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A highly readable, beautifully illustrated study of the homes built by elite colonial Philadelphians as retreats—which balanced English models with developing local taste. Colonial Americans, if they could afford it, liked to emulate the fashions of London and the style and manners of English country society while at the same time thinking of themselves as distinctly American. The houses they built reflected this ongoing cultural tension. By the mid-eighteenth century, Americans had developed their own version of the bourgeois English countryseat, a class of estate equally distinct in social function and form from townhouses, rural plantations, and farms. The metropolis of Philadelphia was surrounded by a particularly extraordinary collection of country houses and landscapes. Taken together, these estates make up one of the most significant groups of homes in colonial America. In this masterly volume, Mark Reinberger, a senior architectural historian, and Elizabeth McLean, an accomplished scholar of landscape history, examine the country houses that the urban gentry built on the outskirts of Philadelphia in response to both local and international economic forces, social imperatives, and fashion. What do these structures and their gardens say about the taste of the people who conceived and executed them? How did their evolving forms demonstrate the persistence of European templates while embodying the spirit of American adaptation? The Philadelphia Country House explores the myriad ways in which these estates—which were located in the country but responded to the ideas and manners of the city—straddled the cultural divide between urban and rural. Moving from general trends and building principles to architectural interiors and landscape design, Reinberger and McLean take readers on an intimate tour of the fine, fashionable elements found in upstairs parlors and formal gardens. They also reveal the intricate working world of servants, cellars, and kitchen gardens. Highlighting an important aspect of American historic architecture, this handsome volume is illustrated with nearly 150 photographs, more than 60 line drawings, and two color galleries.

Women presenting with coronary artery disease (CAD) more often present with fibrous atherosclerotic plaques, which are currently understudied. Phenotypically modulated smooth muscle cells (SMCs) contribute to atherosclerosis in women. How these phenotypically modulated SMCs shape female versus male plaques is unknown. Here, we show sex-stratified gene regulatory networks (GRNs) from human carotid atherosclerotic tissue. Prioritization of these networks identified two main SMC GRNs in late-stage atherosclerosis. Single-cell RNA-sequencing mapped these GRNs to two SMC phenotypes: a phenotypically modulated myofibroblast-like SMC network and a contractile SMC network. The myofibroblast-like GRN was mostly expressed in plaques that were vulnerable in females. Finally, mice orthologs of the female myofibroblast-like genes showed retained expression in advanced plaques from female mice but were downregulated in male mice during atherosclerosis progression. Female atherosclerosis is driven by GRNs that promote a fibrous vulnerable plaque rich in myofibroblast-like SMCs.