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Against the backdrop of environmental challenges and resource constraints, deepening mixed ownership reform and promoting green development of enterprises have become a significant trend, and the resource and governance effects arising from the state-owned (SOE) equity participation in private enterprises (PEs) have become a prominent research topic. The article empirically examines the influence of state-owned equity involvement on the green transformation of private firms using a two-way fixed effects model, utilizing a sample of Shanghai and Shenzhen A-share listed private enterprises from 2013 to 2022. The results indicate that SOE equity participation considerably speeds up the green transformation process of PEs, and the conclusion remains consistent following several robustness tests. Through the two channels of financing efficiency and environmental information disclosure, SOE equity participation encourages the green transformation of PEs; management compensation incentives have a positive moderating effect on SOE equity participation and the green transformation of PEs. According to heterogeneity analyses, SOE ownership has a stronger motivating effect on PEs' green transformation for large-scale, high-tech, and eastern area firms. The findings enrich the inquiry into the economic effects of reverse mixed reform and establish practical methods and theoretical foundations for private enterprises to promote green transformation.

In this study, we describe and illustrate a new species of the genus Laena Dejean, 1821, Laena costata sp. nov. , which was collected in Micangshan Nature Reserve of Sichuan Province, China. Additionally, the COI mitochondrial gene was sequenced to provide additional evidence for this new species’ validity. The results of phylogenetic analyses suggest that this new species is sister to L. maowenica Schawaller, 2008. Furthermore, an updated key to Laena species from Sichuan Province is provided.

Breast cancer remains one of the leading causes of cancer-related mortality among women worldwide. Although the mTOR inhibitor rapamycin exhibits notable anti-tumor activity, its clinical application is limited by metabolic side effects, particularly dyslipidemia. This study aimed to investigate the potential of Ilex latifolia (I. latifolia, large-leaf kudingcha), a traditional Chinese tea known for its lipid-lowering properties, to enhance the therapeutic efficacy of rapamycin in breast cancer. The combined effects of I. latifolia and low-dose rapamycin on tumor cell proliferation, cell cycle progression, apoptosis, and inflammation were assessed in four breast cancer cell lines and a murine breast cancer model. While low-dose I. latifolia alone exhibited limited anti-tumor activity, its combination with low-dose rapamycin synergistically inhibited tumor proliferation, induced cell cycle arrest, promoted apoptosis, and reduced inflammation in vitro. In vivo, dietary supplementation with I. latifolia mitigated rapamycin-induced lipid disturbances, reduced tumor growth, enhanced apoptosis, and alleviated inflammation in tumor tissues. These findings highlight I. latifolia as a promising dietary adjunct to rapamycin, providing a safer and more effective combinatorial strategy for breast cancer treatment.

Allergic asthma is a significant global health issue characterized by chronic airway inflammation. Current treatments only alleviate symptoms but fail to cure the disease due to its complex pathology. Lipid mediators from arachidonate metabolism are pivotal in immune regulation in asthma. Previously, coactosin‐like protein (CLP) is identified as a regulator of leukotriene production in vitro. However, its role in asthma is unclear. In this study, it is found that CLP‐deficient (Cotl1−/−) mice challenged with house dust mite (HDM) exhibits exacerbated airway inflammation, macrophage polarization, and type 2 immune responses. CLP deficiency increased prostaglandin D2 (PGD2) in bronchoalveolar lavage (BAL) and alveolar macrophages (AMs), activating the PGD2 receptor chemoattractant receptor‐homologous molecule expressed on Th2 cells (CRTH2) on immune cells. Notably, HDM exposure reduced pulmonary CLP levels in wild‐type (WT) mice, and overexpression of CLP in Cotl1−/− macrophages decreased HDM‐induced PGD2 in BAL and alleviated inflammation. Cotl1−/− AMs exacerbated HDM‐induced airway inflammation compared to WT AMs, and this effect is dependent on CRTH2 signaling. These findings reveal that CLP modulates macrophage polarization and suppresses the PGD2‐CRTH2 pathway to alleviate airway inflammation, highlighting CLP as a promising therapeutic target for asthma. Coactosin‐like protein inhibits prostaglandin D₂ (PGD2) secretion by modulating alveolar macrophage polarization, thereby suppressing activation of the PGD2 receptor CRTH2 in Th2‐associated immune cells and alleviating allergic airway inflammation.

Purpose: To evaluate the treatment solutions and effectiveness of intravitreal ranibizumab (RBZ) or conbercept in patients with wet age-related macular degeneration (wAMD) in a real-life setting in China. Methods: The medical records of 368 patients with wAMD who started RBZ or conbercept treatment between 1 May 2014 and 30 April 2018 were evaluated. All patients were defined on fundus angiography at baseline to determine the subtype of AMD (PCV or CNV). We report visual acuity (VA) and central retinal thickness (CRT) measurements at baseline and 12 months. Results: The average number of anti-VEGF injections was 2.1 ± 1.2. The BCVA improvement of these two groups was similar with a difference of 1.00 letter (95% CI: −1.4~3.4, p = 0.8505). At the end of the study, a BCVA increase of at least 5 letters was determined to be a satisfactory efficacy endpoint. Several factors were related to the possible improvement in the satisfactory efficacy endpoint, including female sex (OR 2.07, 95% CI 1.22~3.51), number of injections (OR 1.40, 95% CI 1.12~1.75) and VA change at the first month (OR 13.75, 95% CI 7.41~25.51). Additionally, some factors were related to the possible reduction in the satisfactory efficacy endpoint, including diabetes (OR 0.27, 95% CI 0.10~0.73) and disease history (OR 0.75, 95% CI 0.57~0.98). Conclusion: Our study demonstrates that anti-VEGF drugs can effectively improve BCVA and reduce CRT in AMD patients. Sex, number of injections, VA change at the first month, diabetes and disease history are the most important factors affecting visual acuity.

Allergic asthma is a significant global health issue characterized by chronic airway inflammation. Current treatments only alleviate symptoms but fail to cure the disease due to its complex pathology. Lipid mediators from arachidonate metabolism are pivotal in immune regulation in asthma. Previously, coactosin‐like protein (CLP) is identified as a regulator of leukotriene production in vitro. However, its role in asthma is unclear. In this study, it is found that CLP‐deficient ( Cotl1 −/− ) mice challenged with house dust mite (HDM) exhibits exacerbated airway inflammation, macrophage polarization, and type 2 immune responses. CLP deficiency increased prostaglandin D 2 (PGD 2 ) in bronchoalveolar lavage (BAL) and alveolar macrophages (AMs), activating the PGD 2 receptor chemoattractant receptor‐homologous molecule expressed on Th2 cells (CRTH2) on immune cells. Notably, HDM exposure reduced pulmonary CLP levels in wild‐type (WT) mice, and overexpression of CLP in Cotl1 −/− macrophages decreased HDM‐induced PGD 2 in BAL and alleviated inflammation. Cotl1 −/− AMs exacerbated HDM‐induced airway inflammation compared to WT AMs, and this effect is dependent on CRTH2 signaling. These findings reveal that CLP modulates macrophage polarization and suppresses the PGD 2 ‐CRTH2 pathway to alleviate airway inflammation, highlighting CLP as a promising therapeutic target for asthma.