Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
5,846
result(s) for
"Reed, Michael"
Sort by:
Differential effects of synthetic estrogen on serum homocysteine levels before and after menopause
Homocysteine (Hcy), a sulfur-containing amino acid, is produced in prodigious quantities by the methionine cycle in the liver. Hcy is the major biomarker for cardio-vascular disorders and is associated with many other diseases. In previous work, we have explained why menstruating women have lower serum homocysteine than men due to higher concentrations of estradiol. In this study, we first present epidemiological evidence from NHANES data that synthetic estradiol supplementation lowers serum Hcy in post-menopausal women, but raises Hcy in pre-menopausal women. Secondly, we give an explanation of this puzzling phenomenon using previously developed mathematical models of one-carbon and glutathione metabolism. The simulation analysis demonstrated that the non-monotonic response of glutathione to rising estradiol levels may account for the differing Hcy responses to estradiol supplementation in postmenopausal versus premenopausal women, through activation of cystathionine β-synthase, a key enzyme regulating tissue homocysteine levels. Our findings further highlight the importance of considering menopausal status and synthetic hormone use when evaluating the health effects of homocysteine.
Journal Article
التجارة الدولية في المنتجات الزراعية
يتناول كتاب \"التجارة الدولية في المنتجات الزراعية\" والذي قام بتأليفه \"Michael reed\" في حوالي (417) صفحة من القطع المتوسط موضوع (المنتجات الزراعية)، يعتبر هذا الكتاب مرجعا علميا مهما للطلاب الدارسين التجارة الدولية في المنتجات الزراعية في المرحلة الجامعية وفوق الجامعية، وذلك لندرة المراجع الأكاديمية باللغة العربية في جانب حيوي مثل التجارة الدولية للمنتجات الزراعية، فضلا عن الأسلوب السهل والسلس في عرض كثير من النظريات المعقدة، وتدعيم ذلك بالأمثلة الحية من الواقع، وأخيرا فهذا الكتاب يقدم مفاهيم جديدة حول القضايا التي أصبحت مهمة في الآونة الأخيرة في أساس التجارة الزراعية مثل : البيئة، واتفاقيات التجارة التفضيلية، والحواجز التقنية، وسعر الصرف المرن, والمفاوضات التجارية متعددة الأطراف، والاستثمار الأجنبي المباشر والمنافسة. يحتوي هذا الكتاب على خمسة عشر فصلا، العشرة الفصول الأولى تتعلق بجميع المواضيع الأساسية المطلوبة في فهم مقرر التجارة الدولية للمنتجات الزراعية التي تشمل الجانب النظري والتطبيقي، وتتضمن الخمس فصول الأخيرة قضايا الشركات وتفسير نجاحها في الأسواق العالمية، وتحليل الطرق التي يجب أن تتخذها الشركات عند الرغبة في الدخول أو التوسع في الأسواق العالمية.
BOOK
A Global Perspective on Firefly Extinction Threats
Insect declines and their drivers have attracted considerable recent attention. Fireflies and glowworms are iconic insects whose conspicuous bioluminescent courtship displays carry unique cultural significance, giving them economic value as ecotourist attractions. Despite evidence of declines, a comprehensive review of the conservation status and threats facing the approximately 2000 firefly species worldwide is lacking. We conducted a survey of experts from diverse geographic regions to identify the most prominent perceived threats to firefly population and species persistence. Habitat loss, light pollution, and pesticide use were regarded as the most serious threats, although rankings differed substantially across regions. Our survey results accompany a comprehensive review of current evidence concerning the impact of these stressors on firefly populations. We also discuss risk factors likely to increase the vulnerability of certain species to particular threats. Finally, we highlight the need to establish monitoring programs to track long-term population trends for at-risk firefly taxa.
Journal Article
Superman : the unity saga. Vol. 1, Phantom Earth
\"The fallout from the Man of Steel graphic novel has Clark looking at the world through new eyes--with new ideas about what Superman could and should do for the city of Metropolis and the planet Earth. His first job? Getting the planet back out of the Phantom Zone\"-- Provided by publisher.
Book
Comorbid and co-occurring conditions in migraine and associated risk of increasing headache pain intensity and headache frequency: results of the migraine in America symptoms and treatment (MAST) study
BackgroundMigraine has many presumed comorbidities which have rarely been compared between samples with and without migraine. Examining the association between headache pain intensity and monthly headache day (MHD) frequency with migraine comorbidities is novel and adds to our understanding of migraine comorbidity.MethodsThe MAST Study is a prospective, web-based survey that identified US population samples of persons with migraine (using modified International Classification of Headache Disorders-3 beta criteria) and without migraine. Eligible migraine participants averaged ≥1 MHDs over the prior 3 months. Comorbidities “confirmed by a healthcare professional diagnosis” were endorsed by respondents from a list of 21 common cardiovascular, neurologic, psychiatric, sleep, respiratory, dermatologic, pain and medical comorbidities. Multivariable binary logistic regression calculated odds ratios (OR) and 95% confidence intervals for each condition between the two groups adjusting for sociodemographics. Modeling within the migraine cohort assessed rates of conditions as a function of headache pain intensity, MHD frequency, and their combination.ResultsAnalyses included 15,133 people with migraine (73.0% women, 77.7% White, mean age 43 years) and 77,453 controls (46.4% women, 76.8% White, mean age 52 years). People with migraine were significantly (P < 0.001) more likely to report insomnia (OR 3.79 [3.6, 4.0]), depression (OR 3.18 [3.0, 3.3]), anxiety (OR 3.18 [3.0 3.3]), gastric ulcers/GI bleeding (OR 3.11 [2.8, 3.5]), angina (OR 2.64 [2.4, 3.0]) and epilepsy (OR 2.33 [2.0, 2.8]), among other conditions. Increasing headache pain intensity was associated with comorbidities related to inflammation (psoriasis, allergy), psychiatric disorders (depression, anxiety) and sleep conditions (insomnia). Increasing MHD frequency was associated with increased risk for nearly all conditions and most prominent among those with comorbid gastric ulcers/GI bleeding, diabetes, anxiety, depression, insomnia, asthma and allergies/hay fever.ConclusionsIn regression models controlled for sociodemographic variables, all conditions studied were reported more often by those with migraine. Whether entered into the models separately or together, headache pain intensity and MHD frequency were associated with increased risk for many conditions. Future work is required to understand the causal sequence of relationships (direct causality, reverse causality, shared underlying predisposition), the potential confounding role of healthcare professional consultation and treatment, and potential detection bias.
Journal Article
Mary Corse : a survey in light
Mary Corse's first solo museum survey is a long overdue examination of this singular artist's career. Initially trained as an abstract painter, Corse (b. 1945, Berkeley, CA) emerged in the mid-1960s as one of the few women associated with the West Coast Light and Space movement. She shared with her contemporaries a deep fascination with perception and with the possibility that light itself could serve as both a subject and material of art. Yet while others largely migrated away from painting into sculptural and environmental projects, Corse approached the question of light through painting. This focused exhibition highlights critical moments of experimentation as Corse engaged with tropes of modernist painting, from the monochrome to the grid, while charting her own course through studies in quantum physics and complex investigations into a range of \"painting\" materials, from fluorescent light and Plexiglas to metallic flakes, glass microspheres, and clay. The survey will bring together for the first time Corse's key bodies of work-including her early shaped canvases, freestanding sculptures, and light encasements that she engineered in the mid-1960s, in her early twenties, as well as her breakthrough White Light Paintings, begun in 1968, and the Black Earth Series that she initiated after moving in 1970 from downtown Los Angeles to Topanga Canyon, where she lives and works today.
Book
Impact of Migraine on the Family: Perspectives of People With Migraine and Their Spouse/Domestic Partner in the CaMEO Study
To assess the impact of migraine on family members, activities, and relationships from the perspectives of the person with migraine and his or her spouse/domestic partner.
The Chronic Migraine Epidemiology and Outcomes (CaMEO) study is a longitudinal, Web-based study conducted from September 2012 to November 2013. Quota sampling from an online panel identified respondents who met modified International Classification of Headache Disorders, version 3 beta migraine criteria. The Family Burden Module included 24 items covering 6 domains. Findings for respondents with episodic migraine (EM) and chronic migraine (CM) are presented for both the affected individuals and their partners.
Among 13,064 Family Burden Module respondents (65.7% response rate), there were 4022 migraineur-spouse dyads, including 2275 dyads with children. Burden increased with headache frequency across all 6 domains. People with migraine reported higher family burden due to migraine than did their spouse/partner. Reduced participation in family activities due to migraine was reported 1 or more times a month among 48.2% to 57.4% of migraineurs, depending on headache frequency (days/month). Many (low-frequency to high-frequency EM, 24.4%-40.4%; CM, 43.9%) perceived that their spouse/partner did not believe the severity/impact of their headaches. One-third of migraineurs stated that they worried about long-term financial security for themselves or their family because of their headaches. Many migraineurs felt they would be better parents without headaches (low-frequency to high-frequency EM, 29.9%-58.0%; CM, 71.7%).
This analysis quantified the pervasive burden of migraine on the family, highlighting the impact on family activities and relationships. Not surprisingly, the impact was greatest in families of people with CM.
Journal Article
Halo omnibus
\"Witness the electrifying exploits of the UNSC Spartans--including the origin of Sarah Palmer, the Master Chief back in action immediately following the events of Halo 4, and more--as they defend humanity across the galaxy! \"-- Provided by publisher.
Book
Fluctuations in episodic and chronic migraine status over the course of 1 year: implications for diagnosis, treatment and clinical trial design
Background
Relatively little is known about the stability of a diagnosis of episodic migraine (EM) or chronic migraine (CM) over time. This study examines natural fluctuations in self-reported headache frequency as well as the stability and variation in migraine type among individuals meeting criteria for EM and CM at baseline.
Methods
The Chronic Migraine Epidemiology and Outcomes (CaMEO) Study was a longitudinal survey of US adults with EM and CM identified by a web-questionnaire. A validated questionnaire was used to classify respondents with EM (<15 headache days/month) or CM (≥15 headache days/month) every three months for a total of five assessments. We described longitudinal persistence of baseline EM and CM classifications. In addition, we modelled longitudinal variation in headache day frequency per month using negative binomial repeated measures regression models (NBRMR).
Results
Among the 5464 respondents with EM at baseline providing four or five waves of data, 5048 (92.4%) had EM in all waves and 416 (7.6%) had CM in at least one wave. Among 526 respondents with CM at baseline providing four or five waves of data, 140 (26.6%) had CM in every wave and 386 (73.4%) had EM for at least one wave. Individual plots revealed striking within-person variations in headache days per month. The NBRMR model revealed that the rate of headache days increased across waves of observation 19% more per wave for CM compared to EM (rate ratio [RR], 1.19; 95% CI, 1.13–1.26). After adjustment for covariates, the relative difference changed to a 26% increase per wave (RR, 1.26; 95% CI, 1.2–1.33).
Conclusions
Follow-up at three-month intervals reveals a high level of short-term variability in headache days per month. As a consequence, many individuals cross the CM diagnostic boundary of ≥15 headache days per month.Nearly three quarters of persons with CM at baseline drop below this diagnostic boundary at least once over the course of a year. These findings are of interest in the consideration of headache classification and diagnosis, the design and interpretation of epidemiologic and clinical studies, and clinical management.
Journal Article