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"Robinson, Emily"
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Public knowledge, attitudes, social distance and reporting contact with people with mental illness 2009–2017
Our aim was to investigate patterns of change in public knowledge, attitudes, desire for social distance and reporting having contact with people with mental health problems in England during the Time to Change (TTC) programme to reduce stigma and discrimination 2009-2017.
Using data from an annual face-to-face survey of a nationally representative quota sample of adults, we evaluated longitudinal trends of the outcome measures with regression analyses and made assumptions on the basis of a simple random sample. We tested interactions between year and demographic subgroups.
There were improvements in all outcomes in 2017 compared with baseline measures (2008 or 2009). Reported in s.d. units [95% confidence interval (CI)], the improvement for knowledge was 0.17 (0.10-0.23); for attitudes 0.25 (0.18-0.31); and for social distance 0.29 (0.23-0.35). A higher likelihood of reporting contact was also associated with most recent survey year (odds ratio 1.47, 95% CI 1.27-1.71). Statistically significant interactions between year and region of England suggest greatest improvements in attitudes and intended behaviour in London, where both outcomes were significantly worse in the early years of the survey. However, for attitudes, this interaction was only significant among women. Other significant interactions suggest that attitudes improved most in the target age group (25-44).
The results provide support for the effectiveness of TTC across demographic groups. However, other societal changes may influence the results, such as the increasing prevalence of common mental disorder in young women.
Journal Article
Shaking things up : 14 young women who changed the world
This poetic and visual picture book celebrates persistent women throughout history.
BOOK
meta‐analytical review of the effects of elevated CO2 on plant–arthropod interactions highlights the importance of interacting environmental and biological variables
CONTENTS: Summary 321 I. Introduction 322 II. Methods 323 III. Herbivore responses to elevated CO2 328 IV. Plant responses 329 V. Searching for general responses to elevated CO2 332 VI. Limitations and future studies 334 Acknowledgements 335 References 335 SUMMARY: We conducted the most extensive meta‐analysis of plant and animal responses to elevated CO2 to date. We analysed > 5000 data points extracted from 270 papers published between 1979 and 2009. We examined the changes in 19 animal response variables to the main effect of elevated CO2. We found strong evidence for significant variation among arthropod orders and feeding guilds, including interactions in the direction of response. We also examined the main effects of elevated CO2 on: six plant growth and allocation responses, seven primary metabolite responses, eight secondary metabolite responses, and four physical defence responses. We examined these response variable changes under two‐way and three‐way interactions between CO2 and: soil nitrogen, ambient temperature, drought, light availability, photosynthetic pathway, reproductive system, plant growth rate, plant growth form, tissue type, and nitrogen fixation. In general we found smaller effect sizes for many response variables than have been previously reported. We also found that many of the oft‐reported main effects of CO2 obscure the presence of significant two‐ and three‐way interactions, which may help better explain the relationships between the response variables and elevated CO2.
Journal Article
Mental illness stigma after a decade of Time to Change England: inequalities as targets for further improvement
Abstract
Background
England’s Time to Change programme to reduce mental health-related stigma and discrimination included a social marketing campaign using traditional and social media, and targeted middle-income groups aged 25–45 between 2009 and 2016. From 2017, the same age group on low to middle incomes were targeted, and the content focused on men’s mental health, by changing the advertising and adapting the ‘key messages’. This study investigates changes in stigma-related public knowledge, attitudes and desire for social distance in England since Time to Change began in 2008–19 and for 2017–19.
Methods
Using data from a face-to-face survey of a nationally representative quota sample of adults for England, we evaluated longitudinal trends in outcomes with regression analyses and made assumptions based on a simple random sample. The pre-existing survey used a measure of attitudes; measures of knowledge and desire for social distance were added in 2009.
Results
Reported in standard deviation units (95% CI), the improvement for knowledge for 2009–19 was 0.25 (0.19, 0.32); for attitudes, 2008–19, 0.32 (0.26, 0.39) and for desire for social distance, 2009–19 0.29 (0.23, 0.36). Significant interactions between year and both region and age suggest greater improvements in London, where stigma is higher, and narrowing of age differences. There were significant improvements between 2017 and 2019 in knowledge [0.09 (0.02, 0.16)] and attitudes [0.08 (0.02, 0.14)] but not social distance.
Conclusion
The positive changes support the effectiveness of Time to Change but cannot be definitively attributed to it. Inequalities in stigma by demographic characteristics present targets for research and intervention.
Journal Article
Functional movement disorder gender, age and phenotype study: a systematic review and individual patient meta-analysis of 4905 cases
Functional movement disorder (FMD) is a common manifestation of functional neurological disorder presenting with diverse phenotypes such as tremor, weakness and gait disorder. Our current understanding of the basic epidemiological features of this condition is unclear. We aimed to describe and examine the relationship between age at onset, phenotype and gender in FMD in a large meta-analysis of published and unpublished individual patient cases. An electronic search of PubMed was conducted for studies from 1968 to 2019 according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Individual patient data were collected through a research network. We described the distribution of age of onset and how this varied by gender and motor phenotype. A one-stage meta-analysis was performed using multilevel mixed-effects linear regression, including random intercepts for country and data source. A total of 4905 individual cases were analysed (72.6% woman). The mean age at onset was 39.6 years (SD 16.1). Women had a significantly earlier age of onset than men (39.1 years vs 41.0 years). Mixed FMD (23.1%), tremor (21.6%) and weakness (18.1%) were the most common phenotypes. Compared with tremor (40.7 years), the mean ages at onset of dystonia (34.5 years) and weakness (36.4 years) were significantly younger, while gait disorders (43.2 years) had a significantly later age at onset. The interaction between gender and phenotype was not significant. FMD peaks in midlife with varying effects of gender on age at onset and phenotype. The data gives some support to ‘lumping’ FMD as a unitary disorder but also highlights the value in ‘splitting’ into individual phenotypes where relevant.
Journal Article
Characterizing the sublethal effects of SmartStax PRO dietary exposure on life history traits of the western corn rootworm, Diabrotica virgifera virgifera LeConte
The western corn rootworm (WCR), Diabrotica virgifera virgifera LeConte, is an economically important pest of field corn ( Zea mays L.) across the United States (U.S.) Corn Belt. Repeated use of transgenic hybrids expressing Bacillus thuringiensis (Bt) proteins has selected for field-evolved resistance to all current rootworm-active Bt proteins. The newest product available for WCR management is SmartStax ® PRO, a rootworm-active pyramid containing Cry3Bb1, Cry34/35Ab1 [now reclassified as Gpp34Ab1/Tpp35Ab1] and a new mode of action, DvSnf7 dsRNA. Understanding the fitness of adult WCR after dietary exposure to SmartStax ® PRO will identify potential impacts on WCR population dynamics and inform efforts to optimize resistance management strategies. Therefore, the objective of the present study was to characterize the effect of SmartStax ® PRO dietary exposure on WCR life history traits. Adult WCR were collected during 2018 and 2019 from emergence tents placed over replicated field plots of SmartStax ® PRO or non-rootworm Bt corn at a site with a history of rootworm-Bt trait use and suspected resistance to Cry3Bb1 and Cry34/35Ab1. Adult survival was reduced by 97.1–99.7% in SmartStax ® PRO plots relative to the non-rootworm Bt corn plots during the study. Individual male/female pairs were fed different diets of ear tissue to simulate lifetime or adult exposure. Life history parameters measured included adult longevity, adult head capsule width, lifetime female egg production, and egg viability. Results indicate that lifetime or adult exposure to SmartStax ® PRO significantly reduced adult longevity and lifetime egg production. Larval exposure to SmartStax ® PRO significantly reduced WCR adult size. Results from this study collectively suggest that SmartStax ® PRO may negatively impact WCR life history traits, which may lead to reduced population growth when deployed in an area with WCR resistance to Bt traits.
Journal Article
Detection of Feigned ADHD across Two Domains: The MMPI-2-RF and CAARS for Faked Symptoms and TOVA for Simulated Attention Deficits
Psychological assessments of Attention Deficit/Hyperactivity Disorder (ADHD) must consider possible feigning of ADHD symptoms and simulated deficits on attentional measures. Studies have consistently found that motivated examinees can easily feign ADHD with little research focused on its detection. Via a between-subjects simulation design, the current study investigated the MMPI-2-RF and the Conners Infrequency Index (CII) in a university sample by comparing four groups: feigned ADHD, feigned mental disorders, genuine ADHD, and non-ADHD controls. Encouragingly, the CII evidenced moderate discriminability between feigned ADHD and (a) genuine ADHD (d = 0.97) as well as (b) feigned mental disorders (d = 0.96). Because the MMPI-2-RF F-family scores did not differentiate ADHD feigners from other feigners or genuine ADHD, a Dissimulation (Ds) ADHD (Ds-ADHD) scale was developed by utilizing erroneous stereotypes as the detection strategy. While requiring cross-validation, the initial data demonstrated good discriminant validity in distinguishing feigned ADHD from both genuine ADHD and general feigning. As noted in the Discussion, ADHD assessments must systematically take into account examinees’ level of effort and actively evaluate the possibility of feigned ADHD.
Journal Article
Circulating Interleukin-6 and CD16 positive monocytes increase following angioplasty of an arteriovenous fistula
Arteriovenous fistulas are the ideal form of vascular access that allows provision of haemodialysis. Stenotic lesions caused by neointimal hyperplasia commonly occur resulting in patients requiring a fistuloplasty. This is effective but there is a high recurrence rate. We sought to investigate the effects of a fistuloplasty on monocyte populations. Blood samples were taken from patients before and after their fistuloplasty procedure. Samples were analysed using flow cytometry, ELISA and Luminex assays. Univariate cox regression was carried out to investigate associations with post fistuloplasty patency. At 1–2 days post fistuloplasty, the proportion of classical (CD14++CD16−) monocytes decreased (
p
< 0.001), whilst intermediate (CD14++CD16+) and non-classical (CD14+CD16+) monocytes increased (both
p
< 0.01) in a cohort of 20 patients. A time course study carried out in 5 patients showed that this was due to an increase in absolute numbers of non-classical and intermediate monocytes. Higher levels of non-classical monocytes pre-fistuloplasty were associated with an increased risk for patency loss (
p
< 0.05). We measured 41 soluble factors in plasma samples taken before a fistuloplasty in 54 patients, with paired post-fistuloplasty samples (1–2 days) available in 30 patients. After correcting for false discovery, the only factor with a significant change in level was IL-6 (
P
= 0.0003, q = 0.0124). In a further time-course study in 6 patients, peak level of IL-6 occurred 2–3 h post fistuloplasty. This study demonstrates that there is a systemic inflammatory response to the fistuloplasty procedure and that monocyte subsets and IL-6 may be important in the pathophysiology of restenosis.
Journal Article