Explore the vast range of titles available.

Analyses of the cosmic 21 cm signal are hampered by astrophysical foregrounds that are far stronger than the signal itself. These foregrounds, typically confined to a wedge-shaped region in Fourier space, often necessitate the removal of a vast majority of modes, thereby degrading the quality of the data anisotropically. To address this challenge, we introduce a novel deep generative model based on stochastic interpolants to reconstruct the 21 cm data lost to wedge filtering. Our method leverages the non-Gaussian nature of the 21 cm signal to effectively map wedge-filtered 3D lightcones to samples from the conditional distribution of wedge-recovered lightcones. We demonstrate how our method is able to restore spatial information effectively, considering both varying cosmological initial conditions and astrophysics. Furthermore, we discuss a number of future avenues where this approach could be applied in analyses of the 21 cm signal, potentially offering new opportunities to improve our understanding of the Universe during the epochs of cosmic dawn and reionization. Code, pre-trained models, and scripts for making plots in this paper can be found here .

Skin disorders are one of the most common complications of type II diabetes (T2DM). Long-term effects of high blood glucose leave individuals with T2DM more susceptible to cutaneous diseases, but its underlying molecular mechanisms are unclear. Network-based methods consider the complex interactions between genes which can complement the analysis of single genes in previous research. Here, we use network analysis and topological properties to systematically investigate dysregulated gene co-expression patterns in type II diabetic skin with skin samples from the Genotype-Tissue Expression database. Our final network consisted of 8812 genes from 73 subjects with T2DM and 147 non-T2DM subjects matched for age, sex, and race. Two gene modules significantly related to T2DM were functionally enriched in the pathway lipid metabolism, activated by PPARA and SREBF ( SREBP ). Transcription factors KLF10 , KLF4 , SP1 , and microRNA-21 were predicted to be important regulators of gene expression in these modules. Intramodular analysis and betweenness centrality identified NCOA6 as the hub gene while KHSRP and SIN3B are key coordinators that influence molecular activities differently between T2DM and non-T2DM populations. We built a TF-miRNA-mRNA regulatory network to reveal the novel mechanism ( miR-21-PPARA-NCOA6 ) of dysregulated keratinocyte proliferation, differentiation, and migration in diabetic skin, which may provide new insights into the susceptibility of skin disorders in T2DM patients. Hub genes and key coordinators may serve as therapeutic targets to improve diabetic skincare.

ObjectiveOffice environments have been causally linked to workplace-related illnesses and stress, yet little is known about how office workstation type is linked to objective metrics of physical activity and stress. We aimed to explore these associations among office workers in US federal office buildings.MethodsWe conducted a wearable, sensor-based, observational study of 231 workers in four office buildings. Outcome variables included workers’ physiological stress response, physical activity and perceived stress. Relationships between office workstation type and these variables were assessed using structural equation modelling.ResultsWorkers in open bench seating were more active at the office than those in private offices and cubicles (open bench seating vs private office=225.52 mG (31.83% higher on average) (95% CI 136.57 to 314.46); open bench seating vs cubicle=185.13 mG (20.16% higher on average) (95% CI 66.53 to 303.72)). Furthermore, workers in open bench seating experienced lower perceived stress at the office than those in cubicles (−0.27 (9.10% lower on average) (95% CI −0.54 to −0.02)). Finally, higher physical activity at the office was related to lower physiological stress (higher heart rate variability in the time domain) outside the office (−26.12 ms/mG (14.18% higher on average) (95% CI −40.48 to −4.16)).ConclusionsOffice workstation type was related to enhanced physical activity and reduced physiological and perceived stress. This research highlights how office design, driven by office workstation type, could be a health-promoting factor.

Asthma is a common chronic health condition affecting millions of people in the United States. While asthma cannot be cured, it can be managed if we identify and understand triggers and risk factors that cause asthma exacerbations. However, this is challenging because these triggers and risk factors are complex and interconnected, and there are limitations to current mainstream approaches for identifying them. The recent availability of massive amounts of heterogeneous data has opened up new possibilities for asthma triggers and risk factors analyses. In this study, we introduce a data-driven framework, adapt and integrate multiple advanced machine learning techniques, and perform an empirical analysis to (1) derive characteristics of self-reported asthma patients from social media, (2) enable integration and repurposing of highly heterogeneous and commonly available datasets, and (3) uncover the sequential patterns of asthma triggers and risk factors, and their relative importance, both of which are difficult to achieve via retrospective cohort-based studies. Our methods and results can provide guidance for developing asthma management plans and interventions for specific subpopulations and, eventually, have the potential to reduce the societal burden of asthma.

The prediction of fracture risk in osteoporotic patients has been a topic of interest for decades, and models have been developed for the accurate prediction of fracture, including the fracture risk assessment tool (FRAX). As machine‐learning methodologies have recently emerged as a potential model for medical prediction tools, we aimed to develop a novel fracture prediction model using machine‐learning methods in a prospective community‐based cohort. In this study, 2227 participants (1257 females) with a baseline bone mineral density (BMD) and trabecular bone score were enrolled from the Ansung cohort. The primary endpoint was the fragility fractures reported by patients or confirmed by X‐rays. We used 3 different models: CatBoost, support vector machine (SVM), and logistic regression. During a mean 7.5‐year follow‐up (range, 2.5 to 10 years), fragility fractures occurred in 537 (25.6%) of participants. In predicting total fragility fractures, the area under the curve (AUC) values of the CatBoost, SVM, and logistic regression models were 0.688, 0.500, and 0.614, respectively. The AUC value of CatBoost was significantly better than that of FRAX (0.663; p < 0.001), whereas the the SVM and logistic regression models were not. Compared with the conventional models such as SVM and logistic regression, the CatBoost model had the best performance in predicting total fragility fractures (p < 0.001). According to feature importance in the CatBoost model, the top predicting factors (listed in order) were total hip, lumbar spine, and femur neck BMD, subjective arthralgia score, serum creatinine, and homocysteine. The latter three factors were listed higher than conventional predictors such as age or previous fracture history. In summary, we hereby report the development of a prediction model for fragility fractures using a machine‐learning method, CatBoost, which outperforms the FRAX model as well as two conventional machine‐learning models. The model was also able to propose novel high‐ranking predictors. © 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

A bstract We explore the signals of a scenario in which the composite states of a strongly coupled hidden sector couple to the Standard Model through the neutrino portal, giving rise to the neutrino masses. We consider a framework in which the hidden sector is conformal in the ultraviolet and the compositeness scale lies below the weak scale. If the lightest composite state in the hidden sector is a scalar, its decay rate back to the Standard Model is suppressed by angular momentum considerations and can naturally be small, giving rise to long-lived particle signals. We determine the current constraints on this class of models and explore the reach of future collider and beam dump searches. We find that FASER, SHiP, and Belle II can potentially probe a significant part of the unexplored parameter space.

The iPlant Collaborative (iPlant) is a United States National Science Foundation (NSF) funded project that aims to create an innovative, comprehensive, and foundational cyberinfrastructure in support of plant biology research (PSCIC, 2006). iPlant is developing cyberinfrastructure that uniquely enables scientists throughout the diverse fields that comprise plant biology to address Grand Challenges in new ways, to stimulate and facilitate cross-disciplinary research, to promote biology and computer science research interactions, and to train the next generation of scientists on the use of cyberinfrastructure in research and education. Meeting humanity's projected demands for agricultural and forest products and the expectation that natural ecosystems be managed sustainably will require synergies from the application of information technologies. The iPlant cyberinfrastructure design is based on an unprecedented period of research community input, and leverages developments in high-performance computing, data storage, and cyberinfrastructure for the physical sciences. iPlant is an open-source project with application programming interfaces that allow the community to extend the infrastructure to meet its needs. iPlant is sponsoring community-driven workshops addressing specific scientific questions via analysis tool integration and hypothesis testing. These workshops teach researchers how to add bioinformatics tools and/or datasets into the iPlant cyberinfrastructure enabling plant scientists to perform complex analyses on large datasets without the need to master the command-line or high-performance computational services.

This paper proposes an audience selection framework for online brand advertising based on user activities on social media platforms. It is one of the first studies to our knowledge that develops and analyzes implicit brand–brand networks for online brand advertising. This paper makes several contributions. We first extract and analyze implicit weighted brand–brand networks, representing interactions among users and brands, from a large dataset. We examine network properties and community structures and propose a framework combining text and network analyses to find target audiences. As a part of this framework, we develop a hierarchical community detection algorithm to identify a set of brands that are closely related to a specific brand. This latter brand is referred to as the “focal brand.” We also develop a global ranking algorithm to calculate brand influence and select influential brands from this set of closely related brands. This is then combined with sentiment analysis to identify target users from these selected brands. To process large-scale datasets and networks, we implement several MapReduce-based algorithms. Finally, we design a novel evaluation technique to test the effectiveness of our targeting framework. Experiments conducted with Facebook data show that our framework provides significant performance improvements in identifying target audiences for focal brands.

We address the problem of recommending online communities on social media platforms using design science. Our method is grounded in network science and leverages the random surfer model of the web, small-world networks, strength of weak connections, and connectivity to analyze three types of large-scale networks. In doing so, we design features for structural hole assortativity and local clustering coefficient rank to capture both the diversity and evolution of user interests. We also extract general online community features such as size and overlap. Experiments conducted on a large dataset of 34,000 lists created and subscribed to by 1,600 active Twitter users over a six-month period showed that our network features outperform the general and content features in terms of recommending communities at the top position. In addition, a combination of general and network features generated the best results in the top position with a significant performance improvement over using only the content features. A combination of all three types of features gave the best results in the top-5 and top-10 positions while improving the quality of recommendations at every other position. Our work outperforms the latest work on community recommendations on social media platforms and has major implications for the design of online community recommenders.

This paper proposes an audience selection framework for online brand advertising based on user activities on social media platforms. It is one of the first studies to our knowledge that develops and analyzes implicit brand–brand networks for online brand advertising. This paper makes several contributions. We first extract and analyze implicit weighted brand–brand networks, representing interactions among users and brands, from a large dataset. We examine network properties and community structures and propose a framework combining text and network analyses to find target audiences. As a part of this framework, we develop a hierarchical community detection algorithm to identify a set of brands that are closely related to a specific brand. This latter brand is referred to as the “focal brand.” We also develop a global ranking algorithm to calculate brand influence and select influential brands from this set of closely related brands. This is then combined with sentiment analysis to identify target users from these selected brands. To process large-scale datasets and networks, we implement several MapReduce-based algorithms. Finally, we design a novel evaluation technique to test the effectiveness of our targeting framework. Experiments conducted with Facebook data show that our framework provides significant performance improvements in identifying target audiences for focal brands.