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Purpose In this study, we investigated the progression of high-grade dysplasia (HGD)/CRC in patients with hereditary colorectal cancer syndromes (HCSS) and concomitant inflammatory bowel diseases (IBDs). Methods We described the natural history of a series of patients with confirmed diagnosis of hereditary colorectal cancer syndromes (HCCSs) and concomitant IBDs who were referred to the Hereditary Digestive Tumors Registry at the Fondazione IRCCS Istituto Nazionale dei Tumori of Milan. Results Between January 1989 and April 2024, among 450 patients with APC-associated polyposis and 1050 patients with Lynch syndrome (LS), we identified six patients with IBDs (five with UC, one with ileal penetrating CD) and concomitant HCCSs (five with LS, one with APC-associated polyposis). Three patients developed CRC (two patients with stage IIA, and one with stage IIIA); in one patient, CRC occurred over a median follow-up of 12 months after IBD diagnosis, while in two, both conditions were diagnosed simultaneously. The median age at initial diagnosis of CRC was 33 years (range 27–41). Five patients (83.3%) underwent surgical procedures (three colonic resections for carcinoma and two for other reasons). Most of them progressed to precancerous or cancerous colonic lesions at a young age. Notably, all patients with CRC had a diagnosis of UC. Conclusion IBD patients with coexistent HCCSs can develop early CRC onset at an advanced stage. These patients should be always referred to tertiary referral centers for strict surveillance programs and early surgical management of advanced colorectal neoplastic lesions. Noninvasive biomarkers of neoplastic changes are advocated to further improve the management of IBD patients with HCCSs.

The explosive activity of the 2021 Tajogaite eruption eludes pigeonholing into well‐defined eruption styles, with a variety of pyroclast ejection modes occurring both alternately and simultaneously at multiple vents. Visually, we defined four endmembers of explosive activity, referred to as fountaining, spattering, ash‐poor jets and ash‐rich jets. To capture the physical parameters of these activities, we deployed a camera array including one high‐speed camera and three high‐definition cameras in two field campaigns. Transitions between and fluctuations within activity occurred at the time scale of minutes to hours, likely driven by the same shallow conduit and vent processes controlling Strombolian activity at other volcanoes, but at higher gas and magma fluxes. From a physical standpoint, mean pyroclast rise velocity ranged 5–50 m/s, maximum ejection velocity 10–220 m/s, and sub‐second mass flux of lapilli to bomb‐sized pyroclasts at the vent 0.2–200 × 103 kg/s. The largest mass flux occurred during fountaining, which contributed by far more than other activities to cone building. All explosive activity exhibited well‐defined pyroclast ejection pulses, and we found a positive correlation between the occurrence rate of ejection pulses and maximum pyroclast ejection velocity. Despite orders of magnitude variations, physical parameters shift gradually with no boundary from one activity endmember to another. As such, attributing this explosive activity specifically to any currently defined style variations is arbitrary and potentially misleading. The highly variable explosive activity of the Tajogaite eruption recalls previous definitions of violent Strombolian eruptions, an eruption style whose pyroclast ejection dynamics, however, were so far largely undefined. Plain Language Summary The 2021 Tajogaite volcanic eruption offered a rare opportunity to study in detail the physical properties and the controlling factors of explosive activity driven by basaltic magmas. The activity lasted almost uninterrupted for almost 3 months and had visually different manifestations occurring simultaneously and alternating at different volcanic vents. To study the explosive activity, we used one high‐speed camera, taking short, slow motion videos, and three commercial grade high‐definition camcorders recording for many hours. We found that the activity changed in features and intensity at the time scale of minutes to hours, largely controlled by changes in the size and debris cover of the vent, magma viscosity, and magma flux and gas content. The ejection velocity of large volcanic particles ranged 5–220 m/s, with mean values around 10–50 m/s. The mass flux of particles erupted reached peaks of 200 metric tons per second. Particle ejection was never steady but always proceeded in pulses, which were more frequent if the ejection velocity was higher. Our measurements show that the current classification schemes for explosive eruptions of basaltic magmas do not adequately describe the activity of the Tajogaite eruption, which represents a type of eruption that was not yet measured in detail. Key Points High‐definition and high‐speed imaging record the velocity, size, and mass flux of pyroclasts Activity shifted in location, nature and vigor at the time scale of hours and progressed in ejection pulses at the time scale of seconds Physical parameters of explosive activity vary gradually between apparently different activity styles, without any clear boundary

Coarse, molten fragments of low-viscosity magma (volcanic bombs) that are ejected during explosive volcanic eruptions represent a source of hazard and a record of past eruptions. After ejection, bombs tend to break up during flight, but how much this affects their dispersal is unclear. Here, we use high-speed and high-definition imaging of three recent explosive eruptions to parameterise the in-flight fragmentation of bombs. We estimate that in-flight fragmentation involves 73% of bombs coarser than 0.2 m, with bomb-to-bomb collisions and aerodynamic frictional (drag) forces being the main drivers of in-flight fragmentation, depending on eruption style. Drag force increases with increasing bomb velocity and size, selectively fragmenting the coarsest and fastest bombs, acting as a self-limiting factor for the range and energy of falling bombs. These findings pose a quantitative basis for incorporating the in-flight fragmentation processes into the interpretation of volcanic deposits and for modelling hazards from falling bombs.

Background Total colectomy with ileorectal anastomosis (TC/IRA) is one of the prophylactic surgical options in patients with familial adenomatous polyposis (FAP). This study investigated the effectiveness of superior rectal artery (SRA) preservation during TC/IRA in reducing anastomotic leakage (AL). Methods This retrospective study was based on prospectively collected data (01/2000 - 12/2022) at the National Cancer Institute, Milan, Italy. FAP patients undergoing TC/IRA were enrolled. A 1:1  propensity score matching (PSM) was performed. Associations between SRA preservation and complications were investigated using univariate and multivariate analysis. Results The study population included 211 patients undergoing TC/IRA (Sex: 106 Male, 105 Female; Age: median 30 yrs, IQR: 20-48 yrs), 82 with SRA preservation (SRA group) and 129 without SRA preservation (controls). After PSM, 75 patients were considered for each group. SRA preservation was associated with fewer complications (OR 0.331, 95% CI 0.116; 0.942) in univariate logistic regression analysis. AL events were significantly fewer in the SRA group than in the control group (0 vs 12, p  = 0.028). The SRA group had fewer overall surgical complication and pelvic sepsis rates ( p  = 0.020 and p  = 0.028, respectively). Median operative time was significantly longer in the SRA group (340 min vs 240 min, p<0.001), and median hospital stay was significantly shorter (6 vs 7 days, p=0.017). Twenty-seven patients in the SRA group experienced intraoperative anastomotic bleeding, which was controlled endoscopically. Superimposable results were obtained analyzing the whole patient cohort. Conclusions SRA preservation can be considered an advantage in this patient population, despite adding a further technical step during surgery and thereby prolonging the operative time. Intraoperative endoscopic checking of possible anastomotic bleeding sites is recommended.

In 2006, United States public schools participating in federal school meal programs were required to adopt school wellness policies. The effect of these policies on school nutrition environments is well documented; however, evaluation of physical activity policies has received less investigation. We aimed to evaluate how district wellness policies aligned to practice for physical activity implementation in 40 schools with high obesity rates (>24%). Wellness policies were evaluated using the validated Wellness School Assessment Tool (WellSAT). Concurrently, schools completed the validated Alliance for a Healthier Generation's Healthy Schools Program (HSP) self-assessment to evaluate physical activity practices. Overall, 13 of 20 physical activity measures from WellSAT and 12 of 13 physical activity measures from HSP were aligned to match policy with practice. Most policy items scored 0 or 1, indicating either 'no mention in the policy' or 'containing weak or vague language'. Corresponding HSP results indicated that school physical activity practices are 'not in place' or 'under development'. A strong, positive, correlation (r = 0.92, P < 0.001) indicated that a significant relationship exists between policy and implementation. Results indicate that most districts currently have weak policies regarding physical activity, limiting the potential to positively influence school-based physical activity.

The Rome region contains several sites where endogenous gas is brought to the surface through deep reaching faults, creating locally hazardous conditions for people and animals. Lavinio is a touristic borough of Anzio (Rome Capital Metropolitan City) that hosts a country club with a swimming pool and an adjacent basement balance tank. In early September 2011, the pool and the tank had been emptied for cleaning. On 5 September, four men descended into the tank and immediately lost consciousness. On 12 August 2012, after a long coma the first person died, the second one reported permanent damage to his central nervous system, and the other two men recovered completely. Detailed geochemical investigations show that the site is affected by a huge release of endogenous gas (CO2 ≈ 96 vol.% and H2S ≈ 4 vol.%). High soil CO2 and H2S flux values were measured near the pool (up to 898 and 7.155 g·m−2·day−1, respectively), and a high CO2 concentration (23–25 vol.%) was found at 50–70 cm depth in the soil. We were able to demonstrate that gas had been transported into the balance tank from the swimming pool through two hubs connected to the lateral overflow channels of the pool. We show also that the time before the accident (60 hr), during which the balance tank had remained closed to external air, had been largely sufficient to reach indoor nearly lethal conditions (oxygen deficiency and high concentration of both CO2 and H2S). Plain Language Summary Rome volcanic region contains several sites where deep gas consisting mostly of carbon dioxide (CO2) with 1–6% of hydrogen sulfide (H2S) is brought to the surface by faults, locally creating hazardous conditions. Lavinio is a touristic borough of Anzio (Rome province) located near the Tyrrhenian Coast. It hosts a country club with a swimming pool and an adjacent basement balance tank. In early September 2011, four men descended into the tank to clean it and immediately lost consciousness. After a nearly 1‐year coma, the first man died and the second one suffered permanent damage to his central nervous system. Immediately after the accident, we carried out detailed geochemical investigations aimed at ascertaining the accident causes. The results show that the accident occurred because of a nearly lethal gas concentration indoor the emptied balance tank. The gas had been transported into the tank through two hubs connected to the overflow channels of the pool, where we measured very high concentration of both CO2 and H2S. Geoscientific evidence indicates that the pool has been excavated in a severe gas‐risk prone area, and it can be easily inferred that excavation works created new additional ways allowing gas to escape to the surface. Key Points In volcanic and geothermal areas, the emission of deep gas locally creates hazardous conditions for people and animals, as at Lavinio Lavinio country club hosts a swimming pool with a basement tank, where an accident occurred on 5 September 2011 causing the death of a man Geochemical studies show that the man inhaled a nearly lethal CO2‐H2S‐rich air mixture, transported from the pool into the basement tank

Stromboli is known for its mild, persistent explosive activity from the vents located within the summit crater depression at the uppermost part of the Sciara del Fuoco (SdF) depression. Effusive activity (lava flows) at this volcano normally occurs every 5–15 years, involving often the opening of eruptive fissures along the SdF, and more rarely overflows from the summit crater. Between the end of the 2007 effusive eruption and December 2012, the number of lava flows inside and outside the crater depression has increased significantly, reaching a total of 28, with an average of 4.8 episodes per year. An open question is why this activity has become so frequent during the last 6 years and was quite rare before. In this paper, we describe this exceptional activity and propose an interpretation based on the structural state of the volcano, changed after the 2002–2003 and even more after the 2007 flank effusive eruption. We use images from the Stromboli fixed cameras network, as well as ground photos, plume SO 2 and CO 2 fluxes released by the summit crater, and continuous fumarole temperature recording, to unravel the interplay between magma supply, structural and morphology changes, and lava flow output. Our results might help forecast the future behaviour and hazard at Stromboli and might be applicable to other open-conduit volcanoes.

On 5 July 2014, an eruptive fissure opened on the eastern flank of Etna volcano (Italy) at ~3.000 m a.s.l. Strombolian activity and lava effusion occurred simultaneously at two neighbouring vents. In the following weeks, eruptive activity led to the build-up of two cones, tens of meters high, here named Crater N and Crater S. To characterize the short-term (days) dynamics of this multi-vent system, we performed a multi-parametric investigation by means of a dense instrumental network. The experimental setup, deployed on July 15-16th at ca. 300 m from the eruption site, comprised two broadband seismometers and three microphones as well as high speed video and thermal cameras. Thermal analyses enabled us to characterize the style of eruptive activity at each vent. In particular, explosive activity at Crater N featured higher thermal amplitudes and a lower explosion frequency than at Crater S. Several episodes of switching between puffing and Strombolian activity were noted at Crater S through both visual observation and thermal data; oppositely, Crater N exhibited a quasi-periodic activity. The quantification of the eruptive style of each vent enabled us to infer the geometry of the eruptive system: a branched conduit, prone to rapid changes of gas flux accommodated at the most inclined conduit (i.e. Crater S). Accordingly, we were able to correctly interpret acoustic data and thereby extend the characterization of this two-vent system.

In this work, we present preliminary results regarding the nuclear emission lines of a statistically complete sample of 56 early-type galaxies that are part of the Deep Integral Field Spectroscopy View of Nuclei of Galaxies (DIVING3D) Project. All early type galaxies (ETGs) were observed with the Gemini Multi-Object Spectrograph Integral Field Unit (GMOS-IFU) installed on the Gemini South Telescope. We detected emission lines in 93% of the sample, mostly low-ionization nuclear emission-line region galaxies (LINERs). We did not find Transition Objects nor H II regions in the sample. Type 1 objects are seen in ∼23% of the galaxies.

The DIVING3D Survey (Deep Integral Field Spectrograph View of Nuclei of Galaxies) aims to observe, with high signal/noise and high spatial resolution, a statistically complete sample of southern galaxies brighter than B = 12.0 The main objectives of this survey are to study: 1) the nuclear emission line properties; 2) the circumnuclear emission line properties; 3) the central stellar kinematics and 4) the central stellar archaeology. Preliminary results of individual or small groups of galaxies have been published in 18 papers.