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"Reid, Isabel"
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Murder on the Eiffel Tower : a mystery
The shiny, new Eiffel Tower is the pride and glory of the 1889 World Exposition. Unfortunately, on one sunny afternoon a woman collapses and dies on this Paris landmark. Victor Legris, a bookseller who happened to be on the tower at the time of the incident, is determined to find out what actually happened.
Book
Facilitators and barriers to participation of patients with treatment resistant depression in a randomised controlled trial of two forms of personalised magnetic resonance imaging targeted transcranial magnetic stimulation (the BRIGhTMIND trial)
Background
Magnetic resonance imaging (MRI) can personalise the site of transcranial magnetic stimulation (TMS) delivered as a course of 20 sessions for treatment-resistant depression (TRD). Facilitators and barriers to a randomised controlled trial (RCT) of MRI personalised TMS is understudied.
Aim
Qualitative analysis to explore facilitators and barriers behind RCT participants’ experience of personalised MRI-targeted TMS in people with TRD.
Methods
Nineteen participants from the BRIGhTMIND RCT of two forms of MRI personalised TMS, completed semi-structured interviews exploring the reasons behind the uptake and experience of TMS. The sample included fifteen participants who completed the treatment course and four who declined to proceed before randomisation. Interviews were analysed using thematic analysis, co-produced between researchers and patients and public involvement contributors.
Results
Facilitators were “hope” regarding the treatment itself, the influence of research staff, interest in a new treatment, and altruism. Barriers were concerns about their ability to commit to the trial and the nature of the TMS itself. Throughout the themes, clinicians and researchers made a difference by explaining and setting realistic expectations of the treatment and building rapport through daily patient contact.
Conclusion
The study highlights the importance of understanding patients’ concepts and experiences of TMS. The provision of optimal information to patients twinned with offering TMS outside office hours and the most efficacious, acceptable regimes of TMS delivery may maximise participation (Trial registration number ISRCTN19674644, registered on 01/10/2018).
Trial Registration
Trial registration: ISRCTN19674644||
http://www.isrctn.org/
) registered on 01/10/2018.
Trial Identifying numbers: CPMS 39297, IRAS 245025.
Journal Article
Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: study protocol for a randomised double-blind controlled trial (BRIGhTMIND)
IntroductionThe BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action of connectivity guided intermittent theta burst stimulation (cgiTBS) versus standard repetitive transcranial magnetic stimulation (rTMS) in adults with moderate to severe treatment resistant depression.Methods and analysisThe study is a randomised double-blind controlled trial with 1:1 allocation to either 20 sessions of (1) cgiTBS or (2) neuronavigated rTMS not using connectivity guidance. A total of 368 eligible participants with a diagnosis of current unipolar major depressive disorder that is both treatment resistant (defined as scoring 2 or more on the Massachusetts General Hospital Staging Score) and moderate to severe (scoring >16 on the 17-item Hamilton Depression Rating Scale (HDRS-17)), will be recruited from primary and secondary care settings at four treatment centres in the UK. The primary outcome is depression response at 16 weeks (50% or greater reduction in HDRS-17 score from baseline). Secondary outcomes include assessments of self-rated depression, anxiety, psychosocial functioning, cognition and quality of life at 8, 16 and 26 weeks postrandomisation. Cost-effectiveness, patient acceptability, safety, mechanism of action and predictors of response will also be examined.Ethics and disseminationEthical approval was granted by East Midlands Leicester Central Research Ethics Committee (ref: 18/EM/0232) on 30 August 2018. The results of the study will be published in relevant peer-reviewed journals, and then through professional and public conferences and media. Further publications will explore patient experience, moderators and mediators of outcome and mechanism of action.Trial registration numberISRCTN19674644
Journal Article
World Awaits Israel's Response to Attacks from Iran; Federal Judge Unseals Special Counsel's Motion on Immunity; Biden Visits Carolinas, Takes Aerial Tour of Devastation; Port Strike Results in Panic Buying in the U.S.; IDF: Eight Israeli Soldiers Killed In Southern Lebanon; Ukraine Confirms Russian Troops Captured Vuhledar; X Worth Nearly 80 Percent Less Than When Musk Bought It; World Awaits Israel's Response To Attacks From Iran; Federal Judge Unseals Special Counsel's Motion On Immunity; Bid
Iran is vowing stronger response if Israel retaliated, withU.S. President Biden saying Israel's response should be proportionaland not on Iran's nuclear sites. Jack Smith's filing laid outcomprehensive narrative of how former president Trump tried tooverturn the results of the 2020 election. FEMA crews visited ravagedareas of North Carolina where some roads only open to first respondersdue to dangerous conditions. President Biden urged both sides to endport strike to avoid economic impact warning of a man-made disaster aspeople began panic buying toilet paper, not affected by strike. GUESTS: Ryan Patel
Transcript
Kim Jong-Un Orders North Korean Military to Ramp Up War Preparations; Major Carriers Reroute Ships From Red Sea After Houthi Attacks; Legal Victory for Trump in Michigan, Michigan Supreme Court Keeps Trump on Primary Ballot; Former EU Commission President Jacques Delors Dead at 98; New York Times Sues OpenAI, Microsoft in Landmark Lawsuit; SpaceX Aims to Blanket Globe With High-speed Wi-Fi. Aired 2- 3a ET
French President Macron expresses deepest concern to Netanyahuover civilian toll and humanitarian emergency in Gaza; Protests promptconcern for New York's New Year's eve event; Colorado Republican Partyappeals Trump's ballot ban, appeal means Colorado Supreme Court rulingon hold indefinitely; Trump asks Maine Secretary of State to recuseherself from deciding on possible ballot ban; Federal agents crackdown on brutal practice of dog fighting; Apple to begin selling itslatest watches again, U.S. appeals court temporarily blocked importban that affected some watches. GUESTS: Danny Danon, Sean Casey
Transcript
Letter: Your Say - Rescue squad ; In association with POST OFFICE
A BIG thank you to the RSPCA and fire brigade, including the rope rescue...
Newspaper Article
Letter: Your view - Snare shock
This is a cruel and barbaric practice and should be banned. Any animal can get caught in these traps, including protected wild animals and even pets.
Newspaper Article
THE HOME FORUM
Saint John, Saint John, the beautifull High on the rockbound coast of tossing blue Atlantic waves; its loveliness the boast of all its native children With delight our voice we raise to add to their encomiums our feeble note of praise. Here Mother Nature wields her brush with generous, loving hand; and paints a landscape unexcelled in any other land. Magnificent its rivers --the picturesque Saint John, whose dancing, sparkling waters to the ocean deeps roll on; the gracsful Kennebecasis. too. whose broad and winding...
Newspaper Article