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We present the numerical proof of a new sensor concept, based on the Resistive AC-Coupled Silicon Detectors (RSDs) paradigm and standard CMOS process, which benefits from having a 100% fill factor and embedded front-end electronics. The compatibility between these two technologies has been investigated, and our encouraging results suggest that this target could be reliably achieved, enabling the possibility to considerably boost the performance of current silicon detectors intended for timing and 4D-tracking.

Particle therapy exploits the energy deposition pattern of hadron beams. The narrow Bragg Peak at the end of range is a major advantage but range uncertainties can cause severe damage and require online verification to maximise the effectiveness in clinics. In-beam Positron Emission Tomography (PET) is a non-invasive, promising in-vivo technique, which consists in the measurement of the β+ activity induced by beam-tissue interactions during treatment, and presents the highest correlation of the measured activity distribution with the deposited dose, since it is not much influenced by biological washout. Here we report the first clinical results obtained with a state-of-the-art in-beam PET scanner, with on-the-fly reconstruction of the activity distribution during irradiation. An automated time-resolved quantitative analysis was tested on a lacrimal gland carcinoma case, monitored during two consecutive treatment sessions. The 3D activity map was reconstructed every 10 s, with an average delay between beam delivery and image availability of about 6 s. The correlation coefficient of 3D activity maps for the two sessions (above 0.9 after 120 s) and the range agreement (within 1 mm) prove the suitability of in-beam PET for online range verification during treatment, a crucial step towards adaptive strategies in particle therapy.

We assessed the accuracy of a prototype radiation detector with a built in CMOS amplifier for use in dosimetry for high dose rate brachytherapy. The detectors were fabricated on two substrates of epitaxial high resistivity silicon. The radiation detection performance of prototypes has been tested by ion beam induced charge (IBIC) microscopy using a 5.5 MeV alpha particle microbeam. We also carried out the HDR Ir-192 radiation source tracking at different depths and angular dose dependence in a water equivalent phantom. The detectors show sensitivities spanning from (5.8 ± 0.021) × 10−8 to (3.6 ± 0.14) × 10−8 nC Gy−1 mCi−1 mm−2. The depth variation of the dose is within 5% with that calculated by TG-43. Higher discrepancies are recorded for 2 mm and 7 mm depths due to the scattering of secondary particles and the perturbation of the radiation field induced in the ceramic/golden package. Dwell positions and dwell time are reconstructed within ±1 mm and 20 ms, respectively. The prototype detectors provide an unprecedented sensitivity thanks to its monolithic amplification stage. Future investigation of this technology will include the optimisation of the packaging technique.

This work presents the development of a 64-channel application-specific integrated circuit (ASIC), implemented to detect the optical Cherenkov light from sub-orbital and orbital altitudes. These kinds of signals are generated by ultra-high energy cosmic rays (UHECRs) and cosmic neutrinos (CNs). The purpose of this front-end electronics is to provide a readout unit for a matrix of silicon photo-multipliers (SiPMs) to identify extensive air showers (EASs). Each event can be stored into a configurable array of 256 cells where the on-board digitization can take place with a programmable 12-bits Wilkinson analog-to-digital converter (ADC). The sampling, the conversion process, and the main digital logic of the ASIC run at 200 MHz, while the readout is managed by dedicated serializers operating at 400 MHz in double data rate (DDR). The chip is designed in a commercial 65 nm CMOS technology, ensuring a high configurability by selecting the partition of the channels, the resolution in the interval 8–12 bits, and the source of its trigger. The production and testing of the ASIC is planned for the forthcoming months.

There are two available sets of data on the e+e−→Λc+Λ¯c− cross section at energies close to the production threshold, collected by the Belle and by the BESIII Collaborations. The measurement of the former, performed by means of the initial state radiation technique, is compatible with the presence of a resonance, called ψ(4660), observed also in other final states. On the contrary, the latter is measured an almost flat and hence non-resonant cross section in the energy region just above the production threshold, but the data stop before the possible rise in the cross section for the resonant production. We propose an effective model to describe the behavior of the data near this threshold, which is based on a Coulomb-like enhancement factor due to the strong interaction among the final state particles. In the framework of this model, it is possible to describe both datasets.

There are two available sets of data on the e+e−→ Λ c+ Λ ¯ c− cross section at energies close to the production threshold, collected by the Belle and by the BESIII Collaborations. The measurement of the former, performed by means of the initial state radiation technique, is compatible with the presence of a resonance, called ψ(4660) , observed also in other final states. On the contrary, the latter is measured an almost flat and hence non-resonant cross section in the energy region just above the production threshold, but the data stop before the possible rise in the cross section for the resonant production. We propose an effective model to describe the behavior of the data near this threshold, which is based on a Coulomb-like enhancement factor due to the strong interaction among the final state particles. In the framework of this model, it is possible to describe both datasets.

We present the first characterization results of Timespot1, an ASIC designed in CMOS 28 nm technology, featuring a \\(32 \\times 32\\) pixel matrix with a pitch of \\(55 ~ \\mu m\\). Timespot1 is the first small-size prototype, conceived to readout fine-pitch pixels with single-hit time resolution below \\(50 ~ ps_\\text{rms}\\) and input rates of several hundreds of kilohertz per pixel. Such experimental conditions will be typical of the next generation of high-luminosity collider experiments, from the LHC run5 and beyond. Each pixel of the ASIC includes a charge amplifier, a discriminator, and a Time-to-Digital Converter with time resolution indicatively of \\(22.6 ~ ps_\\text{rms}\\) and maximum readout rates (per pixel) of \\(3 ~ MHz\\). To respect system-level constraints, the timing performance has been obtained keeping the power budget per pixel below \\(40 ~ \\mu W\\). The ASIC has been tested and characterised in the laboratory concerning its performance in terms of time resolution, power budget and sustainable rates. The ASIC will be hybridized on a matched \\(32 \\times 32\\) pixel sensor matrix and will be tested under laser beam and Minimum Ionizing Particles in the laboratory and at test beams. In this paper we present a description of the ASIC operation and the first results obtained from characterization tests concerning its performance.

This work presents the first measurements performed on the Timespot1 ASIC. As the second prototype developed for the TimeSPOT project, the ASIC features a 32x32 channels hybrid-pixel matrix. Targeted to space-time tracking applications in High Energy Physics experiments, the system aims to achieve a time resolution of 30 ps or better at a maximum event rate of 3 MHz per channel with a Data Driven interface. Power consumption can be programmed to range between \\(1.2W/cm^{2}\\) and \\(2.6W/cm^{2}\\). The presented results include a description of the ASIC operation and a first characterization of its performance in terms of time resolution.

We present the design and characterization of TIGER (Turin Integrated Gem Electronics for Readout), a 64-channel ASIC developed for the readout of the CGEM (Cylindrical Gas Electron Multiplier) detector, the proposed inner tracker for the 2018 upgrade of the BESIII experiment, carried out at BEPCII in Beijing. Each ASIC channel features a charge sensitive amplifier coupled to a dual-branch shaper stage, optimized for timing and charge measurement, followed by a mixed-mode back-end that extracts and digitizes the timestamp and charge of the input signals. The time-of-arrival is provided by a set of low-power TDCs, based on analogue interpolation techniques, while the charge measurement is obtained either from the Time-over-Threshold information or with a sample-and-hold circuit. The ASIC has been fabricated in a 110 nm CMOS technology and designed to operate with a 1.2 V power supply, an input capacitance of about 100 pF, an input dynamic range between 3 and 50 fC, a power consumption of about 12 mW/channel and a sustained event rate of 60 kHz/channel. The design and test results of TIGER first prototype are presented showing its full functionality.

There are two available set of data on the \\(e^+e^- \\rightarrow \\Lambda^+_c \\bar{\\Lambda}_c^-\\) cross section above threshold. The BELLE measurement, with ISR return, is compatible with the presence of a resonant state, called \\(\\psi(4660)\\) (formerly known as \\(Y(4660)\\)), observed also in other final states. The BESIII dataset has shown a different trend, with a flat cross section. We propose a new solution to fit both datasets by means of a strong correction to the Coulomb enhancement factor. Mass and width of the resonant state is extracted.