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Considering that Cu(tda) chelate (tda: dithioacetate) is a receptor for adenine and related 6-aminopurines, this study reports on the synthesis, molecular and crystal structures, thermal stability, spectral properties and DFT calculations related to [Cu(tda)(9heade)(H2O)]·2H2O (1) [9heade: N9-(2-hydroxyethyl)adenine]. Concerning the molecular recognition of (metal chelate)-(adenine synthetic nucleoside), 1 represents an unprecedented metal binding pattern (MBP) for 9heade. However, unprecedentedly, the Cu(tda)-9heade molecular recognition in 1 is essentially featured in the Cu-N1(9heade) bond, without any N6-H⋯O(carboxyl tda) interligand interaction. Nevertheless, N1 being the most basic donor for N9-substituted adenines, this Cu-N1 bond is now assisted by an O2–water-mediated interaction (N6-H⋯O2 and O2⋯Cu weak contact). Also, in the crystal packing, the O-H(ol) of 9heade interacts with its own adenine moiety as a result of an O3–water-mediated interaction (O(ol)-H⋯O3 plus O3-H36⋯π(adenine moiety)). Both water-mediated interactions seem to be responsible for serious alterations in the physical properties of crystalline or grounded samples. Density functional theory calculations were used to evaluate the interactions energetically. Moreover, the quantum theory of atoms-in-molecules (QTAIM), in combination with the noncovalent interaction plot (NCIPlot), was used to analyze the interactions and rationalize the existence and relative importance of hydrogen bonding, chalcogen bonding and π-stacking interactions. The novelty of this work resides in the discovery of a novel binding mode for N9-(2-hydroxyethyl)adenine. Moreover, the investigation of the important role of water in the solid state of 1 is also relevant, along with the chalcogen bonding interactions demonstrated by the density functional theory (DFT) study.

A total of 5642 hematopoietic cell transplants (HCT) in 5445 patients (2196—40% allogeneic and 3249—60% autologous) were reported by 127 teams in 14 Latin American countries that answered the 2018 LABMT/WBMT Global Transplant Activity survey. The transplant rate (defined as the number of first transplants per 10 million inhabitants per year) was 85 (51 autologous and 34 allogeneic) in 2018. The main indications for allogeneic HCT were acute leukemias (60%), while plasma cell disorders and lymphomas were the most common conditions warranting autologous HCT (50 and 36%, respectively). In the allogeneic HCT, HLA-identical siblings were the main type of donor (44%) followed by related mismatched/haploidentical donors (32%). Peripheral blood stem cells were used in 98% of the autologous and in 64% of the allogeneic transplants. From 2012 to 2018, there was a 64% increase of reported HCT (54% in autologous and 80% in allogeneic). In the allogeneic setting, the most pronounced increase in donor type was observed in haploidentical relatives (from 94 procedures in 2012 up to 710 in 2018), surpassing unrelated donors as of 2017. Significant trends detected in Latin America include rising numbers of the procedures reported, a faster increase in allogeneic HCT compared with autologous HCT and a significant increase in family mismatched/haploidentical donors. The LABMT/WBMT activity survey provides useful data to understand the HCT activity and trends in Latin America.

The phytochemical components and antioxidant capacity of Açaí (Euterpe oleracea) give it nutritional and bioactive characteristics with anti-cancer and anti-inflammatory properties; it is exported mainly from Brazil to various places worldwide. In Ecuador, the cultivated Euterpe oleracea variety has an abundant production that has not been used or studied in depth; because of this, it is relevant to expand the study of this fruit’s phytochemical and antioxidant properties. This paper presents the results of evaluating the concentration of antioxidants and antioxidant activity in different stages of maturation and geographical locations of the Açaí, for which samples obtained in the Ecuadorian provinces of Sucumbíos and Orellana have been evaluated. Antioxidant concentrations were determined with a UV/VIS spectrophotometer at 450–760 nm wavelengths. Antioxidant capacity was determined using the ABTS and FRAP methods. It was evidenced that the values of total polyphenols and total flavonoids decrease with increasing ripening; the opposite effect occurs with total anthocyanins that have a higher concentration in ripe fruits and evidencing an antioxidant capacity that decreases with ripening determined by both methods (FRAP and ABTS).

Teachers need to be prepared to attend to all learners regardless of their abilities or needs. This implies that future teachers must develop, throughout their initial training, the necessary competencies to provide inclusive education to all students. The aim of this research was to analyze the level of development of competencies related to inclusion and attention to diversity among university students of a degree in primary education. Based on the project developed by the European Agency for Development in Special Needs Education (EADSNE) on the profile of the inclusive teacher, an ad hoc survey was prepared based on the four fundamental competencies proposed: valuing student diversity, supporting all students, working as part of a team, and developing one’s professional and personal qualities. This survey was administered to 440 students of the degree in primary education from the University of La Laguna (San Cristóbal de La Laguna, Spain). The results showed a positive development of the four competencies, with a higher development of the competencies of continuing professional development. It was also found that the students had the knowledge, skills, and attitudes necessary for promoting inclusion and encouraging attention to diversity in their classrooms.

We outline a practical approach to engaging Latino communities in dementia care research by establishing a community advisory board (CAB). Acknowledging the historical underrepresentation of Latinos in health research, we aimed to ensure that Latino perspectives and concerns were central to our research endeavors. As an initial step we adapted the Patient Advisor Toolkit 1: Orientation for Patient Advisory Committees (PAT-1) created by the Wisconsin Network for Research Support at the University of Wisconsin - Madison School of Nursing to the needs of Latino/a/e/x populations. We describe the CAB formation process, from initial outreach to community members and organizations to the recruitment, engagement, and retention of CAB members. CAB members provided guidance on the legibility and clarity of study materials and assisted with strategic planning for outreach initiatives related to healthy aging, brain health, and dementia risk reduction. Our enduring connections with CAB members and community partners have ensured that our research activities address community needs, provide benefits to the community, and inform our approach to connecting with Latinos in a culturally appropriate way. To foster successful CAB engagement and retention, we recommend 1) building trust with partners, 2) establishing clear expectations, 3) ensuring inclusive communication formats, 4) maintaining open communication, 5) offering honoraria and recognition, 6) affirming CAB members' contributions, 7) understanding power dynamics between the academic institution and the community, and 8) ensuring adequate staff and programmatic support. This approach fosters trust-based relationships and meaningful engagement that advances health equity.

Maize (Zea mays L.) germplasm accessions in Mexico have been studied for grain yield and other traits. The cornhusk, or totomoxtle, is more important than the grain for Mexican peasant farmers because it generates increased income. However, limited information is available on the level of phenotypic variation in cornhusk traits, and few studies have been performed on the potential of maize landraces for the production of cornhusk. This study assessed maize landraces from three regions in Mexico. These landraces (as well as checks) were evaluated at multiple locations using lattice designs. The measured variables included the per‐plant grain yield, cornhusk length and width, ear coverage, and cornhusk, peduncle and ear weight. A cluster analysis of the data from the three regions grouped populations according to their region of origin. Morphological diversity within the cornhusk traits among maize landraces was found in the three regions, and landraces from Tehuacan had the greatest potential for cornhusk production. The measured cornhusk traits were superior in the maize landraces compared with those of the improved hybrids. The cornhusk weight, length and width, and ear coverage were the most effective traits for grouping according to population origin and discriminating among the populations. Thus, these traits are proposed as phenotypic selection criteria for identifying promising maize populations and initiating breeding programs for improved cornhusk production.

Este artículo analiza el proceso de configuración profesional de la enfermería en la provincia de Tucumán, vinculado a la adopción de conocimientos y prácticas, y a su legitimación a través de un título habilitante necesario para el ejercicio de la profesión. En este sentido, con el objetivo de reconstruir las instancias de dicho proceso en diferentes contextos, abordamos tres cuestiones centrales: el origen de primera Escuela de enfermeros y enfermeras en el ámbito municipal a comienzos del siglo XX; los elementos de continuidad en la línea de la profesionalización en las décadas siguientes; y la creación de otras escuelas de distinta dependencia, en particular la Escuelas de enfermería de la Universidad Nacional de Tucumán y de la provincia a mediados de siglo.

Background Latino/a/e/x caregivers of children or individuals with disabilities or developmental delays face significant stress, which increases their risk for cognitive decline, including Alzheimer's disease and related dementias. While Mindfulness‐Based Interventions effectively reduce stress and promote brain health, culturally tailored programs for this population remain limited. The purpose of this study is to describe the acceptability and feasibility of culturally tailored mindfulness workshop that promotes brain health among Latino/a/e/x caregivers. Method Two workshops were conducted in 2024consisting of six weekly one‐hour sessions incorporating mindfulness techniques. Sessions were conducted in Spanish, with supporting materials tailored for cultural relevance and practical application. In the final session of each workshop, participants shared feedback on how the program helped them better understand their stress responses and behavioral patterns. Result A total of 23 caregivers participated in the workshops hosted by both organizations, with 69.57% attending at least five of the six sessions. During the final session, participants reported a deeper understanding of how stress manifests in their daily lives, including its physical effects such as headaches, fatigue, and muscle tension, as well as its emotional impact, such as irritability and feelings of being overwhelmed. Also, participants highlighted the value of emotional regulation techniques in diffusing tense situations with their families. Others noted that the group discussions fostered a sense of belonging, helping them feel less isolated in their caregiving challenges. Host organizations emphasized that the program was highly relevant to the caregivers' needs and aligned with their cultural values and experiences. However, both programs faced challenges related to scheduling. Sessions rarely started on time, as adjustments were often required to accommodate participants' arrival and to ensure adequate session completion. This logistical issue impacted the overall timing and required flexibility from facilitators. Conclusion These pilot programs demonstrate that culturally adapted mindfulness workshops are feasible and effective in addressing stress among Latino/a/e/x caregivers of children with or without disabilities. These interventions show promise for improving brain health and well‐being in underserved populations.

Latino/a/e/x caregivers of children or individuals with disabilities or developmental delays face significant stress, which increases their risk for cognitive decline, including Alzheimer's disease and related dementias. While Mindfulness-Based Interventions effectively reduce stress and promote brain health, culturally tailored programs for this population remain limited. The purpose of this study is to describe the acceptability and feasibility of culturally tailored mindfulness workshop that promotes brain health among Latino/a/e/x caregivers. Two workshops were conducted in 2024consisting of six weekly one-hour sessions incorporating mindfulness techniques. Sessions were conducted in Spanish, with supporting materials tailored for cultural relevance and practical application. In the final session of each workshop, participants shared feedback on how the program helped them better understand their stress responses and behavioral patterns. A total of 23 caregivers participated in the workshops hosted by both organizations, with 69.57% attending at least five of the six sessions. During the final session, participants reported a deeper understanding of how stress manifests in their daily lives, including its physical effects such as headaches, fatigue, and muscle tension, as well as its emotional impact, such as irritability and feelings of being overwhelmed. Also, participants highlighted the value of emotional regulation techniques in diffusing tense situations with their families. Others noted that the group discussions fostered a sense of belonging, helping them feel less isolated in their caregiving challenges. Host organizations emphasized that the program was highly relevant to the caregivers' needs and aligned with their cultural values and experiences. However, both programs faced challenges related to scheduling. Sessions rarely started on time, as adjustments were often required to accommodate participants' arrival and to ensure adequate session completion. This logistical issue impacted the overall timing and required flexibility from facilitators. These pilot programs demonstrate that culturally adapted mindfulness workshops are feasible and effective in addressing stress among Latino/a/e/x caregivers of children with or without disabilities. These interventions show promise for improving brain health and well-being in underserved populations.

Background Memory loss can significantly impact an individual's quality of life, prompting many to seek professional care. Understanding the motivations behind this decision is crucial for developing effective interventions and outreach strategies. Among Latino individuals, cultural, social, and personal factors play a significant role in the decision to seek memory care. The purpose of this study was to explore these motivations to seek care in a diverse sample of Latino/a/e/x individuals living in the US, to better understand their unique challenges and develop tailored strategies to encourage timely memory care. Methods A validated survey was administered in the United States and Puerto Rico between 2021 and 2024. The study targeted self‐identified Latino/a/e/x adults aged 18 and older. The survey consisted of 47 items, utilizing a 5‐point Likert scale to evaluate knowledge about dementia, and the domains of the theory of planned behavior (behavioral beliefs, normative beliefs, and perceived control). Data were summarized using descriptive statistics, Chi‐square tests, and the non‐parametric Mann‐Whitney U test. A multinomial logistic regression analysis was used to determine factors that were associated with the intention to seek care. Results The survey was completed by 1,019 Latino/a/e/x individuals, 74% of whom were women, with an average age of 46.2 years (range 18–94) (Table 1). Overall, 70% of participants reported being very or extremely likely to see a doctor if they were experiencing memory problems that affected their daily routine (Table 1). The final model identified the following factors as associated with the intention to seek care: age, confidence that doctors would identify the cause, importance of knowing the cause, family approval, and ease of seeking help (Table 2). The model fit statistics indicated a good fit, with a ‐2 Log L of 1030.949 and an AIC of 1054.949. Conclusions The results of our study show that for Latino/a/e/x individuals, the decision to seek care is directly related to age, family approval, and the desire to learn the cause of the symptoms. Future research should explore what factors affect the ease of access to services as their inclusion in standard care could incentivize timely access to healthcare services.