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Childhood obesity is a lifestyle-oriented disorder, which may lead to many comorbidities such as hypertension, coronary diseases, increased incidence of diabetes, and metabolic syndromes. Lack of diet control and increased screen time specifically after the COVID-19 pandemic among children and adolescents are the major reasons for this rising global concern. Despite various campaigns being carried out to lessen the rising rates of childhood obesity, the objectives have not yet been achieved. Ayurveda offers a multidimensional modality in managing children with overweight. The purpose of this study is to evaluate the combined efficacy of Ayurvedic medicine administration, diet restriction, and Sun Salutation. Navak Guggulu is a herbo-mineral compound already proven for its antiobesity action. Vachaharidradi Gana mentioned in Ayurvedic classics is a group of herbs, which are Kaphamedohara and Karshana. Ayurveda also emphasizes the importance of diet and physical activities for the treatment of obesity. The interventions together may help in promoting a healthy weight, improving metabolism, and reducing fat accumulation. So, in this study, the efficacy of Vachaharidradi Gana Vati will be compared with Navak Guggulu to treat children with overweight in addition to diet restrictions and Sun Salutation. The aim of the study is to evaluate the efficacy of Navak Guggulu versus Vachaharidradi Gana Vati along with diet restriction and Sun Salutation in overweight (Sthaulya) children. A double-blind randomized interventional study will be conducted on selected children with overweight in the age group of 10 to 16 years. They will be equally distributed into 2 groups. The control group will be given Navak Guggulu, and the trial group will be given Vachaharidradi Gana Vati for 90 days. Both groups will be advised of diet restrictions and the daily performance of the Sun Salutation. The study duration is 180 days, with assessment at baseline, followed by every 15 days up to 90 days, and at the end point, that is, after 180 days. Appropriate statistical techniques, such as analysis of covariance paired 2-tailed t test, Wilcoxon signed rank test, Mann-Whitney U test, and multivariate regression analysis, will be used to evaluate the efficacy of the interventions. The study got underway in April 2024. Since participants may begin at any time, our goal is for everyone to be finished by May 2025. This research will be useful to provide new insight into the effectiveness of the Ayurveda pharmacological approach in treating obesity in children. The results will guide evidence-based multimodality in treatments aimed at changing lifestyle behaviors in children with obesity, thus reducing social stigmatization in them. Clinical Trial Registry of India CTRI/2023/03/051135; https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=NzgzNzE=&Enc=&userName=. DERR1-10.2196/58838.

Effective treatment of oral homogeneous leukoplakia requires the use of an antioxidant with optimal properties to ensure a regression of the lesion with respect to size and colour, which is evaluated clinically and also with the help of salivary MDA levels. Despite the availability of various antioxidants, an improved standard evaluation system is needed for adjunct therapy of herbal antioxidants to widely systemically administered lycopene; a standardised evaluation system still needs to be improved. To develop a Comparative Cumulative Index (CCI) for assessment of regression of oral homogeneous leukoplakia that systematically evaluates and ranks adjunct herbal antioxidants to systemically administered lycopene based on their regression in size and colour of lesion and salivary MDA levels. CCI was developed through a structured process involving expert identification, panel discussions, and the establishment of scoring criteria. Two herbal antioxidants as an adjunct to systemically administered lycopene and lycopene alone (Groups A, B, C) were evaluated. Mean values for the core properties were calculated, and antioxidants were ranked accordingly. The total CCI for each antioxidant was computed based on the assigned scores for each property. Lesion size, lesion colour, and salivary MDA parameters all showed differences in CCI between the assessed treatment groups. Group C, with a 50% CCI. Group B’s performance, with a CCI of 41%, is highlighted by deficiencies in several properties, whereas Group A came in third with a CCI of 34%. CCI provides a comprehensive antioxidant evaluation approach to assist practitioners in making informed decisions. The significance of balancing regression in lesion size and colour as well as salivary MDA levels is highlighted by Group C’s high CCI. The results are in line with earlier studies that emphasized the significance of these traits in the treatment of oral homogeneous leukoplakia. The CCI makes it easier to compare adjunct antioxidant therapy based on empirical data and offers a reliable and equitable method of evaluating antioxidants. Future research should enhance the index and validate its use in a range of clinical contexts in order to improve treatment outcomes in oral homogeneous leukoplakia.

ABSTRACT Background: The ancient science of life known as Ayurveda uses a variety of formulations or herbal compounds to treat a wide range of illnesses. Male infertility accounts for half of all infertility worldwide, and numerous etiological variables play a role. A pharmacologically active tobacco component called nicotine has a negative impact on male fertility and the reproductive system. Musalyadi Churna (MSC) is one of the polyherbal compound formulations mentioned in Ayurveda Classics for aphrodisiac therapy and recommended for the treatment of male infertility. Objective: The current study aims to evaluate the spermatogenic potential of MSC along with its protective effect against testicular degeneration induced by nicotine in rat models. Materials and Methods: Sixty adult Sprague-Dawley male rats were used in the experiment, which were divided into ten groups of six rats each. Nicotine was administered orally as disease control. The standard and vehicle control were also included along with study drug groups in which MSC was administered orally to the rats. The study was conducted for 70 days for each group with assessment of body weight and food consumption. After treatment, rats were weighed and sacrificed for evaluation of parameters like organ weight, epididymal sperm count, and sperm morphology along with histological assessment. The data were statistically evaluated using analysis of variance test and Bonferroni multiple-comparison range test to compare different treatment groups. Results and Conclusion: In the present study, MSC possesses substantial spermatogenic efficacy, and the result indicates that the study drug possesses a protective effect against nicotine-induced impaired testicular functions in rats, but further research to elucidate its exact mechanism of action is essential.

Rhinitis is a condition characterized by inflammation of the nasal mucosa. It causes obstruction and congestion in the nasal cavity. Clinically, it resembles pratishyaya (rhinitis) in Ayurveda, which is caused by accumulation and downward movement of the tridoshas (3 elements, named vata, pitta, and kapha) in the nasal cavity. Rhinitis is one of the most common diseases among children. There is no role for antibiotics in rhinitis, and nasal decongestants have also not been found to be effective in its management. In Ayurveda, dhoopana (nasal fumigation) is mentioned in the pratishyaya treatment protocol. However, we have found no previous study regarding its efficacy. The efficacy of tulsi, vasa, nirgundi, and nilgiri is already proven when they are used for steam inhalation in respiratory tract infections. Therefore, in this study, a dhoopana of a polyherbal formulation containing tulsi, vasa, nirgundi, and nilgiri will be compared with the inhalation of steam containing arka (a liquid obtained by distillation) of tulsi, vasa, nirgundi, and nilgiri leaves in children with pratishyaya. We aim to evaluate the efficacy of polyherbal steam inhalation as a standard control against dhoopana in children aged 7 to 14 years with pratishyaya. A total of 70 participants fulfilling the inclusion criteria were selected and distributed into 2 groups of 35 each. The intervention group received dhoopana and the control group received polyherbal steam inhalation, both twice daily for 7 days. The primary outcome measure was the change in Total Nasal Symptom Score and a modified cold spatula test. At the same time, the association between prakriti (body constitution) and the prevalence of pratishyaya in children was analyzed as a secondary outcome. Assessments were performed on days 3, 5, and 7, with a follow-up time of 28 days. Appropriate descriptive and inferential statistics will be used for data analysis. As of November 2024, we have completed our enrollment of 70 patients, with 35 patients in each group. Data analysis will be completed by February 2025, and we expect results to be published in March 2025. We anticipate that polyherbal nasal fumigation will be found to be equally as effective as polyherbal steam inhalation in the management of acute rhinitis in the pediatric population. This study may provide a standardized, herbal, safe, and cost-effective treatment for rhinitis in children in the form of dhoopana. DERR1-10.2196/58197.

Cognitive problems like learning difficulties, memory problems, intellectual disability, and ADHD are highly associated with school absenteeism and high dropout rates. The novel approach to improving memory and learning in these children is using nootropic herbs known as Medhya Rasayana (intellect enhancer) in Ayurveda. Brahmi (Bacopa monnieri L. Pannel), one of the Medhya Rasayana, has proven to be useful through extensive research. Still, the other Medhya Rasayana requires thorough research based on the Ayurvedic principle of Prakriti (constitution) to utilize their optimum therapeutic effect. The main objective of this study was to evaluate the comparative efficacy of Mandookaparni in enhancing the memory of healthy boys with dominant Prakriti. The present study was a double-blind, randomized study to evaluate the comparative efficacy of Brahmi (Bacopa monnieri L. Pannel) and Mandookaparni (Centella asiatica L. Urban) in enhancing the memory of 8-10-year-old healthy boys with dominant Prakriti. After obtaining informed consent from parents and assent from the participants, the eligible study participants were randomized to either the Mandookaparni or the Brahmi group. The participants were assessed at baseline and end of the treatment (91st day) for efficacy measures, which included total memory score and various domains of memory assessed by the Post Graduate Institute- Children's Memory Scale (PGI-CMS) and Intelligence Quotient. On analysis of 180 participants, the Brahmi group showed highly significant results in the total memory score, 9 out of 10 subsets of PGI-CMS, and IQ with p < 0.001. The Mandookaparni group showed highly significant results in 8 subsets of PGI-CMS, the total memory score, and IQ with p < 0.001. Brahmi increased the mean total memory score by 9.28 %, while a 13.45 % rise was observed with Mandookaparni. Significant differences were observed chiefly in Pitta Prakriti on Prakriti-wise analysis in the improvement of various memory domains between Brahmi and Mandookaparni. Mandookaparni has clinically equivalent efficacy to Brahmi in enhancing memory. Mandookaparni is better in improving the memory of Pitta Prakriti people while Brahmi is more effective in Kapha and Vata Prakriti. Both drugs are safe and effective in the pediatric population.

[...]to evaluate the efficacy of Ayurveda Polyherbal compound, Madhuyashtyadi granules will be prepared like Gutka in colour, taste and look in crude form with Elaand mint flavor to attract the children to chew it instead of Gutka. [12]These ingredients also used for deaddiction purpose[13].This study is mainly based to assess the effect of herbal compound with awareness in comparison with efficacy of Nicotex chewing gum[14] along with Sadvritta, Satvavajaychikitsa and meditation as standard control group. According to WHO [15], replacement therapy is beneficial so Nicotexchewing gum is planned in parallel group as standard control. Have a respectable and protective attitude towards elders, forefathers, teachers, women, children and colleagues. c. Abstain from telling lies, anger, extreme grief, jealousy and greed d. Avoid company of people with evil thoughts. e. Avoid indulgence in Himsa(any activity which harm others), Asteya (stealing habits), Anyathakma (unlawful sexual activity), vyapada (intention of harming), viparyaya (finding fault with scriptures, elders, etc.) Thus, the person who behaves as per the principles of sadvritta becomes more divine and lives a good quality of life.

The Internet of Things (IoT), which enables seamless connectivity and effective data exchange between physical items and digital systems, has completely changed the way we interact with our surroundings. This study evaluates IoT applications in healthcare, transportation, agriculture, and smart cities, highlighting advancements, opportunities, and challenges. Using a systematic literature review and case study analysis, it identifies essential IoT components, including sensors, communication protocols, data analytics, and security methods. Key findings demonstrate IoT's potential to enhance healthcare through real-time monitoring and cost reduction, optimize transportation systems for resource efficiency, improve agricultural productivity via precision farming, and enable sustainable urban development in smart cities. However, challenges like data privacy, interoperability, and scalability remain critical barriers to widespread adoption. This study underscores the need for interdisciplinary collaboration among researchers, policymakers, and industry stakeholders to address these challenges and unlock IoT's full potential. It provides actionable insights and future directions for realizing a connected, efficient, and sustainable IoT-driven future. Article Highlights The foundations of IoT Uses of IoT in industrial processes, best practices and solutions Possible future possibilities of IoT

Cellulitis is a skin condition that affects both the dermis and the subcutaneous fat. Acute compartment syndrome has been associated with streptococcal infection. The present case highlights the role of physiotherapy in rehabilitating a patient suffering from compartment syndrome due to cellulitis. A 45-year-old female complained of swelling over the left forearm for five days. After being referred to the surgery department, she underwent clinical examinations, indicating cellulitis. As part of the surgical procedure, she had a fasciotomy and split skin grafting. Her pain was assessed using the numerical pain rating scale (NPRS), gradual in onset and progressive in nature, and aggravated on movement. The patient's case demonstrates the importance of following a planned physical therapy treatment regimen to restore functional activity, range of motion (ROM), and muscle strength.

Ganglion cysts are prevalent benign soft tissue tumors, commonly occurring on the dorsal wrist and often associated with underlying joint structures like the scapholunate ligament (SLL), a critical stabilizer of the wrist. SLL instability, frequently resulting from acute trauma or repetitive stress, can significantly impair wrist function, causing pain, reduced range of motion, and decreased grip strength. This case report details the conservative management of a 25-year-old recreational basketball player who presented with SLL instability and a dorsal ganglion cyst following two separate wrist injuries. Despite initial conservative management, the patient continued to experience persistent pain and functional limitations. Diagnostic imaging confirmed the presence of a ganglion cyst arising from the SLL, which necessitated a targeted physiotherapy regimen. The rehabilitation protocol focused on pain relief, wrist stability, muscle strengthening, and functional performance, employing phonophoresis, K-taping, laser therapy, and progressive strengthening exercises. Throughout treatment, the patient exhibited marked improvements in wrist range of motion, muscle strength, and pain reduction, ultimately returning to basketball activities without recurrence of symptoms. This case underscores the potential effectiveness of conservative physiotherapy in managing SLL instability with associated ganglion cysts, emphasizing the importance of a comprehensive, multifaceted approach to rehabilitation in restoring wrist function and enabling a return to sports.

Background As there is high expense of treatment and potential long-term consequences including chronic ankle instability (CAI), lateral ankle sprains (LAS) are common among athletes and represent a substantial healthcare burden. In terms of preventing more injuries and encouraging a full recovery, traditional treatments frequently fall short. Methods At the Department of Sports Physiotherapy, futsal athletes with grade I and grade II lateral ankle sprains will participate in a parallel-group, 1:1 allocation ratio trial. Individuals who fulfil the eligibility requirements will be randomized at random to either the experimental or control group. Conventional physiotherapy treatments will be administered to the control group, and IVR sessions utilizing certain games will be administered to the experimental group in addition to the same therapies. The Y Balance Tool is used to measure dynamic balance, the X Sens MVN system is used to measure vertical jump, and the Balance Error Scoring System (BESS) is used to assess static balance. Result This study aims to offer a new way to improving results for futsal players recovering from lateral ankle sprains by utilizing IVR technology in conjunction with traditional physiotherapy. The results could lead to the creation of more efficient sports-related injury rehabilitation programs, which would improve athlete performance and lessen the incidence of ankle sprains in athletic populations. CTRI Registration Number: CTRI/2024/04/065627 Name of registry: CTRI (Clinical Trials Registry) No. CTRI/2024/04/065627 Date: 12/04/2024 URL: https://ctri.nic.in/Clinicaltrials/rmaindet.php?trialid=102982&EncHid=78848.18761&modid=1&compid=19