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Chronic pain affects more than 6 million Canadians. Patients need to be involved in setting research priorities to ensure a focus on areas important to those who will be most impacted by the results. The aim of this study was to leverage patient experiences to identify chronic pain research priorities in Canada. The process was informed by the James Lind Alliance. After gathering an exhaustive list of questions using surveys, town hall meetings, interviews, and social media consultations, we used a computerized Delphi with four successive iterations to select the final list of research priorities. The final Delphi round was conducted by a panel of ten patients living with chronic pain and ten clinicians from different disciplines. We received more than 5000 suggestions from 1500 people. The Delphi process led to the identification of 14 questions fitting under the following 4 themes: (1) improving knowledge and competencies in chronic pain; (2) improving patient-centered chronic pain care; (3) preventing chronic pain and reducing associated symptoms; and (4) improving access to and coordination of patient-centered chronic pain care. Challenges included the issue of chronic pain being ubiquitous to many diseases, leading to many initial suggestions focusing on these diseases. We also identified the need for further engagement efforts with marginalized groups in order to validate the priorities identified or identify different sets of priorities specific to these groups. The priorities identified can guide patient-oriented chronic pain research to ultimately improve the care offered to people living with chronic pain.

May I add an audience member's response to that Richard Todd's March 18 review of the opening night of Opera Lyra's Madama Butterfly?

Mr. le Carre's constant theme is the struggle between conflicting values in a world whose currency is deception and betrayal. Here the provenance of both [Barley] and \"Goethe\" are key factors, because \"the courier is the message.\" But in the espionage establishment, Eliot's hollow men are all about, bureaucrats with \"their suburban values all in place\": people like Clive, London's top desk man on the operation, and the \"Mormons\" from the CIA. Shrinks, internal security or both, the \"Mormons\" root out a talented if unconventional man from MI5. Palfrey gives Clive's response to the man's removal, adding his own comment: \"Goethe\" -- so called by friends in the U.S.S.R. to protect his identity -- is a wandering scientist who has talked to Barley of bungled projects, falsified reports to the bureaucrats and saving the world. MI5 need to be convinced about him, and so do the Americans. And so they fly in Barley and his entourage of friends -- the pros from MI5 -- for a debriefing on an island off the coast of Maine. The Americans are skeptical, not only about Barley and whether \"Goethe\" really has reliable information for the West, but also about the contingent from MI5.

[ARTHUR MILLER] was born in 1915. His father, one of a large family, had come to New York from Poland in the 1880s and became a successful businessman. By the time Miller was ready for university, the Depression had forced the Millers out of their comfortable Harlem apartment overlooking Central Park into a tiny house in Brooklyn. Their prosperity, which had allowed dreams of West Point and protected Miller's childhood from the racism and bigotry he would later meet, was gone. So Miller worked his way through the University of Michigan without financial help from home. Then, in 1944, came Miller's first Broadway production, The Man Who Had All The Luck. After its very brief run, Miller published nothing for three years beyond his only novel, Focus. In 1947 All My Sons appeared. With this Broadway production, about an industrialist who sells defective airplane parts to the army, Miller established his name, winning the Drama Critics Circle Award and a \"new freedom to create.\" But it also drove Miller, like Tolstoy before him, to take a menial job in a beer-box factory, feeling his identification with life's failures menaced by his success. The job lasted a week. Since 1962, Miller has been married to Inge Morath, an Austrian photographer who survived the Nazis and later worked with Cartier- Bresson and Gjon Mili; and in describing the impassioned arguments between Inge's mentors, Miller introduces some of the endless, elusive humor with which Timebends is leavened. Inge is the mother of Miller's youngest child, Rebecca. In the final part of Timebends Miller says, \"Marriage is a case of mutual forgiveness.\" Time has perhaps tempered idealism.

[KNOWLTON NASH]'s appointment as anchor gave rise to much public misapprehension as well as a long drawn-out union grievance over the hiring of a journalist as an announcer. The grievance was overturned by the strength of the CBC's case that journalistic background is essential for the demands of the job. However, public misapprehensions remain, not only about Nash's appointment, but also about Lloyd Robertson's departure to CTV and Peter Kent's return to overseas reporting after barely two years as anchor. Nash carefully documents each event to straighten the record.

We went on the early evening of Aug. 28, when the elements roared and battered the tent fitter for a rehearsal of The Tempest.

In the debate over the role of health practitioners in inadvertently contributing to opioid abuse, surely one player is getting off far too easily (Pain, Killer--editorial, Oct. 7). If prescription drug companies were forced to act more responsibly in informing...

Low-passage, serum-free cell lines cultured from patient tumour tissue are the gold-standard for preclinical studies and cellular investigations of glioblastoma (GBM) biology, yet entrenched, poorly-representative cell line models are still widely used, compromising the significance of much GBM research. We submit that greater adoption of these critical resources will be promoted by the provision of a suitably-sized, meaningfully-described reference collection along with appropriate tools for working with them. Consequently, we present a curated panel of 12 readily-usable, genetically-diverse, tumourigenic, patient-derived, low-passage, serum-free cell lines representing the spectrum of molecular subtypes of IDH-wildtype GBM along with their detailed phenotypic characterisation plus a bespoke set of lentiviral plasmids for bioluminescent/fluorescent labelling, gene expression and CRISPR/Cas9-mediated gene inactivation. The cell lines and all accompanying data are readily-accessible via a single website, Q-Cell (qimrberghofer.edu.au/q-cell/) and all plasmids are available from Addgene. These resources should prove valuable to investigators seeking readily-usable, well-characterised, clinically-relevant, gold-standard models of GBM.