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We briefly review general concepts of renormalization in quantum field theory and discuss their application to solutions of integral equations with singular potentials in the few-nucleon sector of the low-energy effective field theory of QCD. We also describe a particular subtractive renormalization scheme and consider a specific application to a toy-model with a singular potential serving as its effective field theoretical leading-order approximation.

Our understanding of when and how humans adapted to living on the Tibetan Plateau at altitudes above 2000 to 3000 meters has been constrained by a paucity of archaeological data. Here we report data sets from the northeastern Tibetan Plateau indicating that the first villages were established only by 5200 calendar years before the present (cal yr B.P.). Using these data, we tested the hypothesis that a novel agropastoral economy facilitated year-round living at higher altitudes since 3600 cal yr B.P. This successful subsistence strategy facilitated the adaptation of farmers-herders to the challenges of global temperature decline during the late Holocene.

Integral equations for meson–baryon scattering amplitudes are obtained by utilizing time-ordered perturbation theory for a manifestly Lorentz-invariant formulation of baryon chiral perturbation theory. Effective potentials are defined as sums of two-particle irreducible contributions of time-ordered diagrams and the scattering amplitudes are obtained as solutions of integral equations. Ultraviolet renormalizability is achieved by solving integral equations for the leading order amplitude and including higher order corrections perturbatively. As an application of the developed formalism, pion-nucleon scattering is considered.

A rechargeable lithium anode requires a porous structure for a high capacity, and a stable electrode/electrolyte interface against dendrite formation and polysulfide crossover when used in a lithium-sulfur battery. Here, we design two simple steps of spontaneous reactions for protecting porous lithium electrodes. First, a reaction between molten lithium and sulfur-impregnated carbon nanofiber forms a fibrous network with a lithium shell and a carbon core. Second, we coat the surface of this porous lithium electrode with a composite of lithium bismuth alloys and lithium fluoride through another spontaneous reaction between lithium and bismuth trifluoride, solvated with phosphorous pentasulfide, which also polymerizes with lithium sulfide residual in the electrode to form a solid electrolyte layer. This protected porous lithium electrode enables stable operation of a lithium-sulfur battery with a sulfur loading of 10.2 mg cm −2 at 6.0 mA cm −2 for 200 cycles. Stabilizing lithium anodes has been a crucial yet challenging task in developing high-energy batteries. Here the authors design two simple steps of spontaneous reactions to achieve a porous lithium electrode with a composite protective layer, enabling high-loading Li-S batteries with excellent cyclability.

We study the ground-state octet baryon masses and sigma terms using the covariant baryon chiral perturbation theory (ChPT) with the extended-on-mass-shell (EOMS) renormalization scheme up to next-to-next-to-next-to-leading order (N 3 LO). By adjusting the available 19 low-energy constants (LECs), a reasonable fit of the n f  = 2+1 lattice quantum chromodynamics (LQCD) results from the PACS-CS, LHPC, HSC, QCDSF-UKQCD and NPLQCD collaborations is achieved. Finite-volume corrections to the lattice data are calculated self-consistently. Our study shows that the N 3 LO BChPT describes better the light quark mass evolution of the lattice data than the NNLO BChPT does and the various lattice simulations seem to be consistent with each other. We also predict the pion and strangeness sigma terms of the octet baryons using the LECs determined in the fit of their masses. The predicted pion- and strangeness-nucleon sigma terms are σ π N  = 43(1)(6) MeV and σ sN  = 126(24)(54) MeV, respectively.

Both fast and slow earthquakes are preceded by micro-failure events that radiate energy. According to machine learning, these events can foretell catastrophic failure in laboratory experiment earthquakes.

p40, a Lactobacillus rhamnosus GG (LGG)-derived protein, transactivates epidermal growth factor receptor (EGFR) in intestinal epithelial cells, leading to amelioration of intestinal injury and inflammation. To elucidate mechanisms by which p40 regulates mucosal immunity to prevent inflammation, this study aimed to determine the effects and mechanisms of p40 on regulation of a proliferation-inducing ligand (APRIL) expression in intestinal epithelial cells for promoting immunoglobulin A (IgA) production. p40 upregulated April gene expression and protein production in mouse small intestine epithelial (MSIE) cells, which were inhibited by blocking EGFR expression and kinase activity. Enteroids from Egfrfl/fl, but not Egfrfl/fl-Vil-Cre mice with EGFR specifically deleted in intestinal epithelial cells, exhibited increased April gene expression by p40 treatment. p40-conditioned media from MSIE cells increased B-cell class switching to IgA+ cells and IgA production, which was suppressed by APRIL receptor–neutralizing antibodies. Treatment of B cells with p40 did not show any effects on IgA production. p40 treatment increased April gene expression and protein production in small intestinal epithelial cells, fecal IgA levels, IgA+B220+, IgA+CD19+, and IgA+ plasma cells in lamina propria of Egfrfl/fl, but not of Egfrfl/fl-Vil-Cre, mice. Thus p40 upregulates EGFR-dependent APRIL production in intestinal epithelial cells, which may contribute to promoting IgA production.

Since the coronavirus disease 2019 (COVID-19) pandemic, the value of mRNA vaccine has been widely recognized worldwide. Messenger RNA (mRNA) therapy platform provides a promising alternative to DNA delivery in non-viral gene therapy. Lipid nanoparticles (LNPs), as effective mRNA delivery carriers, have been highly valued by the pharmaceutical industry, and many LNPs have entered clinical trials. We developed an ideal lipid nanoformulation, named LNP3, composed of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) and cholesterol, and observed its release efficiency, sustained release, organ specific targeting and thermal stability. In vitro studies showed that the transfection efficiency of LNP3 was higher than that of LNPs composed of DOTAP-DOPE and DOTAP-cholesterol. The positive to negative charge ratio of LNPs is a determinant of mRNA transfer efficiency in different cell lines. We noted that the buffer affected the packaging of mRNA LNPs and identified sodium potassium magnesium calcium and glucose solution (SPMCG) as a favorable buffer formulation. LNP3 suspension can be lyophilized into a thermally stable formulation to maintain activity after rehydration both in vitro and in vivo. Finally, LNP3 showed sustained release and organ specific targeting. We have developed an ideal lipid nanoformulation composed of DOTAP, DOPE and cholesterol for effective mRNA delivery.

Laser-arc hybrid welding (LAHW) is an efficient and promising joining method for offshore structures made from metallic alloys. Under a high-power laser output, a keyhole is formed that efficiently melts a metal and provides high penetration depths compared to shallow and wide welds made by conventional arc welding, thus it requires much less time for production. A significant reduction in welding time leads to a substantial reduction of welding consumables and electricity use. Higher gap bridging ability can be achieved and tolerances for plate preparation is reduced when an arc is added to a laser beam. This work explicitly presents and compares different welding methods and their efficiency in application for offshore windmill substructures. According to a preliminary calculation, LAHW may reduce welding time by 10–20 times depending on process parameters and up to 15 times lower consumables usage. It was identified that the highest costs in welding is the filler wire followed by a shielding gas and electricity. This leads to high efficiency of LAHW in term of sustainability and reduction of CO 2 emissions in general compared to well-established arc welding. However, the narrow and deep welds made by LAHW may suffer from high hardness in the root area, inhomogeneous filler metal mixing, which may lead to poor microstructure, cracking and porosity. This requires an extensive research work on the process optimization and understanding the underlying physics to provide sound welds which must comply with the international standards.

Household solid fuel have been associated with changes of handgrip strength, and exposure to ambient air pollution might be one risk factor of sarcopenia. However, the prospective association between household solid fuel use and sarcopenia remains limited. A total of 11,924 participants (5,723 men (48%) and 6,201 women (52%) with the average age was 59.17 ± 9.57 years) from the China Health and Retirement Longitudinal Study 2011 were included in cross-sectional analyses. 7,507 participants at baseline were included in longitudinal analyses and were followed up in 2015. Sarcopenia status was defined according to the Asian Working Group for Sarcopenia 2019 (AWGS 2019) criteria. In cross-sectional analyses, the participants who used solid fuel for cooking and heating had higher prevalence of sarcopenia than those who used clean fuel. During the follow-up, 302 (4.02%) participants experienced sarcopenia. In the longitudinal analysis, after multivariable adjustment of age, sex and other risk factors, individuals who used solid fuel for cooking had an elevated risk of new-onset sarcopenia, with corresponding odds ratio of 1.32 (95% confidence interval, 1.03–1.71). Consistently, individuals reported solid fuels use for heating were associated with 20% (odds ratio=1.20, 95% confidence interval: 1.01–1.56) increased risk of sarcopenia. In addition, a self-reported switch from clean to solid fuel for cooking appeared to have an increased sarcopenia risk (odds ratio=1.20, 95% confidence interval: 1.02–1.43). Using household solid fuel for cooking and heating was associated with increased risk of sarcopenia prevalence and incidence.