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Substance use, a significant public health concern, may be associated with worsening social connections and feelings of loneliness among adult populations. This study examined the associations between substance use (i.e., binge alcohol, e-cigarette, and traditional cigarette use) and loneliness among adults aged ≥50 years residing in the US. We conducted a secondary analysis of cross-sectional data from the 2023 Behavioral Risk Factor Surveillance System Social Determinant of Health Equity module. The sample included 138,614 adults aged ≥50 years, representing approximately 55.4 million individuals in this age group. Substance use was the key independent variable and categorized into two groups: no substance use and substance use—participants who reported current use of ≥1 of three substances (i.e., binge alcohol, e-cigarette, and traditional cigarette use). Overall, 19.0% of participants reported using ≥1 substance use, 21.0% reported feeling lonely sometimes, and 5.1% feeling lonely always/usually. Participants who reported using ≥1 substance had a 17.0% higher relative risk of feeling lonely always/usually (compared to feeling never/rarely lonely) than adults who did not report substance use, after adjusting for all covariates (RRR 1.17; 95% CI 1.10–1.35; p = 0.029). These findings underscore the strong link between substance use and loneliness among midlife and older adults.

Racial discrimination has been linked to decreased psychological well-being and physical health. Most Asian Americans in the United States reported discrimination against Asians as a major problem and that inadequate attention is given to racial inequities affecting Asians living in the US. We described the association of racism-related stress and health outcomes among Asian American sexual minority men. We hypothesized that greater racism-related stress is associated with poor general and oral health, increased substance use, and unfavorable attitudes about PrEP. We conducted a secondary analysis of data collected in 2017–2019 through the HIV Oral Self-Testing Infographic Experiment study, a pilot behavioral randomized controlled trial testing effects of an HIV self-testing infographic in 322 emerging adult ethnic and racial sexual minority men. We examined secondary data on racism-related stress and health outcomes in 62 participants using questions derived from the Behavioral Risk Factor Surveillance System, National Survey on Drug Use and Health, PrEP Familiarity and Attitudes Questionnaire, and the Asian American Racism-related Stress Inventory (AARRSI). To describe association between AARRSI scores and health outcomes, we calculated mean total AARRSI scores across categorical variables and assessed differences between groups using one-way ANOVA, and we assessed correlation between continuous variables with scores using Spearman correlation. Findings suggested that greater racism-related stress is linked to increased substance use. More research is needed to confirm these observed trends with larger, more diverse samples, explore intersectional factors such as sexual minority identity and societal discrimination against Asians, and how the current political climate has contributed to negative experiences that amplify health risks.

Sexual minority men with HIV are at an increased risk of cardiovascular disease (CVD) and have been underrepresented in behavioral research and clinical trials. This study aims to explore perceptions of HIV-related comorbidities and assess the interest in and usability of a virtual environment for CVD prevention education in Black and Latinx sexual minority men with HIV. This is a 3-phase pilot behavioral randomized controlled trial. We report on formative phases 1 and 2 that informed virtual environment content and features using qualitative interviews, usability testing, and beta testing with a total of 25 individuals. In phase 1, a total of 15 participants completed interviews exploring HIV-related illnesses of concern that would be used to tailor the virtual environment. In phase 2, usability testing and beta testing were conducted with 10 participants to assess interest, features, and content. In phase 1, we found that CVD risk factors included high blood pressure, myocardial infarction, stroke, and diabetes. Cancer (prostate, colon, and others) was a common concern, as were mental health conditions. In phase 2, all participants completed the 12-item usability checklist with favorable feedback within 30 to 60 minutes. Beta-testing interviews suggested (1) mixed perceptions of health and HIV, (2) high risk for comorbid conditions, (3) virtual environment features were promising, and (4) the need for diverse avatar representations. We identified several comorbid conditions of concern, and findings carry significant implications for mitigating barriers to preventive health screenings, given the shared risk factors between HIV and related comorbidities. Highly rated aspects of the virtual environment were anonymity; meeting others with HIV who identify as gay or bisexual; validating lesbian, gay, bisexual, transgender, queer, and others (LGBTQ+) images and content; and accessibility to CVD prevention education. Critical end-user feedback from beta testing suggested more options for avatar customization in skin, hair, and body representation. Our next phase will test the virtual environment as a new approach to advancing cardiovascular health equity in ethnic and racial sexual minority men with HIV. ClinicalTrials.gov NCT04061915; https://clinicaltrials.gov/study/NCT05242952. RR2-10.2196/38348.

The integration of artificial intelligence in health care presents a significant opportunity to revolutionize patient care. In the United States, an estimated 129 million people have at least 1 chronic illness, with 42% having 2 or more. Despite being largely preventable, the prevalence of chronic illness is expected to rise and impose significant economic burdens and financial toxicity on health care consumers. We leveraged an interdisciplinary team encompassing nursing, public health, and computer science to optimize health through prevention education for cardiovascular and metabolic comorbidities in persons living with HIV. In this tutorial, we describe the iterative, data-based development and evaluation of an intersectionality-informed large language model designed to support patient teaching in this population. First, we curated data by scraping publicly available, authoritative, evidence-based sources to capture a comprehensive dataset, supplemented by publicly available HIV forum content. Second, we benchmarked candidate large language models and generated a fine-tuning dataset using GPT-4 through multiturn question and answer conversations, using standardized metrics to assess baseline model performance. Third, we iteratively refined the selected model via low-rank adaptation and reinforcement learning, integrating quantitative metrics with qualitative expert evaluations. Pre-existing large language models (LLMs) demonstrated poor n-gram agreement, dissonance from model answers (accuracy 4.16, readability 4.63, and professionalism 4.58), and difficult readability (Kincaid 8.54 and Jargon 4.44). After prompt adjustments and fine-tuning, preliminary results demonstrate the potential of a customized Llama-based LLM to provide personalized, culturally salient patient education. We present a data-based, step-by-step tutorial for interdisciplinary development of CARDIO, a specialized LLM, for cardiovascular health education in HIV care. Through comprehensive data curation and scraping, systematic benchmarking, and a dual-stage fine-tuning pipeline, CARDIO's performance improved markedly (accuracy 5.0, readability 4.98, professionalism 4.98, Kincaid 7.17, and Jargon 2.92). Although patient pilot testing remains forthcoming, our results demonstrate that targeted data curation, rigorous benchmarking, and iterative fine-tuning have provided a robust evaluation of the model's potential. By building an LLM tailored to cardiovascular health promotion and patient education, this work lays the foundation for innovative artificial intelligence-driven strategies to manage comorbid conditions in people living with HIV.

In the United States, racial/ethnic and sexual youth and young adults (YYA) of color are disproportionately affected by HIV. Subsequently, YYA experience HIV stigma and engage in increased risk behaviors and reduced HIV testing. HIV communication has been identified as a potential buffer to HIV stigma, resulting in health-seeking behaviors, such as HIV testing. In this study, we respond to a meaningful gap in the literature by examining different types of HIV communication and their impact on HIV stigma and HIV testing in a diverse sample of YYA. We analyzed secondary data from the Kaiser Family Foundation National Survey of Teens and Young Adults on HIV/AIDS. A 40-question, web-based survey was conducted with 1437 youth (ages 15–24). Recruitment included a dual sampling method from households with: (1) listed phone numbers, (2) unlisted phone numbers, (3) telephones, (4) no telephone, and (5) only cell phone access. The purpose of the survey was to establish participants’ HIV knowledge, communication, experiences, and testing behaviors. Findings suggested an association between intimate-partner HIV communication, increased HIV testing, and reduced HIV stigma. We also identified differentials in HIV testing and stigma based on gender, income, age, and sexual minority status, explained by HIV communication. Further research is needed that examines ways to use intimate-partner HIV communication to reduce stigma and increase HIV testing among YYA of different sociodemographic characteristics and sexual orientations.

Background Prior research has consistently shown that the involvement of families plays a vital role in reducing risk behaviors, such as engaging in condomless sex, and promoting HIV prevention behaviors among young Black men who have sex with men (YBMSM). With the aim of expanding the existing knowledge, this study aimed to examine the specific influence of families and other supportive adults in facilitating casual condom use, partner condom use, HIV testing, and preexposure prophylaxis (PrEP) utilization among young Black MSM. Methods A sample of YBMSM aged 18–29 years ( N  = 400) was collected online. We used a path analysis to examine the influence of family factors on PrEP stigma and PrEP use. Respondents were recruited from December 1, 2021, to January 31, 2022. We used a path analysis to examine the direct and indirect effects of family factors on PrEP use through HIV testing and encouraging condom use. Results Among BMSM, other adult support was positive and directly associated with condom use by both casual partners (β = 0.04, p  < .05) and partners (β = 0.17, p  < .01). Condom use by casual partners was negative and was directly associated with HIV testing (β = − 0.15, p  < .01). Conclusion The primary aim of this research was to examine the influence of family and adult support on HIV prevention behaviors among young Black MSM, including condom use, HIV testing, and PrEP use. Our findings highlight the significance of implementing interventions that incorporate families and other supportive adults to enhance the engagement of young Black MSM in HIV prevention behaviors.

Health communication is a key health promotion approach for translating research findings into actionable information. The purpose of this study was to use participatory design to create and then test the usability and comprehension of an HIV self-testing infographic in a sample of 322 emerging adult, sexual minority men of color. Our study objectives addressed three challenges to HIV self-testing: (1) correct usage of the test stick, (2) understanding the number of minutes to wait before reading the result, and (3) how to correctly interpret a negative or a positive HIV result. This study was a two-phase, sequential, mixed methods, pilot, online, randomized controlled trial. Results suggested a significant mean difference between the control and intervention groups on HIV self-testing knowledge, with the control group outperforming the intervention group. However, two-thirds or better of the participants in the intervention group were able to comprehend the three critical steps to HIV self-testing. This was a promising finding that has resulted in the authors’ development of additional recommendations for using participatory design for visual aid development in HIV prevention research. Participatory design of an HIV self-testing infographic is a rigorous approach, as a health communication strategy, to address public health priorities.

Family-based approaches are critical for improving health outcomes in sexual minority men (SMM) of color. Yet, it is unclear how family context, internalized homophobia, and stress influence mental health outcomes among sexual minority men of color. From a cross-sectional sample of 448 participants, aged 16–24 years, survey data were analyzed to examine rates of family social support, the perception of sexuality by family, the stressfulness of life events, internalized homophobia, and other contextual variables on depression using linear regression. Our results indicated that an 86% increase in family social support was related to a −0.14 decrease in depression (ß = −0.14, p = 0.004). In addition, SMM who were separated by family and friends because of their sexuality were statistically significant and positively associated with depression (ß = 0.09, p < 0.001). Findings from our study suggest that the influence from the microsystem is salient in modifying mental health outcomes for SMM of color.

This study employs the ecodevelopmental theory to examine the influence of mother and father bonding, family engagement in healthcare, and family support on PrEP stigma among BLMSM. We used a cross-sectional sample from wave five of the Healthy Young Men (HYM) study, with a survey sample of 399 participants aged 16–24 years. We conducted two-path analyses to test multiple hypotheses: (1) mother/father bonding is associated with an increase in family engagement in healthcare; (2) family engagement in healthcare is associated with family social support; and (3) family social support is associated with PrEP stigma. Family social support was negatively correlated with PrEP stigma (r = −0.15; p < 0.001). The findings show that families either led by a Black/Latino father or mother have a significant impact on the sexual health-seeking behavior of BLMSM and their perception of HIV and PrEP.

Black youth and their families living in urban settings may experience unique stressors that contribute to underlying issues due to the environmental context. Such factors may exacerbate and promote drug use and engagement in risky sexual behaviors, unknowingly. Little is known about how family factors, peer pressure, condom use, and other related factors are associated with substance use and engaging in sexual behaviors while on drugs among urban African American youth aged 12–22 (N = 638). We used regression models to examine associations between parental bonding, parent–adolescent sexual health communication, condom use, peer pressure on substance use, and having sex while on drugs. Multivariate results indicated that parental bonding was statistically significant and associated with drug use (OR: 1.36, 95%CI: 1.36). Our study highlights that parental bonding plays a critical role in youth using drugs while living in urban environments.