Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
10,051
result(s) for
"Rodrigues, José"
Sort by:
المعادلة الإلهية : رواية
\"المعادلة الإلهية\" هو استغراقه في النظريات العلمية الأكثر أهمية في تاريخ تطور العلوم، لا سيما تلك التي وضعها آينشتاين ونيوتن. ف \"المعادلة الإلهية\" هي كناية عن نص روائي يسرد فيه الكاتب أكثر النظريات دقة وتعقيدا. حاولت تلك النظريات تفكيك لغز الكون وبدايات تشكله ومن ثم تطوره وصولا إلى نهايته أو تكرار تشكله إلى ما لا نهاية. وهو أمر تطرقت إليه الأديان السماوية والوضعية ولكن من خلال دلالات رمزية ودروب استندت إلى الغيبية الميتافيزيقية والإيمان بأن ثمة خالقا لهذا الكون. تفسير لغز النشوء الكوني يتراوح في هذه الرواية الممتعة علميا وفلسفيا بين الأدلة العلمية والدلالات الدينية الرمزية لقصة الخلق.
Book
Photodynamic Therapy Review: Principles, Photosensitizers, Applications, and Future Directions
Photodynamic therapy (PDT) is a minimally invasive therapeutic modality that has gained great attention in the past years as a new therapy for cancer treatment. PDT uses photosensitizers that, after being excited by light at a specific wavelength, react with the molecular oxygen to create reactive oxygen species in the target tissue, resulting in cell death. Compared to conventional therapeutic modalities, PDT presents greater selectivity against tumor cells, due to the use of photosensitizers that are preferably localized in tumor lesions, and the precise light irradiation of these lesions. This paper presents a review of the principles, mechanisms, photosensitizers, and current applications of PDT. Moreover, the future path on the research of new photosensitizers with enhanced tumor selectivity, featuring the improvement of PDT effectiveness, has also been addressed. Finally, new applications of PDT have been covered.
Journal Article
رجل القسطنطينية : رواية
\"في التجارة، كما في الحب، كل شيء مباح\" هذا أحد المبادئ التي امتثل بها \"رجل القسطنطينية\" الذي ولد في إمبراطورية عثمانية منهكة وأصبح، بفضل حبه للمغامرة وقوة طموحه، من أغنى رجال العالم وأكثرهم نفوذا. تستمد هذه الرواية الرائعة مادتها من أحداث حقيقية وتحكي المسيرة المدهشة لهذا المغامر، الدبلوماسي، رجل الأعمال وعاشق الفنون، وتبوح لنا بسر ارتقائه الهائل، وتأخذنا معه عبر أزقة بازار إسطنبول المتعرجة، إلى أولى حقول النفط في الشرق الأوسط، مرورا بمارسيليا، لندن، وباريس... حيث نصادف شخصيات من قبيل إيمانويل نوبل، سيزار ريتز وونستون تشرشل، كما نعيش معه بعض الاضطرابات التاريخية ونتلقى، مفتونين، درسا لا يفنى : المعرفة هي القوة. هذا الدرس الجميل في الحياة والتاريخ يضعنا أيضا أمام مسألة لطالما أزقت \"رجل القسطنطينية\" وطرحها سؤالا وهو على فراش الموت : ما هو الجمال؟. فلنسافر، إذا، في هذا العالم من الجمال ولنكتشف العالم العجيب للكاتب البرتغالي جوزيه رودريغيش دوس سانتوس الذي يعد من أعظم كتاب الرواية في الأدب العالمي الحديث، والملقب عن حق ب \"دان براون البرتغالي\".
Book
Photodynamic Therapy for Colorectal Cancer: An Update and a Look to the Future
This review provides an update on the current state of photodynamic therapy (PDT) for colorectal cancer (CRC) and explores potential future directions in this field. PDT has emerged as a promising minimally invasive treatment modality that utilizes photosensitizers and specific light wavelengths to induce cell death in targeted tumor tissues. In recent years, significant progress has been made in understanding the underlying mechanisms, optimizing treatment protocols, and improving the efficacy of PDT for CRC. This article highlights key advancements in PDT techniques, including novel photosensitizers, light sources, and delivery methods. Furthermore, it discusses ongoing research efforts and potential future directions, such as combination therapies and nanotechnology-based approaches. By elucidating the current landscape and providing insights into future directions, this review aims to guide researchers and clinicians in harnessing the full potential of PDT for the effective management of CRC.
Journal Article
Enhanced Photodynamic Therapy: A Review of Combined Energy Sources
Photodynamic therapy (PDT) has been used in recent years as a non-invasive treatment for cancer, due to the side effects of traditional treatments such as surgery, radiotherapy, and chemotherapy. This therapeutic technique requires a photosensitizer, light energy, and oxygen to produce reactive oxygen species (ROS) which mediate cellular toxicity. PDT is a useful non-invasive therapy for cancer treatment, but it has some limitations that need to be overcome, such as low-light-penetration depths, non-targeting photosensitizers, and tumor hypoxia. This review focuses on the latest innovative strategies based on the synergistic use of other energy sources, such as non-visible radiation of the electromagnetic spectrum (microwaves, infrared, and X-rays), ultrasound, and electric/magnetic fields, to overcome PDT limitations and enhance the therapeutic effect of PDT. The main principles, mechanisms, and crucial elements of PDT are also addressed.
Journal Article
Photon bubble turbulence in cold atom gases
Turbulent radiation flow is commonplace in systems with strong, incoherent, light-matter interactions. In astrophysical contexts, photon bubble turbulence is considered a key mechanism behind enhanced radiation transport, and its importance has been widely asserted for a variety of high energy objects such as accretion disks and massive stars. Here, we show that analogous conditions to those of dense astrophysical objects can be obtained in large clouds of cold atoms, prepared in a laser-cooling experiment, driven close to a sharp electronic resonance. By accessing the spatially-resolved atom density, we are able to identify a photon bubble instability and the resulting regime of photon bubble turbulence. We also develop a theoretical model describing the coupled dynamics of both photon and atom gases, which accurately describes the statistical properties of the turbulent regime. This study thus opens the possibility of simulating radiation-dominated astrophysical systems in cold atom experiments.
Photon bubble turbulence is an astrophysical phenomenon involving radiation transport. Here, the authors report analogous behavior in ultracold gas by observing signatures of photon bubble instabilities in Rb atoms trapped in a MOT.
Journal Article
A Quantitative Evaluation of the Influence of Chemical Variables of Biomasses of Poplar SRC Commercial Clones in Torrefaction
This study aimed to evaluate the influence in torrefaction of the chemical structure of biomasses from nine poplar commercial SRC clones, evaluated through analytical pyrolysis. The chemical data were integrated into a dataset including LHV gain, representative of torrefaction aptitude and six chemical variables obtained through analytical pyrolysis, which were: (i) CH2Cl2 extractives; (ii) total extractives; (iii) Py-lignin; (iv) holocellulose; (v) (syringil/guaiacyl) ratio; and (vi) (pentosan/hexosan) ratio. Significant univariate and bivariate linear relations were obtained with LHV gain from torrefaction as dependent variable vs. Py-lignin, CH2Cl2 extractives and (cP/cH) ratio. Representative results were: (i) a negative correlation of −0.82 and −0.76 between LHV gain and the (pentosan/hexosan) ratio and Py-lignin, respectively, and (ii) a positive correlation of 0.79 between LHV gain and CH2Cl2 extractive amounts. Factorial and discriminant analysis allowed for clustering the tested clones in three groups, evidencing relevant influences of (S/G) ratio, Py-lignin, and, to a lesser extent, (cP/cH) ratio in the classification of these groups, clearly showing the impact of chemical variables of feedstock in torrefaction. The results contribute: (i) to the validation of use of the expedite analytical pyrolysis technique for classification of biomasses in accordance with their torrefaction aptitude and, thereby, (ii) to optimizing strategies in technological issues as diverse as poplar clone genetic breeding and modeling biomass torrefaction and pyrolysis.
Journal Article
Improvement of Sugarcane Stillage (Vinasse) Anaerobic Digestion with Cheese Whey as its Co-substrate: Achieving High Methane Productivity and Yield
This study investigated methane production in an anaerobic sequencing batch biofilm reactor (AnSBBR) by co-digesting sugarcane vinasse and cheese whey. The assessment was based on the influence of feed strategy, interaction between cycle time and influent concentration, applied volumetric organic load (OLR
A
), and temperature over system stability and performance. The system showed flexibility with regard to the feed strategy, but the reduction of cycle time and influent concentration, at the same OLR
A
, resulted in lower methane productivity. Increasing organic load, up to the value of 15.27 gCOD L
−1
day
−1
, favored the process, increasing methane yield and productivity. Temperature reduction from 30 to 25 °C resulted in worse performance, although increasing it to 35 °C provided similar results to 30 °C. The best results were achieved at an OLR
A
of 15.27 gCOD L
−1
day
−1
, cycle time of 8 h, fed-batch operation, and temperature of 30 °C. The system achieved soluble COD removal efficiency of 89%, methane productivity of 208.5 molCH
4
m
−3
day
−1
and yield of 15.76 mmolCH
4
gCOD
−1
. The kinetic model fit indicated methanogenesis preference for the hydrogenotrophic route. At the industrial scale estimative, considering a scenario with a sugarcane ethanol plant with ethanol production of 150,896 m
3
year
−1
, it was estimated energy production of 25,544 MWh month
−1
.
Journal Article
Using Physics-Informed Neural Networks (PINNs) for Tumor Cell Growth Modeling
This paper presents a comprehensive investigation into the applicability and performance of two prominent growth models, namely, the Verhulst model and the Montroll model, in the context of modeling tumor cell growth dynamics. Leveraging the power of Physics-Informed Neural Networks (PINNs), we aim to assess and compare the predictive capabilities of these models against experimental data obtained from the growth patterns of tumor cells. We employed a dataset comprising detailed measurements of tumor cell growth to train and evaluate the Verhulst and Montroll models. By integrating PINNs, we not only account for experimental noise but also embed physical insights into the learning process, enabling the models to capture the underlying mechanisms governing tumor cell growth. Our findings reveal the strengths and limitations of each growth model in accurately representing tumor cell proliferation dynamics. Furthermore, the study sheds light on the impact of incorporating physics-informed constraints on the model predictions. The insights gained from this comparative analysis contribute to advancing our understanding of growth models and their applications in predicting complex biological phenomena, particularly in the realm of tumor cell proliferation.
Journal Article
Methane Production by Co-Digesting Vinasse and Whey in an AnSBBR: Effect of Mixture Ratio and Feed Strategy
The most common approach to deal with vinasse (sugarcane stillage) is fertigation, but this technique compromises soil structure and surrounding water bodies. A possible solution is to transport vinasse to local cheese whey producers and perform the co-digestion of these wastewaters together, reducing their organic load and generating bioenergy. Therefore, this study investigated the application of an AnSBBR (anaerobic sequencing batch biofilm reactor) operated in batch and fed-batch mode, co-digesting vinasse and whey at 30 °C. The effect of influent composition and feeding strategy was assessed. In all conditions, the system achieved high organic matter removal (approximately 83%). Increasing the percentage of vinasse from 0 to 100% in the influent resulted in a decrease in methane productivity (76.3 to 51.1 molCH
4
m
−3
day
−1
) and yield (12.7 to 9.1 molCH
4
kgCOD
−1
), but fed-batch mode operation improved reactor performance (73.0 molCH
4
m
−3
day
−1
and 11.5 molCH
4
kgCOD
−1
). From the kinetic metabolic model, it was possible to infer that, at the best condition, methane is produced in a similar way from the acetoclastic and hydrogenotrophic routes. A scheme of four parallel reactors with a volume of 16,950 m
3
each was proposed in the scale-up estimation, with an energy recovery estimated in 28,745 MWh per month.
Journal Article