatile organic compounds and avoids toxic halogenated solvents.

This paper is concerned with the passivity analysis problem for a class of discrete-time stochastic bidirectional associative memory neural networks with time-varying delays. Furthermore, the results are extended to the robust passivity analysis with mixed time delays that consist of both the discrete and distributed time delays, and the uncertainties are assumed to be time-varying norm bounded parameter uncertainties. By constructing a new Lyapunov–Krasovskii functional and introducing some appropriate free-weighting matrices, a delay-dependent passivity criterion is derived in terms of LMIs whose feasibility can be easily checked by some available software packages. Finally, two numerical examples with simulation results are given to demonstrate the effectiveness and usefulness of the proposed results.

This paper investigates the problem of global dissipativity and global exponential dissipativity for a class of uncertain discrete-time stochastic neural networks with multiple time-varying delays. Here the multiple time-varying delays are assumed to be discrete and distributed and the uncertainties are assumed to be time-varying norm-bounded parameter uncertainties. By choosing a novel Lyapunov functional, combining with linear matrix inequality technique (LMI), Jensen’s inequality and stochastic analysis method, a new delay-dependent global dissipativity criterion is obtained in the form of LMI, which can be easily verified numerically using the effective LMI toolbox in Matlab. One important feature presents in our paper is that without employing model transformation and free weighting matrices our obtained result leads to less conservatism. Two illustrative examples are given to show the usefulness of the obtained dissipativity conditions.

This paper analyzes the global asymptotic stability of a class of neural networks with time delay in the leakage term and time-varying delays under impulsive perturbations. Here the time-varying delays are assumed to be piecewise. In this method, the interval of the variation is divided into two subintervals by its central point. By developing a new Lyapunov–Krasovskii functional and checking its variation in between the two subintervals, respectively, and then we present some sufficient conditions to guarantee the global asymptotic stability of the equilibrium point for the considered neural network. The proposed results which do not require the boundedness, differentiability and monotonicity of the activation functions, can be easily verified via the linear matrix inequality (LMI) control toolbox in MATLAB. Finally, a numerical example and its simulation are given to show the conditions obtained are new and less conservative than some existing ones in the literature.

Background On the background of the interventional radiology department of a tertiary hospital converting its periprocedural documentation from paper-based to electronic using a standardised proforma, a study was performed to ascertain the effects of this change on the standard of clinical documentation for radiologically-guided angiographic procedures. Using a retrospective approach, perioperative records were analysed in reverse chronological order for inclusion in the study. The standard for this audit was developed in the form of minimum criteria that all clinical documentation of angiographic procedures were expected to meet. Results The audit was performed at three equally spaced intervals of 6 months, yielding a total of 99 records. The baseline audit of paper-based records concluded > 80% completeness for 8 out of the 14 of parameters measured, with only two of parameters meeting the target of 100% completeness. The second audit cycle performed on electronic records found 7 out of 14 parameters demonstrating absolute improvement in completeness, when compared to paper-based, but with the number of parameters exceeding 80% completeness falling to only 4 out of 14. Again, 100% completeness was observed in only 2 of the parameters. In the final audit cycle, after the introduction of a standardised electronic proforma, performance improved in every dimension with 6 out of 14 parameters reaching completeness of 100% and the 80% completeness threshold met by 12 out of 14 parameters. Conclusion The construction of a procedure-specific perioperative electronic proforma can save clinicians valuable time and encourage safe and effective clinical documentation.

Honeycomb-layered YCrTeO6 is synthesized from the stoichiometric metal oxides Y2O3, Cr2O3 and TeO2 at 1223 K by employing the solid-state reaction method. Phase analysis of the x-ray diffraction pattern revealed a hexagonal structure with space group P3¯. Temperature-dependent magnetization curve of the single-phase YCrTeO6 indicates its paramagnetic nature down to 10 K; however, hysteresis loop at room temperature shows weak antiferromagnetism in pure YCrTeO6 phase. Secondary phase YCrO3 crystallized because of Te volatilization during annealing of the phase-pure material at 1323 K. Two magnetic transitions were noticed in the annealed YCrTeO6, one at 142.08 due to the YCrO3 phase, and another at a low-temperature transition of 13.28 K. Interestingly, the presence of room-temperature antiferromagnetism, ferroelectricity and magnetoelectric coupling, arising as a result of the frustrated crystal lattice in the single phase YCrTeO6 makes it a potential candidate for magnetoelectric devices.

In this article, we investigate the sufficient conditions for the existence of solutions to a Caputo fractional derivative with a class of boundary value problem dependence on the lipschitz first derivative conditions in Banach Space. Our main tool is a fixed point theorem. An numerical example is given to clarify the results.

Microrods of ZnO and Al, Sn-doped ZnO were synthesized by sol–gel hydrothermal procedure. The effect of dopants on the structural and optical properties were analyzed as well as the annealing effect is also investigated. Structural insight from the X-ray diffraction inferred hexagonal wurtzite structure and (002) preferential orientation of the synthesized grains. Scanning electron micrographs showed growth of the microrods on the seed layer in vertical alignment. Annealing the as-synthesized microrods resulted in improved crystallinity and led to shape change of the microrods from cylindrical to sharply pointed microrods. The presence of the Raman phonon modes E 2 high and E 2 low reflected hexagonal wurtzite structure . Transmittance of the ZnO microrods was increased on doping. Al single-doped ZnO and Al, Sn codoped ZnO exhibit bandgap narrowing whereas in the case of Sn single-doped ZnO bandgap broadening was noticed. Annealing widened the bandgap of ZnO and doped ZnO microrods. Observation of high optical transmittance of about 94% and energy bandgap of about 3.05 eV in Sn single-doped ZnO microrods implied their significance in optoelectronic device applications. PL spectra showed an intense violet emission along with the emission in blue, green and green-yellow bands. The doped ZnO microrods showed a blue-shift compared to that of the ZnO microrods sample. The chromaticity graph showed the emissions in the violet-blue region due to electron–hole recombination.

Preoperative (neoadjuvant) chemotherapy and radiotherapy are more effective than similar postoperative treatment for oesophageal, gastric, and rectal cancers, perhaps because of more effective micrometastasis eradication and reduced risk of incomplete excision and tumour cell shedding during surgery. The FOxTROT trial aims to investigate the feasibility, safety, and efficacy of preoperative chemotherapy for colon cancer. In the pilot stage of this randomised controlled trial, 150 patients with radiologically staged locally advanced (T3 with ≥5 mm invasion beyond the muscularis propria or T4) tumours from 35 UK centres were randomly assigned (2:1) to preoperative (three cycles of OxMdG [oxaliplatin 85 mg/m2, l-folinic acid 175 mg, fluorouracil 400 mg/m2 bolus, then 2400 mg/m2 by 46 h infusion] repeated at 2-weekly intervals followed by surgery and a further nine cycles of OxMdG) or standard postoperative chemotherapy (12 cycles of OxMdG). Patients with KRAS wild-type tumours were randomly assigned (1:1) to receive panitumumab (6 mg/kg; every 2 weeks with the first 6 weeks of chemotherapy) or not. Treatment allocation was through a central randomisation service using a minimised randomisation procedure including age, radiological T and N stage, site of tumour, and presence of defunctioning colostomy as stratification variables. Primary outcome measures of the pilot phase were feasibility, safety, and tolerance of preoperative therapy, and accuracy of radiological staging. Analysis was by intention to treat. This trial is registered, number ISRCTN 87163246. 96% (95 of 99) of patients started and 89% (85 of 95) completed preoperative chemotherapy with grade 3–4 gastrointestinal toxicity in 7% (seven of 94) of patients. All 99 tumours in the preoperative group were resected, with no significant differences in postoperative morbidity between the preoperative and control groups: 14% (14 of 99) versus 12% (six of 51) had complications prolonging hospital stay (p=0·81). 98% (50 of 51) of postoperative chemotherapy patients had T3 or more advanced tumours confirmed at post-resection pathology compared with 91% (90 of 99) of patients following preoperative chemotherapy (p=0·10). Preoperative therapy resulted in significant downstaging of TNM5 compared with the postoperative group (p=0·04), including two pathological complete responses, apical node involvement (1% [one of 98] vs 20% [ten of 50], p<0·0001), resection margin involvement (4% [four of 99] vs 20% [ten of 50], p=0·002), and blinded centrally scored tumour regression grading: 31% (29 of 94) vs 2% (one of 46) moderate or greater regression (p=0·0001). Preoperative chemotherapy for radiologically staged, locally advanced operable primary colon cancer is feasible with acceptable toxicity and perioperative morbidity. Proceeding to the phase 3 trial, to establish whether the encouraging pathological responses seen with preoperative therapy translates into improved long-term oncological outcome, is appropriate. Cancer Research UK.