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The production and analysis of distributed sources of 24Na and 222Rn in the Sudbury Neutrino Observatory (SNO) are described. These unique sources provided accurate calibrations of the response to neutrons, produced through photodisintegration of the deuterons in the heavy water target, and to low energy betas and gammas. The application of these sources in determining the neutron detection efficiency and response of the 3He proportional counter array, and the characteristics of background Cherenkov light from trace amounts of natural radioactivity is described.

Gamow-Teller transitions from 24Mg to 24Na were studied via the (t,3He) reaction at 115 AMeV using a secondary triton beam produced via fast fragmentation of 150 AMeV 16O ions. Compared to previous (t,3He) experiments at this energy that employed a primary alpha beam, the secondary beam intensity is improved by about a factor of five. Despite the large emittance of the secondary beam, an excitation-energy resolution of ~200 keV is achieved. A good correspondence is found between the extracted Gamow-Teller strength distribution and those available from other charge-exchange probes. Theoretical calculations using the newly developed USDA and USDB sd-shell model interactions reproduce the data well.

Hints for sizable \\(^2 _13\\) have been reported in earlier global neutrino oscillation data analyses as well as will be reported in this work, and quite recently by the Double Chooz experiment. However, as we enter the era of precision neutrino oscillation experiments, terms linear in \\(_13\\) will no longer be negligible, and its sign would affect the extraction of other oscillation parameters. The sign of \\(_13\\) also plays a crucial role in the determination of the CP-violating phase. In this work we show that by adopting an alternative parametrization for the Pontecorvo-Maki-Nakagawa-Sakata (PMNS) mixing matrix, one already has a chance to infer the sign of each mixing angle in the conventional parametrization using existing global neutrino data. A weak preference for negative \\( _13\\) is found. In particular, the solar data suggest that \\(_13 > 0\\) while all other data the opposite. This leads to the speculation on whether the Mikheyev-Smirnov-Wolfenstein (MSW) effect is responsible. In this work we found that in the new mixing matrix parametrization, the 68% CL constraints on the three mixing angles are comparable to those estimated in the conventional parametrization adopted in the literature. Owing to the strong correlations among the three mixing angles in the new parametrization, the advantages of doing the global neutrino oscillation analysis using data from past, current, and near future neutrino oscillation experiments shall become manifest.

The Long Baseline Neutrino Facility (LBNF) project will build a beamline located at Fermilab to create and aim an intense neutrino beam of appropriate energy range toward the DUNE detectors at the SURF facility in Lead, South Dakota. Neutrino production starts in the Target Station, which consists of a solid target, magnetic focusing horns, and the associated sub-systems and shielding infrastructure. Protons hit the target producing mesons which are then focused by the horns into a helium-filled decay pipe where they decay into muons and neutrinos. The target and horns are encased in actively cooled steel and concrete shielding in a chamber called the target chase. The reference design chase is filled with air, but nitrogen and helium are being evaluated as alternatives. A replaceable beam window separates the decay pipe from the target chase. The facility is designed for initial operation at 1.2 MW, with the ability to upgrade to 2.4 MW, and is taking advantage of the experience gained by operating Fermilab's NuMI facility. We discuss here the design status, associated challenges, and ongoing R&D and physics-driven component optimization of the Target Station.

The Long Baseline Neutrino Facility (LBNF) will utilize a beamline located at Fermilab to provide and aim a neutrino beam of sufficient intensity and appropriate energy range toward the Deep Underground Neutrino Experiment (DUNE) detectors, placed deep underground at the SURF Facility in Lead, South Dakota. The primary proton beam (60-120 GeV) will be extracted from the MI-10 section of Fermilab's Main Injector. Neutrinos will be produced when the protons interact with a solid target to produce mesons which will be subsequently focused by magnetic horns into a 194m long decay pipe where they decay into muons and neutrinos. The parameters of the facility were determined taking into account the physics goals, spatial and radiological constraints, and the experience gained by operating the NuMI facility at Fermilab. The Beamline facility is designed for initial operation at a proton-beam power of 1.2 MW, with the capability to support an upgrade to 2.4 MW. LBNF/DUNE obtained CD-1 approval in November 2015. We discuss here the design status and the associated challenges as well as the R&D and plans for improvements before baselining the facility.

Lead perchlorate, part of the OMNIS supernova neutrino detector, contains two nuclei, 208Pb and 35Cl, that might be used to study nucleon decay. Both would produce signatures that will make them especially useful for studying less-well-studied neutron decay modes, e.g., those in which only neutrinos are emitted.

The forward--backward asymmetry in n p --> d pi^0, which must be zero in the center-of-mass system if charge symmetry is respected, has been measured to be [17.2 +/- 8 (stat) +/- 5.5 (sys)] * 10^-4, at an incident neutron energy of 279.5 MeV. This charge symmetry breaking observable was extracted by fitting the data with GEANT-based simulations and is compared to recent chiral effective field theory calculations, with implications regarding the value of the u d quark mass difference.

An array of Neutral-Current Detectors (NCDs) has been built in order to make a unique measurement of the total active flux of solar neutrinos in the Sudbury Neutrino Observatory (SNO). Data in the third phase of the SNO experiment were collected between November 2004 and November 2006, after the NCD array was added to improve the neutral-current sensitivity of the SNO detector. This array consisted of 36 strings of proportional counters filled with a mixture of \\(^3\\)He and CF\\(_4\\) gas capable of detecting the neutrons liberated by the neutrino-deuteron neutral current reaction in the D\\(_2\\)O, and four strings filled with a mixture of \\(^4\\)He and CF\\(_4\\) gas for background measurements. The proportional counter diameter is 5 cm. The total deployed array length was 398 m. The SNO NCD array is the lowest-radioactivity large array of proportional counters ever produced. This article describes the design, construction, deployment, and characterization of the NCD array, discusses the electronics and data acquisition system, and considers event signatures and backgrounds.

Exercise has a wide range of systemic effects. In animal models, repeated exertion reduces malignant tumor progression, and clinically, exercise can improve outcome for cancer patients. The etiology of the effects of exercise on tumor progression are unclear, as are the cellular actors involved. We show here that in mice, exercise-induced reduction in tumor growth is dependent on CD8+ T cells, and that metabolites produced in skeletal muscle and excreted into plasma at high levels during exertion in both mice and humans enhance the effector profile of CD8+ T-cells. We found that activated murine CD8+ T cells alter their central carbon metabolism in response to exertion in vivo, and that immune cells from trained mice are more potent antitumor effector cells when transferred into tumor-bearing untrained animals. These data demonstrate that CD8+ T cells are metabolically altered by exercise in a manner that acts to improve their antitumoral efficacy. Exercise affects almost all tissues in the body, and scientists have found that being physically active can reduce the risk of several types of cancer as well as improving outcomes for cancer patients. However, it is still unknown how exercise exerts its protective effects. One of the hallmarks of cancer is the ability of cancer cells to evade detection by the immune system, which can in some cases stop the body from eliminating tumor cells. Rundqvist et al. used mice to investigate how exercise helps the immune system act against tumor progression. They found that when mice exercised, tumor growth was reduced, and this decrease in growth depended on the levels of a specific type of immune cell, the CD8+ T cell, circulating in the blood. Additionally, Rundqvist et al. found that CD8+ T cells were made more effective by molecules that muscles released into the blood during exercise. Isolating immune cells after intense exercise showed that these super-effective CD8+ T cells alter how they use molecules for energy production after exertion. Next, immune cells from mice that had exercised frequently were transferred into mice that had not exercised, where they were more effective against tumor cells than the immune cells from untrained mice. These results demonstrate that CD8+ T cells are altered by exercise to improve their effectiveness against tumors. The ability of T cells to identify and eliminate cancer cells is essential to avoid tumor growth, and is one of the foundations of current immune therapy treatments. Exercise could improve the outcome of these treatments by increasing the activation of the immune system, making tumor-fighting cells more effective.

Deep venous thrombosis (DVT) and poor long-term patient outcomes frequently occur in patients with Achilles tendon rupture (ATR). Biomarkers for DVT and their possible relationship to long-term healing outcomes remain unexplored. To identify DVT biomarkers from proteomic profiles during the inflammatory and proliferative healing stages and assess their associations with one-year healing outcomes after surgical repair of ATR. A cohort of 53 patients undergoing standardized ATR repair from previous clinical trials was investigated. Intraoperative inflammatory-stage tendon biopsies were obtained from 40 patients, and tendon microdialysates from 28 patients were collected two weeks later during the proliferative stage. Liquid chromatography-tandem mass spectrometry proteomic profiles were linked to DVT status at two weeks post-surgery using ultrasonography screening and to patient-reported outcomes at one-year post-surgery. Six candidate DVT biomarkers were identified from tendon biopsies, whereof four (ABI3BP, IGKV2-40/IGKV2D-40, PCYOX1, STIP1) were associated with one-year healing outcomes. In tendon microdialysates, 43 candidate DVT biomarkers were identified, but none were associated with healing outcomes. Bioinformatic analysis revealed pathways related to heat shock response, platelet signaling, collagen and extracellular matrix metabolism, and immunoglobulins. The results support shared inflammatory-stage protein pathways in regulating venous thrombosis and reported healing outcomes, where elements of individual hypoxic tolerance and platelet signaling emerge as potential key links.