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In Detail Microsoft Dynamics NAV 7 is a business management solution that helps simplify and streamline highly specialized business processes. Learning NAV programing in NAV 7 gives you the full inside view of an ERP system. Microsoft Dynamics NAV 7 Programming Cookbook covers topics that span a wide range of areas such as integrating the NAV system with other software applications including Microsoft Office, and creating reports to present information from multiple areas of the system,. We will not only learn the essentials of NAV programming, you will also be exposed to the technologies that surround NAV including.NET programming, SQL Server and NAV system administration. Microsoft Dynamics NAV 7 Programming Cookbook is written in a direct, to-the-point style to help you get what you need and continue working in NAV. The first half of the cookbook will help programmers using NAV for the first time, by walking them through the building blocks of writing code and creating objects such as tables, pages, and reports. The second half focuses on using the technologies surrounding NAV to build better solutions. You will learn how to write .NET code that works with the NAV system and how to integrate the system with other software applications such as Microsoft Office or even custom programs. You will learn everything you need to know for developing all types of NAV CSIDE objects, as well as how to integrate and maintain a NAV system. Approach Written in the style of a cookbook. Microsoft Dynamics NAV 7 Programming Cookbook is full of recipes to help you get the job done. Who this book is for If you are a junior / entry-level NAV developer then the first half of the book is designed primarily for you. You may or may not have any experience programming. It focuses on the basics of NAV programming. If you are a mid-level NAV developer, you will find these chapters explain how to think outside of the NAV box when building solutions. There are also recipes that senior developers will find useful.

\"Microsoft Dynamics NAV 7 is a business management solution that helps simplify and streamline highly specialized business processes. Learning NAV programing in NAV 7 gives you the full inside view of an ERP system. Microsoft Dynamics NAV 7 Programming Cookbook covers topics that span a wide range of areas such as integrating the NAV system with other software applications including Microsoft Office, and creating reports to present information from multiple areas of the system,. We will not only learn the essentials of NAV programming, you will also be exposed to the technologies that surround NAV including.NET programming, SQL Server and NAV system administration. Microsoft Dynamics NAV 7 Programming Cookbook is written in a direct, to-the-point style to help you get what you need and continue working in NAV. The first half of the cookbook will help programmers using NAV for the first time, by walking them through the building blocks of writing code and creating objects such as tables, pages, and reports. The second half focuses on using the technologies surrounding NAV to build better solutions. You will learn how to write .NET code that works with the NAV system and how to integrate the system with other software applications such as Microsoft Office or even custom programs. You will learn everything you need to know for developing all types of NAV CSIDE objects, as well as how to integrate and maintain a NAV system.\"

Written in the style of a cookbook. Microsoft Dynamics NAV 7 Programming Cookbook is full of recipes to help you get the job done.If you are a junior / entry-level NAV developer then the first half of the book is designed primarily for you. You may or may not have any experience programming. It focuses on the basics of NAV programming.If you are a mid-level NAV developer, you will find these chapters explain how to think outside of the NAV box when building solutions. There are also recipes that senior developers will find useful

Recent evidence suggests that numerous long non-coding RNAs (lncRNAs) are dysregulated in cancer, and have critical roles in tumour development and progression. The present study investigated the ghrelin receptor antisense lncRNA growth hormone secretagogue receptor opposite strand (GHSROS) in breast cancer. Reverse transcription-quantitative polymerase chain reaction revealed that GHSROS expression was significantly upregulated in breast tumour tissues compared with normal breast tissue. Induced overexpression of GHSROS in the MDA-MB-231 breast cancer cell line significantly increased cell migration in vitro, without affecting cell proliferation, a finding similar to our previous study on lung cancer cell lines. Microarray analysis revealed a significant repression of a small cluster of major histocompatibility class II genes and enrichment of immune response pathways; this phenomenon may allow tumour cells to better evade the immune system. Ectopic overexpression of GHSROS in the MDA-MB-231 cell line significantly increased orthotopic xenograft growth in mice, suggesting that in vitro culture does not fully capture the function of this lncRNA. This study demonstrated that GHSROS may serve a relevant role in breast cancer. Further studies are warranted to explore the function and therapeutic potential of this lncRNA in breast cancer progression.

It is now appreciated that long non-coding RNAs (lncRNAs) are important players in orchestrating cancer progression. In this study we characterized GHSROS , a human lncRNA gene on the opposite DNA strand (antisense) to the ghrelin receptor gene, in prostate cancer. The lncRNA was upregulated by prostate tumors from different clinical datasets. Transcriptome data revealed that GHSROS alters the expression of cancer-associated genes. Functional analyses in vitro showed that GHSROS mediates tumor growth, migration and survival, and resistance to the cytotoxic drug docetaxel. Increased cellular proliferation of GHSROS -overexpressing PC3, DU145, and LNCaP prostate cancer cell lines in vitro was recapitulated in a subcutaneous xenograft model. Conversely, in vitro antisense oligonucleotide inhibition of the lncRNA reciprocally regulated cell growth and migration, and gene expression. Notably, GHSROS modulates the expression of PPP2R2C , the loss of which may drive androgen receptor pathway-independent prostate tumor progression in a subset of prostate cancers. Collectively, our findings suggest that GHSROS can reprogram prostate cancer cells toward a more aggressive phenotype and that this lncRNA may represent a potential therapeutic target.

Background We recently reported the identification of Bacillus sp. NRRL B-14911 that induces heart autoimmunity by generating cardiac-reactive T cells through molecular mimicry. This marine bacterium was originally isolated from the Gulf of Mexico, but no associations with human diseases were reported. Therefore, to characterize its biological and medical significance, we sought to determine and analyze the complete genome sequence of Bacillus sp. NRRL B-14911. Results Based on the phylogenetic analysis of 16S ribosomal RNA (rRNA) genes, sequence analysis of the 16S-23S rDNA intergenic transcribed spacers, phenotypic microarray, and matrix-assisted laser desorption ionization time-of-flight mass spectrometry, we propose that this organism belongs to the species Bacillus infantis , previously shown to be associated with sepsis in a newborn child. Analysis of the complete genome of Bacillus sp. NRRL B-14911 revealed several virulence factors including adhesins, invasins, colonization factors, siderophores and transporters. Likewise, the bacterial genome encodes a wide range of methyl transferases, transporters, enzymatic and biochemical pathways, and insertion sequence elements that are distinct from other closely related bacilli. Conclusions The complete genome sequence of Bacillus sp. NRRL B-14911 provided in this study may facilitate genetic manipulations to assess gene functions associated with bacterial survival and virulence. Additionally, this bacterium may serve as a useful tool to establish a disease model that permits systematic analysis of autoimmune events in various susceptible rodent strains.

The methodology and computation of absolute elastic differential and integral (total) cross-sections of polyatomic molecules by twisted electron beam (Bessel Beam) impact is presented with \\(CO_2\\) as an example. The target molecule is modeled using multicentered wavefunctions with the correlation consistent quadruple zeta basis set cc-pVQZ and optimized by the post-Hartree-Fock Coupled Cluster CCSD method. The electron density is obtained as a function of spatial coordinates and is used to calculate the elastic form factor while considering the active role of all electrons in the molecule. Coulomb direct potentials are used for the interactions of the incident beam with all electrons and nuclei in the First Born Approximation. Orientation averaging of the differential cross-section is performed to mimic experimental situations. The cross sections are calculated at intermediate energies ranging from 300eV to 1keV. The proposed methodology could be applied to any polyatomic molecule. The interactions of Bessel beams (Twisted Electron Beam) with topological charges \\(m_l\\) = 1, 2, and 3 are analyzed. The average over-impact parameters of the differential cross-sections representing the beam's interaction with a large number of uniformly transversely distributed molecules are also studied and presented. Finally, the molecules' Integral elastic cross-section (ICS) by plane waves and twisted beams is calculated and presented.

Background : Oral Gastrografin ® has been used to differentiate partial from complete small bowel obstruction. It may also have a therapeutic effect and predict the need for early surgery in adhesive intestinal obstruction. Aim : To assess the accuracy of Gastrografin ® contrast in predicting the necessity of operative intervention in patients with adhesive intestinal obstruction and to decide on optimum period of observation in patients with adhesive intestinal obstruction. Materials and Methods : This prospective randomized controlled trial was performed on 32 patients with adhesive intestinal obstruction admitted in the Department of Surgery of a tertiary hospital. All patients were diagnosed with adhesive intestinal obstruction and were randomized into two groups, a Control group and a Gastrografin ® group. Patients in the control group were treated conservatively. If symptoms of strangulation developed or if the obstruction did not resolve spontaneously after 48 hours of admission, a laparotomy was performed. Patients in the Gastrografin ® group received 60 ml of Gastrografin ® mixed with 40 ml of distilled water after two hours of gastric tube aspiration following admission. Those in whom the contrast medium reached the colon in 22 hours were considered to have partial intestinal obstruction and were fed orally. Any patient who did not tolerate feeds was surgically explored for persistent obstruction. All patients in whom Gastrografin ® failed to empty into the ceacum within 22 hours of administration, were operated. Findings were analyzed by standard statistical tests. Qualitative data was analyzed by either Chi-square or Fisher Exact test. For the quantitative data, the means were compared by ANOVA-F test in the case of four groups whereas for two groups it was compared by using student′s t test. Results : Oral Gastrografin ® contrast study is safe and can facilitate the prediction of the necessity of early operative intervention compared to a plain radiograph. Oral Gastrografin ® study was found to have an overall accuracy of 82.35% in predicting the need for operative intervention in patients with adhesive small bowel obstruction. Also it was seen that it was sufficient to study the patients for 18 hours after administration of oral Gastrografin rather than 24 hours. Conclusion : Oral Gastrografin ® helps in the management of patients with adhesive intestinal obstruction.