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Photo box : bringing the great photographers into focus
'Photobox' presents a collection of 250 photographs by 200 of the world's most prominent photographers, ranging from legendary masters to contemporary stars. Each image is accompanied by an engaging commentary and a brief biography of the photographer.
Book
Mitochondrial Dynamics, ROS, and Cell Signaling: A Blended Overview
Mitochondria are key intracellular organelles involved not only in the metabolic state of the cell, but also in several cellular functions, such as proliferation, Calcium signaling, and lipid trafficking. Indeed, these organelles are characterized by continuous events of fission and fusion which contribute to the dynamic plasticity of their network, also strongly influenced by mitochondrial contacts with other subcellular organelles. Nevertheless, mitochondria release a major amount of reactive oxygen species (ROS) inside eukaryotic cells, which are reported to mediate a plethora of both physiological and pathological cellular functions, such as growth and proliferation, regulation of autophagy, apoptosis, and metastasis. Therefore, targeting mitochondrial ROS could be a promising strategy to overcome and hinder the development of diseases such as cancer, where malignant cells, possessing a higher amount of ROS with respect to healthy ones, could be specifically targeted by therapeutic treatments. In this review, we collected the ultimate findings on the blended interplay among mitochondrial shaping, mitochondrial ROS, and several signaling pathways, in order to contribute to the dissection of intracellular molecular mechanisms involved in the pathophysiology of eukaryotic cells, possibly improving future therapeutic approaches.
Journal Article
Early Detection of Failing Lead-Acid Automotive Batteries Using the Detrended Cross-Correlation Analysis Coefficient
This work introduces a model for lead-acid battery health monitoring in automobiles, focusing on detecting degradation before complete failure. With the proliferation of electronic modules and increasing power demands in vehicles, along with enhanced sensor data availability, this study aims to investigate battery lifespan. Dead batteries often lead to customer dissatisfaction and additional expenses due to inadequate diagnosis. This study seeks to enhance predictive diagnostics and provide drivers with timely warnings about battery health. The proposed method employs the Detrended Cross-Correlation Analysis Coefficient for end-of-life detection by analyzing the cross-correlation of voltage signals from batteries in different states of health. The results demonstrate that batteries with a good state of health exhibit a coefficient consistently within the statistically significant cross-correlation zone across all time scales, indicating a strong correlation with reference batteries over extended time scales. In contrast, batteries with a deteriorated state of health compute a coefficient below 0.3, often falling within the non-significant cross-correlation zone, confirming a clear decline in correlation. The method effectively distinguishes batteries nearing the end of their useful life, offering a low-computational-cost alternative for real-time battery monitoring in automotive applications.
Journal Article
Development and cross-validation of predictive equations for fat-free mass and lean soft tissue mass by bioelectrical impedance in Brazilian women
Background/ObjectivesBioelectrical impedance is one of the most used clinical techniques to assess body composition; however, it is necessary that the available predictive equations are valid for the evaluated subjects. This study aimed to develop and cross-validate equations for fat-free mass (FFM) and lean soft tissue mass (LSTM) by bioelectrical impedance for Brazilian women, in addition to test the validity of other available equations.Subjects/MethodsCross-sectional study with 222 women aged 20–59 years, randomly divided into two groups: development and cross-validation. The standard technique for assessing fat mass, FFM and LSTM was dual energy X-ray absorptiometry. Paired t test, multiple regression, and Bland–Altman plots were used to test the validity of the proposed models, as well as to perform cross-validation of the models.ResultsThe equations derived in this study were: FFM = 16.284 + 0.442 × (Height2/Resistance) − 0.13 × age + 0.302 × Weight − 0.121 × Waist Circumference; r2 = 0.86; SEE = 2.32 kg; and LSTM = 14.732 + 0.427 × (Height2/Resistance) − 0.125 × age + 0.291 × Weight − 0.115 × Waist Circumference; r2 = 0.92; SEE = 2.29 kg. In addition, the new equation for FFM showed better agreement when compared to another equation developed for a Brazilian population.ConclusionsThe newly developed equations provide a valid FFM and LSTM estimation and are recommended for Brazilian women with similar characteristics.
Journal Article
The Role of Imaging in Monitoring Large Vessel Vasculitis: A Comprehensive Review
Giant cell arteritis (GCA) and Takayasu arteritis (TAK) are forms of primary large vessel vasculitis (LVV) affecting the aorta and its major branches. Timely diagnosis and accurate monitoring are essential to prevent irreversible damage. Current assessment strategies rely heavily on symptoms, physical examination, and inflammatory markers, which lack sensitivity and specificity, particularly in patients treated with IL-6 inhibitors. This narrative review provides a comprehensive overview of the role of imaging in monitoring LVV. Ultrasound, magnetic resonance imaging, and positron emission tomography better reflect disease activity and treatment response compared to conventional clinical and laboratory measures. Notably, emerging imaging-based tools such as the OMERACT GCA Ultrasound Score, the Takayasu Ultrasound Index, and the TAK Integrated Disease Activity Index (TAIDAI) are promising treat-to-target instruments. While computed tomography is primarily used to assess structural damage, conventional angiography now plays a more limited role, mainly reserved for procedural planning and haemodynamic evaluation. A key challenge remains: interpreting persistent vascular abnormalities, which may indicate active disease, vascular remodelling, or irreversible damage. Standardisation of imaging protocols and interpretation is needed, alongside further research on the prognostic value of imaging for relapse risk. This review supports a multimodal, patient-tailored approach in which imaging is central to the long-term management of LVV.
Journal Article
Protective effect of calcitriol on rhabdomyolysis-induced acute kidney injury in rats
Glycerol injection in rats can lead to rhabdomyolysis, with the release of the intracellular muscle content to the extracellular compartment and acute kidney injury (AKI). Oxidative stress and the inflammatory processes contribute to the disturbances in renal function and structure observed in this model. This study evaluated the effect of calcitriol administration in AKI induced by rhabdomyolysis and its relationship with oxidative damage and inflammatory process. Male Wistar Hannover rats were treated with calcitriol (6 ng/day) or vehicle (0.9% NaCl) for 7 days and were injected with 50% glycerol or saline 3 days after the beginning of calcitriol or saline administration. Four days after glycerol or saline injection, urine, plasma and renal tissue samples were collected for renal function and structural analysis. The oxidative stress and the inflammatory processes were also evaluated. Glycerol-injected rats presented increased sodium fractional excretion and decreased glomerular filtration rates. These alterations were associated with tubular injury in the renal cortex. These animals also presented increased oxidative damage, apoptosis, inflammation, higher urinary excretion of vitamin D-binding protein and decreased cubilin expression in renal tissue. All these alterations were less intense in calcitriol-treated animals. This effect was associated with decreases in oxidative damage and inflammation.
Journal Article
Evaluation of sugar meal administered anti-Leishmania compounds on the vectorial capacity of the vector, Lutzomyia longipalpis
Multiple strategies involving the parasite-host-vector triad are necessary to control leishmania sis. One option is to prevent or reduce transmission of the pathogen by the phlebotomine sand fly vectors. In this sense, it is essential to explore compounds that may influence the vectorial capacity of the insect and reduce its longevity. We investigated the effect of anti- Leishmania drugs administered via the sugar meal on longevity, blood feeding, oviposition, and parasite load on the third day of infection of the sand flies, to identify the most promising candidates for vector infection tests. We identified compounds that affected the longevity of sand flies (three pterocarpanquinones – LQB-475, LQB-181, and LQ-03; one hydroxyethylpiperazine, PMIC-4, and Pentamidine), reduced oviposition of females after blood feeding (LQB-181 and PMIC-4), but did not decrease infection rates or parasite loads. The results provide the effect of antiparasitic drugs from the perspective of the insect vector.
Journal Article
Efficacy of vitamin D supplementation in gestational diabetes mellitus: Systematic review and meta-analysis of randomized trials
Trials have examined on the benefits of vitamin D supplementation in pregnant women.
This review aimed to evaluate whether oral vitamin D supplements, when given to pregnant women with gestational diabetes mellitus (GDM), would improve maternal and neonatal outcomes, compared with no treatment or placebo.
We performed a systematic review following Cochrane methodology, and randomized trials were included where pregnant women with GDM received vitamin D supplementation versus placebo/no treatment or vitamin D and calcium versus placebo/no treatment. Primary outcomes were preeclampsia, preterm birth, cesarean delivery, gestational hypertension, and adverse events related to vitamin D supplementation. The search strategies were applied to the following databases: MEDLINE, Embase, LILACS, and CENTRAL. Similar outcomes in at least two trials were plotted using Review Manager 5.3 software. The quality of evidence was generated according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE).
The total of 1224 references were identified, eleven trials were potentially eligible, and six were included in this review (totaling 456 women). The meta-analysis of frequency of cesarean deliveries did not show significant differences between groups, none of the trials evaluated the remaining primary outcomes. For secondary outcomes, our results suggest that vitamin D supplementation in pregnant women with GDM may reduce newborn complications such as hyperbilirubinemia, polyhydramnios (RR: 0.40, 95% CI: 0.23 to 0.68; RR: 0.17, 95% CI: 0.03 to 0.89; respectively), and the need for maternal or infant hospitalization (RR: 0.13; 95% CI: 0.02 to 0.98; RR: 0.40, 95% CI: 0.23 to 0.69). However, the evidence was of low or very low quality.
We did not find moderate or high quality evidence indicating that vitamin D supplementation, when compared with placebo, improves glucose metabolism, adverse maternal and neonatal outcomes related to GDM in pregnant women.
Journal Article
Factors associated with normal-weight obesity in adolescents
A new phenotype of obesity has been studied: normal-weight obesity (NWO), which describes individuals with normal-weight by BMI and excess body fat. Despite normal-weight, individuals with NWO have a higher cardiometabolic risk. There is still a gap in the literature on the subject, especially in adolescents, as studies with this population are scarce. This study aims to investigate the sociodemographic factors, family history of chronic non-communicable diseases, body perception, lifestyle and food consumption associated with NWO in adolescents. This is a cross-sectional study, with 506 normal-weight adolescents aged 10–19 years, of both sexes. Weight and height were obtained, and BMI/age was calculated. Body fat analysis was performed using dual-energy X-ray absorptiometry. Sociodemographic data, level of physical activity, food consumption, body self-perception and lifestyle habits were also obtained. Logistic regression with hierarchical approach was used to analyse the associations. The odds of NWO are greater with age (OR = 1·14; 95 % CI = 1·04, 1·26), lower in male adolescents (OR = 0·21; 95 % CI = 0·11, 0·41) and higher in those with a history of familial dyslipidemia (OR = 1·81; 95 % CI = 1·01, 3·28). Adolescents satisfied with their body (OR = 0·30; 95 % CI 0·16, 0·56) and physically active (OR = 0·44; 95 % CI = 0·24, 0·81) have a lower odds of NWO, compared with the others. In addition, it was observed that the odds of NWO is greater among adolescents who use sweeteners (sugar substitutes) (OR = 3·84; 95 % CI = 1·70, 8·65). The factors associated with NWO were female sex, older age, positive family history of dyslipidemia, lower body satisfaction, lower level of physical activity and greater use of sweeteners.
Journal Article