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"Reis, Ivan"
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Brightest day. Volume two
Once dead, twelve heroes and villains were resurrected by a white light expelled deep within the center of the earth. Now, Aquaman, Martian Manhunter, Firestorm, Hawkman, Hawkgirl, Deadman, Jade, Osiris, Hawk, Captain Boomerang and Zoom must discover the mysterious reason behind their return and uncover the secret that binds them all.
Book
Home-based, supervised, and mixed exercise intervention on functional capacity and quality of life of colorectal cancer patients: a meta-analysis
This systematic review and meta-analysis of randomized controlled trials tested the effects of home-based, supervised, or mixed exercise interventions on the functional capacity (FC) and quality of life (QoL) in colorectal cancer patients. A literature search was performed using the PubMed, Embase, Cochrane, and Medline databases. Two reviewers screened the literature through March 10, 2021 for studies related to exercise and colorectal cancer. Of the 1161 screened studies in the initial search, 13 studies met the eligibility criteria (home-based = 6 studies; supervised or mixed = 7 studies). Overall, 706 patients were enrolled in the trials, and 372 patients were submitted to home-based, supervised, or mixed exercise intervention. The overall results from the main meta-analysis showed a significant effect regarding supervised or mixed intervention (6 studies; p = 0.002; I
2
= 43%; PI 0.41–1.39); however, no significant effect was observed for home-based intervention (5 studies; p = 0.05; I
2
= 25%; PI − 0.34–0.76). A sensitivity analysis based on studies with intervention adherence ≥ 80% (home-based = 3 studies; supervised or mixed = 4 studies) revealed that home-based intervention or intervention entirely supervised or with some level of supervision (mixed) are effective in improving the QoL and FC of CRC patients. In summary, this meta-analysis verified that supervised and home-based exercise can modify QoL and FC when intervention adherence ≥ 80%. Regardless of the supervision characteristics, future RCTs are strongly encouraged to provide a detailed description of the exercise variables in physical interventions for CRC prescription. This perspective will allow a refined exercise prescription for patients with CRC, mainly according to their clinical status.
Journal Article
Superman : the unity saga. Vol. 1, Phantom Earth
\"The fallout from the Man of Steel graphic novel has Clark looking at the world through new eyes--with new ideas about what Superman could and should do for the city of Metropolis and the planet Earth. His first job? Getting the planet back out of the Phantom Zone\"-- Provided by publisher.
Book
Discovery of Protein Phosphatase Inhibitor Classes by Biology-Oriented Synthesis
Protein phosphatases have very recently emerged as important targets for chemical biology and medicinal chemistry research, and new phosphatase inhibitor classes are in high demand. The underlying frameworks of natural products represent the evolutionarily selected fractions of chemical space explored by nature so far and meet the criteria of relevance to nature and biological prevalidation most crucial to inhibitor development. We refer to synthesis efforts and compound collection development based on these criteria as biology-oriented synthesis. For the discovery of phosphatase inhibitor classes by means of this approach, four natural product-derived or -inspired medium-sized compound collections were synthesized and investigated for inhibition of the tyrosine phosphatases VE-PTP, Shp-2, PTP1B, MptpA, and MptpB and the dual-specificity phosphatases Cdc25A and VHR. The screen yielded four unprecedented and selective phosphatase inhibitor classes for four phosphatases with high hit rates. For VE-PTP and MptpB the first inhibitors were discovered. These results demonstrate that biology-oriented synthesis is an efficient approach to the discovery of new compound classes for medicinal chemistry and chemical biology research that opens up new opportunities for the study of phosphatases, which may lead to the development of new drug candidates.
Journal Article
Aquaman by Geoff Johns omnibus
\"Arthur Curry is a man of two worlds. Six years ago he was a surface dweller, raised as the son of a lighthouse keeper. Then tragedy struck. Destiny was revealed. And young Arthur Curry claimed his birthright: the Throne of Atlantis. But his reign was brief. When darkness threatened the surface world, he rose to meet it. As Aquaman, he joined the team of heroes called the Justice League, leaving the rule of his kingdom behind. But even underwater, the past will not stay buried. A sinister force is pushing Aquaman's two worlds to the brink of war, with the fate of the planet in the balance. If Arthur does not reclaim his throne, the throne may well claim his life.\"-- Provided by publisher.
Book
Acute Effects of Different Melatonin Doses on Performance and Psychophysiological Responses During Exhaustive Cycling Exercise: A Double-Blind Crossover Study
Background/Objectives: This study examined the acute effects of different doses of melatonin on performance, physiological, and psychophysiological responses during individualized exhaustive cycling exercise. Methods: Fifteen physically active but cycling-inexperienced men (18–35 years) completed a double-blind, randomized, placebo-controlled, crossover protocol. Following an incremental test to determine the anaerobic threshold (AnT), participants performed four exhaustive exercise sessions at 80% of AnT after ingesting placebo or melatonin (5, 12.5, or 20 mg), administered approximately 30 min before exercise. Time to exhaustion (TLim) was considered the primary performance outcome. Heart rate, peripheral oxygen saturation, blood lactate concentration, blood glucose, and ratings of perceived exertion were assessed before, during, and after exercise. Results: No significant differences were observed between experimental conditions for TLim or for any physiological or psychophysiological variable. Only main effects of time were detected, reflecting expected exercise-induced responses, with small effect sizes and no evidence of a dose–response relationship across melatonin conditions. Baseline values were comparable among sessions. These findings indicate that acute melatonin administration at doses ranging from 5 to 20 mg does not elicit ergogenic effects nor modulate physiological or psychophysiological responses during prolonged individualized cycling exercise in healthy individuals. Conclusions: In male, healthy, physically active individuals inexperienced in cycling, acute melatonin administration at the doses tested did not produce ergogenic effects or alter physiological and psychophysiological responses during prolonged, individualized cycling exercise.
Journal Article
Justice League : the Darkseid War
\"Collected in its entirety, Justice League: The Darkseid War features the epic battle between the Justice League, Darkseid and the Anti-Monitor in this all-new Essential Edition! The Justice League came together to stop the forces of Darkseid from destroying Earth five years ago. Now the ruler of Apokolips returns, but sets his sights on the world-shattering Anti-Monitor. Will the combined might of the Justice League be enough to protect the Earth from the collateral damage as Gods fight? The New York Times best-selling series from Geoff Johns comes to its explosive conclusion here in this massive hardcover!\"-- Provided by publisher.
Book
Exploring New Ways to Analyze Data on the Spontaneous Physical Activity of Rodents Through a Weighing Balance
Background: Weight-based methods can be cost-effective and practical for measuring spontaneous physical activity (SPA) in laboratory animals, but their adoption and exploration of analyses remain limited. Methods: We demonstrate the construction of a balance using accessible components (iron plates and open-source Arduino® electronics) and provide detailed instructions to enable others to build their own systems. Additionally, we propose new analytical strategies, such as using the Mean of Weight Changes (MWC), assessing the dispersion of weight changes, and classifying SPA into domains, to enhance data interpretation. Results: The construction of the weighing balance using accessible components proved to be feasible, and the balance demonstrated sensitivity in distinguishing high SPA under experimental conditions known to modulate it (dark/light phases and small vs. large cages). Regarding the analyses, we were able to confirm that MWC analysis is a valid measure of SPA. Furthermore, the coefficient of variation in weight changes could be used as a complementary analysis to MWC. The proposed SPA domains also proved to be valid, as they aligned with the understanding that rodents spend a greater proportion of time in the higher SPA domains during the dark phase, while lower SPA domains predominate during the light phase. Conclusions: Our findings reinforce the robustness and validity of our weighing balance, designed using a low-cost setup based on iron plates and open-source Arduino® electronics.
Journal Article
Panic in the microverse
\"Batman, Killer Frost and Lobo join Ryan Choi, the JLA's Atom, on a size-shifting mission to find Choi's missing mentor, Ray Palmer. The previous Atom vanished while exploring his greatest discovery--the Microverse. Far, far smaller than modern science has explored before, the Microverse makes up the foundation on which the atoms of our world are built. Though tiny, the Microverse is vast, dangerous and almost completely unexplored. The League must navigate a bizarre and dangerous subatomic world of warring factions, deadly threats and hidden agendas, all leading to the Ignition Point. This fracture in the fabric of the Microverse, if left unchecked, could spread to destroy all reality! Meanwhile, back on Earth, Vixen, Black Canary and the Ray continue their long battle against the Might Beyond the Mirror, as well as the mysterious villain Afterthought!\"-- Provided by publisher.
Book
Hilab system, a new point-of-care hematology analyzer supported by the Internet of Things and Artificial Intelligence
The complete blood count (CBC) is one of the most requested tests by physicians. CBC tests, most realized in conventional hematological analyzers, are restricted to centralized laboratories due to frequent maintenance, large devices, and expensive costs required. On the other hand, most handheld CBC devices commercially available show high prices and are not liable to calibration or control procedures, which results in poor quality compared to standard hematology instruments. The Hilab system is a small-handed hematological platform that uses microscopy and chromatography techniques for blood cells and hematimetric parameters analysis through artificial intelligence, machine learning, and deep learning techniques. For clinical evaluation of the handheld CBC device, 450 blood samples were analyzed. The samples encompassed normal (82%) and pathological conditions (18%), such as thalassemias (2.2%), anemias (6.6%), and infections (9.2%). For all analytes, accuracy, precision, method comparison, and flagging capabilities of the Hilab System, were compared with the Sysmex XE-2100 (Sysmex, Japan) results. The sample source (venous and capillary) influences were also evaluated. Pearson correlation, Student
t
test, bias, and the Bland–Altman plot of each blood count analyte were calculated and shown. The significance level was set at p ≤ 0.05. For clinical evaluation, Hilab System and the Sysmex XE-2100 showed a strong correlation (r ≥ 0.9) for most evaluated parameters. In the precision study, analytes showed CV inside the limits established according to European Federation of Clinical Chemistry and Laboratory Medicine guidelines. The flagging capabilities of the Hilab system, compared to the manual microscopy technique, presented high sensibility, specificity, and accuracy. Venous and capillary samples (p > 0.05) do not differ statistically. Considering the need for point-of-care CBCs, the study indicated that the Hilab system provides fast, accurate, low cost, and robust analysis for reliable clinical use.
Journal Article