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\"Bernard Hinault is Le Blaireau, the Badger. Tough as old boots, he is the old warrior of the French peloton, as revered as he is feared for his ferocious attacks. He has won 5 Tours de France, marking his name into the history books as a member of cycling's most exclusive club. Yet as the 1986 Tour de France ascended into the mountains, a boyish and friendly young American named Greg LeMond threatened the Badger--and France's entire cycling heritage. Known as \"L'Americain\", LeMond rode strongly, unafraid. The stakes were high. Winning for Hinault meant capping his long cycling career by becoming the first man to win the Tour six times. For LeMond, it would bring America its first Tour de France victory. Why did their rivalry shock the world? LeMond and Hinault were on the same team. Cyclists love this famous story but they've never heard it told as in Slaying the Badger. Award-winning author Richard Moore has gathered the absolute best sources, interviewing LeMond and Hinault in their own homes, American Andy Hampsten, their teammates and team directors to tell the story. He tells the race through these interviews so that these narrative voices lend a fresh and fast-paced tone to cycling's favorite rivalry. \"-- Provided by publisher.

It is sometimes argued that while human gestures are produced ostensively and intentionally, great ape gestures are produced only intentionally. If true, this would make the psychological mechanisms underlying the different species’ communication fundamentally different, and ascriptions of meaning to chimpanzee gestures would be inappropriate. While the existence of different underlying mechanisms cannot be ruled out, in fact claims about difference are driven less by empirical data than by contested assumptions about the nature of ostensive communication. On some accounts, there are no reasons to doubt that great ape gestural communication is ostensive. If these accounts are correct, attributions of meaning to chimpanzee gestures would be justified.

On standard readings of Grice, Gricean communication requires (a) possession of a concept of belief, (b) the ability to make complex inferences about others' goal-directed behaviour, and (c) the ability to entertain fourth-order metarepresentations. To the extent that these abilities are pre-requisites of Gricean communication, they are inconsistent with the view that Gricean communication could play a role in their development. In this paper, I argue that a class of 'minimally Gricean' acts satisfy the intentional structure described by Grice, but require none of abilities (a)—(c). As a result, Gricean communicative abilities may indeed contribute to the development of(a)—(c)—in particular, by enabling language development. This conclusion has important implications for our theorizing about cognitive development.

Automated robotic platforms are an important part of precision agriculture solutions for sustainable food production. Agri-robots require robust and accurate guidance systems in order to navigate between crops and to and from their base station. Onboard sensors such as machine vision cameras offer a flexible guidance alternative to more expensive solutions for structured environments such as scanning lidar or RTK-GNSS. The main challenges for visual crop row guidance are the dramatic differences in appearance of crops between farms and throughout the season and the variations in crop spacing and contours of the crop rows. Here we present a visual guidance pipeline for an agri-robot operating in strawberry fields in Norway that is based on semantic segmentation with a convolution neural network (CNN) to segment input RGB images into crop and not-crop (i.e., drivable terrain) regions. To handle the uneven contours of crop rows in Norway’s hilly agricultural regions, we develop a new adaptive multi-ROI method for fitting trajectories to the drivable regions. We test our approach in open-loop trials with a real agri-robot operating in the field and show that our approach compares favourably to other traditional guidance approaches.

Estimating the medical complexity of people aging with HIV can inform clinical programs and policy to meet future healthcare needs. The objective of our study was to forecast the prevalence of comorbidities and multimorbidity among people with HIV (PWH) using antiretroviral therapy (ART) in the United States (US) through 2030. Using the PEARL model-an agent-based simulation of PWH who have initiated ART in the US-the prevalence of anxiety, depression, stage ≥3 chronic kidney disease (CKD), dyslipidemia, diabetes, hypertension, cancer, end-stage liver disease (ESLD), myocardial infarction (MI), and multimorbidity (≥2 mental or physical comorbidities, other than HIV) were forecasted through 2030. Simulations were informed by the US CDC HIV surveillance data of new HIV diagnosis and the longitudinal North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) data on risk of comorbidities from 2009 to 2017. The simulated population represented 15 subgroups of PWH including Hispanic, non-Hispanic White (White), and non-Hispanic Black/African American (Black/AA) men who have sex with men (MSM), men and women with history of injection drug use and heterosexual men and women. Simulations were replicated for 200 runs and forecasted outcomes are presented as median values (95% uncertainty ranges are presented in the Supporting information). In 2020, PEARL forecasted a median population of 670,000 individuals receiving ART in the US, of whom 9% men and 4% women with history of injection drug use, 60% MSM, 8% heterosexual men, and 19% heterosexual women. Additionally, 44% were Black/AA, 32% White, and 23% Hispanic. Along with a gradual rise in population size of PWH receiving ART-reaching 908,000 individuals by 2030-PEARL forecasted a surge in prevalence of most comorbidities to 2030. Depression and/or anxiety was high and increased from 60% in 2020 to 64% in 2030. Hypertension decreased while dyslipidemia, diabetes, CKD, and MI increased. There was little change in prevalence of cancer and ESLD. The forecasted multimorbidity among PWH receiving ART increased from 63% in 2020 to 70% in 2030. There was heterogeneity in trends across subgroups. Among Black women with history of injection drug use in 2030 (oldest demographic subgroup with median age of 66 year), dyslipidemia, CKD, hypertension, diabetes, anxiety, and depression were most prevalent, with 92% experiencing multimorbidity. Among Black MSM in 2030 (youngest demographic subgroup with median age of 42 year), depression and CKD were highly prevalent, with 57% experiencing multimorbidity. These results are limited by the assumption that trends in new HIV diagnoses, mortality, and comorbidity risk observed in 2009 to 2017 will persist through 2030; influences occurring outside this period are not accounted for in the forecasts. The PEARL forecasts suggest a continued rise in comorbidity and multimorbidity prevalence to 2030, marked by heterogeneities across race/ethnicity, gender, and HIV acquisition risk subgroups. HIV clinicians must stay current on the ever-changing comorbidities-specific guidelines to provide guideline-recommended care. HIV clinical directors should ensure linkages to subspecialty care within the clinic or by referral. HIV policy decision-makers must allocate resources and support extended clinical capacity to meet the healthcare needs of people aging with HIV.

\"This friendly guide presents an easy-to-follow overview of the material covered in a typical college-level biochemistry course\"--P. [4] of cover.

The epidemiology of human immunodeficiency virus (HIV) infection in the United States has changed significantly over the past 30 years. HIV/acquired immune deficiency syndrome (HIV/AIDS) is currently a disease of greater demographic diversity, affecting all ages, sexes, and races, and involving multiple transmission risk behaviors. At least 50,000 new HIV infections will continue to be added each year; however, one-fifth of persons with new infections may not know they are infected, and a substantial proportion of those who know they are infected are not engaged in HIV care. Barriers to early engagement in care may be specific to a demographic group. In this paper, the current epidemiology of HIV/AIDS in the United States is reviewed in order to understand the challenges, successes, and best practices for removing the barriers to effective diagnosis and receipt of HIV care within specific demographic groups.