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Non-Technical SummaryThis article takes stock of the 2030 Agenda and focuses on five governance areas. In a nutshell, we see a quite patchy and often primarily symbolic uptake of the global goals. Although some studies highlight individual success stories of actors and institutions to implement the goals, it remains unclear how such cases can be upscaled and develop a broader political impact to accelerate the global endeavor to achieve sustainable development. We hence raise concerns about the overall effectiveness of governance by goal-setting and raise the question of how we can make this mode of governance more effective.Technical SummaryA recent meta-analysis on the political impact of the Sustainable Development Goals (SDGs) has shown that these global goals are moving political processes forward only incrementally, with much variation across countries, sectors, and governance levels. Consequently, the realization of the 2030 Agenda for Sustainable Development remains uncertain. Against this backdrop, this article explores where and how incremental political changes are taking place due to the SDGs, and under what conditions these developments can bolster sustainability transformations up to 2030 and beyond. Our scoping review builds upon an online expert survey directed at the scholarly community of the ‘Earth System Governance Project’ and structured dialogues within the ‘Taskforce on the SDGs’ under this project. We identified five governance areas where some effects of the SDGs have been observable: (1) global governance, (2) national policy integration, (3) subnational initiatives, (4) private governance, and (5) education and learning for sustainable development. This article delves deeper into these governance areas and draws lessons to guide empirical research on the promises and pitfalls of accelerating SDG implementation.Social Media SummaryAs SDG implementation lags behind, this article explores 5 governance areas asking how to strengthen the global goals.

Civil society organizations (CSOs) are shaping the formation of a bottom-up regionality in the context of the 2030 Agenda implementation. Using the Latin America and Caribbean (LAC) region as a case, this article unravels the pivotal role they play in the diffusion and incorporation of the Sustainable Development Goals. Drawing from qualitative content analysis of official documents, critical discourse analysis of primary and secondary sources, and semi-structured interviews, we understand CSOs as institutional entrepreneurs with specific motivations to engage and influence the regional governance process. While many challenges persist, civil society organizations are shaping 2030 Agenda implementation in LAC.

Assess biocompatibility, uptake and photodynamic therapy (PDT) mechanism of metallated porphyrin doped conjugated polymer nanoparticles (CPNs) in human brain and colorectal tumor cells and macrophages. CPNs were developed employing 9,9-dioctylfluorene- -benzothiadiazole, an amphiphilic polymer (PS-PEG-COOH), and platinum octaethylporphyrin. T98G, SW480 and RAW 264.7 cell lines were exposed to CPNs to assess uptake and intracellular localization. Additionally, a PDT protocol using CPNs was employed for the killing of cancer and macrophage cell lines. CPNs were well incorporated into glioblastoma and macrophage cells with localization in lysosomes. SW480 cells were less efficient incorporating CPNs with localization in the plasma membrane. In all cell lines PDT treatment was efficient inducing oxidative stress that triggered apoptosis.

Shrubs can have a net positive effect on the recruitment of other species, especially relict species in dry-stressful conditions. We tested the effects of nurse shrubs and herbivory defoliation on performance (survival and growth) of nursery-grown seedlings of the largest living palm, the relict wine palm Jubaea chilensis. During an 18-month period, a total of more than 300 seedlings were exposed to of four possible scenarios produced by independently weakening the effects of nurse shrubs and browsers. The experiment followed a two-way fully factorial design. We found consistent differences in survival between protected and unprotected seedlings (27.5% and 0.7%, respectively), and herbivory had a dramatic and overwhelmingly negative effect on seedling survival. The invasive rabbit (Oryctolagus cuniculus) is clearly creating a critical bottleneck in the regeneration process and might, therefore, partially explain the general lack of natural regeneration of wine palms under natural conditions. Apparently biotic filters mediated by ecological interactions are more relevant in the early stages of recruitment than abiotic, at least in invaded sites of central Chile. Our data reveal that plant-plant facilitation relationship may be modulated by plant-animal interactions, specifically by herbivory, a common and widespread ecological interaction in arid and semi-arid environments whose role has been frequently neglected. Treatments that protect young wine palm seedlings are mandatory to enable the seedlings to attain a height at which shoots are no longer vulnerable to browsing. Such protection is an essential first step toward the conservation and reintroduction of this emblematic and threatened species.

We examined the role of microRNAs (miRNAs) in targeting the stromal-derived factor 1α/CXCR4 (SDF-1α/CXCR4) axis to overcome chemoresistance of AML cells. Microarray analysis of OCI-AML3 cells revealed that the miRNA let-7a was downregulated by SDF-1α-mediated CXCR4 activation and increased by CXCR4 inhibition. Overexpression of let-7a in AML cell lines was associated with decreased c-Myc and BCL-XL protein expression and enhanced chemosensitivity, both in vitro and in vivo. We identified the transcription factor Yin Yang 1 (YY1) as a link between SDF-1α/CXCR4 signaling and let-7a, as YY1 was upregulated by SDF-1α and downregulated by treatment with a CXCR4 antagonist. ChIP assay confirmed the binding of YY1 to unprocessed let-7a DNA fragments, and treatment with YY1 shRNA increased let-7a expression. In primary human AML samples, high CXCR4 expression was associated with low let-7a levels. Xenografts of primary human AML cells engineered to overexpress let-7a exhibited enhanced sensitivity to cytarabine, resulting in greatly extended survival of immunodeficient mice. Based on these data, we propose that CXCR4 induces chemoresistance by downregulating let-7a to promote YY1-mediated transcriptional activation of MYC and BCLXL in AML cells.