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This paper focuses on the study of the effect of the change of the crystal size on the shape and width of the X-ray diffraction patterns for defatted and deproteinized bones as well as incinerated biogenic hydroxyapatite obtained from bovine, porcine, and human bones. Inductively Couple Plasma showed the presence of some ions such as Mg, K, Al, Fe, Zn, and Na for all samples. The nanometric size of the crystals was determined through High Resolution Transmission Electron Microscopy in which ordered crystals were found. The calcination of raw clean bones at 720 °C produced a transition of crystal size from nano to micro due to a coalescence phenomenon, this was accompanied by a decrease of the peak width of the X-ray diffraction patterns due to the decrease of the inelastic scattering contribution from the microcrystals. A simulation of the effect of the crystallite size on the shape and width of the X-ray patterns was done using PDF-4 software which confirmed that raw ordered bone crystals produce broad peaks which so far have been erroneously assigned to polycrystalline hydroxyapatite with low crystalline quality.

A steady evolution of philosophy, attitude, and practice has led to the increased use of the term global health. [...] on the basis of this analysis, we offer the following definition: global health is an area for study, research, and practice that places a priority on improving health and achieving equity in health for all people worldwide.

The interruption of malaria transmission worldwide is one of the greatest challenges for international health and development communities. The current expert view suggests that, by aggressively scaling up control with currently available tools and strategies, much greater gains could be achieved against malaria, including elimination from a number of countries and regions; however, even with maximal effort we will fall short of global eradication. The Malaria Eradication Research Agenda (malERA) complements the current research agenda--primarily directed towards reducing morbidity and mortality--with one that aims to identify key knowledge gaps and define the strategies and tools that will result in reducing the basic reproduction rate to less than 1, with the ultimate aim of eradication of the parasite from the human population. Sustained commitment from local communities, civil society, policy leaders, and the scientific community, together with a massive effort to build a strong base of researchers from the endemic areas will be critical factors in the success of this new agenda.

Arginine methylation is a post-translational modification involved in gene transcription, signalling pathways, DNA repair, RNA metabolism and splicing, among others, mechanisms that in protozoa parasites may be involved in pathogenicity-related events. This modification is performed by protein arginine methyltransferases (PRMTs), which according to their products are divided into three main types: type I yields monomethylarginine (MMA) and asymmetric dimethylarginine; type II produces MMA and symmetric dimethylarginine; whereas type III catalyses MMA only. Nine PRMTs (PRMT1 to PRMT9) have been characterized in humans, whereas in protozoa parasites, except for Giardia intestinalis, three to eight PRMTs have been identified, where in each group there are at least two enzymes belonging to type I, the majority with higher similarity to human PRMT1, and one of type II, related to human PRMT5. However, the information on the role of most of these enzymes in the parasites biology is limited so far. Here, current knowledge of PRMTs in protozoan parasites is reviewed; these enzymes participate in the cell growth, stress response, stage transitions and virulence of these microorganisms. Thus, PRMTs are attractive targets for developing new therapeutic strategies against these pathogens.

We found serologic evidence of spotted fever group Rickettsia in humans and dogs and typhus group Rickettsia in dogs in Reynosa, Mexico. Our investigation revealed serologic samples reactive to spotted fever group Rickettsia in 5 community members, which highlights a potential rickettsial transmission scenario in this region.

Background Antimicrobial peptides (AMPs) participate in the humoral immune response of insects eliminating invasive microorganisms. The immune deficiency pathway (IMD) and Toll are the main pathways by which the synthesis of these molecules is regulated in response to Gram-negative (IMD pathway) or Gram-positive (Toll pathway) bacteria. Various pattern-recognition receptors (PRRs) participate in the recognition of microorganisms, such as pgrp-lc and toll , which trigger signaling cascades and activate NF-κB family transcription factors, such as relish , that translocate to the cell nucleus, mainly in the fat body, inducing AMP gene transcription. Methods T. pallidipennis  inhibited in Tp pgrp-lc , Tp toll , and Tp relish  were challenged with  E. coli  and  M. luteus  to analyze the expression of AMPs transcripts in the fat body and to execute survival assays. Results In this work we investigated the participation of the pgrp-lc and toll receptor genes and the relish transcription factor (designated as Tp pgrp-lc , Tp toll , and Tp relish ), in the transcriptional regulation of defensin B , prolixicin , and lysozyme B in Triatoma pallidipennis , one of the main vectors of Chagas disease. AMP transcript abundance was higher in the fat body of blood-fed than non-fed bugs. Challenge with Escherichia coli or Micrococcus luteus induced differential increases in AMP transcripts. Additionally, silencing of Tp pgrp-lc , Tp toll , and Tp relish resulted in reduced AMP transcription and survival of bugs after a bacterial challenge. Conclusions Our findings demonstrated that the IMD and Toll pathways in T. pallidipennis preferentially respond to Gram-negative and Gram-positive bacteria, respectively, by increasing the expression of AMP transcripts, but cross-induction also occurs. Graphical Abstract

Linear structural analysis is the method of choice commonly used by practicing engineers to support the seismic design of a structure. The structural models are developed in commercial software and incorporate stiffness modifiers, which lower the stiffness of the members, in recognition of all the sources of flexibility that occur upon cracking of the concrete. This paper describes a mechanicsbased model to compute the stiffness modifiers for columns with a circular cross section. The mechanics-based model accounts for five modes of deformation observed. Calibration of this model was performed with a database of tests reported in the literature on 22 circular-section columns that exhibited ductile response. The paper ends by describing a simplified method for use in design. The mechanics-based model and the design method yield an effective column lateral stiffness that closely aligns with the values obtained from the column database.

Background Mosquito-borne diseases, such as malaria, dengue, Zika and chikungunya, pose significant public health threats in tropical and subtropical regions worldwide. To mitigate the impact of these diseases on human health, effective vector surveillance and control strategies are necessary. Traditional vector control methods, which rely on chemical agents such as insecticides and larvicides, face challenges such as resistance and environmental concerns. Consequently, there has been a push to explore novel surveillance and control tools. Mass trapping interventions have emerged as a promising and environmentally friendly approach to reducing the burden of mosquito-borne diseases. This study assessed mass-trapping interventions using autocidal gravid ovitraps (AGOs) on Aedes aegypti populations in Reynosa, Tamaulipas, Mexico. Methods Four neighborhoods were selected to evaluate the effects of three treatments: AGO mass-trapping, integrated vector control (IVC), which included source reduction and the application of chemical larvicide and adulticide, and AGO + IVC on Ae. aegypti populations. A control area with no interventions was also included. The effectiveness of the interventions was evaluated by comparing Ae. aegypti abundance between the pre-treatment period (9 weeks) and the post-treatment period (11 weeks) for each treatment. Results Only treatment using AGO mass trapping with an 84% coverage significantly reduced Ae. aegypti female populations by 47%, from 3.75 ± 0.32 to 1.96 ± 0.15 females/trap/week. As expected, the abundance of Ae. aegypti in the control area did not differ from the pre- and post-treatment period (range of 4.97 ± 0.59 to 5.78 ± 0.53); Ae. aegypti abundance in the IVC treatment was 3.47 ± 0.30 before and 4.13 ± 0.35 after, which was not significantly different. However, Ae. aegypti abundance in the AGO + IVC treatment increased from 1.43 ± 0.21 before to 2.11 ± 0.20 after interventions; this increase may be explained in part by the low AGO (56%) coverage. Conclusions This is the first report to our knowledge on the effectiveness of mass-trapping interventions with AGOs in Mexico, establishing AGOs as a potential tool for controlling Ae . aegypti in Northeastern Mexico when deployed with sufficient coverage. Graphical Abstract

In recent years, the application of ergonomics to workplace safety monitoring has gained increasing interest from companies and public institutions, allowing for the evaluation of the potential impact that dangerous situations may have on workers during their routine activities. This study presents a method for real-time monitoring of human physiological and motor responses to simulated workplace hazards during virtual reality safety training. The setup allows for precise measurements of both physiological and postural parameters during simulated scenarios. Moreover, a representative case study involving the sudden arrival of a forklift in a warehouse is presented. Five healthy participants were exposed to this scenario, with changes in heart rate variability and trunk posture being captured. The results demonstrate the effectiveness of sensor-based monitoring in detecting stress responses and postural adaptations to hazardous stimuli. This approach provides a basis for understanding human responses in simulated hazardous environments and may help to optimize safety training aimed at increasing workers’ risk perception and improving overall workplace safety. Although based on a small sample, the findings provide preliminary insights into the feasibility of sensor-based monitoring during VR safety training.

In past decades, multistory housing buildings have been constructed in high-seismic-risk regions in Latin America using thin reinforced concrete (RC) walls as the primary earthquake-resistant structural system. Typically, these thin walls are built using a light amount of brittle welded wire mesh placed in a single curtain for longitudinal and transverse reinforcement. This type of construction system is convenient due to the higher speed of construction compared to construction with thicker walls and conventional reinforcement. However, the seismic design of thin walls in buildings is based mainly on limited experimental research, mainly on squat-thin RC walls. A limitation of thin RC walls is that a cold-drawn mesh has low ductility and low energy deformation capacity. Furthermore, thin walls that are subjected to earthquake loading could fail due to out-of-plane instability. A database of RC thin walls tested under compression-tension cycles or cyclic lateral loading by several authors is used in this study to review the mechanics of lateral instability of thin RC walls. This study's results are used to understand better the potential seismic behavior of thin RC walls with a single curtain of welded wire mesh fabric. The drift capacities of typical thin RC walls are estimated in a performance-based seismic design procedure for buildings with RC thin walls.