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Background A large body of literature suggests that certain polysaccharides affect immune system function. Much of this literature, however, consists of in vitro studies or studies in which polysaccharides were injected. Their immunologic effects following oral administration is less clear. The purpose of this systematic review was to consolidate and evaluate the available data regarding the specific immunologic effects of dietary polysaccharides. Methods Studies were identified by conducting PubMed and Google Scholar electronic searches and through reviews of polysaccharide article bibliographies. Only articles published in English were included in this review. Two researchers reviewed data on study design, control, sample size, results, and nature of outcome measures. Subsequent searches were conducted to gather information about polysaccharide safety, structure and composition, and disposition. Results We found 62 publications reporting statistically significant effects of orally ingested glucans, pectins, heteroglycans, glucomannans, fucoidans, galactomannans, arabinogalactans and mixed polysaccharide products in rodents. Fifteen controlled human studies reported that oral glucans, arabinogalactans, heteroglycans, and fucoidans exerted significant effects. Although some studies investigated anti-inflammatory effects, most studies investigated the ability of oral polysaccharides to stimulate the immune system. These studies, as well as safety and toxicity studies, suggest that these polysaccharide products appear to be largely well-tolerated. Conclusions Taken as a whole, the oral polysaccharide literature is highly heterogenous and is not sufficient to support broad product structure/function generalizations. Numerous dietary polysaccharides, particularly glucans, appear to elicit diverse immunomodulatory effects in numerous animal tissues, including the blood, GI tract and spleen. Glucan extracts from the Trametes versicolor mushroom improved survival and immune function in human RCTs of cancer patients; glucans, arabinogalactans and fucoidans elicited immunomodulatory effects in controlled studies of healthy adults and patients with canker sores and seasonal allergies. This review provides a foundation that can serve to guide future research on immune modulation by well-characterized polysaccharide compounds.

Astrophysical observations indicate that dark matter constitutes most of the mass in our universe, but its nature remains unknown. Over the past decade, the Cryogenic Dark Matter Search (CDMS II) experiment has provided world-leading sensitivity for the direct detection of weakly interacting massive particle (WIMP) dark matter. The final exposure of our low-temperature germanium particle detectors at the Soudan Underground Laboratory yielded two candidate events, with an expected background of 0.9 ± 0.2 events. This is not statistically significant evidence for a WIMP signal. The combined CDMS II data place the strongest constraints on the WIMP-nucleon spin-independent scattering cross section for a wide range of WIMP masses and exclude new parameter space in inelastic dark matter models.

Bubble chambers were the dominant technology used for particle detection in accelerator experiments for several decades, eventually falling into disuse with the advent of other techniques. We report here on a new application for these devices. We operated an ultraclean, room-temperature bubble chamber containing 1.5 kilograms of superheated CF₃I, a target maximally sensitive to spin-dependent and -independent weakly interacting massive particle (WIMP) couplings. An extreme intrinsic insensitivity to the backgrounds that commonly limit direct searches for dark matter was measured in this device under operating conditions leading to the detection of low-energy nuclear recoils like those expected from WIMPs. Improved limits on the spin-dependent WIMP-proton scattering cross section were extracted during our experiments, excluding this type of coupling as a possible explanation for a recent claim of particle dark-matter detection.

The high luminosity upgrade of the Large Hadron Collider (HL-LHC) at CERN is expected to provide instantaneous luminosities of 5 × 1034cm−2s−1. The high luminosities expected at the HL-LHC will be accompanied by a factor of 5 to 10 more pileup compared with LHC conditions in 2015, causing general confusion for particle identification and event reconstruction. Precision timing allows to extend calorimetric measurements into such a high density environment by subtracting the energy deposits from pileup interactions. Calorimeters employing silicon as the active component have recently become a popular choice for the HL- LHC and future collider experiments which face very high radiation environments. We present studies of basic calorimetric and precision timing measurements using a prototype composed of tungsten absorber and silicon sensor as the active medium. We show that for the bulk of electromagnetic showers induced by electrons in the range of 20 GeV to 30 GeV, we can achieve time resolutions better than 25 ps per single pad sensor.

One possibility to make a fast and radiation resistant shower maximum (SM) detector is to use a secondary emitter as an active element. We present below test beam results, obtained with different types of photo detectors based on micro channel plates (MCP) as secondary emitter. The SM time resolution – we obtained for this new type of detector is at the level of 20-30 ps. We estimate that a significant contribution to the detector response originates from secondary emission of the MCP.

Asymptomatic aortic stenosis (AS) is a frequent condition that may cause hyponatremia due to neurohumoral activation. We examined if hyponatremia heralds poor prognosis in patients with asymptomatic AS, and whether AS in itself is associated with increased risk of hyponatremia. The study question was investigated in 1,677 individuals that had and annual plasma sodium measurements in the SEAS (Simvastatin and Ezetimibe in AS) trial; 1,873 asymptomatic patients with mild-moderate AS (maximal transaortic velocity 2.5 to 4.0 m/s) randomized to simvastatin/ezetimibe combination versus placebo. All-cause mortality was the primary endpoint and incident hyponatremia (P-Na+ <137 mmol/L) a secondary outcome. At baseline, 4% (n = 67) had hyponatremia. After a median follow-up of 4.3 (interquartile range 4.1 to 4.6) years, 140 (9%) of those with initial normonatremia had developed hyponatremia, and 174 (10%) had died. In multiple regression Cox models, both baseline hyponatremia (hazard ratio [HR] 2.1, [95% confidence interval 1.1 to 3.8]) and incident hyponatremia (HR 1.9, [95% confidence interval 1.0 to 3.4], both p ≤ .03) was associated with higher all-cause mortality as compared with normonatremia. This association persisted after adjustment for diuretics as a time-varying covariate. Higher N-terminal pro b-type natriuretic peptide levels and lower sodium levels at baseline was associated with higher risk of incident hyponatremia. Conversely, assignment to simvastatin/ezetimibe protected against incident hyponatremia. In conclusion, both prevalent and incident hyponatremia associate with increased mortality in patients with AS. The prevalence of hyponatremia is around 4% and the incidence about 2% per year, which is comparable to that of older adults without AS.

Weakly Interacting Massive Particles (WIMPs) are a strong candidate for the Cold Dark Matter of the Universe. CDMS-II is a direct-search WIMP search experiment, operating at 50 mK and housed at the Soudan mine, Minnesota. The 250 gram Ge detectors utilize athermal phonon sensors where tungsten transition edge sensors are operated in negative electrothermal feedback. The search at Soudan is ongoing with an expected final reach of CDMS-II by the end of 2008 of a WIMP-nucleon cross-section sensitivity of 2.1 x10-44 cm2, at a WIMP mass of 60 GeV/c2. To proceed further, we have proposed the SuperCDMS program.

Heavy-liquid bubble chambers can be made stable-enough to be used in searches for Weakly Interacting Massive Particles (WIMPs). Advantages of this approach are optimal choice of target liquid-CF3I, maximally sensitive to both spin-dependent (SD) and spin-independent (SI) WIMP interactions, low cost, good scalability, room temperature operation, extraordinary intrinsic rejection of minimally-ionizing backgrounds, and a number of features permitting rejection of irreducible neutron backgrounds. A 2 kg prototype chamber is currently operating at the depth of 300 meters water equivalent (m.w.e.) NuMi gallery of Fermilab. Even with the small prototype mass, results competitive in the SI channel and surpassing current limits in the SD channel are expected.

Oral ingestion of polysaccharides can elicit immunomodulatory effects, both systemically and in the gut, but their mechanisms of action are not well understood. In a recent study, two aloe vera gel-based mixed polysaccharide dietary supplements (Advanced Ambrotose® powder and Ambrotose® complex) protected rats against dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). To better understand the mechanisms by which these supplements protect against colonic inflammation, we examined the effect of supplement feeding, with exposure to 5% DSS during the last eight days, on colonic gene activity in mice. DSS exposure without supplement feeding induced symptoms of colitis and potently increased expression of genes associated with inflammation, immune cell activation, and pathogen recognition and signaling. Feeding of supplements reduced DSS-induced disease activity, partially prevented colonic shortening, and reduced the expression of colonic pro-inflammatory, immune cell activation, and pathogen-recognition and signaling genes. Interestingly, ingestion of Advanced Ambrotose® powder down-regulated the expression of several genes associated with inflammation, and decreased the expression of genes associated with cell activation in healthy animals. This study demonstrates that DSS-induced colitis results in induction of several genes responsible for inflammation and that ingestion of these polysaccharide supplements can ameliorate some of the symptoms of colitis, possibly through suppression of these genes. [PUBLICATION ABSTRACT]