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Systematic review of cash plus or bundled interventions targeting adolescents in Africa to reduce HIV risk
Background
HIV remains a leading cause of death for adolescents and young people aged 10–24 years. HIV prevention requires multisectoral approaches that target adolescents and young people, addressing HIV risk pathways (e.g., transactional sex, gender-based violence, and school attendance) through bundled interventions that combine economic strengthening, health capabilities, and gender equality education. However, best practices are unknown because evidence on multisectoral programming targeted to adolescents and combining these components has not been systematically reviewed.
Methods
We conducted a systematic review to summarize the evidence on bundled interventions combining health and economic strengthening components for adolescents and young people and their effects on HIV/STI incidence and risk factors. We included studies from Africa published between 2005 and 2023, combining at least one economic strengthening and one health component, directed toward adolescents and young people aged 10–24 years. Included studies measured programmatic impacts on primary outcomes: HIV and STI incidence/prevalence; and mediators as secondary outcomes: sexual behaviours, sexual and reproductive health, school attendance, health-seeking behaviours, and violence. We conducted key word searches in PubMed, EMBASE, and Web of Science, imported titles/abstracts from the initial search, and reviewed them using the inclusion criteria. Full texts of selected articles were reviewed and information was extracted for analysis. Findings from the full texts identified were summarized.
Results
We reviewed 58 studies, including 43 quantitative studies and 15 qualitative studies, evaluating 26 unique interventions. A majority of studies reviewed were conducted in Eastern and Southern Africa. Interventions reviewed showed a greater number of significant results in improving economic outcomes; mental health and psychosocial outcomes; sexual and reproductive health knowledge and services utilization; and HIV prevention knowledge and testing. They showed fewer significant results in improving outcomes related to HIV incidence/prevalence; sexual risk behaviours; gender-based violence; gender attitudes; education; STI incidence, prevalence and testing; and sexual debut.
Conclusions
Our review demonstrated the potential for bundled, multisectoral interventions for preventing HIV and facilitating safe transitions to adulthood. Findings have implications for designing HIV sensitive programmes on a larger scale, including how interventions may need to address multiple strata of the social ecological model to achieve success in the prevention of HIV and related pathways.
Journal Article
Eight-Week Traditional Mat Pilates Training-Program Effects on Adult Fitness Characteristics
We investigated responses of adult, novice practitioners (n = 9) to an 8-week traditional mat Pilates program (P) that met 1 hr/day three times/week. Classes consisted primarily of beginner and intermediate level exercises. Compared to an active control group (C; n = 13) that showed no improvements, those in P significantly (p < .05) improved relative body fat (-1.2%BF), sit-and-reach (+7.5 cm), shoulder reach (+6.9 cm), curl-up (+14 reps), and low back extension (+7 reps) scores, as well as circumferences at the waist (-2.7 cm), chest (-1.7 cm), and arm (-0.5 cm). Baseline differences were noted only for curl-ups and low back extensions, with P being lower than C. Body composition, muscular endurance, and flexibility significantly improved after 8 weeks of traditional mat Pilates.
Journal Article
The influence of gender-equitable attitudes on sexual behaviour among unmarried adolescents in rural Tanzania: a longitudinal study
Patriarchal systems in Africa can perpetuate inequitable gender norms and power differentials that disadvantage women. This study aimed to examine the influence of community and individual gender-equitable attitudes on adolescents’ sexual health and risk behaviour in rural Tanzania, and whether the association of those attitudes differs between males and females. We conducted logistic regression using longitudinal data from a cluster randomised controlled trial in rural Tanzania to examine the association of gender-equitable attitudes with the sexual risk behaviour of 2017 adolescent males and females. High community-level gender-equitable attitudes were significantly associated with higher odds of HIV testing (OR = 1.31, 95% CI [1.00–1.72]) and lower odds of age-disparate partnerships (OR = 0.52, 95% CI [0.30–0.88]) for the pooled male and female sample. High individual-level (but not community) gender-equitable attitudes were associated with increased condom (OR = 2.07, 95% CI [1.07–4.00]) and contraceptive use (OR = 2.08, 95% CI [1.04–4.13]) for girls. Among sexually debuted adolescents, no significant associations were found between community or individual high gender-equitable attitudes and transactional sex, early sexual debut, HIV testing, concurrent sexual partners, or number of sexual partners. We found evidence of effect modification by sex for community-level attitudes and age-disparate sex (p = 0.005) and individual-level attitudes and condom use (p = 0.051). Efforts to incorporate gender transformative programming for whole communities may increase gender-equitable attitudes.Plain language statementGender norms that centre men and disadvantage women create gender inequality, which can lead to risky sexual behaviour. This study examined how both community and individual attitudes toward gender norms influenced risky sexual behaviour in adolescents, and whether that influence was different between males and females. We found that higher gender-equitable attitudes were linked to increased odds of HIV testing in the last 12 months, and decreased odds of engaging in a sexual relationship with a much older partner. Individual high gender-equitable attitudes among girls were also linked to higher odds of them using condoms and contraceptives. Gender-equitable attitudes did not seem to influence early sexual debut, engagement in transactional sex, having multiple sexual partners at the same time, or the number of sexual partners a participant had in the last 12 months. Based on these findings, programming designed to increase gender-equitable attitudes might be helpful in increasing HIV testing and condom and contraceptive use, but it needs to involve the entire community, not just individual boys and girls.
Journal Article
Effect of Different Piperacillin-Tazobactam Dosage Regimens on Synergy of the Combination with Tobramycin against Pseudomonas aeruginosa for the Pharmacokinetics of Critically Ill Patients in a Dynamic Infection Model
We evaluated piperacillin-tazobactam and tobramycin regimens against Pseudomonas aeruginosa isolates from critically ill patients. Static-concentration time-kill studies (SCTK) assessed piperacillin-tazobactam and tobramycin monotherapies and combinations against four isolates over 72 h. A 120 h-dynamic in vitro infection model (IVM) investigated isolates Pa1281 (MICpiperacillin 4 mg/L, MICtobramycin 0.5 mg/L) and CR380 (MICpiperacillin 32 mg/L, MICtobramycin 1 mg/L), simulating the pharmacokinetics of: (A) tobramycin 7 mg/kg q24 h (0.5 h-infusions, t1/2 = 3.1 h); (B) piperacillin 4 g q4 h (0.5 h-infusions, t1/2 = 1.5 h); (C) piperacillin 24 g/day, continuous infusion; A + B; A + C. Total and less-susceptible bacteria were determined. SCTK demonstrated synergy of the combination for all isolates. In the IVM, regimens A and B provided initial killing, followed by extensive regrowth by 72 h for both isolates. C provided >4 log10 CFU/mL killing, followed by regrowth close to initial inoculum by 96 h for Pa1281, and suppressed growth to <4 log10 CFU/mL for CR380. A and A + B initially suppressed counts of both isolates to <1 log10 CFU/mL, before regrowth to control or starting inoculum and resistance emergence by 72 h. Overall, the combination including intermittent piperacillin-tazobactam did not provide a benefit over tobramycin monotherapy. A + C, the combination regimen with continuous infusion of piperacillin-tazobactam, provided synergistic killing (counts <1 log10 CFU/mL) of Pa1281 and CR380, and suppressed regrowth to <2 and <4 log10 CFU/mL, respectively, and resistance emergence over 120 h. The shape of the concentration–time curve was important for synergy of the combination.
Journal Article
The Accident
The late December sun blushes on the western horizon as I walk home along Toronto's Don River trail. 2020 will be over in a few days-my first year back after more than two decades working abroad. The mild weather this December has kept the ground dry and manageable for our mother, whose painful knees make walking-even with two hiking sticks-a challenge. After more than twenty years living on the other side of the globe from my mother, limiting our contact to visits of several weeks once or twice a year, I am still struggling with her impact on my life. How did she get so much shorter than me? I had returned her knickknacks to the wrong spots in the multi-paned windows after I dusted; she remembered where they should go-the bird decoys, construction paper canoes and plasticine animals made by her grandchildren when they were young.
Journal Article