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The North Tehran Fault (NTF) is located at the southernmost piedmont of Central Alborz and crosses the northern suburbs of the Tehran metropolis and adjacent cities, where ∼15 million people live. Extending over a length of about 110 km, the NTF stands out as a major active fault and represents an important seismic hazard for the Iranian capital after historical seismicity. In order to characterize the activity of the NTF in terms of kinematics, magnitude and recurrence intervals of earthquakes, we carried out a first paleoseismological study of the fault within its central part between Tehran and Karaj cities. We opened a trench across a 3 m‐high fault scarp affecting Quaternary deposits. Our study shows that the scarp is the result of repeated events along a main N115°E trending shallow dipping thrust fault, associated with secondary ruptures. From the trench analysis and Infrared Stimulated Luminescence (IRSL) dating of fault‐related sediments, we interpreted between 6 and 7 surface‐rupturing events that occurred during the past 30 kyrs. Their magnitudes (estimated from the displacements along the faults) are comprised between 6.1 and 7.2. The two last events – the largest ‐ occurred during the past 7.9 ± 1.2 ka, which yields a Holocene slip rate of ∼0.3 mm/yr. The 7 earthquakes scenario suggests a regular periodicity with a mean recurrence interval of ∼3.8 kyrs. However, the two most recent events could correspond to the two largest historical earthquakes recorded in the area (in 312–280 B.C. and 1177 A.D.), and therefore suggest that the NTF activity is not regular. Key Points The first paleoseismological study along the North Tehran, Iran 6‐7 events occurred in the past 30 kyrs with magnitudes between 6.1 and 7.2 Mean return period is 3.8 kyrs, but irregular activity is likely

In spite of an increasing number of paleoseismic studies carried out over the last decade along the Himalayan Arc, the chronology of historical and prehistorical earthquakes is still poorly constrained. In this paper, we present geomorphologic and paleoseismic studies conducted over a large river-cut exposure along the Main Fontal Thrust in southwestern Bhutan. The Piping site reveals a 30 m high fault-propagation fold deforming late Holocene alluvial deposits. There, we carried out detailed paleoseismic investigations and built a chronological framework on the basis of 22 detrital charcoal samples submitted to radiocarbon dating. Our analysis reveals the occurrence of at least five large and great earthquakes between 485±125 BCE and 1714 CE with an average recurrence interval of 550±211 years. Coseismic slip values for most events reach at least 12 m and suggest associated magnitudes are in the range of Mw 8.5–9. The cumulative deformation yields an average slip rate of 24.9±10.4 mm yr−1 along the Main Frontal Thrust over the last 2600 years, in agreement with geodetic and geomorphological results obtained nearby.

The 856 A.D. Qumis earthquake (M7.9) is the most destructive earthquake to have occurred in Iran, killing more than 200,000 people and destroying the cities of Damghan and the old Parthian capital of Shahr‐i Qumis (Hecatompylos). This study combines evidence of historical seismicity with observations of the geomorphology and paleoseismology to provide the first detailed description of active faulting in the Damghan region of the east Alborz mountains, Iran. Regional left‐lateral shear is accommodated on the Astaneh, Damghan, and North Damghan faults. Quaternary alluvial fans have been displaced along the Astaneh fault, with 15–20 m stream offsets recording the cumulative displacement over the last two to five earthquakes. A paleoseismology study from a single trench along a 5–10 km segment of the Astaneh fault reveals a rupture prior to 1300 A.D. and significantly later than 600 B.C. Despite the limitations of a single trench in documenting the spatial and temporal evolution of the fault over the late Quaternary, we are nevertheless able to bracket the last event to a time period consistent with the 856 A.D. earthquake. Two older earthquakes were also identified during the Holocene occurring between 600 B.C. and 4600 B.C. and between 4600 B.C. and 9600 B.C. The location of our trench within a bend on the Astaneh fault, which could act as a barrier to rupture propagation, means the three earthquakes recovered from our trench over the Holocene may represent a minimum. Further trenching will reveal how the Astaneh fault ruptures over repeated earthquakes and, consequently, the magnitude and extent of slip during the 856 A.D. earthquake.

In this work, we reappraise the seismogenic potential of the geologic structures in the western Tell Atlas of Algeria, considered active host to moderate to low magnitude earthquakes. The direct identification of active faults is generally a difficult task in northern Algeria. The active tectonics in the Oran Plio-Quaternary age basin (Northwestern Algeria) is analyzed and characterized through a morpho-structural study combining topographic, geomorphologic, geological, and neotectonic data. Folds and fault scarps affecting Quaternary deposits show that the region is affected by compressional deformation still active nowadays, as shown by the recorded seismic activity. Our new observations enable a better understanding of the present seismotectonic context of the Oran region, particularly with regard to the magnitude and source of the 1790 Oran damaging event. The obtained result helps to shed some light on the elusive active tectonics characterizing this coastal area, and to assess regional seismic hazard, particularly in coastal zones where large seismogenic areas straddle the onshore–offshore zones.

Coastal Quaternary deposits of western Oranie show typical soft-sediment deformations including sedimentary dykes, sand volcanoes, sismoslumps, thixotropic bowls, thixotropic wedges, diapir-like structures, and faults grading. Field observations indicate that these deformations exist at several levels of the studied deposits along the west Oranian coast. This study demonstrated that these structures are earthquakes-related, by analysis of potential trigger sources. Several arguments demonstrate the seismic origin: the depositional environment rich in water that located in an active tectonic region, the thixotropic nature of deformations and their large vertical and horizontal diffusion in the Quaternary series consistent with a seismic recurrence. This allows characterizing these Quaternary soft-sediment deformations as seismites that were triggered by earthquakes.

The activity of the Damavand volcano (Central Alborz, northern Iran) began 1.8 Ma ago and continued up to 7 ka BP. Although the volcanic suite is clearly of shoshonitic affinity, only two petrographic types can be distinguished in the studied lavas: (1) weakly differentiated absarokites (49 < %SiO 2  < 51), scattered around the volcano but with a regional extension, (2) highly differentiated banakites (59 < %SiO 2  < 63), which form the bulk of the 4,000 m thick volcanic pile. All lavas are alkalic (3.7 < %K 2 O < 5), REE and LILE-rich (e.g., 85 < La < 148 ppm; 9 < Th < 32 ppm) and show highly fractionated REE patterns (69 < La/Yb < 115) and pronounced Nb–Ta negative anomalies. The absarokites are characterised by Sr (0.7045–0.7046) and Nd (0.51266–0.51269) isotope compositions close to the Bulk Earth values, and distinct from those of the banakites (0.7047 <  87 Sr/ 86 Sr < 0.7049, 0.51258 <  143 Nd/ 144 Nd < 0.51262). The Pb isotope ratios are also slightly lower in the absarokites than in the banakites (18.71 <  206 Pb/ 204 Pb < 18.77, 15.62 <  207 Pb/ 204 Pb < 15.63, 38.85 <  208 Pb/ 204 Pb < 38.91, and 18.77 <  206 Pb/ 204 Pb < 18.84, 15.62 <  207 Pb/ 204 Pb < 15.64, 38.94 <  208 Pb/ 204 Pb < 39.06, respectively). Overall, there is a clear tendency towards higher Sr, Pb and lower Nd isotope ratios with increasing degree of differentiation. This study suggests that the absarokites result from a low degree of partial melting (∼5%) of a highly metasomatized mantle source, which inherited its characteristics from an old subduction setting. The initiation of volcanic activity 1.8 Ma ago results from variations in the lithospheric thermal regime, probably related to lithospheric delamination as proposed for Anatolia (Pearce et al. 1990 ). The banakites are mainly generated by extensive fractional crystallisation (∼70%) of the absarokitic magma, with a limited amount (a few percents) of assimilation of an old crustal component, in the form of bulk assimilation or AFC processes, which both can explain the Sr, Nd and Pb isotope data.

Objectives: Increased energy expenditure (EE) has been proposed as an important mechanism for weight loss following Roux-en-Y gastric bypass (RYGB). However, this has never been investigated in a controlled setting independent of changes in energy balance. Similarly, only few studies have investigated the effect of RYGB on glycaemic control per se . Here, we investigated the effect of RYGB on EE, appetite, glycaemic control and specific signalling molecules compared with a control group in comparable negative energy balance. Subjects/Methods: Obese normal glucose-tolerant participants were randomized to receive RYGB after 8 ( n =14) or 12 weeks ( n =14). The protocol included a visit at week 0 and three visits (weeks 7, 11 and 78) where 24-h EE, appetite and blood parameters were assessed. Participants followed a low-calorie diet from weeks 0–11, with those operated at week 12 serving as a control group for those operated at week 8. Results: Compared with controls, RYGB-operated participants had lower body composition-adjusted 24-h EE and basal EE 3 weeks postoperatively (both P <0.05) but EE parameters at week 78 were not different from preoperative values (week 7). Surgery changed the postprandial response of glucagon-like peptide-1 (GLP-1), peptide YY 3–36 (PYY), ghrelin, cholecystokinin, fibroblast growth factor-19 and bile acids (all P <0.05). Particularly, increases in GLP-1, PYY and decreases in ghrelin were associated with decreased appetite. None of HOMA-IR (homeostasis model assessment-estimated insulin resistance), Matsuda index, the insulinogenic index, the disposition index and fasting hepatic insulin clearance were different between the groups, but RYGB operated had lower fasting glucose ( P <0.05) and the postprandial glucose profile was shifted to the left ( P <0.01). Conclusions: Our data do not support that EE is increased after RYGB. More likely, RYGB promotes weight loss by reducing appetite, partly mediated by changes in gastrointestinal hormone secretion. Furthermore, we found that the early changes in glycaemic control after RYGB is to a large extent mediated by caloric restriction.

Cognitive impairment can be influenced by a number of factors. The potential effect of nutrition has become a topic of increasing scientific and public interest. In particular, there are arguments that nutrients (food and/or supplements) such as vitamins, trace minerals, lipids, can affect the risk of cognitive decline and dementia, especially in frail elderly people at risk of deficiencies. Our objective in this paper is to review data relating diet to risk of cognitive decline and dementia, especially Alzheimer's disease (AD). We chose to focus our statements on homocysteine-related vitamins (B-vitamins), antioxidant nutrients (vitamins E and C, carotenoids, flavonoids, enzymatic cofactors) and dietary lipids. Results of epidemiological studies may sometimes appeared conflicting; however, certain associations are frequently found. High intake of saturated and trans-unsaturated (hydrogenated) fats were positively associated with increased risk of AD, whereas intake of polyunsaturated and monounsaturated fats were protective against cognitive decline in the elderly in prospective studies. Fish consumption has been associated with lower risk of AD in longitudinal cohort studies. Moreover, epidemiologic data suggest a protective role of the B-vitamins, especially vitamins B9 and B12, on cognitive decline and dementia. Finally, the results on antioxidant nutrients may suggest the importance of having a balanced combination of several antioxidant nutrients to exert a significant effect on the prevention of cognitive decline and dementia, while taking into account the potential adverse effects of these nutrients. There is no lack of attractive hypotheses to support research on the relationships between nutrition and cognitive decline. It is important to stress the need to develop further prospective studies of sufficiently long duration, including subjects whose diet is monitored at a sufficiently early stage or at least before disease or cognitive decline exist. Meta analyses should be developed, and on the basis of their results the most appropriate interventional studies can be planned. These studies must control for the greatest number of known confounding factors and take into account the impact of the standard social determinants of food habits, such as the regional cultures, social status, and educational level.

Alzheimer's disease (AD) is the most frequent form of dementia and according to the most recent estimation it affects nearly 27 million people in the world. The onset of the disease is generally insidious. It is becoming increasingly evident that the underlying pathophysiological mechanisms are active long before the appearance of the clinical symptoms of the disease. In the current context, it is important to develop strategies to delay the onset of cognitive decline. Delaying the onset by 5 years would reduce the prevalence by half at term, and a delay of 10 years would reduce it by three-quarters. The effectiveness of currently suggested preventive approaches remains to be confirmed, but certain strategies could be applied straight away to at-risk subjects. We propose that a health-promoting memory consultation should be set up for elderly persons who have attended a specialized memory consultation and in whom the diagnosis of dementia and of AD in particular, has not been established by standardized tools. Through this consultation, they would be offered full multidimensional investigation of all aspects of their health status, follow-up could be organized, general practitioners in private practice could be made more conscious of this population and the elderly could be made more aware of the risk factors to which they are exposed. The development of an information policy for the elderly would meet a present need. In our reflection, we must take into account the question of how to give this preventive consultation its due place in the healthcare pathway of the elderly person in order to ensure coordinated follow-up with all the other health professionals involved. The principle of the health-promoting memory consultation is undergoing validation in a large French multicentre preventive trial in 1200 frail elderly persons aged 70 years followed for three years, the Multidomain Alzheimer Preventive Trial (MAPT).

Maximum lifespan of a species is the oldest that individuals can survive, reflecting the genetic limit of longevity in an ideal environment. Here we report methylation-based models that accurately predict maximum lifespan (r=0.89), gestational time (r=0.96), and age at sexual maturity (r=0.87), using cytosine methylation patterns collected from over 12,000 samples derived from 192 mammalian species. Our epigenetic maximum lifespan predictor corroborated the extended lifespan in growth hormone receptor knockout mice and rapamycin treated mice. Across dog breeds, epigenetic maximum lifespan correlates positively with breed lifespan but negatively with breed size. Lifespan-related cytosines are located in transcriptional regulatory regions, such as bivalent chromatin promoters and polycomb-repressed regions, which were hypomethylated in long-lived species. The epigenetic estimators of maximum lifespan and other life history traits will be useful for characterizing understudied species and for identifying interventions that extend lifespan.