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"Rodriguez, Maria"
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The shocking secret of the electric eel... and more!
Tag along with scientists as they uncover intriguing adaptations that help animals survive in their environments. Discover the electric eels hunting tactics and an unexpected defense strategy, why some fish sleep in mucous cocoons, how jumping spiders hear from across a room, what the shape of a European eels head reveals about its diet, and why midshipman fish sing only at night.
Book
Honeybees disrupt the structure and functionality of plant-pollinator networks
The honeybee is the primary managed species worldwide for both crop pollination and honey production. Owing to beekeeping activity, its high relative abundance potentially affects the structure and functioning of pollination networks in natural ecosystems. Given that evidences about beekeeping impacts are restricted to observational studies of specific species and theoretical simulations, we still lack experimental data to test for their larger-scale impacts on biodiversity. Here we used a three-year field experiment in a natural ecosystem to compare the effects of pre- and post-establishment stages of beehives on the pollination network structure and plant reproductive success. Our results show that beekeeping reduces the diversity of wild pollinators and interaction links in the pollination networks. It disrupts their hierarchical structural organization causing the loss of interactions by generalist species, and also impairs pollination services by wild pollinators through reducing the reproductive success of those plant species highly visited by honeybees. High-density beekeeping in natural areas appears to have lasting, more serious negative impacts on biodiversity than was previously assumed.
Journal Article
The secret of the bird's smart brain ... and more!
\"Students will enter the world of scientists as they uncover the secrets behind birds' brains, the most underappreciated of birds senses, the way frigate birds fly non-stop, how mama bears protect their cubs, and what grunts and bellows mean for pigs and alligators\"--Amazon.com.
Book
Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer
Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death. Most cases of CRC are detected in Western countries, with its incidence increasing year by year. The probability of suffering from colorectal cancer is about 4%–5% and the risk for developing CRC is associated with personal features or habits such as age, chronic disease history and lifestyle. In this context, the gut microbiota has a relevant role, and dysbiosis situations can induce colonic carcinogenesis through a chronic inflammation mechanism. Some of the bacteria responsible for this multiphase process include Fusobacterium spp, Bacteroides fragilis and enteropathogenic Escherichia coli. CRC is caused by mutations that target oncogenes, tumour suppressor genes and genes related to DNA repair mechanisms. Depending on the origin of the mutation, colorectal carcinomas can be classified as sporadic (70%); inherited (5%) and familial (25%). The pathogenic mechanisms leading to this situation can be included in three types, namely chromosomal instability (CIN), microsatellite instability (MSI) and CpG island methylator phenotype (CIMP). Within these types of CRC, common mutations, chromosomal changes and translocations have been reported to affect important pathways (WNT, MAPK/PI3K, TGF-β, TP53), and mutations; in particular, genes such as c-MYC, KRAS, BRAF, PIK3CA, PTEN, SMAD2 and SMAD4 can be used as predictive markers for patient outcome. In addition to gene mutations, alterations in ncRNAs, such as lncRNA or miRNA, can also contribute to different steps of the carcinogenesis process and have a predictive value when used as biomarkers. In consequence, different panels of genes and mRNA are being developed to improve prognosis and treatment selection. The choice of first-line treatment in CRC follows a multimodal approach based on tumour-related characteristics and usually comprises surgical resection followed by chemotherapy combined with monoclonal antibodies or proteins against vascular endothelial growth factor (VEGF) and epidermal growth receptor (EGFR). Besides traditional chemotherapy, alternative therapies (such as agarose tumour macrobeads, anti-inflammatory drugs, probiotics, and gold-based drugs) are currently being studied to increase treatment effectiveness and reduce side effects.
Journal Article
First law for Kerr Taub-NUT AdS black holes
A
bstract
The first law of black hole mechanics, which relates the change of energy to the change of entropy and other conserved charges, has been the main motivation for probing the thermodynamic properties of black holes. In this work, we investigate the thermodynamics of Kerr Taub-NUT AdS black holes. We present geometric Komar definitions for the black hole charges, that by construction satisfy the Smarr formula. Further, by a scaling argument based on Euler’s theorem, we establish the first law for the Kerr Taub-NUT AdS black holes. The corresponding first law includes variations in the cosmological constant, NUT charges and angular momenta. The key new ingredient in the construction are the independent variations of both angular momenta, the black hole and Misner string angular momenta. Employing the Brown-York quasi-local charge definitions we show that our expression for the mass and spin coincide with our generalized Komar expressions. We indicate the relevance of these results to the thermodynamics of rotating AdS black holes, including the proper choice of time-like Killing vector to produce the correct thermodynamic mass.
Journal Article
FOXO transcription factors as mediators of stress adaptation
The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6) transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16, which gained notoriety for its capability to double lifespan in the absence of daf-2 (the gene encoding the worm insulin receptor homologue). Since then, research has provided many mechanistic details on FOXO regulation and FOXO activity. Furthermore, conditional knockout experiments have provided a wealth of data as to how FOXOs control development and homeostasis at the organ and organism levels. The lifespan-extending capabilities of DAF-16/FOXO are highly correlated with their ability to induce stress response pathways. Exogenous and endogenous stress, such as cellular redox stress, are considered the main drivers of the functional decline that characterizes ageing. Functional decline often manifests as disease, and decrease in FOXO activity indeed negatively impacts on major age-related diseases such as cancer and diabetes. In this context, the main function of FOXOs is considered to preserve cellular and organismal homeostasis, through regulation of stress response pathways. Paradoxically, the same FOXO-mediated responses can also aid the survival of dysfunctional cells once these eventually emerge. This general property to control stress responses may underlie the complex and less-evident roles of FOXOs in human lifespan as opposed to model organisms such as C. elegans.Forkhead box (FOXO) transcription factors are important mediators of cell stress responses, generally considered to preserve homeostasis and counteract ageing. However, FOXO-mediated mechanisms can also support the survival of cancer and other dysfunctional cells, thereby complicating the link between FOXOs and lifespan extension.
Journal Article
Understanding the influence of abortion on 2024 US elections
Dara Kass and colleagues consider why, despite predictions to the contrary, abortion was not a major driver of votes during the presidential election and what it means for future advocacy
Journal Article
Immunological impact of cell death signaling driven by radiation on the tumor microenvironment
Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-survival and pro-death pathways in malignant, stromal, endothelial and immune cells, hence causing a profound cellular and biological reconfiguration via multiple, non-redundant mechanisms. Such mechanisms include the selective elimination of particularly radiosensitive cell types and consequent loss of specific cellular functions, the local release of cytokines and danger signals by dying radiosensitive cells, and altered cytokine secretion by surviving radioresistant cells. Altogether, these processes create chemotactic and immunomodulatory cues for incoming and resident immune cells. Here we discuss how cytoprotective and cytotoxic signaling modules activated by radiation in specific cell populations reshape the immunological tumor microenvironment.
Radiation therapy has for decades been a standard form of treatment for many cancers. A Review by Galluzzi and colleagues explores the effects of radiation therapy in the context of the immune response.
Journal Article
Interplay between metabolic identities in the intestinal crypt supports stem cell function
The glycolytic activity of Paneth cells provides lactate, which is required by self-renewing intestinal stem cells for oxidative metabolism to activate p38 MAP kinase, ensuring regeneration of a mature crypt.
Metabolism and gut regeneration
Small intestine crypts are regenerated throughout life thanks to self-renewing stem cells located at the bottom of crypts. Differentiated Paneth cells provide the signalling molecules that modulate the regenerative properties of these stem cells. The influence of metabolism on the self-renewal of the crypt has not been studied in great detail. Burgering and colleagues now show that, whereas intestinal stem cells rely on mitochondrial activity for their metabolic needs, Paneth cells use glycolysis, a process that provides the lactate that is required by the stem cells for their oxidative metabolism. This activates the p38 MAP kinase to ensure regeneration of a mature crypt. The findings suggest that the metabolism of certain intestinal cells has an important role in supporting stem cell function.
The small intestinal epithelium self-renews every four or five days. Intestinal stem cells (Lgr5
+
crypt base columnar cells (CBCs)) sustain this renewal and reside between terminally differentiated Paneth cells at the bottom of the intestinal crypt
1
. Whereas the signalling requirements for maintaining stem cell function and crypt homeostasis have been well studied, little is known about how metabolism contributes to epithelial homeostasis. Here we show that freshly isolated Lgr5
+
CBCs and Paneth cells from the mouse small intestine display different metabolic programs. Compared to Paneth cells, Lgr5
+
CBCs display high mitochondrial activity. Inhibition of mitochondrial activity in Lgr5
+
CBCs or inhibition of glycolysis in Paneth cells strongly affects stem cell function, as indicated by impaired organoid formation. In addition, Paneth cells support stem cell function by providing lactate to sustain the enhanced mitochondrial oxidative phosphorylation in the Lgr5
+
CBCs. Mechanistically, we show that oxidative phosphorylation stimulates p38 MAPK activation by mitochondrial reactive oxygen species signalling, thereby establishing the mature crypt phenotype. Together, our results reveal a critical role for the metabolic identity of Lgr5
+
CBCs and Paneth cells in supporting optimal stem cell function, and we identify mitochondria and reactive oxygen species signalling as a driving force of cellular differentiation.
Journal Article
Native bacteria isolated from roots and rhizosphere of Solanum lycopersicum L. increase tomato seedling growth under a reduced fertilization regime
In semiarid regions is important to use native strains best adapted to these environments to optimize plant-PGPR interaction. We aimed to isolate and characterize PGPR from roots and rhizosphere of a tomato crop, as well as studying the effect of its inoculation on tomato seedlings growth. We selected four strains considering their effectiveness of fixing nitrogen, solubilizing phosphate, producing siderophores and indole acetic acid. They belong to the genera
Enterobacter
,
Pseudomonas
,
Cellulosimicrobium,
and
Ochrobactrum
. In addition, we also analyzed the ability to solubilize Ca
3
(PO
4
)
2
, FePO
4
and AlPO
4
and the presence of one of the genes encoding the cofactor PQQ in their genome.
Enterobacter
64S1 and
Pseudomonas
42P4 showed the highest phosphorus solubilizing activity and presence of
pqq
E gene. Furthermore, in a tomato-based bioassay in speed-bed demonstrated that a sole inoculation at seedling stage with the strains increased dry weight of roots (49–88%) and shoots (39–55%), stem height (8–13%) and diameter (5–8%) and leaf area (22–31%) and were equal or even higher than fertilization treatment. Leaf nitrogen and chlorophyll levels were also increased (50–80% and 26–33%) compared to control. These results suggest that
Enterobacter
64S1 and
Pseudomonas
42P4 can be used as bio-inoculant in order to realize a nutrient integrated management.
Journal Article