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"Reichel, Alexander"
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Furnishing | Zoning
What is the process of forming rooms, which elements are used and how are room-shaping components defined?The fourth volume in the SCALE series, Furnishing | Zoning, deals with the relationships between building typology and building structure, and between spatial composition and interior design.
eBook
Furnish - zone: space concepts, fitting-out, materials
What is the process of forming rooms, which elements are used and how are room-shaping components defined? The fourth volume in the SCALE series, Furnishing | Zoning, deals with the relationships between building typology and building structure, and between spatial composition and interior design. The relationship between the briefing and the catalogue of requirements, and between shell construction and fit-out, is elucidated. Connections at walls, ceilings and floors are explained in detail and illustrated with case studies of selected projects. In addition, the authors demonstrate how a well-designed sequence of spaces can create added value by means, for example, of the choice of materials and the lighting scheme, or adaptability to accommodate new functions. Following the introductory chapter on the subject of space, the volume is divided into chapters on floors, walls, ceilings, and furniture and fixtures. Furnishing | Zoning examines the subject from different professional angles and thereby provides valuable support for practical interior design.
eBook
Support/materialise: wall, column, slab, roof
Designing and constructing load-bearing building elements Columns, walls and floors make up the skeleton of nearly every building. This third volume in the series SCALE, Support | Materialise, takes an in-depth look at these load-bearing structures, covering the development and realization of appropriate constructions from idea and design intention all the way to constructional implementation. Following the traditional building methods of massive, cross-wall, and skeleton construction, it points the way toward a material-appropriate constructional approach to these defining structural elements - columns, walls, and floors. Special attention is given to how constructional and technical considerations can be harmonized with spatial and formal commitments. The load-bearing elements are organized, described, and explored in detail from a material as well as a formal and constructional perspective. Their practical implementation is illustrated by a series of international examples.
eBook
Support I Materialise
Tragende Bauteile gestalten und konstruieren Wand, Stütze, Decke und Dach formen das Gerippe nahezu jedes Gebäudes. Der dritte Band der Reihe SCALE, Tragen und Materialisieren, befasst sich dezidiert mit diesen tragenden Strukturen. Von der Idee, der Entwurfsabsicht, bis zur konstruktiven Umsetzung wird die Entwicklung und Realisierung angemessener Konstruktionen begleitet. Das Buch folgt dabei den tradierten Bauweisen Massiv-, Schotten- und Skelettbau und weist den Weg zu einem materialgerechten konstruktiven Umgang mit den gestaltprägenden tragenden Bauteilen Wand, Stütze, Decke und Dach. Ein wichtiges Augenmerk liegt darauf, wie im Gestaltungsprozess konstruktiv-technische Überlegungen mit räumlichen und formalen Bindungen in Einklang gebracht werden. Die tragenden Bauteile werden sowohl nach ihrer Materialität als auch formal und konstruktiv geordnet, beschrieben und detailliert. Eine Reihe internationaler Beispiele erläutert die praktische Umsetzung anschaulich.
eBook
Plaster, Render, Paint and Coatings
Plasters, paints and coatings are what define surfaces, create spatial effects and interplay with light. How they are used is decisive for a building s appearance, and they also serve as a protective layer. A new volume in the DETAIL practice series, Plaster, Render, Paint and Coatings presents a survey of impressive proven and innovative solutions. The authors describe and define the basic essentials, show what to look for and offer valuable tips for practical applications. Taking two example buildings, the authors also document the structural design of all important connection points at a scale of 1:10. New building or renovation: solutions for the application of plaster and paint Guide: Which paint for which surfaces? Design details for solutions with external thermal insulation composite systems Separate manufacturer s guidelines for plasters and paints
eBook
Building with Steel
A handbook for quick, goal-oriented reading and implementation. Case study projects exemplify common norm details using large-scale drawings. The fundamentals of planning load-bearing structures provide design and planning help.
eBook
Halo- and Solvato-Fluorochromic Polymer Nanoassemblies for Cancer Theranostics
Theranostics is an emerging treatment approach that combines diagnostics with therapy in order to personalize treatment regimens for individual patients and decrease cancer mortality. Previously, nanoparticles entrapping conventional fluorescent dyes were developed for cancer theranostics, but fluorescent nanoparticles did not allow clinicians to significantly improve cancer treatments. The use of fluorescent dyes that are sensitive to solvent acidity (halofluorochromism) and polarity (solvato-fluorochromism) may overcome the limitations of fluorescent nanoparticles and improve cancer therapy by enabling researchers to detect chemical properties within the nanoparticle core environment. The model halo- and solvato-fluorochromic dye Nile blue was attached to the core of nanoscale drug delivery systems called polymer nanoassemblies (PNAs), which were created by tethering hydrophilic polymers and hydrophobic groups to a cationic polymer scaffold. The fluorescence of empty PNAs increased by 100% at pH 5.0 compared to pH 7.4, and the fluorescence of drug-loaded PNAs increased up to 300% compared to empty PNAs. A comparison of the fluorochromic properties between PNAs with various core properties indicated that both hydrophobic pendant groups and scaffold amines contributed to the fluorochromism of PNAs. The halo-fluorochromism of PNAs allowed investigators to minimize the detection of fluorescence signals in healthy organs such as the liver. Fluorescence imaging of halo-fluorochromic PNAs diffused into tissue mimics indicated that fluorescence of PNAs in tissues increased by 100% at pH 7.0 compared to pH 7.4. In addition, halo-fluorochromic PNAs identified the acidic perimeter surrounding metastatic tumors in orthotopic metastatic tumor models. Computational simulations of metastatic lesions verified that some halo-fluorochromic PNAs accumulate in the hypoxic/acidic regions of metastatic tumors following intravenous administration. These simulations also indicated that the accumulation of PNAs in the hypoxic regions of tumors doubles at 12 hours post-treatment compared to 1.8 hours post-treatment.
Dissertation