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"Reed, Ken"
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Peripheral Neuromodulation and Headaches: History, Clinical Approach, and Considerations on Underlying Mechanisms
Implantable peripheral neurostimulation was introduced in 1969 as a potential treatment for certain neuropathic pain syndromes, primarily involving the limbs. While a few early studies included implants for occipital neuralgia, serious interest in its potential as a treatment for head pain came only after our 1999 report of positive findings in a series of patients with occipital neuralgia. Subsequent investigators confirmed these initial findings, and then extended the application to patients with various primary headache disorders, including migraine. While most found a therapeutic response, the degree of that response varied significantly, and analysis suggests that the issue of paresthesia concordancy may be central, both in explaining the data, as well as providing direction for future endeavors. Therefore, while at present peripheral neurostimulation is gaining increasing acceptance as a treatment for chronic headaches, the precise clinical indications and procedures, as well as the underlying neurophysiological mechanisms, are still being worked out.
Journal Article
Office 365
Everything you need to get productive in the Cloud with Office 365 With 70 million users worldwide, Microsoft Office 365 combines the familiar Office desktop suite with cloud-based versions of Microsoft's next-generation communications and collaboration services. It offers many benefits including security, reliability, compatibility with other products, over-the-air updates in the cloud that don't require anything from the user, single sign on for access to everything right away, and so much more. Office 365 For Dummies offers a basic overview of cloud computing and goes on to cover Microsoft cloud solutions and the Office 365 product in a language you can understand. This includes an introduction to each component which leads into topics around using each feature in each application. Get up to speed on instant messaging Use audio, video, and web conferencing Get seamless access to the Office suite with Office Web apps Access information anywhere, anytime Office 365 is the key to office productivity -- and now you can put it to use for you!
Book
Reflections on a Flawed Baseball Idol
As a child, I picked my sports idols based on how far and how dramatically they hit home runs (Reggie Jackson), how cool- sounding their names were (Roman Gabriel, Bob McAdoo), how sweet their uniforms looked (Roger Staubach), and how many championships they'd won (Bill Russell). As a Denver native, I grew up without Major League Baseball (MLB). My first favorite team was the Minnesota Twins because my cousins lived in Duluth and when we'd visit, my uncle would take us to a Twins game. But everything changed for me on July 13, 1971, while watching the MLB All- Star Game on television with my dad. Going into the game, I had become intrigued by the Oakland A's flashy new kelly green and Ft. Knox gold uniforms and matching wedding gown white shoes. The A's colorful uniforms were a stark contrast to the old gray and white uniforms of the day and an appealing symbol of rebellion for someone a few months shy of his thirteenth birthday
Journal Article
Rediscovery
\"Superwoman Lana Lang is at a crossroads. Her memories are out of sync with the reality around her, her superpowers are killing her...and the only hope for her survival may mean giving up the superhero career she's barely begun! In the aftermath of SUPERMAN REBORN, Superman, Steel, Natasha Irons and former fellow Superwoman Lois Lane all want Lana to continue on as a hero, but what does Lana want? And what role will the mysterious Insect Queen armor play in helping Lana make her decision? Meanwhile, as Lana struggles to find a way to go on as Superwoman, the monstrous villain known as Skyhook--who has hurt those closest to Lana before--menaces Lana's loved ones once more. With or without powers, will Lana be able to stop him and embrace her destiny as a hero to the people of Metropolis?\"-- Provided by publisher.
Book
Confidence in Australian Institutions 1983–2005
This paper examines changes in the level of institutional confidence in Australia between 1983 and 2005. The principal aim of the paper is to disaggregate the general trend in social trust and overall institutional confidence. Using data drawn from three waves of the World Values Survey undertaken in 1983, 1995 and 2005 we examine whether social trust and confidence have declined and the differing patterns of confidence for different birth cohorts in Australia. The results show a significant decrease in social trust and a large decline in confidence between 1983 and 1995. There was little change in confidence between 1995 and 2005, but social trust returned to the 1983 level over that period. A cohort analysis shows that the oldest cohort, those born before WWII, reported the largest decline in confidence, while by 2005 the baby boomers (or middle cohort born between 1944 and 1955) were the most confident, with the oldest group reporting the least confidence. Throughout the 1990s and early 2000s confidence has been at a much lower level than in the early 1980s.
Journal Article
The Use of Correspondence Analysis to Develop a Scale to Measure Workplace Morale from Multi-level Data
Reed focuses on the issue of comparing social groups or collectivities using measures derived from individual-level multivariate data. He presents a scale of \"workplace morale\" derived from the responses of employees in a large sample of workplaces to questions concerning satisfaction with various facets of their job and their workplace.
Journal Article
The relationship between D2 receptor occupancy and plasma levels on low dose oral haloperidol: a PET study
The purpose of this study was to determine the relationship between dopamine D2 receptor occupancy and plasma haloperidol. Twelve patients treated with 1-5 mg/day of haloperidol had their D2 occupancy measured using [11C]-raclopride and positron emission tomography and haloperidol plasma levels measured using gas chromatograph mass spectrophotometer. The patients exhibited haloperidol plasma levels ranging from 0.5 to 5.8 ng/ml and D2 occupancy from 53 to 88%. The D2 occupancy was related to the plasma level as a saturating rectangular hyperbola relationship (r2 = 0.84) and it showed that, on average, 50% D2 occupancy was achieved with 0.51 ng/ml and 80% D2 occupancy with 2.0 ng/ml. Our findings demonstrate that 2-5 mg/day of haloperidol, which usually leads to plasma levels of 1-2 ng/ml, would be expected to induce 60-80% dopamine D2 receptor occupancy. If, as has been claimed, 70% D2 occupancy is adequate for typical neuroleptic response, then the conventional use of > 10 mg/day may have been too high, since 70% occupancy can be achieved in most patients by 2-5 mg/day. On the other hand, if as others have suggested, 8-12 ng/ml of haloperidol is the correct therapeutic window for plasma levels, then the required therapeutic D2 occupancy is closer to 90%, not 70%. The implications of the D2 occupancy findings for the optimal dosing of neuroleptics are discussed.
Journal Article