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Oven Controlled Crystal Oscillators (OCXOs) have been employed for precision timing and frequency distribution and synchronization applications, such as telecommunication, instrumentation, and test equipment in today’s Commercial, Military, Scientific, Space and Low Earth Orbit markets. Since 1978, Wenzel Laboratory has been researching and developing outstanding performance oscillators to provide the lowest phase noise, as low as -190dBc/Hz, and highest short-term stability for these markets. In this paper, various compensation techniques developed at Quantic Wenzel are discussed and compared. Quantic Wenzel employs such techniques to greatly improve the stability of its OCXOs in various mild to harsh vibration environments. Consequently, this lends itself to provide quieter performance in multiple applications, whether OCXOs are exposed to micro-vibration environments caused by disturbance sources onboard spacecraft or noisy environments such as a jet aircraft landing or taking off on a carrier. An example of a compact microcontroller-based vibration compensated OCXO developed at Quantic Wenzel will be presented. Such digitally controlled OCXOs can also be employed to correct for thermal drift or errors in GPS location when GPS signals become unavailable in telecom and navigation systems.

Introduction/Background*Endometrial cancer (EC) patients have a good prognosis at early stages, but for recurrent or metastatic EC the prognosis remains poor. EC treatments are related to known prognostic factors included in ESMO-ESGO-ESTRO risk classes classification, but they are not sufficient to predict outcomes or recurrence rate of early stages. To improve patient clinical management and allow personalized therapy a better characterization of risk classes in EC is needed. To fill this gap, we investigated EC immune escape processes, customized on the knowledge of maternal-fetal interface immune mechanisms, since the two processes share common pathways.MethodologyThis has been addressed by the identification of potential shared immune-based signatures between maternal-fetal interface and EC, such as those linked to lectin-type oxidized LDL receptor 1 (LOX-1) and NALP3 inflammasome, in order to achieve a potential immune score implementation to better characterize EC risk classes. The immunohistochemical assessment of LOX-1 and NALP3 was performed on formalin-fixed paraffin-embedded (FFPE) endometrial tissues.Result(s)*41 patients divided in 3 groups were enrolled: healthy endometrial tissue, endometrial hyperplasia and EC. We detected an increased expression of LOX-1, by immunohistochemistry (IHC), within the endometrial carcinoma tissues, a lower expression in cases of hyperplasia, to arrive to an absent staining in the healthy endometrial tissue (*p< 0.05, *Kruskal-Wallis followed by Mann-Whitney test). This grading is inverted in NALP3, which expression appears to be lower in EC (*p< 0.05). A proportional relationship between LOX-1 and NALP3 expression was demonstrated (p=0.006, Spearman test, confirmed through a linear regression test): increasing the expression of LOX-1, NALP3 decreases.Abstract 501 Figure 1Immunohistochemical staining on formalin-fixed paraffin-embedded samples of endometrical tissue showing expression of LOX-1 and NALP3 markersAbstract 501 Table 1Clinical and pathologic features of enrolled featuresConclusion*An increased LOX-1 and a decreased NALP3 expression seems be associated with EC progression. To identify patients at risk of developing EC from pre-cancerous lesions, by searching potential immune prognostic factors, such as LOX-1 and NALP3 on endometrial biopsy, could re-defy the actual EC risk classes through a potential ’immune score’ creation. Nevertheless, further studies are needed to define EC transcriptome immune-based signature. Furthermore, pathways detected by deciphering the immune changes linked to EC progression, could be potential target for immunotherapy.

An intense positron sources is a demanding element in the design of future lepton colliders. A crystal-based hybrid positron source could be an alternative to a more conventional scheme based on the electron conversion into positron in a thick amorphous target. The conceptual idea of the hybrid source is to have two separate objects, a photon radiator and a photon-to-positron converter target. In such a scheme an electron beam crosses a thin axially oriented crystal with the emission of a channeling radiation, characterized by a considerably larger amount of photons if compared to Bremsstrahlung. The net result is an increase in the number of produced positrons at the converter target. In this paper we present the results of a beam test conducted at the DESY TB 21 with 5.6 GeV electron beam and a crystalline tungsten radiator. Experimental data clearly highlight an increased production of photons and they are critically compared with the outcomes of novel method to simulate the number of radiated photons, showing a very good agreement. Strong of this, the developed simulation tool has been exploited to design a simple scheme for a positron source based on oriented crystal, demonstrating the advantages in terms of reduction of both deposited energy and the peak energy deposition density if compared to conventional sources. The presented work opens the way for a realistic and detailed design of a hybrid crystal-based positron source for future lepton colliders.

Building on the work of earlier chroniclers of the Woolfs' Hogarth Press, [Helen Southworth] (Univ. of Oregon) broadens the scope to document how the Woolfs as publishers promoted the work of writers and artists (many less known) from diverse \"networks\" of the modernist era.

Ronchetti reviews The library of Leonard and Virginia Woolf: a short-title catalog compiled and edited by Julia King and Laila Miletic-Vejzovic.

46-3593 PS228 2008-15076 CIP Matuozzi, Robert N. Literary research and the American modernist era, by Robert N. Matuozzi and Elizabeth Blakesley Lindsay. Scarecrow, 2008. 173p bibl index afp (Strategies and sources, 3) ISBN 081086116X pbk, $35.00; ISBN 9780810861 169 pbk, $35.00

The availability of coherent time series of crop statistics is essential for better analyzing the past, understanding the present, and predicting future trends in yield, area, and production. Importantly, such data also underpin assessments and subsequent policy actions that can shape future food systems that are more resilient in the face of climate change and that are sustainable in terms of resource use efficiency. In the European Union (EU), there currently is no legal obligation for EU countries to provide subnational crop statistics. However, such data could improve in-season crop forecasts, climate change impacts and adaption need assessments, and evaluation of agri-environmental schemes. The dataset described in this paper includes a harmonized collection of subnational crop statistics on area, production, and yield, collected for the EU from National Statistical Institutes (NSIs) and the EUROSTAT REGIO database – subnational crop statistics voluntarily contributed by EU countries. The crops considered are wheat (including soft and durum wheat), barley (including winter and spring barley), grain maize, sunflower, and sugar beet. All data are harmonized towards the hierarchical structure of the EUROSTAT legend and the regional classification of NUTS (Nomenclature of Territorial Units for Statistics) version 2016, to provide coherent time series. A total of 344 282 records is presented here (115 974 for wheat, 122 705 for barley, 35 274 for grain maize, 34 916 for sugar beet, and 35 413 for sunflower) for a total of 961 regions in 27 EU countries. Statistics are reported from 1975 to 2020, with a median time-span range of 21 years. A flagging system details, for each data record, information on data sources, processing steps, and quality-checking results. This includes consistency checks between reported values for area, yield and production, identification of null values, missing and calculated data, information on crop legend matching, and NUTS versioning. We illustrate the value of this dataset by analyzing impacts on crops and production zone shifts in Europe due to climatic and economic factors. Recommendations and future developments of collecting subnational statistics at the EU level are briefly discussed.

We systematically reviewed and meta‐analyzed bulk RNA sequencing (RNAseq) studies comparing Alzheimer's disease (AD) patients to controls in human brain tissue. We searched PubMed, Web of Science, and Scopus for human brain bulk RNAseq studies, excluding re‐analyses and studies limited to small RNAs or gene panels. We developed 10 criteria for quality assessment and performed a meta‐analysis on three high‐quality datasets. Of 3266 records, 24 qualified for the systematic review, and one study with three datasets qualified for the meta‐analysis. The meta‐analysis identified 571 differentially expressed genes (DEGs) in the temporal lobe and 189 in the frontal lobe, including CLU and GFAP. Pathway analysis suggested reactivation of developmental processes in the adult AD brain. Limited data availability constrained the meta‐analysis. These findings underscore the need for rigorous methods in AD transcriptomic research to better identify transcriptomic changes and advance biomarker and therapeutic development. This review is registered in PROSPERO (CRD42023466522). Highlights Comprehensive review: Conducted the first systematic review and meta‐analysis of bulk RNA sequencing (RNAseq) studies comparing Alzheimer's disease (AD) patients with non‐demented controls using primary human brain tissue. Key findings: Identified 571 differentially expressed genes (DEGs) in the temporal lobe and 189 in the frontal lobe of patients with AD, revealing potential therapeutic targets. Pathway discovery: Highlighted key overlapping pathways such as “tube morphogenesis” and “neuroactive ligand‐receptor interaction” that may play critical roles in AD. Quality assessment: Emphasized the importance of methodological rigor in transcriptomic studies, including quality assessment tools to guide future research in AD. Study limitation: Acknowledged limited access to complete data tables and lack of diversity in existing datasets, which constrained some of the analysis.