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The current study used meta-regression to establish trends in bullying from 1998 to 2017, to identify factors that help explain variation in bullying trends, and to determine differences in the trends by gender and grade. This study focused on trends of face-to-face (FTF) bullying victimization and perpetration, cyberbullying victimization, relational bullying victimization, verbal bullying victimization, and physical bullying victimization, as well as characteristics of the youth involved. It also explored methodological and survey differences to help determine which factors contribute to variation from study to study. A systematic search found 91 studies reporting trends of bullying, from 1998 to 2017, that met predefined inclusion and exclusion criteria. The findings illustrate no significant time trend when looking at FTF bullying victimization, yet an increasing time trend for cyberbullying victimization. Additional trends begin to emerge when stratifying the findings by grade and gender, with FTF bullying victimization among boys declining, while FTF bullying victimization among girls is increasing. Across both FTF bullying victimization and cyberbullying victimization, younger adolescents report significantly more bullying than older adolescents, and this is consistent over time. Verbal and physical bullying victimization as well as FTF bullying perpetration have significantly declined over time. This study also identified key variables that contribute to the variation from trend study to trend study. The implications of these findings inform both policy and practice and provide insight into the overall scope of bullying within the United States.

Mental health problems are inseparable from the environment. With virtual reality (VR), computer-generated interactive environments, individuals can repeatedly experience their problematic situations and be taught, via evidence-based psychological treatments, how to overcome difficulties. VR is moving out of specialist laboratories. Our central aim was to describe the potential of VR in mental health, including a consideration of the first 20 years of applications. A systematic review of empirical studies was conducted. In all, 285 studies were identified, with 86 concerning assessment, 45 theory development, and 154 treatment. The main disorders researched were anxiety (n = 192), schizophrenia (n = 44), substance-related disorders (n = 22) and eating disorders (n = 18). There are pioneering early studies, but the methodological quality of studies was generally low. The gaps in meaningful applications to mental health are extensive. The most established finding is that VR exposure-based treatments can reduce anxiety disorders, but there are numerous research and treatment avenues of promise. VR was found to be a much-misused term, often applied to non-interactive and non-immersive technologies. We conclude that VR has the potential to transform the assessment, understanding and treatment of mental health problems. The treatment possibilities will only be realized if – with the user experience at the heart of design – the best immersive VR technology is combined with targeted translational interventions. The capability of VR to simulate reality could greatly increase access to psychological therapies, while treatment outcomes could be enhanced by the technology's ability to create new realities. VR may merit the level of attention given to neuroimaging.

Groundwater-influenced ecosystems (GIEs) are increasingly vulnerable due to groundwater extraction, land-use practices, and climate change. These ecosystems receive groundwater inflow as a portion of their baseflow or water budget, which can maintain water levels, water temperature, and chemistry necessary to sustain the biodiversity that they support. In some systems (e.g., springs, seeps, fens), this connection with groundwater is central to the system’s integrity and persistence. Groundwater management decisions for human use often do not consider the ecological effects of those actions on GIEs. This disparity can be attributed, in part, to a lack of information regarding the physical relationships these systems have with the surrounding landscape and climate, which may influence the environmental conditions and associated biodiversity. We estimate the vulnerability of areas predicted to be highly suitable for the presence of GIEs based on watershed (U.S. Geological Survey Hydrologic Unit Code 12 watersheds: 24–100 km2) and pixel (30 m × 30 m pixels) resolution in the Atlantic Highlands and Mixed Wood Plains EPA Level II Ecoregions in the northeastern United States. We represent vulnerability with variables describing adaptive capacity (topographic wetness index, hydric soil, physiographic diversity), exposure (climatic niche), and sensitivity (aquatic barriers, proportion urbanized or agriculture). Vulnerability scores indicate that ~26% of GIEs were within 30 m of areas with moderate vulnerability. Within these GIEs, climate exposure is an important contributor to vulnerability of 40% of the areas, followed by land use (19%, agriculture or urbanized). There are few areas predicted to be suitable for GIEs that are also predicted to be highly vulnerable, and of those, climate exposure is the most important contributor to their vulnerability. Persistence of GIEs in the northeastern United States may be challenged as changes in the amount and timing of precipitation and increasing air temperatures attributed to climate change affect the groundwater that sustains these systems.

Globally, groundwater-influenced ecosystems (GIEs) are increasingly vulnerable to groundwater extraction and land use practices. Groundwater supports these ecosystems by providing inflow, which can maintain water levels, water temperature, and the chemistry necessary to sustain the biodiversity that they support. Many aquatic systems receive groundwater as a portion of baseflow, and in some systems, the connection with groundwater is significant and important to the system’s integrity and persistence. There is a lack of information about where these systems are found and their relationships with environmental conditions in the surrounding landscape. Additionally, groundwater management for human use often does not address maintaining the ecological functions of GIEs. We used correlative distribution modeling methods (GLM, GAM, MaxEnt, Random Forest) to predict landscape-scale habitat suitability for GIEs in two ecologically distinct ecoregions (EPA Level II ecoregions: Atlantic Highlands and Mixed Wood Plains) in the northeastern United States. We evaluated and combined the predictions to create ensemble models for each ecoregion. The accuracy of the ensemble models was 75% in the Atlantic Highlands and 86% in the Mixed Wood Plains. In the Mixed Wood Plains, hydric soil, surface materials, and soil permeability were the best predictors of GIE presence, whereas hydric soil, topographic wetness index, and elevation were the best predictors of GIE presence in the Atlantic Highlands. Approximately 1% of the total land area in each ecoregion was predicted to be suitable for GIEs, highlighting that there likely is a small proportion of the landscape occupied by these systems.

Childhood sexual abuse (CSA) and bullying victimization are well-established risk factors for deliberate self-harm (DSH) and suicidal ideation (SI). Research ties aspects of self-concept, such as self-esteem, with victimization and self-harm. Yet, there is limited evidence of the role of multidimensional self-concept in the victimization-self-harm association. Using a longitudinal sample of 422 adolescent girls from a large midwestern city, 35% with recently substantiated CSA-exposure and 51% with recent bullying victimization at baseline, we examined pathways from CSA-exposure and bullying victimization to subsequent DSH and SI, with global self-worth and five subscales of self-concept as mediators (social competence, close friendships, physical appearance, scholastic competence, and behavioral conduct). Data was collected from 2012 to 2015. CSA-exposure directly increased the risk of both SI ( B .50, SE .23, p < .05) and DSH ( B .53, SE .22, p < 5), while global self-worth fully mediated the relationship between bullying victimization, SI ( B .21, SE .07, 95% BCB-CI 1.17–1.95, p < .01), and DSH ( B .15, SE .06, 95% BCB-CI 1.10–1.69, p < .05), We found no evidence of mediation for the subscales model. Both CSA-exposure and bullying victimization directly reduced specific subscales of self-concept, while behavioral conduct increased the risk of DSH. The role of self-concept in the bullying/self-harm association and the direct effects of CSA-exposure on self-harm highlight areas of need in social work practice, specifically the need to incorporate an emphasis on trusting relationships, overall well-being, and the reduction of shame into trauma-informed therapy and bullying prevention efforts.

Northern peatlands cover more than 350 million ha and are an important source of methane (CH4) and other biogenic gases contributing to climate change. Free-phase gas (FPG) accumulation and episodic release has recently been recognized as an important mechanism for biogenic gas flux from peatlands. It is likely that gas production and groundwater flow are interconnected in peatlands: groundwater flow influences gas production by regulating geochemical conditions and nutrient supply available for methanogenesis, while FPG influences groundwater flow through a reduction in peat permeability and by creating excess pore water pressures. Water samples collected from three well sites at Caribou Bog, Maine, show substantial dissolved CH4 (5–16 mg L−1) in peat waters below 2 m depth and an increase in concentrations with depth. This suggests production and storage of CH4 in deep peat that may be episodically released as FPG. Two min increment pressure transducer data reveal approximately 5 cm fluctuations in hydraulic head from both deep and shallow peat that are believed to be indicative of FPG release. FPG release persists up to 24 h during decreasing atmospheric pressure and a rising water table. Preferential flow is seen towards an area of relatively lower hydraulic head associated with the esker and pool system. Increased CH4 concentrations are also found at the depth of the esker crest, suggesting that the high permeability esker is acting as a conduit for groundwater flow, driving a downward transport of labile carbon, resulting in higher rates of CH4 production.

1. The Hudson Bay Lowlands have been rising isostatically for the past 7000 years, creating a regional chronosequence as new land emerges from the sea. Rates of uplift are most rapid in the eastern portion of the lowlands near the lower Albany River study area. 2. The stratigraphy of three raised bogs was investigated to determine rates and pathways of peatland development in the Albany River region. The bogs are distributed evenly along the regional chronosequence from the oldest site at Oldman (5980 +/- 100 BP) to progressively younger sites at Albany River (4810 +/- 70) and Belec Lake (3960 +/- 60). 3. Each bog had the same stratigraphic sequence, beginning with a basal tidal marsh assemblage that was rapidly replaced by a Larix-dominated swamp forest, followed by a Picea-forested bog, and ultimately a non-forested bog. The bog-fen boundary is marked by the disappearance of fen indicators, dominance of bog-forming Sphagna, and a sharp decline in nitrogen. Each of these successional stages was associated with different rates of vertical growth. 4. The rate of successional change was more rapid at the younger sites, and their vertical growth curve was more curvilinear. The formation of a raised bog, for example, was 1.3 times more rapid at Albany River and 5.5 times more rapid at Belec Lake than at Oldman. Belec Lake reached its ultimate successional stage first, although it was the last site to emerge from the sea. 5. The differential rate of isostatic uplift across this region rather than climate was the principal environmental driver for peatland development. The faster rate of uplift on the lower reaches of the drainage basin continues to reduce the regional slope, impede drainage and shift river channels, continually altering the local hydrogeological setting. 6. Groundwater flow simulations based on the Dupuit equation show that the growth of these raised bogs was probably constrained by their local hydrogeological setting. Bog formation was first induced by the creation of interfluvial divides between headwardly eroding streams or shifting river channels, and further bog growth was ultimately constrained by the width of the interfluve and the depth of river incision. The Belec Lake bog was the first to approach its limiting height because its narrow interfluve could only support a low water-table mound. 7. Although peatland succession largely followed the same conservative pathway at each site, both the pace and direction of these pathways were set by geological processes, which are probably the decisive drivers for the evolution of this large peat basin.

Screening for specific biomarkers of early-stage detection of ovarian cancer is a major health priority due to the asymptomatic nature and poor survival characteristic of the disease. We utilised two-dimensional gel electrophoresis (2DE) to identify differentially expressed proteins in the serum of ovarian cancer patients that may be useful as biomarkers of this disease. In this study, 38 ovarian cancer patients at different pathological grades (grade 1 ( n =6), grade 2 ( n =8) and grade 3 ( n =24)) were compared to a control group of eight healthy women. Serum samples were treated with a mixture of Affigel-Blue and protein A (5 : 1) for 1 h to remove high abundance protein (e.g. immunoglobulin and albumin) and were displayed using 11 cm, pH 4–7 isoelectric focusing strips for the first dimension and 10% acrylamide gel electrophoresis for the second dimension. Protein spots were visualised by SYPRO-Ruby staining, imaged by FX-imager and compared and analysed by PDQuest software. A total of 24 serum proteins were differentially expressed in grade 1 ( P <0.05), 31 in grade 2 ( P <0.05) and 25 in grade 3 ( P <0.05) ovarian cancer patients. Six of the protein spots that were significantly upregulated in all groups of ovarian cancer patients were identified by nano-electrospray quadrupole quadrupole time-of-flight mass spectrometry (n-ESIQ(q)TOFMS) and matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOFMS) as isoforms of haptoglobin-1 precursor (HAP1), a liver glycoprotein present in human serum. Further identification of the spots at different pathological grades was confirmed by Western blotting using monoclonal antibody against a haptoglobin epitope contained within HAP1. Immunohistochemical localisation of HAP1-like activity was present in malignant ovarian epithelium and stroma but strong immunostaining was present in blood vessels, areas with myxomatous stroma and vascular spaces. No tissue localisation of HAP1-like immunoreactivity was observed in normal ovarian surface epithelium. These data highlight the need to assess circulating concentration of HAP1 in the serum of ovarian cancer patients and evaluate its potential as a biomarker in the early diagnosis of ovarian cancer.

Abstract Our view is that insomnia may be a causal factor in the occurrence of psychotic experiences such as paranoia and hallucinations. However, the causal relationship is not established. The aim of the study was to investigate the causal role of insomnia in psychotic experiences via a sleep restriction manipulation. The study was a within-subjects crossover design that included a planned mediation analysis. Sixty-eight nonclinical volunteers underwent a sleep loss condition (restricted to 4 h sleep for 3 nights) and a control condition (standard sleep) in randomized order in 2 consecutive weeks, with a weekend washout period. Psychotic experiences (paranoia, hallucinations, grandiosity, and cognitive disorganization) and candidate mediating variables (negative affect and related processes, working memory, decision making, and perceptual processing) were assessed before and after each condition. Actigraphy verified an average sleep duration of 5 h 15 min in the sleep loss condition, vs 6 h 58 min in the control condition. After the sleep loss condition, relative to the control condition, participants reported significant increases in paranoia, hallucinations, and cognitive disorganization, with no significant changes in grandiosity. The sleep loss condition was also associated with significant increases in negative affect, negative self and other cognitions, worry, and working memory impairment. Mediation analyses indicated that changes in psychotic experiences were mediated by changes in negative affect and related processes, but not memory impairment. The overall conclusion is that insomnia has a causal role in the occurrence of certain psychotic experiences, and that a key route is via negative affect.

Atmospheric pressure (Patm) is known to regulate methane emissions from northern peatlands. However, recent conceptual models differ in how gas production and release occurs in shallow (defined here as less than 1 m depth) versus intermediate to deep peat soils (i.e., more than 1 m depth). We used ground penetrating radar (GPR) measurements to non‐invasively estimate the vertical distribution of free‐phase gas and the dependence of this distribution on atmospheric pressure in a northern peatland. Variations in the travel time of the electromagnetic wave to three interfaces in the peat column were used in conjunction with deformation rod data and a petrophysical model relating electromagnetic wave velocity to free‐phase gas content to model changes in the vertical distribution of free‐phase gas over time. We found a negative linear relation between changes in free‐phase gas content and changes in Patm for shallow peat soils and a positive linear relation for deeper soils. Our results suggest that (1) free‐phase gas content confined in deep peat soils is larger and less variable to changes in Patm than gas in shallow/intermediate peat soils; (2) increases in Patm result in gas release from shallow peat soils into the atmosphere (i.e., rapid ebullition); and (3) decreases in Patm result in upward gas movement from intermediate layers to replenish shallow layers. Our results suggest that changes in Patm drive changes in the vertical distribution of free phase gas in peat soil and regulate methane ebullition from peat soils to the atmosphere. Our data shows a relationship between free phase gas and depth that may be due to changes in peat properties or increasing water pressure with depth. Key Points Gas content in deep peat soils is larger and less variable than shallow peat Increases in atmospheric pressure result in gas release from shallow peat Decreases in atmospheric pressure result in upward gas movement