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The purpose of this work was to study changes in the level of cell-free DNA (cfDNA) in the blood of young and old rats in the normal state and with induced benign prostatic hyperplasia (BPH). Male Wistar rats were divided into 4 groups—young (3 months), old (20 months), intact, or with testosterone-induced BPH. Groups with BPH were subjected to surgical castration and administration of testosterone esters at a dose of 25 mg/kg for a total of 7 injections for 20 days. In intact animals, the level of cfDNA in old rats (2.00±0.14 ng/μl) was significantly higher than that in the young (1.02±0.30 ng/μl). The body and the prostate weights of old rats were 1.6 and 1.4 times larger than those of the young, without an increase in the prostate index (PI). The testosterone level in the blood of young rats was 1.6 times higher than that of old (6.20±0.93 nmol/l vs. 3.77±0.55 nmol/l; NS). In animals with BPH, the level of cfDNA in old rats (3.14±0.76 ng/μl) was significantly higher than that in young rats (0.80±0.14 ng/μl). The body and the prostate weights in old rats were 1.8 and 2.3 times larger, than those in young rats, with an increase in the PI. The level of testosterone in the blood of young (15.76±0.51 nmol/l) and old (16.99±1.1 nmol/l) rats was not significantly different. Morphological signs of BPH were observed in the prostate of both young and old rats. During the induction of BPH in the experiment, according to the level of cfDNA, cell death processes have not changed significantly in young rats but significantly increased in old rats. A similar trend was observed in the group of intact animals. The obtained data indicate that apoptosis processes are enhanced during the development of BPH despite the growth of tissues in the prostate itself.

This paper investigates the features of the generation of fast and slow MHD shock waves in the lower layers of the solar corona. An analytical solution is obtained at the shock front for both types of shock waves and it is shown that the primary role in the formation of anomalous heating belongs to weak MHD shock waves, which do not have a lower speed limit for generation in the upper layers of the solar chromosphere.

For a continuous semicascade on a metrizable compact set ${\\rm\\Omega}$, we consider the weak$^{\\ast }$ convergence of generalized operator ergodic means in $\\text{End}\\,C^{\\ast }({\\rm\\Omega})$. We discuss conditions under which: every ergodic net contains a convergent sequence; all ergodic nets converge; all ergodic sequences converge. We study the relationships between the convergence of ergodic means and the properties of transitivity of the proximality relation on ${\\rm\\Omega}$, minimality of supports of ergodic measures, and uniqueness of minimal sets in the closure of trajectories of a semicascade. These problems are solved in terms of three associated algebraic-topological objects: the Ellis semigroup $E$, the Köhler operator semigroup ${\\rm\\Gamma}\\subset \\text{End}\\,C^{\\ast }({\\rm\\Omega})$, and the semigroup $G=\\overline{\\text{co}}\\,{\\rm\\Gamma}$. The main results are stated for semicascades with metrizable $E$ and for tame semicascades.

We studied the Fourier spectrum of the light-scattering profiles of single particles in the Rayleigh-Gans-Debye (RGD) and Wentzel–Kramers–Brillouin (WKB) approximations. In the case of a homogeneous sphere, we found the relationship between the key parameters of the spectrum (including its phase) and the sphere characteristics – both analytically and numerically in the framework of the approximations and the rigorous Lorentz–Mie theory, respectively. Based on these results, we have improved the existing spectral characterization method for spheres extending the applicability range to particles with a higher refractive index.

Sodium ( 23 Na) magnetic resonance imaging (MRI) provides information about intra- and intercellular processes useful for medical diagnostics, such as Huntington’s disease, diabetes, etc. 23 Na MRI is also used for technological applications such as the analysis of salt content in food products and the assessment of their characteristics using relaxation measurements. Due to 3–4 order difference in the MRI sensitivity for proton and sodium detection, 23 Na MRI is usually performed using high-field MRI scanners. Current study explores feasibility of 23 Na MRI at the low field 0.5T clinical scanner using different fish species. Using the 3D gradient echo method with the parameters: repetition time = 44.7 ms, echo time = 12 ms, and flip angle = 75°, 23 Na MRI of euthanized and thawed fish of different orders (according to biological classification) with an isotropic resolution of 6 mm were obtained. For the assignment of anatomical structures of fish, proton images with an isotropic resolution of 2 mm were also obtained, and combined 1 H and 23 Na images were constructed. The analysis of the obtained images, including anatomical aspects, has been carried out. Using 23 Na nuclear magnetic resonance spectroscopy methods, the rate of sodium excretion was assessed for typical methods of fish conservation for their subsequent use as anatomical specimens and exhibits in museums and scientific laboratories. The results of this work can be used to assess the potential of low-field multinuclear MRI, in biology, and technological (non-medical) applications, particularly, in the analysis of food and the development of methods for preservation of living tissues.

Two devices intended for copper cylindrical liner gasdynamic acceleration to velocities of 5–7 km/s using the chemicals explosion energy have been investigated. It has been demonstrated that the acceleration of quasi-isentropically and isentropically loaded liners under the conditions of high-level dynamics, symmetry of deposition, and suppression of shock-induced dusting is feasible.

The main aspects of assembling automation of hydropress connections are considered - increasing the assembling performance, its stability and ensuring the quality of hydropress connections. A control system for the technological complex of hydropress assembling on a base of fuzzy logic methods has been developed, it provides the control of technological assembling modes, including: pressing speed, oil pressure, control of the force and pressing length, without identifying the parameters of assembling process, as well as the guaranteed presence of liquid friction in the non-linearity conditions of assembling process. The structure and control algorithm of automated hydropress assembling that ensure the maintenance of the working oil pressure during assembling are proposed. The algorithm is based on a set of feedbacks: pressure and position sensors, that provides a qualitative transition from boundary to liquid friction. A prototype of the technological complex of hydropress assembling of interference fits has been developed, that allows to assemble joints with a coupling diameter up to 50 mm in an automated mode. The results of experimental studies of automated assembling of steel and titanium joints are presented.

This paper considers the relevance of the control with rill-washing corrosion. The flow of fluid in the pipe is modeled by the example of a conditional pipeline. This will allow one to determine the moment of formation of the flow of a two-phase fluid flow and to determine the interval for placement of the dissecting couplings. A scheme is proposed for arranging dissecting couplings along the whole route of the field pipeline.

The study of safe information environment as an indicator and a factor of influence on the quality of management in the educational institution. Theoretical techniques include theoretical and methodological, scientific and theoretical analysis of the literature on the problem under study, simulation, and forecasting. Empirical techniques are the study and generalization of pedagogical experience of systematic approach application in educational professional institutions, participant observation, questionnaires, and expert evaluation. Conceptual provisions of a safe information environment creation in the educational institution are formulated, their essence revealed, and presented in the form of management objectives. It is established that the implementation of the presented in the study approaches of effective management in educational institutions provides the necessary conditions for a comfortable professional training of future specialists in higher professional institutions. The course \"Information security of educational institution\" is developed. It aims at professional development in the field of information security of employees in educational institutions. The notion \"safe information environment of the educational institution\", considered as a dynamic indicator of the quality of educational institution management, is clarified. Perspective directions of innovative transformations in the system of educational institution management are defined. The main parameters of a safe information and educational environment are established in accordance with the objectives, results and management of pedagogical systems that ensure the effective application of the system approach as the basis for the design of a management system of the educational institution. The obtained results allow improving the quality of the innovative development of the management system by the educational institution and thus raise the results of professional training of future specialists to a new level.

Strategic management model for the development of vocational training in higher education establishments. Theoretical: theoretical and methodological analysis, theoretical modelling and designing. Empirical: experience generalization in the application of the system, activity, competency, synergetic and cultural-based approaches. There has been developed a conceptual model for strategic management based on the vast experience analysis and generalization for management training of future specialists in higher education establishments. In accordance with market demands, a conceptual model of strategic management for professional training of future specialists is developed, which decides the challenge of increasing the quality of highly qualified personnel training in higher education establishments more efficiently. It presents the methodological basis for the theory and practice of strategic management training of specialists. It also gives the characteristics of structural and substantive basis of the model of strategic management in higher education establishments. Managerial and pedagogical conditions of effective strategic management training are developed, including educator instruction and managerial support in higher education establishments. Thus, an attempt to justify the strategic management training in higher education establishments enriches the theory of management training of modern specialists. Perspective directions of changes in the training management system in higher education are defined. The results obtained in educational and industrial practice will improve the effectiveness of innovative development of highly qualified specialist training. The study records can be used in practice for designing modern control systems, and developing the training and professional refreshment of administrative and managerial staff at the university.