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Following the successful Run 1 experiment, the Advanced Proton Driven Plasma Wakefield Acceleration Experiment (AWAKE) Run2 experiment requires the design and implementation of a compact electron source. The “high-quality Electron Accelerator driven by a Reliable Laser wakefield for Industrial uses” (EARLI) project aims to design a stand-alone high-quality electron injector based on a laser wakefield accelerator (LWFA) as an alternative proposal to AWAKE’s baseline design of an X-band electron gun. This project is currently in the design phase, including simulations and experimental tests. Exhaustive beam physics studies for conventional accelerators are applied to LWFA physics.

Rhabdomyosarcomas (RMSs) are one of the most common solid tumor of childhood. Rhabdomyosarcoma (RMS) cells fail to both complete the skeletal muscle differentiation program and irreversibly exit the cell cycle as a consequence of an active repression exerted on the muscle-promoting factor MyoD. Myostatin is a negative regulator of normal muscle growth, we have thus studied its possible role in RMS cells. Here, we present evidence that overexpression of myostatin is a common feature of RMS since both subtypes of RMS (embryonal RD and alveolar Rh30 cells) express high levels of myostatin when compared to nontumoral skeletal muscle cells. Interestingly, we found that inactivation of myostatin through overexpression of antisense myostatin or of follistatin (a myostatin antagonist) constructs enhanced differentiation of RD cells. In addition, RD and Rh30 cells treated with blocking antimyostatin antibodies progress into the myogenic terminal differentiation program. Finally, our results suggest that high levels of myostatin could impair MyoD function in RMS cells. These results show that an autocrine myostatin loop contributes to maintain RMS cells in an undifferentiating stage and suggest that new therapeutic approaches could be exploited for the treatment of RMS based on inactivation of myostatin protein.

The IRS has proposed changes to Section 501(c)(3) of the Internal Revenue Code that could affect the tax-exempt status of not-for-profit healthcare organizations. Healthcare financial managers should ensure that their organizations maintain compliance with the tax-exempt requirements and remain above reproach, particularly in the areas of: An organization's intent for public service. Implications of Section 4958 on the organization's tax-exempt status. Political activities. Operating an affiliated business.

The infinite combinations of physical characteristics and cultural teachings and experiences result in vast differences among ethnic groups and individuals. Understanding and embracing cultural differences among employees and customers directly translates into economic prosperity and survival in a global economy. For this reason, it is important that internal auditors understand the fundamental aspects of culture, the significance of culture to the immediate and long-term viability of the organization, how to manage cultural risk exposures, and how to introduce cultural auditing as a routine practice. The language barrier among cultures can be a major obstacle. An array of behaviors that affect consumer purchase decisions as well as employee performance are based on religious faith. Wardrobe tastes and preferences vary considerably from culture to culture. Auditors should also examine their organization's approach to gender equality. Internal auditors have a professional obligation to assess risk exposure and align audit resources to address areas in which value can be added.

Field tests and lab work indicate mud losses in highly depleted sands can be reduced with a new formation sealing product. A discussion of a newly developed Deformable Sealant (DS) that can be added to a water-based fluid at 2 to 4% volume is presented.

Emission of light by a single electron moving on a curved trajectory (synchrotron radiation) is one of the most well-known fundamental radiation phenomena. However experimental situations are more complex as they involve many electrons, each being exposed to the radiation of its neighbors. This interaction has dramatic consequences, one of the most spectacular being the spontaneous formation of spatial structures inside electrons bunches. This fundamental effect is actively studied as it represents one of the most fundamental limitations in electron accelerators and at the same time a source of intense terahertz radiation (Coherent Synchrotron Radiation, or CSR). Here we demonstrate the possibility to directly observe the electron bunch microstructures with subpicosecond resolution, in a storage ring accelerator. The principle is to monitor the terahertz pulses emitted by the structures, using a strategy from photonics, time-stretch, consisting in slowing-down the phenomena before recording. This opens the way to unpreceeded possibilities for analyzing and mastering new generation high power coherent synchrotron sources.

The eastern Mediterranean (EM) is one of the regions in the world where elevated concentrations of primary and secondary gaseous air pollutants have been reported frequently, mainly in summer. This review discusses published studies of the atmospheric dispersion and transport conditions characterizing this region during the summer, followed by a description of some essential studies dealing with the corresponding concentrations of air pollutants such as ozone, carbon monoxide, total reactive nitrogen, methane, and sulfate aerosols observed there. The interlaced relationship between the downward motion of the subsiding air aloft induced by global circulation systems affecting the EM and the depth of the Persian Trough, a low-pressure trough that extends from the Asian monsoon at the surface controlling the spatiotemporal distribution of the mixed boundary layer during summer, is discussed. The strength of the wind flow within the mixed layer and its depth affect much the amount of pollutants transported and determine the potential of the atmosphere to disperse contaminants off their origins in the EM. The reduced mixed layer and the accompanying weak westerlies, characterizing the summer in this region, led to reduced ventilation rates, preventing an effective dilution of the contaminants. Several studies pointing at specific local (e.g., ventilation rates) and regional peculiarities (long-range transport) enhancing the build-up of air pollutant concentrations are presented. Tropospheric ozone (O3) concentrations observed in the summer over the EM are among the highest over the Northern Hemisphere. The three essential processes controlling its formation (i.e., long-range transport of polluted air masses, dynamic subsidence at mid-tropospheric levels, and stratosphere-to-troposphere exchange) are reviewed. Airborne campaigns and satellite-borne initiatives have indicated that the concentration values of reactive nitrogen identified as precursors in the formation of O3 over the EM were found to be 2 to 10 times higher than in the hemispheric background troposphere. Several factors favor sulfate particulate abundance over the EM. Models, aircraft measurements, and satellite-derived data have clearly shown that sulfate has a maximum during spring and summer over the EM. The carbon monoxide (CO) seasonal cycle, as obtained from global background monitoring sites in the EM, is mostly controlled by the tropospheric concentration of the hydroxyl radical (OH) and therefore demonstrates high concentrations over winter months and the lowest concentrations during summer when photochemistry is active. Modeling studies have shown that the diurnal variations in CO concentration during the summer result from long-range CO transport from European anthropogenic sources, contributing 60 to 80 % of the boundary-layer CO over the EM. The values retrieved from satellite data enable us to derive the spatial distribution of methane (CH4), identifying August as the month with the highest levels over the EM. The outcomes of a recent extensive examination of the distribution of methane over the tropospheric Mediterranean Basin, as part of the Chemistry-Aerosol Mediterranean Experiment (ChArMEx) program, using model simulations and satellite measurements, are coherent with other previous studies. Moreover, this methane study provides some insight into the role of the Asian monsoon anticyclone in controlling the variability of CH4 pollutant within mid-to-upper tropospheric levels above the EM in summer.

The PHEND (Past Has Ears at Notre-Dame) collaborative research project is being carried out by a team of multidisciplinary researchers interested in the acoustic history of Notre-Dame Cathedral in Paris. The project involved the creation of seven digital models representing the interior of the monument between 1182 and 2018. To support one of the virtual reconstructions, that of 1868, a technical report was drawn up based on the written and iconographic archives of the restorations carried out between 1845 and 1870 by the architects Eugène Viollet-le-Duc (1814–1879) and Jean-Baptiste-Antoine Lassus (1807–1857). The archives come mainly from the “Fonds Viollet-le-Duc”, from the work diary of the “Médiathèque du patrimoine et de la photographie” (MPP), and from the archives of the Notre-Dame chapter. In order to select the most relevant data for the digital reconstruction, the research addresses specific questions regarding the cathedral’s materiality, such as structural modifications, restorations, and the choice of materials and furnishings. To understand how the interior of the cathedral was transformed in the 19th century, a detailed inventory of its condition was compiled at two points in time: at the beginning of the restoration in 1848 and following its completion in 1868. In parallel with this work, to provide a graphic representation of the changes that had occurred in each area, comparative illustrations were produced showing the situation before and after restoration. The modifications were then detailed by area: general restoration (vaults, openings, paving), and redevelopment of the choir and the main body of the building (chapels, transept, nave). This research revealed the building’s profound structural changes and the fact that the renovations spared no space. These included mainly modifications to the high windows, a complete redesign of the decorative layout of the choir and chapels, the restoration of all the vaults and paving at different levels, and a complete restoration of the organ.