Explore the vast range of titles available.

During the last decades satellite remote sensing has become an emerging technology producing big data for various application fields every day. However, data quality checking as well as the long-time management of data and models are still issues to be improved. They are indispensable to guarantee smooth data integration and the reproducibility of data analysis such as carried out by machine learning models. In this paper we clarify the emerging need of improving data quality and the management of data and models in a geospatial database management system before and during data analysis. In different use cases various processes of data preparation and quality checking, integration of data across different scales and references systems, efficient data and model management, and advanced data analysis are presented in detail. Motivated by these use cases we then discuss emerging research questions concerning data preparation and data quality checking, data management, model management and data integration. Finally conclusions drawn from the paper are presented and an outlook on future research work is given.

Recessive dystrophic epidermolysis bullosa (RDEB) is a lifelong genodermatosis associated with blistering, wounding, and scarring caused by mutations in COL7A1 , the gene encoding the anchoring fibril component, collagen VII (C7). Here, we evaluated beremagene geperpavec (B-VEC), an engineered, non-replicating COL7A1 containing herpes simplex virus type 1 (HSV-1) vector, to treat RDEB skin. B-VEC restored C7 expression in RDEB keratinocytes, fibroblasts, RDEB mice and human RDEB xenografts. Subsequently, a randomized, placebo-controlled, phase 1 and 2 clinical trial (NCT03536143) evaluated matched wounds from nine RDEB patients receiving topical B-VEC or placebo repeatedly over 12 weeks. No grade 2 or above B-VEC-related adverse events or vector shedding or tissue-bound skin immunoreactants were noted. HSV-1 and C7 antibodies sometimes presented at baseline or increased after B-VEC treatment without an apparent impact on safety or efficacy. Primary and secondary objectives of C7 expression, anchoring fibril assembly, wound surface area reduction, duration of wound closure, and time to wound closure following B-VEC treatment were met. A patient-reported pain–severity secondary outcome was not assessed given the small proportion of wounds treated. A global assessment secondary endpoint was not pursued due to redundancy with regard to other endpoints. These studies show that B-VEC is an easily administered, safely tolerated, topical molecular corrective therapy promoting wound healing in patients with RDEB. Preclinical data and results from a phase 1 and 2 trial demonstrate preliminary safety and efficacy of topical gene therapy for recessive dystrophic epidermolysis bullosa

The 100 years since the publication of Albert Einstein’s theory of general relativity saw significant development of the understanding of the theory, the identification of potential astrophysical sources of sufficiently strong gravitational waves and development of key technologies for gravitational-wave detectors. In 2015, the first gravitational-wave signals were detected by the two US Advanced LIGO instruments. In 2017, Advanced LIGO and the European Advanced Virgo detectors pinpointed a binary neutron star coalescence that was also seen across the electromagnetic spectrum. The field of gravitational-wave astronomy is just starting, and this Roadmap of future developments surveys the potential for growth in bandwidth and sensitivity of future gravitational-wave detectors, and discusses the science results anticipated to come from upcoming instruments.In the past few years, gravitational-wave observations provided stunning insights into some of the most cataclysmic events in the Universe, heralding a bright future for gravitational-wave physics and astronomy. This is a Roadmap for the field in the coming two decades.

Purpose Pain and anxiety-inducing interventions have a major impact on pediatric patients. Pain reduction by virtual reality (VR) during port and vein punctures is well studied. This study investigates peri-interventional reduction of pain, anxiety and distress using VR compared to the standard of care (SOC) in a pediatric oncology outpatient clinic. Methods In a randomized, controlled cross-over design, patients aged 6–18 years experience potentially painful interventions accompanied by VR. Observational instruments include NRS, FPS-r, BAADS, mYPAS-SF, PedsQL and SSKJ3-8R. All patients undergo two observations: SOC (A) and VR (B) in a randomized order. In addition, parents and staff are interviewed. Specific conditions for VR in an outpatient clinic setting derived from interprofessional focus group discussion are being explored. Results Between July 2021 and December 2022 57 eligible patients were included and randomized to the orders A/B ( n  = 28) and B/A ( n  = 29). Thirty-eight patients completed both observations. Characteristics in both groups did not differ significantly. More than half of the patients had no previous experience with VR, 5% decided to discontinue VR prematurely. Peri-interventional pain, anxiety and distress were significantly reduced by VR compared with SOC. 71% of patients and 76% of parents perceived punctures with VR to be more relaxed than previous ones. 95% of patients perceived fun with VR goggles. Detailed questionnaires on individual stress and anxiety were returned from 26 of 38 patients. Focus group discussion with staff yielded evidence for successful implementation of VR in an outpatient clinic. Conclusions The present study shows that VR can be used for peri-interventional reduction of pain, anxiety, and distress in the special environment of a pediatric outpatient clinic. Specific conditions must be met for successful implementation. Further studies are needed to identify particularly susceptible patients and to illuminate alternatives for distraction that are feasible to implement with limited resources. Trial registration number (ClinicalTrials.gov ID): NCT06235723; 01/02/2024; retrospectively registered. This study adheres to the standard checklist of CONSORT guidelines. Key messages What is known • Interventions in pediatrics cause anxiety, distress and pain. • Pain-reducing methods require specific conditions in the context of an outpatient clinic. • Virtual reality has the potential to reduce anxiety and pain in addition to other methods. What is new • VR enjoys great popularity among pediatric oncology patients, parents, and staff. • Self- and peer-assessment tools for pain, anxiety, and stress can be used for intra- and inter-individual comparison. • For the implementation of VR to succeed in an outpatient clinic, specific conditions need to be taken into account. • Questionnaires could be used to identify particularly susceptible patients in advance.

Launched onboard the BepiColombo Mercury Planetary Orbiter (MPO) in October 2018, the Mercury Radiometer and Thermal Infrared Spectrometer (MERTIS) is on its way to planet Mercury. MERTIS consists of a push-broom IR-spectrometer (TIS) and a radiometer (TIR), which operate in the wavelength regions of 7-14 μm and 7-40 μm, respectively. This wavelength region is characterized by several diagnostic spectral signatures: the Christiansen feature (CF), Reststrahlen bands (RB), and the Transparency feature (TF), which will allow us to identify and map rock-forming silicates, sulfides as well as other minerals. Thus, the instrument is particularly well-suited to study the mineralogy and composition of the hermean surface at a spatial resolution of about 500 m globally and better than 500 m for approximately 5-10% of the surface. The instrument is fully functional onboard the BepiColombo spacecraft and exceeds all requirements (e.g., mass, power, performance). To prepare for the science phase at Mercury, the team developed an innovative operations plan to maximize the scientific output while at the same time saving spacecraft resources (e.g., data downlink). The upcoming fly-bys will be excellent opportunities to further test and adapt our software and operational procedures. In summary, the team is undertaking action at multiple levels, including performing a comprehensive suite of spectroscopic measurements in our laboratories on relevant analog materials, performing extensive spectral modeling, examining space weathering effects, and modeling the thermal behavior of the hermean surface.

In this trial, administering aspirin before surgery and during the early postsurgical period did not affect the rate of death or nonfatal MI but increased the risk of major bleeding. This was true in patients who had not been taking aspirin and in those on a long-term aspirin regimen. Myocardial infarction is the most common major vascular complication that occurs after noncardiac surgery. 1 – 3 Noncardiac surgery is associated with platelet activation, 4 and coronary-artery thrombus may be a mechanism of perioperative myocardial infarction. 5 , 6 Aspirin inhibits platelet aggregation, 7 and the perioperative administration of aspirin may prevent major vascular complications by inhibiting thrombus formation. 8 In a meta-analysis of data from large, randomized trials involving more than 110,000 patients who were not undergoing surgery, the use of aspirin was shown to prevent myocardial infarction and major vascular events. 9 High-dose aspirin has not been shown to be superior to low-dose aspirin in preventing . . .

We review the first direct detection of gravitational waves in the first observing run of the newly installed Advanced LIGO gravitational-wave detectors. This opens a new window on the universe, using an entirely new phenomena as the messenger to explore the cosmos. We also describe prospects for the future exploration of this new frontier.

The Amaldi 10 Parallel Session C3 on Advanced Gravitational Wave detectors gave an overview of the status and several specific challenges and solutions relevant to the instruments planned for a mid-decade start of observation. Invited overview talks for the Virgo, LIGO, and KAGRA instruments were complemented by more detailed discussions in presentations and posters of some instrument features and designs.

We report on the design and performance of small optic suspensions developed to suppress seismic motion of out-of-cavity optics in the Input Optics subsystem of the Advanced LIGO interferometric gravitational wave detector. These compact single stage suspensions provide isolation in all six degrees of freedom of the optic, local sensing and actuation in three of them, and passive damping for the other three.