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Due to their simplicity and versatility of design, straight strip or rectangular pad anode structures are frequently employed with micro-pattern gas detectors to reconstruct high precision space points for various tracking applications. The particle impact point is typically determined by interpolating the charge collected by several neighboring pads. However, to effectively extract the inherent positional information, the lateral spacing of the straight pads must be significantly smaller than the extent of the charge cloud. In contrast, highly interleaved anode patterns, such as zigzags, can adequately sample the charge with a pitch comparable to the size of the charge cloud or even larger. This has the considerable advantage of providing the same performance while requiring far fewer instrumented channels. Additionally, the geometric parameters defining such zigzag structures may be tuned to provide a uniform detector response without the need for so-called pad response functions, while simultaneously maintaining excellent position resolution. We have measured the position resolution of a variety of zigzag shaped anode patterns optimized for various MPGDs, including GEM, Micromegas, and micro-RWELL and compared this performance to the same detectors equipped with straight pads of varying pitch. We report on the performance results of each readout structure, evaluated under identical conditions in a test beam.