Explore the vast range of titles available.

We investigated Bordetella holmesii and Bordetella pertussis in 935 suspected pertussis cases in northern India (2019-2023) using PCR and serology. B. holmesii showed increased prevalence in pertussis cases, particularly in older children, highlighting its emerging role and the need for ongoing surveillance and adjusted prevention strategies.

Abstract Background Stenotrophomonas sepilia, identified in 2021, is part of the Stenotrophomonas maltophilia complex (Smc) and shares high genomic identity with S. maltophilia. Resistance to levofloxacin, the recommended fluoroquinolone for S. maltophilia, is being increasingly reported. Recent studies indicate that levonadifloxacin, a novel benzoquinolizine, may be more effective. This study evaluates the antimicrobial efficacy of levofloxacin and levonadifloxacin against clinical isolates of S. sepilia. Objectives To assess the antibacterial effectiveness of levofloxacin and levonadifloxacin against novel pathogen S. sepilia. Methods A total of 116 S. maltophilia isolates, identified by MALDI-TOF MS, were collected from five centres across India. S. sepilia was confirmed by PCR using primers targeting a unique genomic sequence (NCBI accession number LXXZ00000000.1). Minimum inhibitory concentrations (MICs) of levonadifloxacin and levofloxacin were determined by using the microbroth-dilution method and Etest as per CLSI guidelines. The levofloxacin breakpoint was used to interpret MICs of levonadifloxacin. Results Among a total of 116 circulating S. maltophilia isolates collected, 46 were identified as S. sepilia, representing a prevalence rate of (∼40%), thus highlighting its significance as an important pathogen within the Smc. Both levofloxacin and levonadifloxacin demonstrated a 98% inhibition rate against the 46 S. sepilia tested. Only one S. sepilia isolate resistant to levofloxacin showed intermediate susceptibility to levonadifloxacin, which consistently had lower MICs. Conclusions Levofloxacin and levonadifloxacin show similar susceptibility rates against S. sepilia, with levonadifloxacin exhibiting lower MICs. Further studies are required to establish clinical utility of levonadifloxacin in managing these infections.

Differentiating a GIST from a pelvic mass by radiological studies is challenging. [...]preoperative diagnosis of GIST may be difficult, especially in the case of an atypical pelvic mass. [See PDF for image] Fig. 1 CECT whole abdomen axial section of pelvis showing mildly enhancing soft tissue density solid mass in right adnexal adjacent to right ovary In concurrence with surgeons, an exploratory laparotomy was planned with a preoperative diagnosis of right ovarian tumor. After multidisciplinary tumor board discussion which included histopathologist, radiologist, radiation oncologists, GI surgeons, and medical oncologists, the patient was started on imatinib due to the large size and high grade of tumor. On immunohistochemical staining, 95% are CD117 (c-kit) positive, 70% are CD34 positive, and 40% stains are positive for α-smooth muscle actin (α-SMA) and negative for desmin and S100 protein.

Cellulosic biomass hydrolysis yields a nanoscale substance known as nanocrystalline cellulose (NCC). Gel, liquid, or powder is adaptable to a variety of uses. Nanocrystalline cellulose has unique renewability, biodegradability, and mechanical and physicochemical qualities, and abundance boosts the material’s mechanical strength by many orders of magnitude when introduced into the material matrix (polymer, ceramic, or metal). Nanocrystalline cellulose is not related with any serious environmental issues because it is a natural substance. The progress of this biomaterial as a green and renewable biomaterial for the fabrication of lightweight and biodegradable composite materials gives further impetus. The current aim of nanocrystalline cellulose research is to optimise nanocrystalline cellulose characteristics for dispersion in hydrophilic and hydrophilic media. To assess the nanocrystalline cellulose reinforcing, antibacterial, stability, hydrophilicity, and biodegradability, imaging methods and protocols in complicated matrices will need to be developed. This review includes a discussion on nanocrystalline cellulose biocomposites.