Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
1,715
result(s) for
"Robinson, Michelle"
Sort by:
How to wash a woolly mammoth
\"Follow this step-by-step guide to successfully clean up your hairy friend. But be forewarned. A mammoth's tummy is terribly tickly\"-- Provided by publisher.
Book
Different dose regimens of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373) in younger and older adults: A phase 2 randomized placebo-controlled trial
NVX-CoV2373 is a recombinant severe acute respiratory coronavirus 2 (rSARS-CoV-2) nanoparticle vaccine composed of trimeric full-length SARS-CoV-2 spike glycoproteins and Matrix-M1 adjuvant. The phase 2 component of our randomized, placebo-controlled, phase 1 to 2 trial was designed to identify which dosing regimen of NVX-CoV2373 should move forward into late-phase studies and was based on immunogenicity and safety data through Day 35 (14 days after the second dose). The trial was conducted at 9 sites in Australia and 8 sites in the United States. Participants in 2 age groups (aged 18 to 59 and 60 to 84 years) were randomly assigned to receive either 1 or 2 intramuscular doses of 5-[mu]g or 25-[mu]g NVX-CoV2373 or placebo, 21 days apart. Primary endpoints were immunoglobulin G (IgG) anti-spike protein response, 7-day solicited reactogenicity, and unsolicited adverse events. A key secondary endpoint was wild-type virus neutralizing antibody response. After enrollment, 1,288 participants were randomly assigned to 1 of 4 vaccine groups or placebo, with 1,283 participants administered at least 1 study treatment. Of these, 45% were older participants 60 to 84 years. Reactogenicity was predominantly mild to moderate in severity and of short duration (median <3 days) after first and second vaccination with NVX-CoV2373, with higher frequencies and intensity after second vaccination and with the higher dose. Reactogenicity occurred less frequently and was of lower intensity in older participants. Both 2-dose regimens of 5-[mu]g and 25-[mu]g NVX-CoV2373 induced robust immune responses in younger and older participants. For the 2-dose regimen of 5 [mu]g, geometric mean titers (GMTs) for IgG anti-spike protein were 65,019 (95% confidence interval (CI) 55,485 to 76,192) and 28,137 (95% CI 21,617 to 36,623) EU/mL and for wild-type virus neutralizing antibody (with an inhibitory concentration of 50%-MN.sub.50%) were 2,201 (95% CI 1,343 to 3,608) and 981 (95% CI 560 to 1,717) titers for younger and older participants, respectively, with seroconversion rates of 100% in both age groups. Neutralizing antibody responses exceeded those seen in a panel of convalescent sera for both age groups. Study limitations include the relatively short duration of safety follow-up to date and current lack of immune persistence data beyond the primary vaccination regimen time point assessments, but these data will accumulate over time. The study confirmed the phase 1 findings that the 2-dose regimen of 5-[mu]g NVX-CoV2373 is highly immunogenic and well tolerated in younger adults. In addition, in older adults, the 2-dose regimen of 5 [mu]g was also well tolerated and showed sufficient immunogenicity to support its use in late-phase efficacy studies.
Journal Article
What to do if an elephant stands on your foot
Advises the reader on how to handle encounters with various animals in the jungle, where a mistake while avoiding one can attract the attention of another.
Book
Approaching Equality? Media Treatment of Male and Female Members of Presidential Cabinets in a Cross-Country Comparison
Generalizability of extant findings about media treatment of women in politics is uncertain because most research examines candidates for the legislature or heads of government, and little work moves beyond Anglo-American countries. We examine six presidential cabinets in Costa Rica, Uruguay, and the United States, which provide differing levels of women’s incorporation into government. These cases permit us to test hypotheses arguing that differences in media treatment of men and women cabinet ministers will decrease as women’s inclusion in government expands, and that media treatment of women is more critical when women head departments associated with masculine gender stereotypes. Results show that greater incorporation of women into government is associated with fewer gendered differences in media coverage, tone of minister coverage is more favorable for women who hold masculine stereotyped portfolios, and that the media does present qualifications of women cabinet ministers.
Journal Article
The pawed piper
\"A small girl wants a cat of her very own: a furry fluffball to cuddle, just like the one in her book or her grandmother's cat, Hector. So she lays a trail: balls of wool, saucers of milk, cardboard boxes, and anything else that could lure a feline friend. And who should arrive the next morning but somebody furry, warm, soft, and so very purry. It's Hector, along with dozens of other cats. The girl is happy as can be, but when LOST CAT posters show up all over town, she realizes her plan might have worked a little too well\"--Provided by publisher.
Book
Women Ministers in Latin American Government: When, Where, and Why?
We examine factors that affect the supply of and demand for female cabinet ministers in Latin America and seek to understand the frequency with which women join cabinets and the types of portfolios women receive. Our analysis covers 18 Latin American democracies from 1980 to 2003. We find that presidents from parties of the left appoint more women. Increases in the percentage of women in the legislature and higher human development correlate with more women in the cabinet. Intense partisan competition increases the likelihood that a cabinet will contain a woman. Women are more likely to receive high-prestige cabinet posts from leftist presidents and when the percentage of women in the legislature increases. In addition, an international diffusion effect appears to explain the rapid expansion of women in Latin American cabinets.
Journal Article
Tooth fairy in training
\"Tate's tooth-fairy training starts today, and her big sister, May, is taking her out on her very first tooth-collecting mission. After practicing at home, Tate is ready to test her skills, and May leads her to their first stop: a herd of hippos in a lake! After all, human children aren't the only young creatures that lose their teeth. In fact, being a tooth fairy is a dangerous job, and Tate must visit all kinds of toothy predators before the night is up. Will she be able to collect the teeth from narwhals, anacondas, and more--all without waking a single creature?\"-- Provided by publisher.
Book
Direct Identification of Tyrosine Sulfation by using Ultraviolet Photodissociation Mass Spectrometry
Sulfation is a common post-translational modification of tyrosine residues in eukaryotes; however, detection using traditional liquid chromatography-mass spectrometry (LC-MS) methods is challenging based on poor ionization efficiency in the positive ion mode and facile neutral loss upon collisional activation. In the present study, 193 nm ultraviolet photodissociation (UVPD) is applied to sulfopeptide anions to generate diagnostic sequence ions, which do not undergo appreciable neutral loss of sulfate even using higher energy photoirradiation parameters. At the same time, neutral loss of SO
3
is observed from the precursor and charge-reduced precursor ions, a spectral feature that is useful for differentiating tyrosine sulfation from the nominally isobaric tyrosine phosphorylation. LC-MS detection limits for UVPD analysis in the negative mode were determined to be around 100 fmol for three sulfated peptides, caerulein, cionin, and leu-enkephalin. The LC-UVPD-MS method was applied for analysis of bovine fibrinogen, and its key sulfated peptide was confidently identified.
Figure
ᅟ
Journal Article
And the robot went ...
\"In this cumulative tale, a group of animals assembles a robot\"-- Provided by publisher.
Book
Safety and immunogenicity of a plant-derived rotavirus-like particle vaccine in adults, toddlers and infants
•Non-replicating rotavirus-like particle (Ro-VLP) vaccine was produced in plants.•The first clinical trial was conducted in healthy adults, toddlers and infants.•Ro-VLP vaccine was well-tolerated in all age groups tested.•Ro-VLP vaccine demonstrated an encouraging immunogenicity in infants.
This study is the first clinical trial for a parenteral non-replicating rotavirus vaccine developed using virus-like particle (VLP) technology.
This open-labeled, randomized, placebo-controlled trial was conducted in two parts: Part A (a first-in-human study in Australian adults) and Part B (ascending dose and descending age in South African adults, toddlers and infants). In Part A, two cohorts of 10 adults were assigned to receive a single intramuscular injection of 1 of 2 escalating dose levels of the rotavirus VLP (Ro-VLP) vaccine (7 μg or 21 μg) or placebo. In Part B, one cohort of 10 adults was assigned to receive a single injection of the Ro-VLP vaccine (21 μg) or placebo, two cohorts of 10 toddlers were assigned to receive 2 injections of 1 of 2 escalating dose levels of the Ro-VLP vaccine (7 μg or 21 μg) or placebo 28 days apart, and three cohorts of 20 infants were assigned to receive 3 injections of 1 of 3 escalating dose levels of the Ro-VLP vaccine (2.5 μg, 7 μg or 21 μg) or placebo or 2 doses of oral Rotarix 28 days apart. Safety, reactogenicity and immunogenicity were assessed.
There were no safety or tolerability concerns after administration of the Ro-VLP vaccine. The Ro-VLP vaccine induced an anti-G1P[8] IgG response in infants 4 weeks after the second and third doses. Neutralizing antibody responses against homologous G1P[8] rotavirus were higher in all Ro-VLP infant groups than in the placebo group 4 weeks after the third dose. No heterotypic immunity was elicited by the Ro-VLP vaccine.
The Ro-VLP vaccine was well tolerated and induced a homotypic immune response in infants, suggesting that this technology platform is a favorable approach for a parenteral non-replicating rotavirus vaccine.
Clinical Trial Registration: NCT03507738.
Journal Article