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شراكات المدرسة والأسرة والمجتمع : دليلك للعمل =
كتاب ثري وعملي يشجعك على البدء في بناء شراكة فاعلة بين المدرسة والأسرة والمجتمع ويقدم لك مختلف الأدوات التي تحتاجها لتبدأ ستجد نموذجا مميزا لمساعدة كل مدرسة على بناء خطة العام للشراكة مع الأسر والمجتمع بالتفصيل ستحصل على خطوات تكوين فرق الشراكة في داخل المدرسة ستحصل على نماذج جاهزة للعمل أيضا قوائم بأنشطة هادفة يمكن تنفيذها وأثبتت جدواها عبر دراسات.
BOOK
A quantitative assessment of the indirect impacts of human-elephant conflict
Human-wildlife conflict has direct and indirect consequences for human communities. Understanding how both types of conflict affect communities is crucial to developing comprehensive and sustainable mitigation strategies. We conducted an interview survey of 381 participants in two rural areas in Myanmar where communities were exposed to human-elephant conflict (HEC). In addition to documenting and quantifying the types of direct and indirect impacts experienced by participants, we evaluated how HEC influences people’s attitudes towards elephant conservation. We found that 99% of participants suffered from some type of indirect impact from HEC, including fear for personal and family safety from elephants and fear that elephants will destroy their home. Despite experiencing moderate levels of indirect impacts from HEC at the community level, participants expressed attitudes consistent with supporting future elephant conservation programs.
Journal Article
Mortality attributable to hot and cold ambient temperatures in India: a nationally representative case-crossover study
Most of the epidemiological studies that have examined the detrimental effects of ambient hot and cold temperatures on human health have been conducted in high-income countries. In India, the limited evidence on temperature and health risks has focused mostly on the effects of heat waves and has mostly been from small scale studies. Here, we quantify heat and cold effects on mortality in India using a nationally representative study of the causes of death and daily temperature data for 2001-2013.
We applied distributed-lag nonlinear models with case-crossover models to assess the effects of heat and cold on all medical causes of death for all ages from birth (n = 411,613) as well as on stroke (n = 19,753), ischaemic heart disease (IHD) (n = 40,003), and respiratory diseases (n = 23,595) among adults aged 30-69. We calculated the attributable risk fractions by mortality cause for extremely cold (0.4 to 13.8°C), moderately cold (13.8°C to cause-specific minimum mortality temperatures), moderately hot (cause-specific minimum mortality temperatures to 34.2°C), and extremely hot temperatures (34.2 to 39.7°C). We further calculated the temperature-attributable deaths using the United Nations' death estimates for India in 2015. Mortality from all medical causes, stroke, and respiratory diseases showed excess risks at moderately cold temperature and hot temperature. For all examined causes, moderately cold temperature was estimated to have higher attributable risks (6.3% [95% empirical confidence interval (eCI) 1.1 to 11.1] for all medical deaths, 27.2% [11.4 to 40.2] for stroke, 9.7% [3.7 to 15.3] for IHD, and 6.5% [3.5 to 9.2] for respiratory diseases) than extremely cold, moderately hot, and extremely hot temperatures. In 2015, 197,000 (121,000 to 259,000) deaths from stroke, IHD, and respiratory diseases at ages 30-69 years were attributable to moderately cold temperature, which was 12- and 42-fold higher than totals from extremely cold and extremely hot temperature, respectively. The main limitation of this study was the coarse spatial resolution of the temperature data, which may mask microclimate effects.
Public health interventions to mitigate temperature effects need to focus not only on extremely hot temperatures but also moderately cold temperatures. Future absolute totals of temperature-related deaths are likely to depend on the large absolute numbers of people exposed to both extremely hot and moderately cold temperatures. Similar large-scale and nationally representative studies are required in other low- and middle-income countries to better understand the impact of future temperature changes on cause-specific mortality.
Journal Article
Interaction-induced hopping phase in driven-dissipative coupled photonic microcavities
The Bose-Hubbard model (BHM) describes bosons hopping across sites and interacting on-site. Inspired by the success of BHM simulators with atoms in optical lattices, proposals for implementing the BHM with photons in coupled nonlinear cavities have recently emerged. Two coupled semiconductor microcavities constitute a model system where the hopping, interaction and decay of exciton polaritons—mixed light-matter quasiparticles—can be engineered in combination with site-selective coherent driving to implement the driven-dissipative two-site optical BHM. Here we explore the interplay of interference and nonlinearity in this system, in a regime where three distinct density profiles can be observed under identical driving conditions. We demonstrate how the phase acquired by polaritons hopping between cavities can be controlled through polariton-polariton interactions. Our results open new perspectives for synthesizing density-dependent gauge fields using polaritons in two-dimensional multicavity systems.
Coupled semiconductor microcavities constitute a model system where the hopping, interaction, and decay of exciton polaritons can be engineered. Here, Rodriguez
et al
. show how the phase acquired by polaritons hopping between cavities can be controlled through polariton-polariton interactions.
Journal Article
PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer
There is a strong rationale to therapeutically target the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway in breast cancer since it is highly deregulated in this disease and it also mediates resistance to anti-HER2 therapies. However, initial studies with rapalogs, allosteric inhibitors of mTORC1, have resulted in limited clinical efficacy probably due to the release of a negative regulatory feedback loop that triggers AKT and ERK signaling. Since activation of AKT occurs via PI3K, we decided to explore whether PI3K inhibitors prevent the activation of these compensatory pathways. Using HER2-overexpressing breast cancer cells as a model, we observed that PI3K inhibitors abolished AKT activation. However, PI3K inhibition resulted in a compensatory activation of the ERK signaling pathway. This enhanced ERK signaling occurred as a result of activation of HER family receptors as evidenced by induction of HER receptors dimerization and phosphorylation, increased expression of HER3 and binding of adaptor molecules to HER2 and HER3. The activation of ERK was prevented with either MEK inhibitors or anti-HER2 monoclonal antibodies and tyrosine kinase inhibitors. Combined administration of PI3K inhibitors with either HER2 or MEK inhibitors resulted in decreased proliferation, enhanced cell death and superior anti-tumor activity compared with single agent PI3K inhibitors. Our findings indicate that PI3K inhibition in HER2-overexpressing breast cancer activates a new compensatory pathway that results in ERK dependency. Combined anti-MEK or anti-HER2 therapy with PI3K inhibitors may be required in order to achieve optimal efficacy in HER2-overexpressing breast cancer. This approach warrants clinical evaluation.
Journal Article
Black Dreams, Electric Mirror
Sci-fi has the power to open dialogue because its alternate world-building enables students to feel far enough from reality to discuss social problems unreservedly. In this essay, I review an assignment I developed using Black Mirror and Philip K. Dick’s Electric Dreams that present episodes in which militarized policing, segregation, and genocide occur with the consent and complicity of populations convinced that these measures enable their safety. Paralleling U.S. carceralism, the fictional communities have been inundated with media and political advertising for greater segregation but have themselves never experienced the criminalized violence that justifies widespread state harms. Through a generative dialogue engaging the media, a discussion question, and the concept of state terrorism, students move to observe their positionality and critically assess state violence. Therefore, I recommend this teaching tool for any critical instructors—especially minoritized professors teaching primarily White classrooms—to inspire a stimulating dialogue in service of connection-making and peacemaking in the classroom.
Journal Article
Inferring Discharge From River Geometry on Titan
Titan's dense atmosphere, composed mainly of methane and nitrogen, maintains a methane cycle that shapes its surface. Like water on Earth, methane precipitation erodes Titan's surface, carving river networks at all latitudes, as revealed by the Cassini‐Huygens mission. On Earth, it is well known that laboratory and natural rivers exhibit a power‐law relationship between their bankfull geometry and water discharge, as described by the threshold theory. Here, we investigate this hydraulic‐geometric relationship on two rivers on Titan, one near the equator and the other at the south pole. We hypothesize that this relationship can be applied to any river, and test it for the first time on extraterrestrial rivers. Having shown that Titan's rivers are consistent with the threshold theory, we use this relationship to estimate river discharge from bankfull geometry. As a perspective, we then use these discharges to infer precipitation rates, which could help to better understand Titan's climate. Plain Language Summary Titan, Saturn's largest moon, and Earth are the only bodies in the Solar System with active rivers. Their geometries are strikingly similar, although on Titan the rivers are filled with methane instead of water and are carved out of consolidated water ice. Our aim is to show that these rivers form in the same way as terrestrial rivers, and that their shape is governed by the same laws. We investigate two rivers on Titan, at the equator and at the south pole, and use a physics‐based analytical model derived from terrestrial rivers to deduce their discharge. Key Points Threshold theory is applied for the first time to an extraterrestrial body Threshold theory correctly predicts the geometry of alluvial and bedrock rivers on Earth The discharge of two rivers on Titan is estimated, with potential application to the rough evaluation of precipitations rates
Journal Article
Supersymmetric Expansion Algorithm and Complete Analytical Solution for the Hulthén and Anharmonic Potentials
Abstract
An algorithm for providing analytical solutions to Schrödinger’s equation with nonexactly solvable potentials is elaborated. It represents a symbiosis between the logarithmic expansion method and the techniques of supersymmetric quantum mechanics as extended toward non-shape-invariant potentials. The complete solution to a given Hamiltonian $H_{0}$ is obtained from the nodeless states of the Hamiltonian $H_{0}$ and of a set of supersymmetric partners $H_{1}, H_{2},..., H_{r}$. The nodeless states (dubbed “edge” states) are unique and in general can be ground or excited states. They are solved using the logarithmic expansion which yields an infinite system of coupled first-order hierarchical differential equations, converted later into algebraic equations with recurrence relations which can be solved order by order. We formulate the aforementioned scheme, termed the “Supersymmetric Expansion Algorithm,” step by step and apply it to obtain for the first time the complete analytical solutions of the 3D Hulthén, and the 1D anharmonic, oscillator potentials.
Journal Article
The Economies of Queer Inclusion
The Anti-Homosexuality (dubbed \"Kill the Gays\") Bill of 2009 propelled Uganda to the forefront of global media.In its initial manifestation, the Bill threatened to penalize \"aggravated homosexuality\" with the death penalty.
eBook
NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress
Spatial management of stress-induced protein aggregation is an integral part of the proteostasis network. Protein modification by the ubiquitin-like molecule NEDD8 increases upon proteotoxic stress and it is characterised by the formation of hybrid NEDD8/ubiquitin conjugates. However, the biological significance of this response is unclear. Combination of quantitative proteomics with biological analysis shows that, during proteotoxic stress, NEDDylation promotes nuclear protein aggregation, including ribosomal proteins as a major group. This correlates with protection of the nuclear Ubiquitin Proteasome System from stress-induced dysfunction. Correspondingly, we show that NEDD8 compromises ubiquitination and prevents targeting and processing of substrates by the proteasome. Moreover, we identify HUWE1 as a key E3-ligase that is specifically required for NEDDylation during proteotoxic stress. The study reveals a specific role for NEDD8 in nuclear protein aggregation upon stress and is consistent with the concept that transient aggregate formation is part of a defence mechanism against proteotoxicity.
Protein NEDDylation increases upon proteotoxic stress but the function of this response remains to be elucidated. Here, the authors show that NEDDylation contributes to the cellular defence against proteotoxicity by promoting nuclear protein aggregation and protecting the ubiquitin proteasome system.
Journal Article