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Cystic echinococcosis (CE) is a zoonotic helminthiasis caused by different species of the genus Echinococcus, and is a major economic and public health concern worldwide. Synthetic anthelmintics are most commonly used to control CE, however, prolonged use of these drugs may result in many adverse effects. This study aims to discuss the in vitro/in vivo scolicidal efficacy of different medicinal plants and their components used against Echinococcus granulosus. Google Scholar, ScienceDirect, PubMed and Scopus were used to retrieve the published literature from 2000-2020. A total of 62 published articles met the eligibility criteria and were reviewed. A total of 52 plant species belonging to 22 families have been reported to be evaluated as scolicidal agents against E. granulosus worldwide. Most extensively used medicinal plants against E. granulosus belong to the family Lamiaceae (25.0%) followed by Apiaceae (11.3%). Among various plant parts, leaves (36.0%) were most commonly used. Essential oils of Zataria multiflora and Ferula asafetida at a concentration of 0.02, and 0.06 mg/ml showed 100% in vitro scolicidal activity after 10 min post application, respectively. Z. multiflora also depicted high in vivo efficacy by decreasing weight and size while also causing extensive damage to the germinal layer of the cysts. Plant-based compounds like berberine, thymol, and thymoquinone have shown high efficacy against E. granulosus. These plant species and compounds could be potentially used for the development of an effective drug against E. granulosus, if further investigated for in vivo efficacy, toxicity, and mechanism of drug action in future research.

Automotive dashboard cameras are widely used to record driving events and often serve as critical evidence in accident investigations and insurance claims. However, the availability of free and low-cost editing tools has increased the risk of video tampering, underscoring the need for reliable methods to verify video authenticity. Temporal tampering typically involves manipulating frame order through insertion, deletion, or duplication. This paper proposes a computationally efficient framework that transforms high-dimensional video into compact one-dimensional temporal signals and learns tampering patterns using a shallow one-dimensional convolutional neural network (1D-CNN). Five complementary features are extracted between consecutive frames: frame-difference magnitude, structural similarity drift (SSIM drift), optical-flow mean, forward–backward optical-flow consistency error, and compression-aware temporal prediction error. Per-video robust normalization is applied to emphasize intra-video anomalies. Experiments on a custom dataset derived from D2-City demonstrate strong detection performance in single-attack settings: 95.0% accuracy for frame deletion, 100.0% for frame insertion, and 95.0% for frame duplication. In a four-class setting (non-tampered, insertion, deletion, duplication), the model achieves 96.3% accuracy, with AUCs of 0.994, 1.000, 0.997, and 0.988, respectively. Efficiency analysis confirms near real-time CPU inference (≈12.7–12.9 FPS) with minimal memory overhead. Cross-dataset tests on BDDA and VIRAT reveal domain-shift sensitivity, particularly for deletion and duplication, highlighting the need for domain adaptation and augmentation. Overall, the proposed multi-feature 1D-CNN provides a practical, interpretable, and resource-aware solution for temporal tampering detection in dashcam videos, supporting trustworthy video forensics in IoT-enabled transportation systems.

Background: Haemonchus contortus is an important pathogenic nematode parasite and major economic constraint of small ruminants in tropics and subtropics regions. This review is an attempt to systematically address the; (a) efficacy of different plants against H. contortus by in vitro and in vivo proof; (b) toxicology, mechanism of action, and active phyto-compounds involve in anti-haemonchiasis activity; (c) and comparative analysis of plant species evaluated both in vitro and in vivo . Methods: Online databases (Google Scholar, PubMed, Scopus, and ScienceDirect) were searched and published research articles (1980–2020) were gathered and reviewed. Results: A total of 187 plant species were reported belonging to 59 families and 145 genera with Asteraceae and Fabaceae being frequently used. Out of the total plant species, 171 species were found to be evaluated in vitro and only 40 species in vivo . Twenty-four species were commonly evaluated for in vitro and in vivo anti-haemonchiasis activity. Among the reported assays, egg hatching test (EHT) and fecal egg count reduction (FECR) were the most widely used assays in vitro and in vivo , respectively. Moreover, sheep were the frequently used experimental model in vivo . After comparative analysis, Lachesiodendron viridiflorum , Corymbia citriodora , Calotropis procera , and Artemisia herba-alba were found highly effective both in vitro and in vivo . L. viridiflorum inhibited enzymatic activities and metabolic processes of the parasite and was found to be safe without toxic effects. C. citriodora was moderately toxic in vivo , however, the plant extract produced promising nematicidal effects by causing muscular disorganization and changes in the mitochondrial profile. Additionally, C. procera and A. herba -alba despite of their high anti-haemonchiasis activity were found to be highly toxic at the tested concentrations. C. procera caused perforation and tegumental disorganization along with adult worm paralysis. Nineteen compounds were reported, among which anethole and carvone completely inhibited egg hatching in vitro and significantly reduced fecal egg count, decreased male length, and reproductive capacity of female in vivo . Conclusion: This review summarized different medicinal plants owing to nematicidal activities against H. contortus eggs, larvae, and adult worms. Plants like L. viridiflorum, C. citriodora, C. procera, and A. herba-alba , while compounds anethole and carvone having promising nematicidal activities and could be an alternative source for developing novel drugs after further investigation.

This study examines how rainfall and groundwater recharge can help mitigate drought conditions, using the Standardized Precipitation Evapotranspiration Index (SPEI) as the drought indicator. It focuses on the top ten countries experiencing groundwater overexploitation and incorporates a global average perspective to provide deeper insights into these critical relationships. These insights are essential for informed policy-making and integrated decision-making, involving a range of stakeholders from local users to international policymakers on drought mitigation efforts from 1961 to 2022. The analysis employs the novel technique to estimate Dynamic Panel Threshold Regression (DPThR) model. The findings reveal that a 1-millimeter increase in rainfall improves the SPEI by 0.003 units, thereby reducing drought likelihood. The threshold for mitigating drought effects is identified at 614.41 millimeters of annual rainfall, with Pakistan, Iran, and Saudi Arabia being the most at-risk countries when rainfall falls below this level. Conversely, a one-standard-deviation increase in groundwater recharge enhances the SPEI by 5.06 units, indicating a substantial reduction in drought incidence. The threshold for mitigating drought effects is identified at –0.0039 standard deviations, with China, Iran, Mexico, Pakistan, Saudi Arabia, Turkey, and the United States being the most drought-prone when recharge falls below this level. Furthermore, it was found that temperature exerts a consistently negative and highly significant effect, indicating that warming intensifies drought through evapotranspiration and soil moisture depletion. While CO 2 emissions show no significant direct impact. Moreover, the study identifies unidirectional causality running from rainfall, groundwater recharge, temperature, and CO 2 emissions, reinforcing the dominance of hydro-climatic forces in driving drought variability. Policy recommendations include advancing artificial rainfall, enhancing groundwater recharge, and maintaining country-specific water use thresholds to reduce drought risk and strengthen water and climate resilience in overexploited regions.

The current research deals with analytical analysis of Marangoni convection on ethylene glycol base hybrid nanofluid two-dimension flow with viscous dissipation through a porous medium, which have some important application in mechanical, civil, electronics, and chemical engineering . Two types of nanoparticles one is sliver and other is graphene oxide and ethylene glycol is used as base fluid in this research work. The authors applied appropriate transformations to convert a collection of dimension form of nonlinear partial differential equations to dimensionless form of nonlinear ordinary differential equations. The transformed nonlinear ordinary differential equations are solved with the help of an approximate analytical method known as the homotopy analysis method. The effects of various parameters, including nanoparticle volume fraction, porosity parameter, Marangoni convection, and Eckert number, on energy and momentum profiles are analyzed, with the results illustrated using graphs. A physical explanation is provided to simulate and evaluate the behavior of nanofluid structures, such as temperature and velocity, in response to changes in these influencing factors.

Cutaneous leishmaniasis is a neglected tropical disease caused by Leishmania spp. and transmitted by female sandflies. Terrorism and counter-insurgency military operations in Federally Administered Tribal Areas (FATA) lead to a large-scale migration of internally displaced persons (IDPs) in Khyber Pakhtunkhwa and thus, new outbreaks of several infectious diseases such as cutaneous leishmaniasis occurred. This study intended to find the prevalence of cutaneous leishmaniasis in people with cutaneous lesions suspected of having cutaneous leishmaniasis in four remote districts of Khyber Pakhtunkhwa and to assess the participant's knowledge, attitude, and practices about the infection and its control. A cross-sectional study was carried out in four remote districts of Khyber Pakhtunkhwa including Karak, Lakki Marwat, Tank, and Dera Ismail Khan (D. I. Khan) and a total of 1,674 participants were recruited using a convenience sampling technique. The prevalence of cutaneous leishmaniasis among the participants with cutaneous lesions was 50.4% and the infection was comparatively more prevalent in district Karak. Among participants, 56.8% were male and mostly, 53.8% were under the age of 16 years with 52.8% living in kutcha houses and were from rural areas. Multiple skin lesions were more common, and the face was frequently affected body part. The ratio of participants with lesions older than a month was higher and the majority confronted infections with blood protozoan parasites for the first time. Most participants were unaware of the signs/symptoms of the disease, basic knowledge of the vectors, anthroponotic spread, preventive measures, secondary infections, and reservoir hosts. The use of wood/animal dung as fuel, closeness with reservoir animals, and no use of insect repellents were some of the notable risk factors. Cutaneous leishmaniasis is highly prevalent in the study area and a very low level of awareness was reported among the participants. This study necessitates the planning and execution of regulations and preventive programs, public health education, awareness campaigns, and disease management practices to overcome future incidence of cutaneous leishmaniasis.

Background: Local communities use animals and plants as common traditional therapies for various diseases. The study aimed to document animals and animal-plant mixture recipes that are used as alternative and complementary medicine in southern regions of Khyber Pakhtunkhwa, Pakistan. Methods: The data were collected (2017–2018) in three remote areas (Dera Ismail Khan, Bannu, and Lakki Marwat) through questionnaires and face-to-face interviews with local inhabitants. Data on ethnomedicinal uses and cultural values of animal products or parts and their mixture with plants were analyzed using various indices such as frequency of citation (FC), informant consensus (FIC), and fidelity level (FL) to find the highly preferred species in the area. Results: A total of 185 informants (117 females and 68 males) were interviewed. The study documented 32 animal species, vertebrates ( n = 24) and invertebrates ( n = 8), for curing 37 types of diseases. Mammals ( n = 13) were among the most commonly utilized species followed by birds ( n = 8), arthropods ( n = 7), reptiles ( n = 2), and fishes and annelids ( n = 1 each). Among the reported animals, Herpestes edwardsi (mongoose), Macaca mulatta (monkey), Labeo rohita (rohu), Oryctolagus cuniculus (rabbit), and Streptopelia decaocto (dove) were the newly reported species used as alternative medicine. The meat of Capra hircus (goat), monkey, and rabbit was used to treat chronic diseases such as hepatitis C, cancer, epilepsy, and asthma. A total of 17 plants belonging to 15 botanical families were used in combination with animal parts/products. The commonly used families were Piperaceae (31%) followed by Apiaceae (27%). The notable plant species in combination with animal products were Curcuma longa, Piper nigrum, Coriandrum sativum, Brassica rapa, and Phoenix dactylifera . Seeds were the highest used part in animal-plant mixture recipes. Gallus gallus (chicken) and Columba livia (pigeon) secured the highest (FC = 28) and (FL = 80%), respectively. FIC results had shown the highest degree of consensus for general body weakness (FIC = 0.88) and pyrexia (FIC = 0.86). Conclusion: Our findings suggest that local communities in the southern regions of Khyber Pakhtunkhwa have substantial knowledge about the formulation of ethnomedicines from both flora and fauna that need urgent documentation to avoid eroding and for conservational purposes. The newly reported phytozootherapeutic recipes and animal species can potentially be a source of pharmacologically active constituents and should be checked experimentally for further confirmation.

The objective of this work is to investigate the dynamics of a self-propelled undulating sheet in a non-Newtonian electrolyte solution inside a wavy channel under the electroosmotic effect. The electrolyte solution, which is non-Newtonian, is modeled as a Carreau-Yasuda fluid. The flow generated by a combination of an undulating sheet and electroosmotic effect is obtained by solving the continuity and momentum equations. The electroosmotic body force term is derived using the Poisson-Boltzmann equation for the electric potential. A fourth-order ordinary differential equation for the stream function is solved under the Stokes flow regime. The dynamics of the undulating sheet’s speed and the energy dissipation it, are investigated. The combined effects of electroosmosis and the viscoelastic properties of the ambient fluid on the undulating sheet are discussed.

Background Cystic echinococcosis (CE) is one of the principal causes of economic loss to the livestock industry because of its morbidity and mortality of food-producing animals and condemnation of important visceral organs. Pakistan being an agricultural country having an extensive livestock sector, is mostly practiced by poor people, which has a fundamental role in the economy. The present study was aimed to conduct a cross-sectional survey and PCR based confirmation of Echinococcus granulosus in sheep, goats, cows, and buffaloes from southern regions (three districts: Lakki Marwat, Bannu, and Karak) of Khyber Pakhtunkhwa, Pakistan. During the study, a total of 2833 animals were examined randomly including; sheep ( n  = 529), goats ( n  = 428), cows ( n  = 1693), and buffaloes ( n  = 183). Hydatid cysts were collected and examined for the presence of protoscoleces using microscopy. Detection of DNA was performed by using PCR and two mitochondrial genetic markers namely; NAD-1 and COX-1 were amplified. Results The overall prevalence of CE was found to be (9%) among the examined animals. The hydatid cyst infection was highly prevalent in buffaloes (12%), followed by sheep (10%), cows (9%), and goats (5.1%). Cystic echinococcosis was more prevalent (10%; 96/992) in district Lakki Marwat followed by district Bannu (9%; 112/1246) and Karak (7%; 39/595). Female animals were more likely to be infected with CE (11.6%) than male animals (5.3%) ( p  = 0.001). Similarly, the infection was higher in the older group of animals as compared to younger ( p  = 0.001). Mostly (52.2%; n  = 129) of hydatid cysts were found in the liver, while (64.4%; n  = 159) cysts of the infected animals were infertile. PCR based identification confirmed the presence of E. granulosus sensu stricto (s.s) in the study area. Conclusion Cystic echinococcosis was found to be highly prevalent in southern regions of Khyber Pakhtunkhwa and could be a potential threat to human health. Moreover, molecular sequencing and phylogenetic analyses should be carried out in future to identify the prevailing genotype (s) of E. granulosus s.s .

[This corrects the article DOI: 10.1371/journal.pone.0255138.].